The hepatorenal syndrome

Pediatric Nephrology

Volumn 10, Issue 1, 1996, Pages 100-107

  Van Roey, Guy ^a,b   Moore, Kevin ^a  

^a ROYAL FREE HOSPITAL   (United Kingdom)

^b UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

Cirrhosis; Hepatorenal syndrome; Liver failure; Renal failure

Indexed keywords

CYTOKINE; DOPAMINE; ENDOTHELIN; NITRIC OXIDE; NORADRENALIN; ORNIPRESSIN; POTASSIUM CHANNEL; PROSTACYCLIN; THROMBOXANE A2; VASOACTIVE AGENT; VASOPRESSIN;

ADRENERGIC SYSTEM; DIALYSIS; ENDOTOXEMIA; GLOMERULUS CAPILLARY; GLOMERULUS FILTRATION; HEPATORENAL SYNDROME; HUMAN; KIDNEY FAILURE; KIDNEY PERFUSION; LIVER DISEASE; LIVER FAILURE; LIVER TRANSPLANTATION; PARACENTESIS; PRIORITY JOURNAL; PROGNOSIS; REVIEW; ULTRAFILTRATION; VASOCONSTRICTION; VASODILATATION;

ADULT; CHILD; HEPATORENAL SYNDROME; HUMANS;

EID: 0030032777     PISSN: 0931041X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004670050077     Document Type: Review

References (110)

1. Epstein M (1988) Hepatorenal syndrome. In: Epstein M (ed) The kidney in liver disease. Williams and Wilkins, Baltimore, pp 89-118
2. Dudley F, Kanel G, Wood L, Reynolds T (1986) Hepatorenal syndrome without avid sodium retention. Hepatology 6: 248-251
3. Mandal AK, Lansing M, Fahmy A (1982) Acute tubular necrosis in hepatorenal syndrome: an electron microscopic study. Am J Kidney Dis 2: 368-374
4. Wilkinson SP, Hirst D, Williams R (1978) Spectrum of renal tubular damage in renal failure secondary to cirrhosis and fulminant hepatic failure. J Clin Pathol 31: 101-107
5. Papper S (1983) Hepatorenal syndrome. In: Epstein M (ed) The kidney in liver disease, 2nd edn. Elsevier, New York, pp 87-106
6. Solez K, Racusen LC, Jewell LD (1988) Pathology of acute renal failure occurring in liver disease. In: Epstein M (ed) The kidney in liver disease, 3rd edn. Williams and Wilkins, Baltimore, pp 182-206
7. Gonwa TA, Morris CA, Goldstein RM, Husberg BS, Klinthalm GB (1991) Long-term survival and renal function following liver transplantation in patients with and without hepatorenal syndrome-experience in 300 patients. Transplantation 51: 428-430
8. Ellis D, Avner ED, Starzl TE (1986) Renal failure in children with hepatic failure undergoins liver transplantation J Pediatr 108: 393-398
9. Wood RP, Ellis D, Starzl TE (1987) The reversal of the hepatorenal syndrome in four pediatric patients following successful orthotopic liver transplantation. Ann Surg 205: 415-419
10. Distant DA, Gonwa TA (1993) The kidney in liver transplantation. J Am Soc Nephrol 4: 129-136
11. Otte B, Ville de Goyet J de, Reding R, Hausleithner V, Sokal E, Chardot C, Debande B (1994) Sequential treatment of biliary atresia with portoenterostomy and liver transplantation: a review. Hepatology 20: 41S-48S
12. Mowat AP (1992) Orthotopic liver transplantation in Liver-based metabolic disorders. Eur J Pediatr 151 [Suppl 1]: S32-S38
13. Kalayoglu M, Stratta RJ, Sollinger HW, Hoffmann RM, D'Alessandro AM, Pirsch JD, Beizer FO (1989) Liver transplantation in infants and children. J Pediatr Surg 24: 70-76
14. Shaw BW Jr, Wood RP, Kaufman SS, Williams L, Antonson DL, Kelly DA, Vanderhoof JA (1988) Liver transplantation therapy for children. II. J Pediatr Gastroenterol Nutr 7: 797-815
15. Filipponi F, Soubrane O, Labrousse F, Devictor D, Bernard O, Valayer J, Houssin D (1994) Liver transplantation for end-stage liver disease associated with alpha-1-antitrypsin deficiency in children: pretransplant natural history, timing and results of transplantation. J Hepatol 20: 72-78
16. Devictor D, Desplanques L, Debray D, Ozier Y, Dubousset AM, Valayer J, Houssin D, Bernard O, Huault G (1992) Emergency liver transplantation for fulminant liver failure in infants and children. Hepatology 16: 1156-1162
17. Psacharopoulos HT, Mowat AP, Davies M, Portmann B, Silk DB, Williams R (1980) Fulminant hepatic failure in childhood. Arch Dis Child 55: 252-258
18. Saunders SJ, Hickman R, Macdonald R, Terblanche SJ (1972) The treatment of acute liver failure. In: Popper H, Schaffner F (eds) Progress in liver disease, vol 4. Grune and Stratton, New York, pp 333-344
19. Rueff B, Benhamou JP (1973) Progress report. Acute hepatic necrosis in fulminant hepatic failure. Gut 14: 805-815
20. Selkurt EE (1946) The relation of renal blood flow to effective arterial pressure in the intact kidney of the dog. Am J Physiol 147: 537-549
21. Stein JH (1990) Regulation of the renal circulation. Kidney Int 38: 571-576
22. Navar LG (1978) Renal autoregulation: perspectives from whole kidney and single nephron studies. Am J Physiol 234: F357-F370
23. Persson PB, Ehmke H, Nafz B, Kirchheim HR (1990) Sympathetic modulation of renal autoregulation by carotid occlusion in conscious dogs. Am J Physiol 258: F364-F370
24. Fernandez-Seara J, Prieto J, Quiroga J, Zozaya JM, Cobos MA, Rodriguez-Eire JL, et al. (1989) Systemic and regional hemodynamics in patients with liver cirrhosis and ascites with and without functional renal failure. Gastroenteroiogy 97: 1304-1312
25. Mullane JR, Gliedman ML (1966) Elevation of the pressure of the abdominal inferior vena cava as a cause of the hepatorenal syndrome in cirrhosis. Surgery 59: 1135-1146
26. Cade R, Wagemaker H, Vogel S, Mars D, Hood-Lewis D, Privette M, et al. (1987) Hepatorenal syndrome: studies on the effect of vascular volume and intraperitoneal pressure on renal and hepatic function. Am J Med 82: 427-438
27. Henriksen JH, Ring-Larsen H (1988) Raised renal venous pressure: direct cause of renal sodium retention in cirrhosis? Lancet II: 8602
28. Panos MZ, Moore K, Vlavianos P, Chambers JB, Anderson JV, Gimson AE, Slater JD, Rees LH, Westaby D, Williams R (1990) Single, total paracentesis for tense ascites: sequential hemodynamic changes and right atrial size Hepatology 11: 662-667
29. Schrier R, Arroyo V, Bernardi M, Epstein M, Henriksen J, Rodes J (1988) Peripheral vasodilation hypothesis. A proposal for the initiation of renal sodium and water retention in cirrhosis. Hepatology 8: 1151-1157
30. Fernandez-Rodriguez CM, Prieto J, Zozaya JM, Quiroga J, Guitian R (1993) Arteriovenous shunting, hemodynamic changes, and renal sodium retention in liver cirrhosis. Gastroenteroiogy 104: 1139-1145
31. Groszmann RJ (1994) Hyperdynamic circulation of liver disease 40 years later: pathophysiology and clinical consequences. Hepatology 20: 1359-1363
32. Schrier RW (1988) Pathogenesis of sodium and water retention in high-output and low output cardiac failure, nephrotic syndrome, cirrhosis and pregnancy. N Engl J Med 319: 1127-1134
33. Vallance P, Moncada S (1991) Hyperdynamic circulation in cirrhosis: a role for nitric oxide? Lancet 337: 776-778
34. Bomzon A, Blendis LM (1994) The nitric oxide hypothesis and the hyperdynamic circulation in cirrhosis. Hepatology 20: 1343-1350
35. Stark ME, Szurszewski JH (1992) Role of nitric oxide in gastro-intestinal and hepatic function and disease. Gastroenterology 103: 1928-1949
36. Hecker M, Mülsch A, Bassenge E, Busse R (1993) Vasoconstriction and increased flow: two principle mechanisms of shear stress-dependent endothelial autacoid release. Am J Physiol 265: H828-H833
37. Pak JM, Lee SS (1994) Review: glucagon in portal hypertension. J Hepatol 20: 825-832
38. Hirokawa K, O'Shaughnessy K, Moore K, Ramrakha P, Wilkins MR (1994) Induction of nitric oxide synthase in cultured vascular smooth muscle cells: the role of cyclic AMP. Br J Pharmacol 112: 396-402
39. Guarner F, Guarner C, Prieto J, Colina L, Quiroga J, Casas J, Freixa R, Rosello J, Gelpi E, Balanzo J (1986) Increased synthesis of systemic prostacyclin in cirrhotic patients. Gastroenterology 90: 687-694
40. Moore K, Ward P, Taylor G, Williams R (1991) Systemic and renal production of thromboxane A2 and prostacyclin in decompensated liver disease and hepatorenal syndrome. Gastroenterology 100: 1069-1077
41. Bruix J, Bosch J, Kravetz D, Mastai R, Rodés J (1985) Effects of prostaglandin inhibition on systemic and hepatic hemodynamics in patients with cirrhosis of the liver Gastroenterology 88: 430-435
42. Moreau R, Komeichi H, Kirstetter P, Ohsuga M, Cailmail S, Lebrec D (1994) Altered control of vascular tone by adenosine triphosphate sensitive potassium channels in rats with cirrhosis. Gastroenterology 106: 1016-1023
43. Wilkinson SP, Moodie H, Stamatakis JD, Kakkar VV, Williams R (1976) Endotoxaemia and renal failure in cirrhosis and obstructive jaundice BMJ 2: 1415-1418
44. Triger DR (1991) Endotoxemia in liver disease-time for re-appraisal? J Hepatol 12: 136-138
45. Bourgoignie JJ, Valle GA (1988) Endotoxin and renal dysfunction in liver disease. In: Epstein M (ed) The kidney in liver disease, 3rd edn. Williams and Wilkins, Baltimore, pp 486-507
46. Lumsden AB, Henderson JM, Kutner MH (1988) Endotoxin levels measured by a chromogenic assay in portal hepatic and peripheral venous blood in patients with cirrhosis. Hepatology 8: 232-236
47. Levy M, Wexler MJ (1984) Subacute endotoxemia in dogs with experimental cirrhosis and ascites: effect on kidney function. Can J Physiol Pharmacol 62: 673-679
48. Lee SS, Pak JM (1992) Adenosine receptor blockade reduces splanchnic hyperemia in cirrhotic rats. Hepatology 15: 1107-1111
49. Rossi N, Churchill P, Ellis V, Amore B (1988) Mechanism of adenosine receptor-induced renal vasoconstriction in rats. Am J Physiol 255. H885-H890
50. Schroeder ET, Eich RH, Smulyan H, et al. (1970) Plasma renin level in hepatic cirrhosis: relation to functional renal failure. Am J Med 49: 189-191
51. Bernardi M, Trevisam F, Gasbarrini G (1990) The renin-angiotensin-aldosterone system in liver disease. In: Bomzon A, Blendis LM (eds) Cardiovascular complications of liver disease. CRC Press, Boca Raton, pp 29-62
52. Barnardo D, Summerskill WHJ, Strong CG, Baldus WP (1970) Renal function, renal activity and endogenous vasoactive substances in cirrhosis. Ana J Dig Dis 15: 419-425
53. Laragh JH, Cannon PJ, Bentzel CJ, et al. (1963) Angiotensin II, norepinephrine, and renal transport of electrolytes and water in normal man and in cirrhosis with ascites. J Clin Invest 42: 1179-1192
54. Cobden I, Shore A, Wilkinson R, Record CO (1985) Captopril in the hepatorenal syndrome. J Clin Gastroenterol 7: 354-360
55. Wilkinson SP, Williams R (1980) Renin-angiotensin-aldosterone system in cirrhosis. Gut 21: 545-554
56. Gentilini P, Romanelli RG, La Villa G, et al. (1993) Effects of low dose captopril on renal hemodynamics and function in patients with cirrhosis of the liver. Gastroenterology 104: 588-594
57. Pariente EA, Bataille C, Bercoff E, Lebrec D (1985) Acute effects of captopril on systemic and renal hemodynamics and renal function in cirrhotic patients with ascites. Gastroenterology 88: 1255-1259
58. Wood LJ, Goergen S, Stockigt JR, et al. (1985) Adverse effects of captopril in treatment of resistant ascites, a state of functional bilateral renal artery stenosis (letter). Lancet II: 1008-1009
59. Schroeder ET, Anderson GH (1976) Effect of blockade of angiotensin II on blood pressure, renin and aldosterone in cirrhosis. Kidney Int 9: 511-519
60. Epstein M, Weitzman RE, Preston S, Denunzio AG (1984) Relationship between plasma arginine vasopressin and renal water handling in decompensated cirrhosis. Miner Electrolyte Metab 10: 155-165
61. Bichet D, Szatalawicz W, Chaimovitz C, Schrier RW (1982) Role of vasopressin in abnormal water excretion in cirrhosis patients. Ann Intern Med 96: 413-417
62. Clàra J, Jiménez W, Arroyo V, et al. (1991) Effect of VI-vasopressin receptor blockade on arterial pressure in conscious rats with cirrhosis and ascites. Gastroenterology 100: 494-501
63. Lenz K, Hortnagl H, Druml W, Reither H, Schmid R, Schneeweiss B, et al. (1991) Ornipressin in the treatment of functional renal failure in decompensated cirrhosis. Gastroenterology 101: 1060-1067
64. Kew MC, Varna RR, Sampson DJ, Sherlock S (1972) The effect of octapressm on renal and intrarenal blood flow in cirrhosis. Gut 13: 293-296
65. Conn JN, Tristani FE, Khatri IM (1968) Systemic vasoconstrictor and renal vasodilator effect of PVL2 (octapressin) in man. Circulation 38: 151-157
66. Epstein M (1986) Renal prostaglandins and the control of renal function in liver disease. Am J Med 80: 46-61
67. Laffi G, La Villa G, Pinzani M, et al. (1986) Altered renal and platelet arachidonic acid metabolism in cirrhosis. Gastroenterology 90: 274-282
68. Zipser R, Hoefs J, Speckart P, Zia P, Horton R (1979) Prostaglandins: modulators of renal function and pressor resistance in chronic liver disease. J Clin Endocrinol Metab 48: 895-900
69. Rimola A, Gines P, Arroyo V, Camps J, Peres-Ayuso RM, Quintero E, Gaya J, Rivera F, Rodes J (1986) Urinary excretion of 6-keto-prostaglandin F1 alpha, thromboxane B2 and prostaglandin E2 in cirrhosis with ascites: relationship to functional renal failure (hepatorenal syndrome). J Hepatol 3: 111-117
70. Guarner C, Colina I, Guarner F, Corzo J, Prieto J, Vilardi F (1986) Renal prostaglandins in cirrhosis of the liver. Clin Sci 70: 477-484
71. Boyer T, Zia P, Reynolds T (1979) Effect of indomethacin and prostaglandin A, on renal function and plasma renin activity in alcoholic liver disease. Gastroenterology 77: 215-222
72. Fevery J, Van Cutsem E, Nevens F, Van Steenbergen W, Verberckmoes R, De Groote J (1990) Reversal of the hepatorenal syndrome in four patients by peroral misoprostol and albumin administration. J Hepatol 11: 153-158
73. Van Roey G, Van Nerom C, Fevery J (1993) Misoprostol causes increased diuresis without changing GFR/RPF in cirrhotic rats with ascites. J Hepatol 18: S61
74. Arieff A, Chidsey C (1974) Renal function in cirrhosis and the effects of prostaglandin A1. Am J Med 56: 695-703
75. Govindarajan S, Nast CC, Smith WL, et al. (1987) Immunohistochemical distribution of renal endoperoxide synthase and prostacyclin synthase: diminished endoperoxide synthase in the hepatorenal syndrome. Hepatology 7: 654-659
76. Henriksen JH, Ring-Larsen H (1994) Hepatorenal disorders: role of the sympathetic nervous system. Semin Liver Dis 14: 35-43
77. Nicholls KM, Shapiro MD, Van Putten VJ, et al. (1985) Elevated plasma norepinephrine concentrations in decompensated cirrhosis. Association with increased secretion rates, normal clearance rates, and suppressibility by control blood volume expansion. Circ Res 56: 457-461
78. Zambraski EJ, DiBona GF (1988) Sympathetic nervous system in hepatic cirrhosis. In: Epstein M (ed) The kidney in the liver disease, 3rd edn. Williams and Wilkins, Baitimore, pp 469-485
79. Bichet DG, Van Putten VJ, Schrier RW (1982) Potential role of increased sympathetic activity in impaired sodium and water excretion in cirrhosis. N Engl J Med 307: 1552-1557
80. Gaudin C, Braillon A, Poo JL, Moreau R, Hadengue A, Lebrec D (1991) Regional sympathetic activity, severity of liver disease and hemodynamics in patients with cirrhosis. J Hepatol 13: 161-168
81. Henriksen JH, Ring-Larson H Christensen NJ, (1981) Noradrenaline and adrenaline concentrations in various vascular beds in patients with cirrhosis. Relation to haemodynamics. Clin Physiol 1: 293-304
82. Henriksen JH, Ring-Larson H, Christensen NJ (1988) Kidney, lower limb, and whole-body uptake and release of catecholamines in alcoholic liver disease. Clin Physiol 8: 203-210
83. Kostreva D, Castaner A, Kampine J (1980) Reflex effects of hepatic baroreceptors on renal and cardiac sympathetic nerve activity. Am J Physiol 238: R390-R394
84. Levy M, Wexler MJ (1987) Hepatic denervation alters first-phase urinary sodium excretion in dogs with cirrhosis. Am J Physiol 253: F664-F671
85. Lang F, Tschernko E, Schulze E, Ottl I, Ritter M, Völkl H, Hallbrucker C, Häussinger D (1991) Hepatorenal reflex regulating kidney function. Hepatology 14: 590-594
86. Kjaer K, Jurlander J, Keiding S, Galbo H, Kirkegaard P, Hage E (1994) No reinnervation of hepatic sympathetic nerves after liver transplantation in human subjects. J Hepatol 20: 97-100
87. Solis-Herruzo JA, Duran A, Favelza V, Castellano G, Madrid JL, Munoz-Yague, et al. (1987) Effects of lumbar sympathetic block on kidney function in cirrhotic patients with hepatorenal syndrome. J Hepatol 5: 167-173
88. Wilkinson SP, Bernardi M, Smith K, et al. (1977) Effect of β-adrenergic blocking drugs on the renin-aldosterone system, sodium excretion, and renal hemodynamics in cirrhosis with ascites. Gastroenterology 73: 659-663
89. Rector WG, Reynolds TB (1984) Propranolol in the treatment of cirrhotic ascites. Arch Intern Med 144: 1761-1763
90. Shohat J, Laina A, Serban I, et al. (1979) The effect of propranolol on renal sodium handling in patients with cirrhosis. Biomed 31: 128-131
91. Hecker R, Sherlock S (1956) Electrolyte and circulatory disturbances in terminal liver failure. Lancet II: 348-350
92. Ring-Larsen H, Palazzo U (1981) Renal failure in fulminant hepatic failure and terminal cirrhosis: a comparison between incidence, types, and prognosis Gut 22: 585-891
93. Moller S, Emmeluth C, Henriksen JH (1993) Elevated circulating plasma endothelin-1 concentrations in cirrhosis. J Hepatol 19: 285-290
94. Asbert M, Gines A, Gines P, Jimenez W, Claria J, Salo J, et al. (1993) Circulating levels of endothelin in cirrhosis. Gastroenterology 104: 1485-1491
95. Uchihara M, Izumi N, Sato C, Marumo F (1992) Clinical significance of elevated plasma endothelin concentration in patients with cirrhosis. Hepatology 16: 95-99
96. Moore K, Wendon J, Frazer M, Karani J, Williams R, Badr K (1992) Plasma endothelin immunoreactivity in liver disease and the hepatorenal syndrome. N Engl J Med 327: 1774-1778
97. Sorensen SS, Madsen JK, Pedersen EB (1994) Systemic and renal effect of intravenous infusion of endothelin-1 in healthy human volunteers. Am J Physiol 266: F411-F418
98. Asbert M, Gines A, Gines P, Jimenez W, Claria J, Salo J, Arroyo V, Rivera F, Rodes J (1993) Circulating levels of endothelin in cirrhosis. Gastroenterology 104: 1485-1491
99. Moore KP, Taylor GW, Gove C, Wood J, Tan KC, Eason J, Williams R (1992) Synthesis and metabolism of cysteinyl leukotrienes by the isolated pig kidney. Kidney Int 41: 1543-1548
100. Moore KP, Taylor GW, Maltby NH, Siegers D, Fuller RW, Dollery CT, Williams R (1990) Increased production of cysteinyl leukotrienes in hepatorenal syndrome. J Hepatol 11: 263-271
101. Uemura M, Buchholz U, Kojima H, Keppler A, Hafkemeyer P, Fukui H, Tsujii T, Keppler D (1994) Cysteinyi leukotrienes in the urine of patients with liver diseases. Hepatology 20: 804-812
102. Huber M, Kastner S, Scholmerich J, Gerok W, Keppler D (1989) Analysis of cysteinyl leukotrienes in human urine: enhanced excretion in patients with liver cirrhosis and hepatorenal syndrome. Eur J Clin Invest 19: 53-60
103. Zipser RD, Radvan GH, Kronborg IJ, Duke R, Little TE (1983) Urinary thromboxane B2 and prostaglandin E2 in the hepatorenal syndrome: evidence for increased vasoconstrictor and decreased vasodilator factors. Gastroenterology 84: 697-703
104. Zipser RD, Kronborg I, Rector W, Reynolds T, Daskalopoulos G (1984) Therapeutic trial of thromboxane synthesis inhibition in the hepatorenal syndrome. Gastroenterology 87: 1228-1232
105. Bennett WM, Keeffe E, Melnyk C, Mahler D, Rosch J, Porter GA (1975) Response to dopamine hydrochloride in the hepatorenal syndrome. Arch Intern Med 135: 964-971
106. Barnardo DE, Baldus WP, Maher FT (1970) Effects of dopamine on renal function in patients with cirrhosis. Gastroenterology 58: 524-531
107. Linas SL, Schaefer JW, Moore EE, Good JT Jr, Giansiracusa R (1986) Peritoneovenous shunt in the management of the hepatorenal syndrome. Kidney Int 30: 736-740
108. Ochs A, Rossle M, Haag K, Hauenstein KH, Peibert P, Siegerstetter V, Huonker M, Langer M, Blum H (1995) The transjugular intrahepatic portosystemic stent shunt procedure for refractory ascite. N Engl J Med 332: 1192-1197
109. Iwatsuki S, Popovtzer MM, Corman JL, Ishikawa M, Putman CW, Katz FH, Starzl TE (1973) Recovery from "hepatorenal syndrome" after orthotopic liver transplantation. N Engl J Med 289: 1155-1159
110. Morrow JD, Moore KP, Awad JA, Ravenscraft MD, Marini G, Badr KF, Williams R, Roberts LJ II (1993) Marked over-production of non-cyclooxygenase derived prostanoids (F2-isoprostanes) in the hepatorenal syndrome. J Lipid Mediators 6: 417-420