Quantitative assessment of the epithelial and inflammatory cell populations in large airways of normals and individuals with cystic fibrosis

American Journal of Respiratory and Critical Care Medicine

Volumn 153, Issue 1, 1996, Pages 362-368

  Danel, Claire ^b   Erzurum, Serpil C ^b   Mcelvaney, Noel C ^b   Crystal, Ronald C ^a  

^a WEILL CORNELL MEDICAL CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BRONCHUS BIOPSY; CILIATED EPITHELIUM; CONTROLLED STUDY; CYSTIC FIBROSIS; FEMALE; HUMAN; HUMAN CELL; INFLAMMATORY CELL; MALE; PRIORITY JOURNAL; QUANTITATIVE DIAGNOSIS; RESPIRATORY EPITHELIUM;

EID: 0030032624     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.153.1.8542144     Document Type: Article

References (35)

1. Boat, T. F., M. J. Welsh, and A. L. Beaudet. 1989. The metabolic basis of inherited disease. In C. R. Scriver, A. L. Beaudet, W. S. Sly, and D. Valle, editors. Cystic Fibrosis. McGraw-Hill, New York. 2649-2680.
2. Rommens, J. M., M. C. Iannuzzi, B.-S. Kerem, M. L. Drumm, G. Melmer, M. Dean, R. Rozmahel, J. L. Cole, D. Kennedy, N. Hidaka, M. Zsiga, M. Buchwald, J. R. Riordan, L.-C. Tsui, and F. S. Collins. 1989. Identification of the cystic fibrosis gene: chromosome walking and jumping. Science 245:1059-1065.
3. - channel activity in Xenopus oocytes expressing the cystic fibrosis gene. J. Biol. Chem. 266:19142-19145.
4. Welsh, M. J., and A. E. Smith. 1991. Molecular mechanisms of CFTR chloride channel dysfunction in cystic fibrosis. Cell 73:1251-1254.
5. 1-antitrypsin to suppress the burden of active neutrophil elastase on the respiratory epithelial surface in cystic fibrosis. Lancet 337:392-394.
6. Birrer, P., N. G. McElvaney, A. Rudeberg, C. Wirz-Sommer, S. Liechti-Gallati, R. Kraemer, R. Hubbard, and R. G. Crystal. 1994. Protease-antiprotease imbalance in the lungs of children with cystic fibrosis. Am. J. Respir. Crit. Care Med. 150:207-213.
7. Zabner, J., L. A. Couture, R. J. Gregory, S. M. Graham, A. E. Smith, and M. J. Welsh. 1993. Adenovirus-mediated gene transfer transiently corrects the chloride transport defect in nasal epithelia of patients with cystic fibrosis. Cell 75:207-216.
8. Crystal, R. G., N. G. McElvaney, M. A. Rosenfeld, C.-S. Chu, A. Mastrangeli, J. G. Hay, S. L. Brody, H. A. Jaffe, N. T. Eissa, and C. Danel. 1994. Administration of an adenovirus vector containing the normal human CFTR cDNA to the respiratory tract of individuals with cystic fibrosis. Nat. Genet. 8:42-51.
9. McElvaney, N. G., and R. G. Crystal. 1995. IL-6 release associated with airway administration of human CFTR cDNA adenovirus vector. Nat. Med. 1:182-184.
10. Michaelson, E. D., and S. M. Serafini. 1975. Quantitative differences in the cellular yield of two bronchial brushes. Am. Rev. Respir. Dis. 112:267-268.
11. Bedrossian, C. W. M., and D. L. Rybka. 1976. Bronchial brushing during fiberoptic bronchoscopy for the cytodiagnosis of lung cancer: comparison with sputum and bronchial washings. Acta Cytol. 20:446-453.
12. Zavala, D. C. Bronchoscopy, lung biopsy, and other procedures. In J. F. Murray and J. A. Nadel, editors. Respiratory Medicine. W. B. Saunders, Philadelphia. 562-596.
13. Rutland, J., A. Dewar, T. Cox, and P. Cole. 1981. Nasal brushing for the study of ciliary ultrastructure. Tech. Methods 8:357-359.
14. Trapnell, B. C., C.-S. Chu, P. K. Paakko, T. C. Banks, K. Yoshimura, V. J. Ferrans, M. S. Chernick, and R. G. Crystal. 1991. Expression of the cystic fibrosis transmembrane conductance regulator gene in the respiratory tract of normal individuals and individuals with cystic fibrosis. Proc. Natl. Acad. Sci. U.S.A. 88:6565-6569.
15. 1-antitrypsin gene to the lung epithelium in vivo. Science 252:431-434.
16. Rosenfeld, M. A., K. Yoshimura, B. C. Trapnell, K. Yoneyama, E. R. Rosenthal, W. Dalemans, M. Fukayama, J. Bargon, L. E. Stier, L. Stratford-Perricaudet, M. Perricaudet, W. B. Guggino, A. Pavirani, J.-P. Lecocq, and R. G. Crystal. 1992. In vivo transfer of the human transfer cystic fibrosis transmembrane conductance regulator gene to the airway epithelium. Cell 68:143-155.
17. Bedrossian, C. W. M., P. A. Accetta, and L. V. Kelly. 1983. Cytopathology of nonneoplastic pulmonary disease. Lab. Med. 14:86-95.
18. Verra, F., J. Fleury-Feith, M. Boucherai, M.-C. Pinchon, J. Bignon, and E. Escudier. 1993. Do nasal ciliary changes reflect bronchial changes? Am. Rev. Respir. Dis. 147:908-913.
19. Bridges, M. A., A. George, F. Davidson, and D. C. Walker. 1991. Cystic fibrosis and control nasal epithelial cells harvested by a brushing procedure. J. In Vitro Cell Dev. Biol. 27A:684-686.
20. Kelsen, S. G., I. A. Mardini, Z. Shuangwen, J. L. Benovic, and N. C. Higgins. 1992. A technique to harvest viable tracheobronchial epithelial cells from living human donors. Am. J. Respir. Cell Mol. Biol. 7:66-72.
21. Riise, G. C., S. Larsson, and B. A. Anderson. 1992. A bronchoscopic brush biopsy study of large airway mucosal pathology in smokers with chronic bronchitis and in healthy nonsmokers. Eur. Respir. J. 5: 382-386.
22. Gilain, L., E. Escudier, C. Chapelin, M. Boucherat, V. Faulcon, and R. Peynegre. 1992. Brush technique in cytological analysis of the nasal mucosa. A critical and comparative analysis. Ann. Otolaryngol. 109:397-401.
23. 2. J. Appl. Physiol. 75:1256-1262.
24. + adenovirus vectors for gene therapy for the respiratory manifestations of cystic fibrosis. Hum. Gene. Ther. 5:1105-1114.
25. Saltini, C., A. J. Hance, V. J. Ferrans, F. Basset, P. B. Bitterman, and R. G. Crystal. 1984. Accurate quantification of cells recovered by bronchoalveolar lavage. 130:650-658.
26. Breeze, R. G., and E. B. Wheeldon. 1977. The cells of the pulmonary airways. Am. Rev. Respir. Dis. 116:705-777.
27. Reid, L., and R. Jones. 1978. Bronchial mucosal cells. Fed. Proc. 38:191-196.
28. McDowell, E. M., L. A. Barren, F. Glavin, C. C. Harris, and B. F. Trump. 1978. The respiratory epithelium. I. Human Bronchus. J. Natl. Cancer Inst. 61:539-545.
29. Jeffery, P. K. 1983. Morphologic features of airway surface epithelial cells and glands. Am. Rev. Respir. Dis. 128:514-520.
30. Hay, J. G., and D. M. Geddes. 1985. Transepithelial potential difference in cystic fibrosis. Thorax 40:493-496.
31. Walton, E. W. F. W., J. G. Hay, C. Munro, and D. M. Geddes. 1987. Measurement of nasal potential difference in adult cystic fibrosis, Young's syndrome, and bronchiectasis. Thorax 42:815-817.
32. Knowles, M., J. Gatzy, and R. Boucher. 1981. Increased bioelectric potential difference across respiratory epithelia in cystic fibrosis. N. Engt. J. Med. 305:1489-1495.
33. Heino, M., K. Juntunen-Backman, M. Leijala, J. Rapola, and L. A. Laitinen. 1990. Bronchial epithelial inflammation in children with chronic cough after early lower respiratory tract illness. Am. Rev. Respir. Dis. 141:428-432.
34. Boucher, R. C., M. R. Van Scott, N. Willumsen, and M. J. Stutts. 1988. Epithelial injury: mechanisms and cell biology of airway epithelial injury. Am. Rev. Respir. Dis. 138:541-544.
35. Bedrossian, C. W. M., S. D. Greenberg, D. B. Singer, J. J. Hansen, and H. S. Rosenbert. 1976. The lung in cystic fibrosis. A quantitative study including prevalence of pathologic findings among different age groups. Hum. Pathol. 7:195-204.