Inhibition of nitric oxide synthesis reduces coronary blood flow response but does not increase cardiac contractile response to β-adrenergic stimulation in normal dogs

Journal of Cardiovascular Pharmacology

Volumn 27, Issue 2, 1996, Pages 247-254

  Kaneko, Haruo ^a   Endo, Takao ^a   Kiuchi, Kaname ^a   Hayakawa, Hirokazu ^a  

^a NIPPON MEDICAL SCHOOL   (Japan)

Author keywords

Cardiac contractility; Coronary blood flow; Isoproterenol; N(G) nitro D arginine methyl ester; N(G) nitro L arginine methyl ester; Nitric oxide

Indexed keywords

ISOPRENALINE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOREGULATION; BETA ADRENERGIC STIMULATION; BLOOD VESSEL TONE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; CORONARY ARTERY CIRCUMFLEX BRANCH; CORONARY ARTERY DILATATION; DOG; DOSE RESPONSE; DRUG EFFECT; ENZYME INHIBITION; HEART MUSCLE CONTRACTILE FORCE; HEART MUSCLE CONTRACTILITY; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; PRIORITY JOURNAL; VASCULAR RESISTANCE;

ACETYLCHOLINE; ADRENERGIC BETA-AGONISTS; ANIMALS; CORONARY CIRCULATION; DOGS; FEMALE; HEART RATE; HEMODYNAMIC PROCESSES; HYPERTROPHY, LEFT VENTRICULAR; ISOPROTERENOL; MALE; MYOCARDIAL CONTRACTION; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE;

EID: 0030032387     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-199602000-00011     Document Type: Article

References (33)

1. Moncada S, Palmer RMJ, Higgs EA. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 1991;43:109-42.
2. Moncada S, Higgs A. The L-arginine-nitric oxide pathway. N Engl J Med 1993;329:2002-12.
3. Ignarro LJ. Biosynthesis and metabolism of endothelium-derived nitric oxide. Annu Rev Pharmacol Toxicol 1990;30:535-60.
4. Dinerman JL, Lowenstein CJ, Snyder SH. Molecular mechanisms of nitric oxide regulation: potential relevance to cardiovascular disease. Circ Res 1993;73:217-22.
5. 2+-independent nitric oxide synthase in the myocardium. Br J Pharmacol 1992;105:575-80.
6. Finkel MS, Oddis CV, Jacob TD, Watkins SC, Hattler BG, Simmons RL. Negative inotropic effects of cytokines on the heart mediated by nitric oxide. Science 1992;257:387-9.
7. Brady AJB, Poole-Wilson PA, Harding SE, Warren JB. Nitric oxide production within cardiac myocytes reduces their contractility in endotoxemia. Am J Physiol 1992;263:H1963-6.
8. Brady AJB, Warren JB, Poole-Wilson PA, Williams TJ, Harding SE. Nitric oxide attenuates cardiac myocyte contraction. Am J Physiol 1993;265:H176-82.
9. Gulick T, Chung MK, Pieper SJ, Lange LG, Schreiner GF. Interleukin 1 and tumor necrosis factor inhibit cardiac myocyte β-adrenergic responsiveness. Proc Natl Acad Sci USA 1989;86:6753-7.
10. Balligand J-L, Ungureanu D, Kelly RA, et al. Abnormal contractile function due to induction of nitric oxide synthesis in rat cardiac myocytes follows exposure to activated macrophage-conditioned medium. J Clin Invest 1993;91:2314-9.
11. Amrani M, O'Shea J, Allen NJ, et al. Role of basal release of nitric oxide on coronary flow and mechanical performance of the isolated rat heart. J Physiol 1992;456:681-7.
12. Balligand J-L, Kelly RA, Marsden PA, Smith TW, Michel T. Control of cardiac muscle cell function by an endogenous nitric oxide signaling system. Proc Natl Acad Sci USA 1993;90:347-51.
13. Weyrich AS, Ma X-L, Buerke M, et al. Physiological concentrations of nitric oxide do not elicit an acute negative inotropic effect in unstimulated cardiac muscle. Circ Res 1994;75:692-700.
14. Hare JM, Keaney JF Jr, Balligand J-L, Loscalzo J, Smith TW, Colucci WS. Role of nitric oxide in parasympathetic modulation of β-adrenergic myocardial contractility in normal dogs. J Clin Invest 1995;95:360-6.
15. Hare JM, Keaney JF Jr, Kelly RA, et al. Inhibition of nitric oxide synthase potentiates the positive inotropic response to β-adrenergic stimulation in normal dogs [Abstract]. Circulation 1993;88:I-355.
16. Parent R, Al-Obaidi M, Lavalée M. Nitric oxide formation contributes to β-adrenergic dilation of resistance coronary vessels in conscious dogs. Circ Res 1993;73:241-51.
17. Kirkebøen KA, Naess PA, Offstad J, Ilebekk A. Effects of regional inhibition of nitric oxide synthesis in intact porcine hearts. Am J Physiol 1994;266:H1516-27.
18. Yamabe H, Okumura K, Ishizaka H, Tsuchida T, Yasue H. Role of endothelium-derived nitric oxide in myocardial reactive hyperemia. Am J Physiol 1992;263:H8-14.
19. Kostic MM, Schrader J. Role of nitric oxide in reactive hyperemia of the guinea pig heart. Circ Res 1992;70:208-12.
20. Parent R, Paré R, Lavallée M. Contribution of nitric oxide to dilation of resistance coronary vessels in conscious dogs. Am J Physiol 1992;262:H10-6.
21. Smith TP Jr, Canty JM Jr. Modulation of coronary autoregulatory responses by nitric oxide. Evidence for flow-dependent resistance adjustments in conscious dogs. Circ Res 1993;73:232-40.
22. Chu A, Chambers DE, Lin C-C, Kuehl WD, Cobb FR. Nitric oxide modulates epicardial coronary basal vasomotor tone in awake dogs. Am J Physiol 1990;258:H1250-4.
23. Chu A, Chambers DE, Lin C-C, et al. Effects of inhibition of nitric oxide formation on basal vasomotion and endothelium-dependent responses of the coronary arteries in awake dogs. J Clin Invest 1991;87:1964-8.
24. Broten TP, Miyashiro JK, Moncada S, Feigl EO. Role of endothelium-derived relaxing factor in parasympathetic coronary vasodilation. Am J Physiol 1992;262:H1579-84.
25. Rubanyi G, Vanhoutte PM. Endothelium-removal decreases relaxations of canine coronary arteries caused by β-adrenergic agonists and adenosine. J Cardiovasc Pharmacol 1985;7:139-44.
26. Grace GC, Macdonald PS, Dusting GJ. Cyclic nucleotide interactions involved in endothelium-dependent dilatation in rat aortic rings. Eur J Pharmacol 1988;148:17-24.
27. Gray DW, Marshall I. Novel signal transduction pathway mediating endothelium-dependent β-adrenoceptor vasorelaxation in rat thoracic aorta. Br J Pharmacol 1992;107:684-90.
28. Macdonald PS, Dubbin PN, Dusting GJ. β-Adrenoceptors on endothelial cells do not influence release of relaxing factor in dog coronary arteries. Clin Exp Pharmacol Physiol 1987;14:525-34.
29. Rees DD, Palmer RMJ, Schulz R, Hodson HF, Moncada S. Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. Br J Pharmacol 1990;101:746-52.
30. Schlotzhouser SD, Littell RC. SAS system for elementary statistical analysis. Cary. NC: SAS Institute, 1987:236.
31. De Belder AJ, Radomski MW, Why HJF, et al. Nitric oxide synthase activities in human myocardium. Lancet 1993;341:84-5.
32. Bernstein R, Shen W, Xu X, Hintze TM. Nitro-L-arginine (NLA) decreases myocardial oxygen consumption in response to isoproterenol infusion in awake dogs [Abstract]. Circulation 1994;90:I-104.
33. Schächinger V, Zeiher AM, Krause T, Minners J, Moser E. Impaired endothelium-dependent dilation of coronary resistance vessels is associated with exercise-induced myocardial ischemia [Abstract]. Circulation 1994;90:1-114.