Impact of immunization on Haemophilus influenzae type b disease

Infectious Agents and Disease

Volumn 5, Issue 1, 1996, Pages 8-20

  Madore, Dace Viceps ^a,b  

^a PFIZER INC   (United States)

^b Biologicals Research   (United States)

Author keywords

Haemophilus influenzae type b; Meningitis; Vaccine

Indexed keywords

HAEMOPHILUS INFLUENZAE VACCINE;

BACTERIAL INFECTION; BACTERIAL MENINGITIS; COST BENEFIT ANALYSIS; HAEMOPHILUS INFLUENZAE TYPE B; HUMAN; INFECTION PREVENTION; INFECTION RISK; PRIORITY JOURNAL; REVIEW;

ADULT; CARRIER STATE; CHILD; CHILD, PRESCHOOL; COST-BENEFIT ANALYSIS; HAEMOPHILUS INFECTIONS; HAEMOPHILUS INFLUENZAE; HAEMOPHILUS VACCINES; HUMANS; IMMUNIZATION; INFANT; MENINGITIS, HAEMOPHILUS;

EID: 0030032294     PISSN: 10562044     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (129)

1. Adams WG, Deaver KA, Cochi SL, Plikaytis BD, Zell ER, Broome CV, Wenger JD. Decline of childhood Haemophilus influenzae type b (Hib) disease in the Hib vaccine era. JAMA 1993;269:221-6.
2. Anderson G, Rados M. Progress toward elimination of Haemophilus influenzae type b disease among infants and children - United States, 1987-1993. MMWR Morb Mortal Wkly Rep, 1994;43:144-8.
3. Anderson G, Smithee L, Rados M, Boughman W, Veterans Administration Medical Services, National Center for Infectious Diseases, National Immunization Program, and Epidemiology Program Office. Progress toward elimination of Haemophilus influenzae type b disease among infants and children - United States, 1987-1993. JAMA 1994;271:1231-2.
4. Baker M, Martin D. Hib disease rate plummets following immunisation programme. N Z Public Health Rep 1995;2:13-4.
5. Barbour ML, Mayon-White RT, Coles C, Crook DWM, Moxon ER. The impact of conjugate vaccine on carriage of Haemophilus influenzae type b. J Infect Dis 1995;171:93-8.
6. Beck RA, Kambiss S, Bass JW. The retreat of Haemophilus influenzae type b invasive disease: analysis of an immunization program and implications for OTO-HNS. Otolaryngol Head Neck Surg 1993;109:712-21.
7. Bent JP III, Beck RA. Bacterial meningitis in the pediatric population: paradigm shifts and ramifications for otolaryngology-head and neck surgery. Int J Pediatr Otorhinolaryngol 1994;30:41-9.
8. Black SB, Shinefield HR, Fireman B, Hiatt R. Safety, immunogenicity, and efficacy in infancy of oligosaccharide conjugate Haemophilus influenzae type b vaccine in a United States population: possible implications for optimal use. J Infect Dis 1992;165:S139-43.
9. Black SB, Shinefield HR, Fireman B, Hiatt R, Polen M, Vittinghoff E, The Northern California Kaiser Permanente Vaccine Study Center Pediatrics Group. Efficacy in infancy of oligosaccharide conjugate Haemophilus influenzae type b (HbOC) vaccine in a United States population of 61,080 children. Pediatr Infect Dis J 1991;10:97-104.
10. Black SB, Shinefield HR, Hiatt RA, Fireman BH. Efficacy of Haemophilus influenzae type b capsular polysaccharide vaccine. Pediatr Infect Dis J 1988;7:149-56.
11. Black SB, Shinefield HR, The Northern California Kaiser Permanente Vaccine Study Center Pediatrics Group. Immunization with oligosaccharide conjugate Haemophilus influenzae type b (HbOC) vaccine on a large health maintenance organization population: extended follow-up and impact on Haemophilus influenzae disease epidemiology. Pediatr Infect Dis J 1992;11:610-3.
12. Boase J, Alexander R. Decline in Haemophilus influenzae type b meningitis - Seattle-King County, Washington, 1984-1989. MMWR Morb Mortal Wkly Rep 1990;39:924.
13. Booy R, Hodgson S, Carpenter L, Mayon-White RT, Slack MPE, Macfarlane JA, Haworth EA, Kiddle M, Shribman S, Roberts JSC, Moxon ER. Efficacy of Haemophilus influenzae type b conjugate vaccine PRP-T. Lancet 1994;344:362-5.
14. Broadhurst LE, Erickson RL, Kelley PW. Decreases in invasive Haemophilus influenzae diseases in US Army children, 1984 through 1992. JAMA 1993;269:227-31.
15. Buchanan GA, Darville T. Impact of immunization against Haemophilus influenzae type b (HIB) on the incidence of HIB meningitis treated at Arkansas Children's Hospital. South Med J 1994;87:38-40.
16. Carrangis J. Hib vaccine-introduction and impact in South Australia, 1 July 1993 to 31 December 1994. CDI 1995;19:96-7.
17. Centers for Disease Control. Polysaccharide vaccine for prevention of Haemophilus influenzae type b disease. MMWR Morb Mortal Wkly Rep 1985;34:201-5.
18. Centers for Disease Control. Haemophilus influenzae type b vaccine. MMWR Morb Mortal Wkly Rep 1988;36:832.
19. Centers for Disease Control. MMWR Morb Mortal Wkly Rep 1993;41:67.
20. Centers for Disease Control. MMWR Morb Mortal Wkly Rep 1994;42:11.
21. Centers for Disease Control. Reported vaccine-preventable diseases-United States, 1993, and the childhood immunization initiative. MMWR Morb Mortal Wkly Rep 1994;43:57-60.
22. Centers for Disease Control. Vaccination coverage of 2-year-old children-United States, 1993. MMWR-Morb Mortal Wkly Rep 1994;43:705-9.
23. Centers for Disease Control. MMWR-Morb Mortal Wkly Rep 1995;43:967.
24. Claesson B, Trollfors B, Jodal U, Rosenhall U. Incidence and prognosis of Haemophilus influenzae meningitis in children in a Swedish region. Pediatr Infect Dis J 1984;3:35-9.
25. Clements DA. Cost of treatment and prevention of Haemophilus influenzae type b disease. PharmacoEconomics 1994;6:442-52.
26. Cochi SL, Broome CV, Hightower AW. Immunization of US children with Haemophilus influenzae type b polysaccharide vaccine. A cost-effectiveness model of strategy assessment. JAMA 1985;253:521-9.
27. Cochi SL, O'Mara D, Preblud SR. Progress in Haemophilus type b polysaccharide vaccine use in the United States. Pediatrics 1988;81:166-8.
28. Department of Health (UK). Changing patterns of infectious diseases. Commun Dis Rep Wkly 1994;4:1.
29. Department of Health (UK). Invasive Haemophilus influenzae infections: changing patterns. Commun Dis Rep CDR Wkly 1994;4:229.
30. Desgrandchamps D, Schmid R, Zimmermann HP, Imahorn P, Kabus K, Schubiger G. Effect of conjugated PRP vaccines on the incidence of invasive diseases caused by Haemophilus influenzae type B in childhood. Schweiz Med Wochenschr 1994;124:575-82.
31. Eskola J, Kayhty H, Takala AK, Peltola H, Ronnberg PR, Kela E, Pekkanen E, McVerry PH, Makela PH. A randomized, prospective field trial of a conjugate vaccine in the protection of infants and young children against invasive Haemophilus influenzae type b disease. N Engl J Med 1990;323:1381-7.
32. Eskola J, Takala AK, Kayhty H. Haemophilus influenzae type b polysaccharide-protein conjugate vaccines in children. Curr Opin Pediatr 1993;5:55-9.
33. Eskola J, Takala A, Kayhty H, Peltola H, Makela PH. Experience in Finland with Haemophilus influenzae type b vaccines. Vaccine 1991;9:S14-6.
34. Ewert DP, Westman S, Ward B, Bendana N, Halbert R, Vadheim CM, Ward JI, Mascola L. An increase in Haemophilus influenzae type b vaccination among preschoolaged children in inner-city Los Angeles, 1990 through 1992. Am J Public Health 1994;84:1154-7.
35. Falla TJ, Crook DWM, Anderson EC, Ward JI, Santosham M, Eskola J, Moxon ER. Characterization of capsular genes in Haemophilus influenzae from H. influenzae type b vaccine recipients. J Infect Dis 1995;171:1075-6.
36. Fothergill LD, Wright J. Influenzal meningitis-the relation of age incidence to the bactericidal power of blood against the causal organism. J Immunol 1933;24:273-84.
37. Frantz TD, Rasgon BM. Acute epiglottis: changing epidemiologic patterns. Otolaryngology 1993;109:457-60.
38. Frasch CE, Hiner EE, Gross TP. Haemophilus b disease after vaccination with Haemophilus b polysaccharide or conjugate vaccine. Am J Dis Child 1991 ;145:1379-82.
39. Fritzell B, Plotkin S. Efficacy and safety of a Haemophilus influenzae type b capsular polysaccharide-tetanus protein conjugate vaccine. J Pediatr 1992;121:355-61.
40. Gellert G, Wenger J, Brilla A. Haemophilus influenzae type b disease in Latvia. Lancet 1994;344:959.
41. Gilbert GL, Clements DA, Broughton SJ. Haemophilus influenzae type b infections in Victoria, Australia, 1985 to 1987. Pediatric Infect Dis J 1990;9:252-7.
42. Gilsdorf JR, McDonnell WM. Mucosal antibodies to Haemophilus influenzae type b capsular polysaccharide. Pediatr Res 1991;29:420-3.
43. Ginsburg GM, Kassis I, Dagan R. Cost benefit analysis of Haemophilus influenzae type b vaccination programme in Israel. J Epidemiol Community Health 1993;47:485-90.
44. Glode MP, Daum RS, Boies EG, Ballard TL, Murray M, Granoff DM. Effect of rifampin chemoprophylaxis on carriage eradication and new acquisition of Haemophilus influenzae type b in contacts. Pediatrics 1985;76:537-42.
45. Glode MP, Halsey NA, Murray M, Ballard TL, Barenkamp S. Epiglottitis in adults: association with Haemophilus influenzae type b colonization and disease in children. Pediatr Infect Dis J 1984;3:548-51.
46. Gorelick MH, Baker MD. Epiglottitis in children, 1979 through 1992: effect of Haemophilus influenzae type b immunization. Arch Pediatr Adolesc Med 1994;148:47-50.
47. Granoff DM, Sheetz K, Pandey JP, Nahm MH, Rambeck JH, Jacobs JL, Musser J, Selander RK, Kabeer M, Murphy TV, Osterholm MT. Host and bacterial factors associated with Haemophilus influenzae type b disease in Minnesota children vaccinated with type b polysaccharide vaccine. J Infect Dis 1989;159:908-16.
48. Greenberg DP, Vadheim CM, Bordenave N, Ziontz L, Christenson P, Waterman SH, Ward JI. Protective efficacy of Haemophilus influenzae type b polysaccharide and conjugate vaccines in children 18 months of age and older. JAMA 1991;265:987-92.
49. Greene GR. Meningitis due to Haemophilus influenzae other than type b: case report and review. Pediatrics 1978;62:1021-5.
50. Hall CB, Granoff DM, Gromisch DS, Halsey NA, Kohl S, Marcuse EK, Marks MI, Nankervis GA, Pickering LK, Scott GB, Steele RW, Yogev R. Haemophilus influenzae type b conjugate vaccines: recommendations for immunization with recently and previously licensed vaccines. Pediatrics 1993;92:480-8.
51. Hanna J. The epidemiology and prevention of Haemophilus influenzae infections in Australian Aboriginal children. J Paediatr Child Health 1992;28:354-61.
52. Hanna J, Messer R. Haemophilus influenzae type b meningitis in Far North Queensland, 1989 to 1994. CDI 1995;19:91-3.
53. Hanna JN. The epidemiology of invasive Haemophilus influenzae infections in children under five years of age in the Northern Territory: a three-year study. Med J Aust 1990;152:234-40.
54. Harris A, Hendrie D, Bower C, Payne J, Klerk ND, Stanley F. The burden of Haemophilus influenzae type b disease in Australia and an economic appraisal of the vaccine PRP-OMP. Med J Aust 1994;160:483-8.
55. Harrison LH, Broome CV, Hightower AW, Haemophilus Vaccine Efficacy Study Group. Haemophilus influenzae type b polysaccharide vaccine: an efficacy study. Pediatrics 1989;84:255-61.
56. Harrison LH, Broome CV, Hightower AW, Hoppe CC, Makintubee S, Sitze SL, Taylor JA, Gaventa S, Wenger JD, Facklam RR. A day care-based study of the efficacy of Haemophilus b polysaccharide vaccine. JAMA 1988;260:1413-8.
57. Harrison LH, Tajkowski C, Groll J, Reid R, Hu D, Brenneman G, Weatherholtz RC, Santosham M. Postlicensure effectiveness of the Haemophilus influenzae type b polysaccharide-Neisseria meningitidis outer-membrane protein complex conjugate vaccine among Navajo children. J Pediatr 1994;125:571-6.
58. Hay JW, Daum RS. Cost-benefit analysis of two strategies for prevention of Haemophilus influenzae type b infection. Pediatrics 1987;80:319-29.
59. Hay JW, Daum RS. Cost-benefit analysis of Haemophilus influenzae type b prevention: conjugate vaccination at eighteen months of age. Pediatr Infect Dis J 1990;9:246-52.
60. Herceg A. Haemophilus influenzae type B cases in Australia from 1 July 1993 to 30 June 1994: results of the Hib case reporting scheme including immunisation status and vaccine failures. CDI 1995;19:86-90.
61. Hussey G. Epidemiology of invasive Haemophilus influenzae infections in Cape Town, South Africa. Ann Trop Paediatr 1994;14:97-103.
62. Jonsdottir KE, Hansen H, Guobjornsdottir H, Guomundsdottir M, Olafsson O, Jonasson M, Schaart W, Barreto L. Epidemiology of invasive Haemophilus influenzae b (Hib) disease in Iceland from 1974 and impact of vaccination programme launched in 1989. Arctic Med Res 1994;53:619-21.
63. Jonsdottir KE, Steingrimsson O, Olafsson O. Immunization of infants in Iceland against Haemophilus influenzae type b. Lancet 1992;340:252-3.
64. Kessler A, Wetmore RF, Marsh RR. Childhood epiglottitis in recent years. Int J Pediatr Otorhinolaryngol 1993;25:155-62.
65. Levine OS, Ortiz E, Contreras R, Lagos R, Vial P, Misraji A, Ferreccio C, Espinoza C, Alderstein L, Herrera P, Casar C. Cost-benefit analysis for the use of Haemophilus influenzae type b conjugate vaccine in Santiago, Chile. Am J Epidemiol 1993;37:1221-8.
66. Li KI, Wald ER, Dashefsky B. Nasal colonization with Haemophilus and immunization status [Letter]. Pediatr Infect Dis J 1987;6:303-4.
67. Loughlin AM, Marchant CD, Lett S, Shapiro ED. Efficacy of Haemophilus influenzae type b vaccines in Massachusetts children 18 to 59 months of age. Pediatr Infect Dis J 1992;11:374-9.
68. Lucas AH, Granoff DM. Functional differences in idiotypically defined IgG1 anti-polysaccharide antibodies elicited by vaccination with Haemophilus influenzae type B polysaccharide-protein conjugates. J Immunol 1995;4195-202.
69. Madore DV, Phipps DC, Eby R, Johnson CL, Smith DH. Immune response of young children vaccinated with Haemophilus influenzae type b conjugate vaccines. Contrib Microbiol Immunol 1989;10:125-50.
70. McIntyre P, Hall J, Leeder S. An economic analysis of alternatives for childhood immunisation against Haemophilus influenzae type b. Aust J Public Health 1994;18:394-400.
71. Meade BJ, Finger RF, Sosin DM. Incidence of Haemophilus influenzae type b disease in Kentucky: relationship to immunization, 1988 through 1993. KMA J 1994;92:490-5.
72. Michaels RH, Norden CW. Pharyngeal colonization with Haemophilus influenzae type b: a longitudinal study of families with a child with meningitis or epiglottitis due to H. influenzae type b. J Infect Dis 1977;136:222-8.
73. Michaels RH, Poziviak CS, Stonebraker FE, Norden CW. Factors affecting pharyngeal Haemophilus influenzae type b colonization rates in children. J Clin Microbiol 1976;4:413-7.
74. Mohle-Boetani JC, Ajello G, Breneman E, Deaver KA, Harvey C, Plikaytis BD, Farley MM, Stephens DS, Wenger JD. Carriage of Haemophilus influenzae type b in children after widespread vaccination with conjugate Haemophilus influenzae type b vaccines. Pediatr Infect Dis J 1993;12:589-93.
75. Moxon ER. The carrier state: Haemophilus influenzae. J Antimicrob Chemother 1986;18:17-24.
76. Murphy TV, Granoff D, Chrane DF, Olsen KD, Barenkamp SJ, Dowell SF, McCracken GHJ. Pharyngeal colonization with Haemophilus influenzae type b in children in a day care center without invasive disease. J Pediatr 1985;106:712-6.
77. Murphy TV, Osterholm MT, Pierson LM, White KE, Breedlove JA, Seibert GB, Kuritsky JN, Granoff DM. Prospective surveillance of Haemophilus influenzae type b disease in Dallas County, Texas, and in Minnesota. Pediatrics 1987;79:173-80.
78. Murphy TV, Pastor P, Medley F, Osterholm MT, Granoff DM. Decreased Haemophilus colonization in children vaccinated with Haemophilus influenzae type b conjugate vaccine. J Pediatr 1993;122:517-23.
79. Murphy TV, White KE, Pastor P, Gabriel L, Medley F, Granoff DM, Osterholm MT. Declining incidence of Haemophilus influenzae type b disease since introduction of vaccination. JAMA 1993;269:246-8.
80. National Advisory Committee on Immunization. Statement on Haemophilus influenzae type b conjugate vaccines for use in infants and children. Can Commun Dis Rep 1992;18-23:169-76.
81. Nelson WL, Granoff DM. Protective efficacy of Haemophilus influenzae type b polysaccharide-diphtheria toxoid-conjugate vaccine. Am J Dis Child 1990;144:292-5.
82. Nitta DM, Jackson MA, Burry VF, Olson LC. Invasive Haemophilus influenzae type f disease. Pediatr Infect Dis J 1995;14:157-60.
83. Noack R, Padelt H. Infections by Haemophilus influenzae type b; epidemiology, vaccination, chemoprophylaxis. Kinderarztl Praxis 1991;59:365-7.
84. Osterholm MT, Rambeck JH, White KE, Jacobs JL, Pierson LM, Neaton JD, Hedberg CW, MacDonald KL, Granoff DM. Lack of efficacy of Haemophilus b polysaccharide vaccine in Minnesota. JAMA 1988;260:1423-8.
85. 197 protein vaccines in infancy. Arch Pediatr Adolesc Med 1994;148:620-5.
86. Peltola H, Kayhty H, Sivonen A, Makela H. Haemophilus influenzae type b capsular polysaccharide vaccine in children: a double-blind field study of 100,000 vaccines 3 months to 5 years of age in Finland. Pediatrics 1977;60:730-7.
87. Peltola H, Kilpi T, Anttila M. Rapid disappearance of Haemophilus influenzae type b meningitis after routine childhood immunization with conjugate vaccines. Lancet 1992;340:592-4.
88. Phillips Emmerson SG, Richman B, Spahn T. Changing patterns of epiglottitis in children. Otolaryngol Head Neck Surg 1991;104:287-92.
89. Rathore MH, Dick M, Buckner P, Ayoub EM. Haemophilus influenzae type b invasive disease in urban and rural children: immunization patterns and prevalence of disease. South Med J 1994;87:1083-7.
90. Reinert P, Liwartowski A, Dabernat H, Guyot C, Boucher J, Carrere C. Epidemiology of Haemophilus influenzae type b disease in France. Vaccine 1993;11:S38-42.
91. Robbins JB, Schneerson R. Evaluating the Haemophilus influenzae type b conjugate vaccine PRP-D. N Engl J Med 1990;323:1415-6.
92. Santosham M. Prevention of Haemophilus influenzae type b disease. Vaccine 1993;11:S52-7.
93. Santosham M, Rivin B, Wolff M, Reid R, Newcomer W, Letson GW, Almeido-Hill J, Thompson C, Siber GR. Prevention of Haemophilus influenzae type b infections in Apache and Navajo children. J Infect Dis 1992;165:S144-51.
94. Santosham M, Wolff M, Reid R, Hohenboken M, Bateman M, Goepp J, Cortese M, Sack D, Hill J, Newcomer W, Capriotti L, Smith J, Owen M, Gahagan S, Hu D, Kling R, Lukacs L, Ellis RW, Vella PP, Calandra G, Matthews H, Ahonkhai V. The efficacy in Navajo infants of a conjugate vaccine consisting of Haemophilus influenzae type b polysaccharide and Neisseria meningitidis outer-membrane protein complex. TV Engl J Med 1991 ;324:1767-72.
95. Scheifele D, Gold R, Law B, Dery P, Halperin S, Marchessault V, Duclos P. Decline in Haemophilus influenzae type b invasive infections at five Canadian pediatric centres. Can Commun Dis Rep 1993;19-12:88-91.
96. Schlech WF III, Ward JI, Band JD, Hightower A, Fraser DW, Broome CV. Bacterial meningitis in the United States, 1978-1981: The National Bacterial Meningitis Surveillance Study. JAMA 1985;253:1749-54.
97. Schlesinger Y, Granoff DM, The Vaccine Study Group. Avidity and bactericidal efficacy of antibody elicited by different Haemophilus influenzae type b conjugate vaccines. JAMA 1992;267:1489-94.
98. Schoendorf KC, Adams WG, Kiely JL, Wenger JD. National trends in Haemophilus influenzae meningitis mortality and hospitalization among children, 1980 through 1991. Pediatrics 1994;93:663-8.
99. Schreiber JR, Boxerbaum B, Morrissey AB. Decline of Haemophilus disease in Cleveland. Pediatr Infect Dis J 1992;11:779-80.
100. Schulte EE, Birkhead GS, Kondracki SF, Morse DL. Patterns of Haemophilus influenzae type b invasive disease in New York State, 1987 to 1991: the role of vaccination requirements for day-care attendance. Pediatrics 1994;94:1014-6.
101. Senior BA, Radkowski D, MacArthur C, Sprecher RC, Jones D. Changing patterns in pediatric supraglottitis: a multi-institutional review, 1980 to 1992. Laryngoscope 1994;104:1314-22.
102. Shapiro ED, Murphy TV, Wald ER, Brady CA. The protective efficacy of Haemophilus b polysaccharide vaccine. JAMA 1988;260:1419-22.
103. Shapiro ED, Ward JI. The epidemiology and prevention of disease caused by Haemophilus influenzae type b. Epidemiol Rev 1991;13:113-42.
104. Singleton RJ, Davidson NM, Desmet IJ, Berner JE, Wainwright RB, Bulkow LR, Lilly CM, Siber OR. Decline of Haemophilus influenzae type b disease is a region of high risk: impact of passive and active immunization. Pediatr Infect Dis J 1994;13:362-7.
105. Standaert SM Jr, Horan JM, Hutcheson RH, Schaffner W. The reporting of communicable diseases: a controlled study of Neisseria meningitidis and Haemophilus influenzae infections. Clin Infect Dis 1995;20:30-6.
106. Takala AK, Eskola J, Leinonen M, Kayhty H, Nissinen A, Pekkanen E, Makela PH. Reduction of oropharyngeal carriage of Haemophilus influenzae type b (Hib) in children immunized with an Hib conjugate vaccine. J Infect Dis 1991;164:982-6.
107. Takala AK, Eskola J, Peltola H, Makela PH. Epidemiology of invasive Haemophilus influenzae type b disease among children in Finland before vaccination with Haemophilus influenzas type b conjugate vaccine. Pediatr Infect Dis J 1989;8:297-302.
108. Takala AK, Peltola H, and Eskola J. Disappearance of epiglottitis during large-scale vaccination with Haemophilus influenzae type b conjugate vaccine among children in Finland. Laryngoscope 1994;104:731-5.
109. Takala AK, Ronnberg PR, Kela E, Eskola J, Makela M. Increased risk of primary invasive Haemophilus influenzae type B disease in twins. Pediatr Infect Dis J 1989;8:799-800.
110. Takala AK, Santosham M, Almeido-Hill J, et al. Vaccination with Haemophilus influenzae type b meningococcal protein conjugate vaccine reduces oropharyngeal carriage of Haemophilus influenzae type b among American Indian children. Pediatr Infect Dis J 1993;12:593-9.
111. Teare EL, Fairley CK, White J, Begg NT. Efficacy of Hib vaccine. Lancet 1994;344:828-9.
112. Teele DW. Immunisation for Haemophilus influenzae type b and rates of meningitis due to this organism. N Z Med J 1994;107:184.
113. Trollfors B. Cost-benefit analysis of general vaccination against Haemophilus influenzae type b in Sweden. Scand J Infect Dis 1994;26:611-4.
114. Urwin G, Yuan MF, Feldman RA. Prospective study of bacterial meningitis in North East Thames region, 1991-3, during introduction of Haemophilus influenzae vaccine. BMJ 1994;309:1412-4.
115. Vadheim CM, Greenberg DP, Eriksen E, Hemenway L, Bendana N, Mascola L, Ward JI, The Kaiser-UCLA Study Group. Eradication of Haemophilus influenzae type b disease in Southern California. Arch Pediatr Adolesc Med 1994;148:51-6.
116. Vadheim CM, Greenberg DP, Ericksen E, Hemenway L, Christenson P, Ward B, Mascola L, Ward JI. Protection provided by Haemophilus influenzae type b conjugate vaccines in Los Angeles County: a case-control study. Pediatr Infect Dis J 1994;13:274-80.
117. van Alphen L, Spanjaard L, van der Ende A, Dankert J. Predicted disappearance of Haemophilus influenzae type b meningitis in Netherlands. Lancet 1994;344:195.
118. van Alphen L, Takala AK, Geelen-van den Broek L, Dankert J, Eskola J. Changes in the distribution of Hae-mophilus influenzae type b clones associated with widespread infant vaccination in Finland. J Infect Dis 1992;166:1340-5.
119. Varughesee PV. Statement on Haemophilus b conjugate vaccine. Can Dis Wkly Rep 1988;14-9:37-40.
120. Venezia RA, Robertson RG. Bactericidal substance produced by Haemophilus influenzae b. Can J Microbiol 1975;21:1597-94.
121. Walker P, Crysdale WS. Croup, epiglottitis, retropharyngeal abscess, and bacterial tracheitis: evolving patterns of occurrence and care. Int Anesthesiol Clin 1992;30:57-70.
122. Ward J, Brenneman G, Letson GW, Heyward WL, The Alaska H. influenzae Vaccine Study Group. Limited efficacy of a Haemophilus influenzae type b conjugate vaccine in Alaska native infants. N EngI J Med 1990;323:1393-401.
123. Ward J, Cochi S. Haemophilus influenzae vaccines. In: Plotkin S, Mortimer E, eds. Vaccines. Philadelphia: WB Saunders, 1988:300-32.
124. Ward JI, Lum MK, Hall DB, Silimperi DR, Bender TR. Invasive Haemophilus influenzae type b disease in Alaska: background epidemiology for a vaccine efficacy trial. J Infect Dis 1986;153:17-26.
125. Wenger JD. Impact of Haemophilus influenzae type b vaccines on the epidemiology of bacterial meningitis. Infect Agents Dis 1994;2:324-32.
126. Wenger JD, Hightower AW, Facklam RR, Gaventa S, Broome CV, Bacterial Meningitis Study Group. Bacterial meningitis in the United States, 1986: report of a multistate surveillance study. J Infect Dis 1990;162:1316-23.
127. Wenger JD, Pierce R, Deaver K, Franklin R, Bosely G, Pigott N, Broome CV, The Haemophilus influenzae Study Group. Invasive Haemophilus influenzae disease: a population-based evaluation of the role of capsular polysaccharide serotype. J Infect Dis 1992;165:S34-5.
128. Wenger JD, Pierce R, Deaver KA, Plikaytis BD, Facklam RR, Broome CV, The Haemophilus influenzae Vaccine Efficacy Study Group. Efficacy of Haemophilus influenzae type b polysaccharide-diphtheria toxoid conjugate vaccine in US children aged 18-59 months. Lancet 1991;338:395-8.
129. Zielen S, Ahrens P, Hofmann D. Efficacy of Hib vaccine. Lancet 1994;344:828.