The Salmonella typhimurium flgM gene, which encodes a negative regulator of flagella synthesis and is involved in virulence, is present and functional in other Salmonella species

FEMS Microbiology Letters

Volumn 135, Issue 2-3, 1996, Pages 281-285

  Schmitt, Clare K ^a   Darnell, Stephen C ^a   O'Brien, Alison D ^a  

^a Uniformed Services University of the Health Sciences and the Walter Reed National Military Medical Center   (United States)

Author keywords

Flagella; FlgM; Regulation; Salmonella; Virulence

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; BACTERIAL GENE; BACTERIAL VIRULENCE; DNA SEQUENCE; FEMALE; FLAGELLUM; MOUSE; NONHUMAN; PHENOTYPE; PLASMID; PRIORITY JOURNAL; SALMONELLA TYPHIMURIUM;

EID: 0030032231     PISSN: 03781097     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-1097(95)00467-X     Document Type: Article

References (19)

1. Gillen, K.L. and Hughes, K.T. (1991) Negative regulatory loci coupling flagellin synthesis to flagellar assembly in Salmonella typhimurium. J. Bacteriol. 173, 2301-2310.
2. Ohnishi, K., Kutsukake, K., Suzuki, H. and Iino, T. (1992) A novel transcriptional regulation mechanism in the flagellar regulon of Salmonella typhimurium: an anti-sigma factor, σF. Mol. Microbiol. 6, 3149-3157.
3. Schmitt, C.K., Darnell, S.C., Tesh, V.L., Stocker, B.A.D. and O'Brien, A.D. (1994) Mutation of flgM attenuates virulence of Salmonella typhimurium, and mutation of fliA represses the attenuated phenotype. J. Bacteriol. 176, 368-377.
4. Akerley, B.J. and Miller, J.F. (1993) Flagellin gene transcription in Bordetella bronchiseptica is regulated by the BvgAS virulence control system. J. Bacteriol. 175, 3468-3479.
5. Andrews, G.P. and Maurelli, A.T. (1992) mxiA of Shigella flexneri 2a, which facilitates export of invasion plasmid antigens, encodes a homolog of the low-calcium-response protein, LcrD, of Yersinia pestis. Infect. Immun. 60, 3287-3295.
6. Cohen, S.N., Chang, A.C.Y. and Hsu, L. (1972) Nonchromosomal antibiotic resistance in bacteria: genetic transformation of Escherichia coli by R-factor DNA. Proc. Natl. Acad. Sci. USA 69, 2110-2114.
7. Tsai, S.P., Martin, R.J. and Ryu, J.I. (1989) Transformation in restriction-deficient Salmonella typhimurium LT2. J. Gen. Microbiol. 135, 2561-2567.
8. Sizemore, D.R., Fink, P.S., Ou, J.T., Baron, L., Kopecko, D.J. and Warren, R.L. (1991) Tn5 mutagenesis of the Salmonella typhimurium 100 kb plasmid: definition of new virulence regions. Microb. Pathog. 10, 493-499.
9. Gillen, K.L. and Hughes, K.T. (1991) Molecular characterization of flgM, a gene encoding a negative regulator of flagellin synthesis in Salmonella Typhimurium. J. Bacteriol. 173, 6453-6459.
10. Norander, J., Kempe, T. and Messing, J. (1983) Construction of improved M13 vectors using oligonucleotide-directed mutagenesis. Gene 26, 101-106.
11. Devereux, J., Haeberli, P. and Smithies, O. (1984) A comprehensive set of sequence analysis programs for the VAX. Nucleic Acids Res. 12, 387-407.
12. Miller, J.H. (1972) Experiments in Molecular Genetics. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
13. National Institutes of Health (1985) Guide for the care and use of laboratory animals. National Institutes of Health publication no. 85-23, National Institutes of Health, Bethesda, MD.
14. Hornick, R.B., Griesman, S.E., Woodward, T.E., Dupont, H.L., Dawkins, A.T. and Synder, M.J. (1970) Typhoid fever: pathogenesis and immunological control. N. Eng. J. Med. 282, 686-691.
15. O'Brien, A.D. (1982) Innate resistance of mice to Salmonella typhi infection. Infect. Immun. 38, 948-952.
16. Collins, F.M., Mackaness, G.B. and Blander, R.V. (1966) Infection-immunity in experimental salmonellosis. J. Exp. Med. 124, 601-619.
17. Carsiotis, M., Weinstein, D.L., Karch, H., Holder, I.A. and O'Brien, A.D. (1984) Flagella of Salmonella typhimurium are a virulence factor in infected C57BL/6J mice. Infect. Immun. 46, 814-818.
18. Weinstein, D.L., Carsiotis, M., Lissner, C.L. and O'Brien, A.D. (1984) Flagella help Salmonella typhimurium survive within murine macrophages. Infect. Immun. 46, 819-825.
19. Gillen, K.L. and Hughes, K.T. (1993) Transcription from two promoters and autoregulation contribute to the control of expression of the Salmonella typhimurium flagellar regulatory gene flgM. J. Bacteriol. 175, 7006-7015.