A gene highly homologous to ACP1 encoding cysteine proteinase 3 in Entamoeba histolytica is present and expressed in E. Dispar

Parasitology Research

Volumn 82, Issue 2, 1996, Pages 189-192

  Bruchhaus, Iris ^a   Tannich, Egbert ^a  

^a BERNHARD NOCHT INSTITUTE FOR TROPICAL MEDICINE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; CYSTEINE;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; ENTAMOEBA HISTOLYTICA; GENE EXPRESSION; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BASE SEQUENCE; CYSTEINE ENDOPEPTIDASES; DNA, PROTOZOAN; ENTAMOEBA; ENTAMOEBA HISTOLYTICA; GENE EXPRESSION; GENES, PROTOZOAN; MOLECULAR SEQUENCE DATA; PROTOZOAN PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SEQUENCE HOMOLOGY, NUCLEIC ACID;

ENTAMOEBA DISPAR; ENTAMOEBA HISTOLYTICA;

EID: 0030032169     PISSN: 00443255     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004360050093     Document Type: Article

References (16)

1. Bruchhaus I, Leippe M, Lioutas C, Tannich E (1993) Unusual gene organization in the protozoan parasite Entamoeba histolytica. DNA Cell Biol 12:925-933
2. Brumpt E (1925) Étude sommaire de l'«Entamoeba dispar» n.sp. Amibe a kystes quadrinucléés, parasite de l'homme. Bull Acad Med (Paris) 94:943-952
3. Diamond LS, Clark CG (1993) A rediscription of Entamoeba histolytica Schaudinn, 1903 (emended Walker 1911) separating it from Entamoeba dispar Brumpt 1925. J Euk Microbiol 40:340-344
4. Gadasi H, Kobiler D (1983) Entamoeba histolytica: correlation between virulence and content of proteolytic enzymes. Exp Parasitol 55:105-110
5. Horstmann RD, Leippe M, Tannich E (1992) Recent progress in the molecular biology of Entamoeba histolytica. Trop Med Parasitol 43:213-218
6. Keene WE, Hidalgo ME, Orozco E, McKerrow JH (1990) Entamoeba histolytica: correlation of the cytopathic effect of virulent trophozoites with secretion of a cysteine proteinase. Exp Parasitol 71:199-206
7. Leippe M, Sievertsen HJ, Tannich E, Horstmann RD (1995) Spontaneous release of cysteine proteinases but not of pore-forming peptides by viable Entamoeba histolytica. Parasitology (in press)
8. Luaces AL, Barrett AJ (1988) Affinity purification and biochemical characterization of histolysin, the major cysteine proteinase of Entamoeba histolytica. Biochem J 250:903-909
9. Reed SL, Keene WE, McKerrow JH (1989) Thiol proteinase expression and pathogenicity of Entamoeba histolytica. J Clin Microbiol 27:2772-2777
10. Reed SL, Bouvier J, Pollack AS, Engel JC, Brown M, Hirata K, Que X, Eakin A, Hagblom P, Gillin F, McKerrow JH (1993) Cloning of a virulence factor of Entamoeba histolytica. Pathogenic strains possess a unique cysteine proteinase gene. J Clin Invest 91:1532-1540
11. Scholze H, Schulte W (1988) On the specificity of a cysteine proteinase from Entamoeba histolytica. Biomed Biochim Acta 27:115-123
12. Scholze H, Tannich E (1994) Cysteine endopeptidases of Entamoeba histolytica. In: Abelson JN, Simon MI (eds) Methods in enzymology: proteolytic enzymes, vol 244, part D. Academic Press, Orlando, Florida, pp 512-523
13. Schulte W, Scholze H (1989) Action of the major protease from Entamoeba histolytica on proteins and extracellular matrix. J Protozool 36:538-543
14. Stanley SL, Zhang T, Rubin D, Li E (1995) Role of the Entamoeba histolytica cysteine proteinase in amebic liver abscess formation in severe combined immunodeficient mice. Infect Immun 63:1587-1590
15. Tannich E, Scholze H, Nickel R, Horstmann RD (1991) Homologous cysteine proteinases in pathogenic and nonpathogenic Entamoeba histolytica: differences in structure and expression. J Biol Chem 266:4798-4803
16. Tannich E, Nickel R, Buß H, Horstmann RD (1992) Mapping and partial sequencing of the genes coding for two different cysteine proteinases in pathogenic Entamoeba histolytica. Mol Biochem Parasitol 54:109-112