Glial fibrillary acidic protein-immunoreactive astrocytosis in elderly patients with schizophrenia and dementia

Acta Neuropathologica

Volumn 91, Issue 3, 1996, Pages 269-277

  Arnold, Steven E ^a   Franz, Bryan R ^a   Trojanowski, John Q ^a   Moberg, Paul J ^a   Gur, Raquel E ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Neurofibrillary tangle; Orbitofrontal cortex; Subiculum; Vimentin

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN; MONOCLONAL ANTIBODY; TAU PROTEIN; VIMENTIN;

AGED; ARTICLE; ASTROCYTE; ASTROCYTOSIS; CLINICAL ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; DEMENTIA; DISABILITY; FEMALE; FRONTAL LOBE; HUMAN; HUMAN TISSUE; HYPOTHALAMUS VENTROMEDIAL NUCLEUS; IMMUNOHISTOCHEMISTRY; INSTITUTIONALIZATION; MALE; NEUROFIBRILLARY TANGLE; NEUROPSYCHOLOGY; OPTICAL DENSITY; PRIORITY JOURNAL; SCHIZOPHRENIA; TEMPORAL LOBE;

AGED; AGED, 80 AND OVER; AGING; ASTROCYTES; CELL COUNT; DEMENTIA; FEMALE; GLIAL FIBRILLARY ACIDIC PROTEIN; GLIOSIS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICROSCOPY; SCHIZOPHRENIA;

EID: 0030031869     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004010050425     Document Type: Article

References (68)

1. Amaral DG, Insausti R (1990) Hippocampal formation. In: Paxinos G (ed) The human nervous system. Academic Press, San Diego, pp 711-755
2. Amaral DG, Insausti R, Cowan WM (1987) The entorhinal cortex of the monkey. I. Cytoarchitectonic organization. J Comp Neurol 264: 326-355
3. American Psychiatric Association, Committee on Nomenclature and Statistics (1987) Diagnostic and statistical manual of mental disorders, revised 3rd edn. American Psychiatric Association, Washington, D.C.
4. Andreasen NC (1983) The scale for the assessment of negative symptoms (SANS). University of Iowa, Iowa City
5. Andreasen NC (1984) The scale for the assessment of positive symptoms (SAPS). University of Iowa, Iowa City
6. Arai H, Lee VM-Y, Messinger ML, Greenberg BD, Lowery DE, Trojanowski JQ (1991) Expression patterns of b-amyloid precursor protein (b-APP) in neural and nonneural human tissues from Alzheimer's disease and control subjects. Ann Neurol 30: 686-693
7. Arnold SE, Hyman BT, Hoesen GWV, Damasio AR (1991) Some cytoarchitectural abnormalities of the entorhinal cortex in schizophrenia. Arch Gen Psychiatry 48: 625-632
8. Arnold SE, Lee VMY, Gur RE, Trojanowski JQ (1991) Abnormal expression of two microtubule-associated proteins (MAP2 and MAP5) in specific subfields of the hippocampal formation in schizophrenia. Proc Natl Acad Sci USA 88: 10850-10854
9. Arnold SE, Franz BR, Trojanowski JQ (1994) Elderly patients with schizophrenia exhibit infrequent neurodegenerative lesions. Neurobiol Aging 15: 299-303
10. Arnold SE, Franz BR, Gur RC, Gur RE, Shapiro RM, Moberg PJ, Trojanowski JQ (1995) Smaller neuron size in schizophrenia in hippocampal subfields that mediate cortical-hippocampal interactions. Am J Psychiatry 152: 738-748
11. Arnold SE, Gur RE, Shapiro RM, Fisher KR, Moberg PJ, Gibney MR, Gur RC, Blackwell P, Trojanowski JQ (1995) Prospective clinicopathological studies of schizophrenia: accrual and assessment. Am J Psychiatry 152: 731-737
12. Arnold SE, Trojanowski JQ (1996) Human fetal hippocampal development. II. The neuronal cytoskeleton. J Comp Neurol (in press)
13. Balasingam V, Tejada-Berges T, Wright E, Bouckava R, Yong VW (1994) Reactive astrogliosis in the neonatal mouse brain and its modulation by cytokines. J Neurosci 14: 846-856
14. Benes FM, Davidson J, Bird ED (1986) Quantitative cytoarchitectural studies of the cerebral cortex of schizophrenics. Arch Gen Psychiatry 43: 31-35
15. Benes FM, McSparren J, Bird ED, SanGiovanni JP, Vincent SL (1991) Deficits in small interneurons in prefrontal and cingulate cortices of schizophrenic and schizoaffective patients. Arch Gen Psychiatry 48: 996-1001
16. Benes FM, Sorensen I, Bird ED (1991) Reduced neuronal size in posterior hippocampus of schizophrenic patients. Schizophr Bull 17: 597-608
17. Bogerts B, Hantsch J, Herzer M (1983) A morphometric study of the dopamine-containing cell groups in the mesencephalon of normals, Parkinson patients, and schizophrenics. Biol Psychiatry 18: 951-969
18. Bruton CJ, Crow TJ, Frith CD, Johnstone EC, Owens DGC, Roberts GW (1990) Schizophrenia and the brain: a prospective clinico-neuropathological study. Psychol Med 20: 285-304
19. Casanova MF, Stevens JR, Kleinman JE (1990) Astrocytosis in the molecular layer of the dentate gyrus: a study in Alzheimer's disease and schizophrenia. Psychiatry Res 35: 149-166
20. Chavis DA, Pandya DN (1976) Further observations on corticofrontal connections in the rhesus monkey. Brain Res 117: 369-386
21. Cochard P, Paulin D (1984) Initial expression of neurofilaments and vimentin in the central and peripheral nervous system of the mouse embryo in vivo. J Neurosci 4: 2080-2094
22. Cohen M, Roessmann U (1994) In utero brain damage: relationship of gestational age to pathological consequences. Dev Med Child Neurol 36: 263-268
23. Conrad AJ, Abebe T, Austin R, Forsythe S, Scheibel AB (1991) Hippocampal pyramidal cell disarray in schizophrenia as a bilateral phenomenon. Arch Gen Psychiatry 48: 413-417
24. Davidson M, Harvey PD, Powchik P, Parella M, White L, Knobler HY, Losonczy MF, Keefe RSE, Katz S, Frecska E (1995) Severity of symptoms in chronically institutionalized geriatric schizophrenic patients. Am J Psychiatry 152: 197-207
25. Deakin JFW, Slater P, Simpson MDC, Gilchrist AC, Skan WJ, Royston MC, Reynolds GP, Cross AJ (1989) Frontal cortical and left temporal glutamatergic dysfunction in schizophrenia. J Neurochem 52: 1781-1786
26. Duchen LW (1992) General pathology of neurons and neuroglia. In: Adams JH, Duchen LW (eds) Greenfield's neuropathology. Oxford University Press, New York, pp 1-68
27. El-Mallakh RS, Kirch DG, Shelton R, Fan KJ, Pezeshkpour G, Kanhouwa S, Wyatt RJ, Kleinman JE (1991) The nucleus basalis of Meynert, senile plaques, and intellectual impairment in schizophrenia. J Neuropsychiatry Clin Neurosci 3: 383-386
28. Eslinger PJ, Damasio AR (1985) Severe disturbance of higher cognition after bilateral frontal lobe ablation: patient EVR. Neurology 35: 1731-1741
29. Falkai P, Bogerts B, Rozumek M (1988) Limbic pathology in schizophrenia: the entorhinal region - a morphometric study. Biol Psychiatry 24: 515-521
30. Folstein MF, Folstein S, McHugh PR (1975) Mini-mental state: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12: 189-198
31. Fuster JM (1989) The prefrontal cortex: anatomy, physology, and neuropsychology of the frontal lobe, 2nd edn. Raven Press, New York
32. Gibney M, Moberg PJ, Arnold SE, Shapiro R, Fisher K, Gur RE (1993) Neuropsychological functioning in elderly persons with schizophrenia: a pilot study. Presented at the Annual Meetins of the Eastern Psychological Association, Arlington, VA, April 21-24, 1993
33. Greenberg SG, Davies P (1990) A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide eel electrophoresis. Proc Natl Acad Sci USA 87: 5827-5831
34. Hansen LA, Armstrong DM, Terry RD (1987) An immunohistochemical quantification of fibrous astrocytes in the aging of the human cerebral cortex. Neurobiol Aging 8: 1-6
35. Haroutunian V, Davidson M, Kanof PD, Perl DP, Powchik P, Losonezy M, McCrystal J, Purohit DP, Bierer LM, Davis KL (1994) Cortical cholinergic markers in schizophrenia. Schizophr Res 12: 137-144
36. Harvey PD, Davidson M, Powchik P, Parrella M, White L, Mohs RC (1992) Assessment of dementia in elderly schizophrenics with structured rating scales. Schizophr Res 7: 85-90
37. Harvey PD, White L, Parella M, Putnam KM, Kincaid MM, Powchik P, Mohs RC, Davidson M (1995) The longitudinal stability of cognitive impairment in schizophrenia: Mini-mental state scores at one-and two-year follow-ups in geriatric inpatients. Br J Psychiatry (in press)
38. Horton K, Forsyth CS, Sibtain N, Ball S, Bruton CJ, Royston MC, Roberts GW (1993) Ubiquitination as a probe for neurodegeneration in the brain in schizophrenia: the prefrontal cortex. Psychiatry Res 48: 145-152
39. Jakob H, Beckmann H (1986) Prenatal developmental disturbances in the limbic allocortex in schizophrenics. J Neural Transm 65: 303-326
40. Karson CN, Casanova MF, Kleinman JF, Griffin WS (1993) Choline acetyltransferase in schizophrenia. Am J Psychiatry 150: 454-459
41. Khachaturian ZS (1985) Diagnosis of Alzheimer's disease Arch Neurol 42: 1097-1105
42. Kovelman JA, Scheibel AB (1984) A neurohistological correlate of schizophrenia. Biol Psychiatry 19: 1601-1621
43. Larson EB, Reifler BV, Featherston HJ, English DR (1984) Dementia in elderly outpatients: a prospective study. Ann Intern Med 100: 417
44. Lawton MP, Brody EM (1969) Physical self-maintenance scale (functional assessment). Gerontologist 9: 179-186
45. Lorente de No R (1933) Studies on the structure of the cerebral cortex. I. The area entorhinalis. J Psychol Neurol 45: 381-438
46. Moberg PJ, Mahr R, Gibney M, Arnold SE, Shapiro R, Kumar A, Gottlieb G, Gur RE (1995) Neuropsychological functioning in elderly patients with schizophrenia and Alzheimer's disease. JINS 1: 132
47. Morris JC, Heyman A, Mohs RC, Hughes JP, Belle GV, Fillenbaum G, Mellits ED, Clark C, Investigators C (1989) The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part I. Clinical and neuropsychological assessment of Alzheimer's disease. Neurology 39: 115-116
48. Nieto D, Escobar A (1972) Major psychoses. In: Minckler J (ed) Patholoay of the nervous system. McGraw-Hill, New York, pp 2654-2665
49. Norton WT, Aquino DA, Hozumi I, Chiu F-C, Brosnan CF (1992) Quantitative aspects of reactive gliosis: a review. Neurochem Res 17: 877-885
50. Overall JR, Gorham DR (1980) The brief psychiatric rating scale. J Oper Psychiatry 11: 46-64
51. Powchik P, Davidson M, Nemeroff CB, Haroutunian V, Purohit DP, Losonczy M, Bissette G, Perl D, Ghanbari H, Miller B, Davis K (1993) Alzheimer's-disease-related protein in geriatric schizophrenic patients with cognitive impairment. Am J Psychiatry 150: 1726-1727
52. Prohovnik I, Dwork AJ, Kaufman MA, Wilson N (1993) Alzheimer-type neuropathology in elderly schizophrenia patients. Schizophr Bull 19: 805-816
53. Purohit DP, Davidson M, Perl DP, Powchik P, Haroutunian VH, Bierer LM, McCrystal J, Losonsczy M, Davis KL (1993) Severe cognitive impairment in elderly schizophrenic patients: a clinicopathological study. Biol Psychiatry 33: 255-260
54. Roberts GW, Colter N, Lofthouse R, Bogerts B, Zech M, Crow TJ (1986) Gliosis in schizophrenia: a survey. Biol Psychiatry 21: 1043-1050
55. Roberts GW, Colter N, Lofthouse R, Johnstone EC, Crow TJ (1987) Is there gliosis in schizophrenia? Investigation of the temporal lobe. Biol Psychiatry 22: 1459-1468
56. Rosene DL, Hoesen GWV (1977) Hippocampal efferents reach widespread areas of cerebral cortex and amygdala in the rhesus monkey. Science 198: 315-317
57. Schmidt ML, Lee VM-Y, Hurtig H, Trojanowski JQ (1988) Properties of antigenic determinants that distinguish neurofibrillary tangles in progressive supranuclear palsy and Alzheimer's disease. Lab Invest 59: 460-466
58. Stevens CD, Altshuler LL, Bogerts B, Falkai P (1988) Quantitative study of gliosis in schizophrenia and Huntington's chorea. Biol Psychiatry 24: 697-700
59. Stevens JR (1982) Neuropathology of schizophrenia. Arch Gen Psychiatry 39: 1131-1139
60. Stevens JR, Casanova MF (1988) Is there a neuropathology of schizophrenia? Biol Psychiatry 24: 123-128
61. Stevens JR, Casanova M, Poltorak M, Germain L, Buchan GC (1992) Comparison of immunocytochemical and Holzer's methods for detection of acute chronic gliosis in human postmortem material. J Neuropsychiatry Clin Neurosci 4: 168-173
62. Swanson LW, Cowan WM (1977) An autoradiographic study of the organization of the efferent connections of the hippocampal formation in the rat. J Comp Neurol 172: 49-84
63. Trojanowski JQ, Gordon D, Obrocka M, Lee VM-Y (1984) The developmental expresssion of neurofilament and glial filament proteins in the human pituitary gland: an immunohistochemical study with monoclonal antibodies. Dev Brain Res 13: 229-239
64. Van Hoesen GW (1982) The parahippocampal gyrus. New observations regarding its cortical connections in the monkey. Trends Neurosci 5: 345-350
65. Van Hoesen GW, Damasio AR (1987) Neural correlates of cognitive impairment in Alzheimer's disease. In: Plum F (ed) Handbook of physiology. American Physiological Society, Washington, D.C., pp 871-898
66. Van Hoesen GW, Pandya DN (1975) Some connection of the entorhinal (area 28) and perirhinal (area 35) cortices of the rhesus monkey. I. Temporal lobe afferents. Brain Res 95: 1-24
67. Wisniewski HM, Constantinidis J, Wegiel J, Bobinski M, Tarnawski M (1994) Neurofibrillary pathology in brains of elderly schizophrenics. Alzheimer Dis Assoc Disord 8: 211-227
68. Wisniewski KE, Segan SM, Miesejeski CM, Sersen EA, Rudelli RD (1991) The Fra(X) syndrome: neurological, electrophysiological, and neuropathological abnormalities. Am J Med Genet 38: 476-480