Amperometric enzyme biosensors for the analysis of drugs and metabolites

Advanced Drug Delivery Reviews

Volumn 18, Issue 2, 1996, Pages 163-191

  Harwood, G W John ^a,b   Pouton, Colin W ^b  

^a HULL ROYAL INFIRMARY   (United Kingdom)

^b University of Bath   (United Kingdom)

Author keywords

Biological monitoring; Feedback device; Microbial enzyme; Miniaturization; NAD reduction; NADP reduction; Plasma analysis; Responsive drug delivery; Rhodium complex; Therapeutic monitoring; Warfarin biosensor

Indexed keywords

BIOSENSORS; CHARGE TRANSFER; DRUG PRODUCTS; ENZYME IMMOBILIZATION; ENZYMES; GLUCOSE SENSORS; METABOLITES; MONITORING; OXIDATION; RHODIUM;

ANALYTES; BIOLOGICAL FLUIDS; BIOLOGICAL MONITORING; FEEDBACK DEVICE; MINIATURIZATION; NAD REDUCTION; NADP REDUCTION; RESPONSIVE DRUG DELIVERY; THERAPEUTIC MONITORING; WARFARIN SENSORS;

AMPEROMETRIC SENSORS;

ENZYME; FERROCENE DERIVATIVE; GLUCOSE; GLUCOSE OXIDASE; MICROBIAL ENZYME; OXIDOREDUCTASE; POLYMER; POLYPYRROLE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; RHODIUM; WARFARIN;

AMPEROMETRY; BIOSENSOR; BODY FLUID; COENZYME; DRUG ANALYSIS; DRUG METABOLISM; ELECTRON TRANSPORT; ENZYME IMMOBILIZATION; FEEDBACK SYSTEM; HUMAN; MONITORING; NONHUMAN; PRIORITY JOURNAL; REVIEW; TECHNOLOGY;

EID: 0030031148     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0169-409X(95)00093-M     Document Type: Review

References (156)

1. Turner, A.P.F., Karube, I. and Wilson, G.S. (1987) Biosensors, Oxford University Press, Oxford.
2. Akhtar, M., Lowe, C.R. and Higgins. I.J. (1987) Phil. Trans. Roy. Soc. Lond. 316, 1-181. (Now published as a book entitled Biosensors, Royal Society of London.)
3. Cass, A.E.G. (1990) Biosensors - A Practical Approach, IRL Press, Oxford.
4. Frew, J.E. and Hill, H.A.O. (1988) Electrochemical Biosensors. Anal. Chem. 59, 933A-944A.
5. Bartlett, P N. and Whitaker, R.G. (1987/88) Strategies for the development of amperometric enzyme electrodes. Biosensors 3, 359-379.
6. Turner, A.P.F. (1988) Current trends in biosensor research and development. Sensors Actuators 17, 433-450.
7. Vadgama, P. and Crump, P.W. (1992) Biosensors: Recent trends-A review. Analyst 117, 1657-1670.
8. Higson, S.P.J. and Vadgama, P.M. (1994) Biosensors-a viable moitoring technology. Med. Biol. Eng. Comput. 32, 601-609.
9. Leech, D. (1994) Affinity biosensors. Chem. Soc. Rev. 23, 205-213.
10. Pantano, P. and Kuhr, W.G. (1995) Enzyme-modified microelectrodes for in vivo neurochemical measurements. Electroanalysis 7, 405-416.
11. Jaffari, S.A. and Turner, A.P.F. (1995) Recent advances in amperometric glucose biosensors for in vivo monitoring. Physiol. Measurement 16, 1-15.
12. Clarke, L.C. Jr and Lyons, C. (1962) Electrode systems for continuous monitoring in cardiovascular surgery. Ann. NY Acad. Sci. 102, 29-45.
13. Gough, D.A., Lucisano, J.Y. and Tse, P.H.S. (1985) Two-dimensional enzyme electrode sensor for glucose. Anal. Chem. 57, 2351-2357.
14. Guilbault, G.G. and Lubrano, G.J. (1973) An enzyme electrode for the amperometric determination of glucose. Anal. Chim. Acta 64, 439-455.
15. Foulds, N.C. and Lowe, C.R. (1986) Enzyme entrapment in electrically conducting polymers. J. Chem. Soc. Faraday Trans. I 82, 1259-1264.
16. Foulds, N.C. (1987). A new approach to amperometric biosensors. Ph.D thesis, Cambridge University.
17. Adams, R.N. (1968) Electrochemistry at solid electrodes, Marcel Dekker, New York.
18. Kanapieniene, J.J., Dedinaite, A.A. and Laurinavicius, V.-S.A. (1992) Miniature glucose sensor with extended linearity. Sensors Actuators B 10, 37-40.
19. Pickup, J.C., Shaw, G.W. and Clairmont, D.J. (1987/88) Implantable glucose sensors: Choosing the appropriate sensing strategy. Biosensors 3, 335-346.
20. Yeary, R.A. (1969) Chronic toxicity of dicyclopentadienyliron (ferrocene) in dogs. Toxicol. Appl. Pharmacol. 15, 666-676.
21. Kulys, J.J., Simkeviciene, V. and Higgins, I.J. (1992) Concerning the toxicity of two compounds used as mediators in biosensor devices: 7,7,8,7-tetracyanoquinodimethane (TCNQ) and tetrathiafulvalene (TTF). Biosensors Bioelectronics 7, 495-501.
22. Gasiorowski, L., Szyba, K., Urban, J., Cieslakgolonka, M., Zakeeruddin, S.M., Gratzel, M. and Fraser, D.M. (1995) Mutagenic activity of Group VIII metal organic complexes in the Ames test - evaluation of potential glucose biosensor components. Biometals 8, 257-262.
23. Tor, R. and Freeman, A. (1986) New enzyme membrane for enzyme electrodes. Anal. Chem. 58, 1042-1046.
24. Rishpon, J., Gottesfeld, S., Campbell, C., Davey and J., Zawodzinski, T.A. (1994) Amperometric glucose sensors based on glucose oxidase immobilized in Nafion. Electroanalysis 6, 17-21.
25. Alva, S., Phadke, R.S. and Govil, G. (1993) Glucose oxidase immobilized in polyurethane matrix-a biosensor for amperometric estimation of glucose. J. Indian Chem. Soc. 70, 403-408.
26. Groom, C.A. and Luong, J.H.T. (1994) Electrical communication between a water-soluble 1,1-dimethylferrocene-2-hydroxypropyl-β-cyclodextrin complex and glucose oxidase - biosensor applications. Biosensors Bioelectronics 9, 305-313.
27. Kutner, W., Wu, H.H. and Kadish, K.M. (1994) Condensation α-cyclodextrin polymer membrane with covalently immobilized glucose oxidase and molecularly included mediator for amperometric glucose biosensor. Electroanalysis 6, 934-944.
28. Ianniello, R.M. and Yacynych, A.M. (1981) Immobilised enzyme chemically modified electrode as an amperometric sensor. Anal. Chem. 53, 2090-2095.
29. Kulys, J.J. (1986) Enzyme electrodes based on organic metals. Biosensors 2, 3-13.
30. Kulys, J.J., Samalius, A.S. and Svirmickas, G.J.S. (1980) Electron exchange between the enzyme active centre and organic metal. FEBS Lett. 114, 7-10.
31. Albery, W.J. and Bartlett, P.N. (1985) Amperometric enzyme electrodes-Part 1. Theory. J. Electroanal. Chem. 194, 211-222.
32. Albery, W.J., Bartlett, P.N., Bycroft, M., Craston, D.H. and Driscoll, B.J. (1987) Amperometric enzyme electrodes-Part III. A conducting salt electrode for the oxidation of four different flavoenzymes. J. Electroanal. Chem. 218, 119-126.
33. Albery W.J., Bartlett, P.N. and Craston, D.H. (1985) Amperometric Enzyme Electrodes-Part II. Conducting salts as electrode materials for the oxidation ofglucose oxidase. J. Electroanal. Chem. 194, 223-235.
34. Kong, J.L., Liu, H.Y. and Deng, J.Q. (1995) Cyclic voltammetric response of tetrathiafulvalene glucose oxidase-modified electrode and results for digital simulation. Anal. Lett. 28, 1339-1357.
35. Cespedes, F., Martinezfabregas, E. and Alegret, S. (1994) Amperometric glucose biosensor based on a tetrathiafulvalene-mediated epoxy-graphite composite. Electroanalysis 6, 759-763.
36. Karyakin, A.A., Gitelmacher, O.V. and Karyakina, E.E. (1995) Prussian Blue-based first-generation biosensor-a sensitive amperometric electrode for glucose. Anal. Chem. 67, 2419-2423.
37. Kulys, J., Wang, L., Hansen, H.E., Buchrasmussen, T., Wang, J. and Ozsoz, M. (1995) Methylene green-mediated carbon-paste glucose biosensor. Electroanalysis 7, 92-94.
38. Wang, J., Liu, J., Chen, L. and Lu, F. (1994) Highly selective membrane-free, mediator-free glucose biosensor. Anal. Chem. 66, 3600-3603.
39. Sakslund, H., Wang, J. and Hammerich, O. (1994) A critical evaluation of a glucose sensor made by codeposition of palladium and glucose oxidase on glassy-carbon. J. Electroanal. Chem. 374, 71-79.
40. Koopal, C.G.J., Bos, A.A.C.M. and Nolte, R.J.M. (1994) 3rd generation glucose biosensor incorporated in a conducting printing ink. Sensors Actuators B Chem. 18, 166-170.
41. Nagata, R., Clark, S.A., Yokoyama, K., Tamiya, E. and Karube, I. (1995) Amperometric glucose biosensor manufactured by a printing technique. Anal. Chim. Acta 304, 157-164.
42. Ikariyama, Y., Yamauchi, S., Yukiashi, T. and Ushioda, H. (1989) Electrochemical fabrication of amperometric microenzyme sensor. J. Electrochem. Soc. 136, 702-706.
43. Johnson, K.W. (1991) Reproducible electrodeposition of biomolecules for the fabrication of miniature electroenzymatic biosensors. Sensors Actuators B 5, 85-89.
44. Schuhmann, W. (1994) Conducting polymers and their application in amperometric sensors. Am. Chem. Soc. Symp. Ser. 556, 110-123.
45. Diaz, A.F. and Castillo, J.I. (1980) A polymer electrode with variable conductivity: Polypyrrole. J. Chem. Soc. Chem. Commun. 9, 397-398.
46. Diaz, A.F. and Hall, B. (1983) Mechanical properties of electrochemically prepared polypyrrole films. IBM J. Res. Devel. 27, 342-347.
47. Genies, E.M., Bidan, G. and Diaz, A.F. (1983) Spectroelectrochemical study of polypyrrole films. J. Electroanal. Chem. 149, 101-113.
48. Asavapiriyanont, S., Chandler, G.K., Gunawardena, G.A. and Pletcher, D. (1984) The electrodeposition of polypyrrole films from aqueous solutions. J. Electroanal. Chem. 177, 229-244.
49. Umana, M. and Waller J. (1986) Protein-modified electrodes. The glucose oxidase/polypyrrole system. Anal. Chem. 58, 2979-2983.
50. Koopal, C.G.J, Feiters, M.C., Nolte, R.J.M., de Ruiter, B., Schasfoort, R.B.M., Czajka, R. and Van Kempen, H. (1992) Polypyrrole microtubules and their use in the construction of a third generation biosensor. Synthetic Metals 51, 397-405.
51. Cooper, J.M. and Bloor, D. (1993) Evidence for the functional mechanism of a polypyrrole glucose oxidase electrode. Electroanalysis 5, 883-886.
52. Gros, P. and Bergel, A. (1995) Improved model of a polypyrrole glucose oxidase modified electrode. J. Electroanal. Chem. 386, 65-73.
53. Begum, A., Tsushima, H., Suzawa, T., Shinohara, H., Ikariyama, Y. and Aizawa, M. (1993) Amperometric enzyme sensor using conducting organic salt containing polypyrrole matrix. Sensors Actuators B 13/14, 576-577.
54. Reynolds, E.R., Geise, R.J., Yacynych, A.M. (1992) Electropolymerised films for the construction of ultramicrobiosensors and electron-mediated amperometric biosensors. ACS Symp. Ser. 487, 164-174.
55. Cocheguerente, L., Deronzier, A, Mailley, P. and Moutet, J.C. (1994) Electrochemical immobilization of glucose oxidase in pol(amphiphilic pyrrole) films and its application to the preparation of an amperometric glucose sensor. Anal. Chim. Acta 289, 143-153.
56. Schuhmann, W., Kranz, C., Huber, J. and Wohlschlager, H. (1993) Conducting polymer-based amperometric enzyme electrodes - towards the development of miniaturized reagentless biosensors. Synthetic Metals 61, 31-35.
57. Guiseppielie, A., Wilson, A.M., Tour, J.M., Broc-kmann, T.W., Zhang, P. and Allara, D.L. (1995) Specific immobilization of electropolymerized polypyrrole thin-films onto interdigitated microsensor electrode arrays. Langmuir 11, 1768-1776.
58. Contractor, A.O., Suresh Kumar, T.N., Lal, R., Srinivasa, R. and Narayan, R. (1992) Conducting polymer based biosensors. Abstracts Am. Chem. Soc. 204, 71.
59. Cass, A.E.G., Davis, G., Francis, G.D., Hill, H.A.O., Aston, W.J., Higgins, I.J., Plotkin, E.V., Scott, L.D.L. and Turner, A.P.F. (1984) Ferrocene-mediated enzyme electrode for amperometric determination of glucose. Anal. Chem. 56, 667-671.
60. Matthews, D.R., Holman, R.R., Bown, E., Steemson, J., Watson, A., Hughes, S. and Scott, D. (1987) Pen-sized digital 30-second blood glucose meter. Lancet i, 778-779.
61. Claremont, D.J., Penton, C. and Pickup, J.C. (1986) Potentially-implantable, ferrocene mediated glucose sensor. J. Biomed. Eng. 8, 272-274.
62. Degani Y. and Heller, A. (1987) Direct electrical communication between chemically modified enzymes and metal electrodes. 1. Electron transfer from glucose oxidase to metal electrodes via electron relays, bound covalently to the enzyme. J. Phys. Chem. 91, 1285-1289.
63. Bartlett, P.N., Whitaker, R.G., Green, M.J. and Frew J. (1987) Covalent binding of electron relays to glucose oxidase. J. Chem. Soc. Chem. Commun. 16, 1603-1604.
64. Heller, A. (1992) Biosensors based on direct electrical connection of redox centers of enzymes to metal electrodes. Abstr. Am. Chem. Soc. 203, 475.
65. Foulds, N.C. and Lowe, C.R. (1988) Immobilisation of glucose oxidase in ferrocene-modified pyrrole polymers. Anal. Chem. 60, 2473-2478.
66. Green, M.J. and Hill, H.A.O. (1986) Amperometric Enzyme Electrodes. J. Chem. Soc. Faraday Trans. I 82, 1237-1243.
67. Nicholson, R.S. and Shain, I. (1964) Theory of stationary electrode polarography. Anal. Chem. 36, 706-723.
68. Weibel, M.K. and Bright, H.J. (1971) The glucose oxidase mechanism. J. Biol. Chem. 246, 2734-2744.
69. Ho, M.Y.K. and Rechnitz, G.A. (1987) Highly stable biosensor using an artificial enzyme. Anal. Chem. 59, 536-537.
70. Schultz, P.G. (1988) The interplay between chemistry and biology in the design of enzymatic catalysts. Science 24, 426-433.
71. Mascini, M. (1992) Biosensors for medical applications. Sensors Actuators B 6, 79-82.
72. Guilbault, G.G., Palleschi, G. and Lubrano, G.J. (1995) Noninvasive biosensors in clinical analysis. Biosensors Bioelectronics 10, 379-392.
73. Faridnia, M.H., Palleschi, G., Lubrano, G. J. and Guilbault, G.G. (1993) Amperometric biosensor for determination of lactate in sweat. Anal. Chim. Acta 278, 35-40.
74. Palmisano, F., Centonze, D. and Zambonin, P.G. (1994) An in situ electrosythesized amperometric biosensor based on lactate oxidase immobilized in a poly-o-phenylenediamine film - determination of lactate in serum by flow injection-analysis. Biosensors Electronics 9, 471-479.
75. Wang, J and Chen, Q. (1994) Lactate biosensor based on a lactate dehydrogenase-nicotinamide adenine dinucleotide biocomposite. Electroanalysis 6, 850-854.
76. Mulchandani, A., Bassi, A.S. and Nguyen, A. (1995) Tetrathiafulvalene-mediated biosensor for L-lactate in dairy products. J. Food Sci. 60, 74-78.
77. + and cellulose acetate. Anal. Chim. Acta 304, 17-24.
78. Montagne, M., Erdmann, H., Comtat, M. and Marty, J.L. (1995) Comparison of the performances of 2 bienzymatic sensors for the detaction of lactate. Sensors Actuators B Chem. 27, 440-443.
79. Shoham, B., Migron, Y., Riklin, A., Willner, I. and Tartakovsky, B. (1995) A bilirubin biosensor based on a multilayer network enzyme electrode. Biosensors Bioelectronics 10, 341-352.
80. Kacaniklic, V., Johansson, K., Markovarga, G., Gorton, L., Jonssonpettersson, G. and Csoregi, E. (1994) Amperometric biosensors for the detection of L-amino and D-amino acids based on coimmobilized peroxidase and L-amino and D-amino acidoxidases in carbon paste electrodes. Electroanalysis 6, 381-390.
81. Zilkha, E., Koshy, A., Obrenovitch, T.P., Benetto, H.P. and Symon, L. (1994) Amperometric biosensors for online monitoring of extracellular glucose and glutamate in the brain. Anal. Lett. 27, 453-473.
82. Katsu, T, Yang, X.R. and Rechnitz, G.A. (1994) Amperometric biosensor for adenosine-5-triphosphate based on a platinum-dispersed carbon-paste enzyme electrode. Anal. Lett. 27, 1215-1224.
83. Karyakin, A.A., Karyakina, E.E., Shuhmann, W., Schmidt, H.L. and Varfolomeyev, S.D. (1994) New amperometric dehydrogenase electrodes based on electrocatalytic NADH oxidation at poly(methylene blue)-modified electrodes. Electroanalysis 6, 821-829.
84. Compagnone, D., McNeil, C.J., Athey, D., Diilio, C. and Guilbault, G.G. (1995) An amperometric NADH biosensor based on NADH oxidase from Thermus aquaticus. Enzyme Microbial Technol. 17, 472-476.
85. Kano, K., Morikage, K, Uno, B., Esaka, Y. and Goto, M. (1994) Enzyme microelectrodes for choline and acetylcholine and their applications. Anal. Chim. Acta 299, 69-74.
86. Gunther, A. and Bilitewski, U. (1995) Characterisation of inhibitors of acetylcholinesterase by an automated amperometric flow-injection system. Anal. Chim. Acta 300, 117-125.
87. Larosa, C., Pariente, F., Hernandez, L. and Lorenzo, E. (1994) Determination of organophosphorous and carbamic pesticides with an acetylcholinesterase amperometric biosensor using 4-aminophenyl acetate as substrate. Anal. Chim. Acta 295, 273-282.
88. Larosa, C., Pariente, F., Hernandez, L. and Lorenzo, E. (1995) Amperometric flow-through biosensor for the determination of pesticides. Anal. Chim. Acta 308, 129-136.
89. Guilbault, G.G. and Schmid, R D. (1991) Biosensors for the determination of drug substances. Biotechnol. Appl. Biochem. 14, 133-145.
90. di Gleria, K., Green, M.J., Hill, H.A.O. and McNeil, C.J. (1986) Homogenous ferrocene-mediated amperometric immunoassay. Anal. Chem. 58, 1203-1205.
91. Morris, N.A., Cardosi, M.F., Birch, B.J. and Turner, A.P.F. (1992) An electrochemical capillary fill device for the analysis of glucose incorporating glucose oxidase and ruthenium (III) hexamine as mediator. Electroanalysis 4, 1-9.
92. Fasco, M.J., Piper, L.J and Kaminsky, L.S. (1977) Biochemical applications of a quantitative high-pressure liquid chromatographic assay of warfarin and its metabolites. J. Chromatogr. 131, 365-373.
93. Smith, R.V. and Rosazza, J.P. (1975) Microbial models of mammalian metabolism. J. Pharm. Sci. 64, 1737-1759.
94. Griffiths, D.A., Best, D.J. and Jezequel, S.G. (1991) The screening of selected microorganisms for use as models of mammalian drug metabolism. Appl. Microbiol. Biotechnol. 10, 373-381.
95. Jürgens, T.M. and Clark, A.M. (1990) The Metabolism of CGP-291: The use of microorganisms as models of mammalian metabolism. Pharm. Res. 7, 742-745.
96. Davis, P.J. and Rizzo, J.D. (1982) Microbial Transformations of warfarin: Sterioselective reduction by Nocardia corallina and Arthrobacter species. Appl. Environ. Microbiol. 43, 884-890.
97. Rizzo, J.D. and Davis, P.D. (1989) Microbial models of mammalian metabolism: Conversion of warfarin to 4′-hydroxywarfarin using Cunninghamela bainieri. J. Pharm. Sci. 78, 183-189.
98. Finnerty, W. R. (1992) The biology and genetics of the genus Rhodococcus. Annu. Rev. Microbiol 46, 193-218.
99. Parker, M.T. and Duerden, B.I. (1990) Topley and Wilson's Principles of Bacteriology, Virology and Immunity, 8th Edn, Vol. 2 - Systematic Bacteriology, Edward Arnold, London.
100. Wong, Y.W.J. and Davis, P.J. (1989) Microbial models of mammalian metabolism: Sterioselective metabolism of warfarin in the fungus Cunninghamella elegans. Pharm. Res. 6, 982-987.
101. Fitzgerald, Y.J., Hanlon, G.W., Hutt, A J. and Olliff, C.J. (1987) An amperometric biosensor for the determination of warfarin. J. Pharm. Pharmacol. 39, 149P.
102. Moreland, T.A. and Hewick, D.S. (1975) Studies on a ketone reductase in human and rat liver and kidney soluble fraction using warfarin as a substrate. Biochem. Pharmacol. 24,1953-1957.
103. Apanovitch, D., Kitareewan, S. and Walz, F.G. Jr (1992) Exocyclic-keto reductase activities for progesterone and S-warfarin in hepatic microsomes from adult male rats. Biochem. Biophys. Res. Commun., 184, 338-346.
104. Shen, G.-J., Wang, Y.-F., Bradshaw, C. and Wong, C.-H (1990) A new NAD-dependent alcohol dehydrogenase with opposite facial selectivity useful for asymmetric reduction and cofactor regeneration. J. Chem. Soc. Chem. Commun. 19, 677-679.
105. West, B.D., Preis, S., Schroeder, C.H. and Link, K.P. (1961) Studies on the 4-hydroxycoumarins. XVII. The resolution and absolute configuration of warfarin. J. Am. Chem. Soc. 83, 2676-2679.
106. Trager, W.F., Lewis, R.J. and Garland, W.A. (1970) Mass spectral analysis in the identification of human metabolites of warfarin. J. Med. Chem. 13, 1196-1204.
107. Chan, K.K., Lewis, R.J. and Trager, W.F. (1972) Absolute configurations of the four warfarin alcohols. J. Med. Chem. 15, 1265-1270.
108. Harwood, G.R.J (1993) Towards amperometric biosensors based on microbial ketone reductases for the measurement of novel substrates. Ph.D Thesis, The University of Bath.
109. Wong, Y.W.J. and Davis, P.J. (1989) Analysis of warfarin and its metabolites by reversed-phase ion-pair liquid chromatography with fluorescence detection. J. Chromatogr. 469, 281-291.
110. Bachur, N.R. and Huffman, D.H. (1971) Daunorubicin metabolism: Estimation of daunorubicin reductase. Br. J. Pharmacol. 43, 828-833.
111. Bachur, N R. and Gee, M. (1971) Daunorubicin metabolism by rat tissue preparations. J. Pharmacol. Exp. Ther. 177, 567-572.
112. Bachur, N.R. (1971) Daunorubicinol, a major metabolite of daunorubicin: Isolation from human urine and enzymatic reactions. J. Pharmacol. Exp. Ther. 177, 573-578.
113. Bowman, W.C. and Rand, J.C. (1980) Textbook of Pharmacology, 2nd Edn, Blackwell Scientific Publications, Oxford, pp. 21.4-21.12.
114. Turner, R.F.B., Harrison, D.J., Baltes, H.P. (1987) A CMOS potentiostat for amperometric chemical sensors. IEEE J. Solid-State Circuits SC-22, 473-478.
115. Harrison, D.J., Turner, R.F.B and Baltes, H.P. (1988) Characterization of perfluorosulfonic acid polymer coated enzyme electrodes and a miniature integrated potentiostat for glucose analysis in whole blood. Anal. Chem. 60, 2002-2007.
116. Huang, H.-J, He, P and Faulkner, L.R. (1986) Current multiplier for use with ultramicroelectrodes. Anal. Chem. 58, 2889-2891.
117. Brodie, I. and Muray J.J. (1982) The Physics of Microfabrication, Plenum Press, New York.
118. Sansen, W., Lambrechts, M. and Suls, J. (1985) Fabrication of voltammetric sensors with planar techniques. In: Digest of Technical Papers; 3rd International Conference on Solid State Sensors and Actuators (Transducers 85); Philadelphia, PA, pp. 344-347.
119. Takatsu, I. and Moriizumi, T. (1987) Solid state biosensors using thin-film electrodes. Sensors Actuators 11, 309-317.
120. Tamia, E. and Karube, I. (1988) Micro-biosensors for clinical analyses. Sensors Actuators 15, 199-207.
121. Gernet, S., Koudelka, M. and De Rooij, N.F. (1989) Fabrication and characterization of a planar electrochemical cell and its application as a glucose sensor. Sensors Actuators 18, 59-70.
122. Tamia, E., Karube, I., Hattori, S., Suzuki, M. and Yokoyama, K. (1989) Micro glucose sensors using electron mediators immobilized on a polypyrrole-modified electrode. Sensors Actuators 18, 297-307.
123. Matsuo, T. and Wise, K.D. (1974) An integrated field-effect electrode for biopotential recording. IEEE Trans. Biomed. Eng. 21, 485-487.
124. Moss, S.D., Janata, J and Johnson, C. (1975) Potassium ion-sensitive field effect transistor. Anal. Chem. 47, 2238-2243.
125. Matsuo, T. and Esashi, M. (1981) Methods of ISFET fabrication. Sensors Actuators 1, 77-96.
126. Smith, R., Huber, R.J. and Janata, J (1984) Electrostatically protected ion sensitive field effect transistors. Sensors Actuators 5, 127-136.
127. Albery W.J., Bartlett, P.N., Cass, A.E.G and Koon Weng, S. (1987) Amperometric enzyme electrodes -Part IV. An enzyme electrode for ethanol. J. Electroanal. Chem. 218, 127-134.
128. + and reductive cleavage of NADH and NADPH yielding NAD and NADP. J. Electroanal. Chem. 252, 383-394.
129. Jaegfeld, H. (1981) A study of the products formed in the electrochemical reduction of nicotinamide-adeninedinucleotide. Biochem. Bioenerg. 8, 355-370. (A section of J. Electroanal. Chem. and constituting vol. 128, 1981)
130. Jaegfeld, H. (1981) A study of the products formed in the electrochemical reduction of nicotinamide-adeninedinucleotide. Biochem. Bioenerg. 8, 355-370. (A section of J. Electroanal. Chem. and constituting vol. 128, 1981)
131. Miksic, J.R. and Brown P.R. (1977) Complementary use of the reversed-phase and anion-exchange modes of high-pressure liquid chromatography for studies of reduced nicotinamide adenine dinucleotide. J. Chromatogr. 142, 641-649.
132. Wang, S.S. and King, C-K. (1990) The use of coenzymes in biochemical reactors. Adv. Biochem. Eng. 12, 119-146.
133. + to 1,4-NADH without an enzyme. J. Chem. Soc. Chem. Commun. 15, 885-886.
134. Wienkamp, R. and Steckhan, E. (1982) Indirect electrochemical regeneration of NADH by a bipyridinerhodium(I) complex as electron-transfer agent. Angew. Chem. Int. Ed. Engl. 21, 782-783.
135. + with formate catalysed by cationic rhodium complexes. J. Chem. Soc. Chem. Commun., 1150-1151.
136. +} modified electrodes; a molecularly-based material for hydrogen evolution (bpy = 2,2′-bipyridine). J. Chem. Soc. Chem. Commun., 1259-1261.
137. 2. Angew. Chem. Int. Ed. Engl. 26, 567-570.
138. Harris, C.M. and McKenzie, E.D. (1963) The preparation and colour of tris-2,2′-bipyridyl-and bis-2,2′,2″- terpyridylrhodium(III) salts. J. Inorg. Nucl. Chem. 25, 171-174.
139. Martin, B. and Waind, G.M. (1958) 2:2′-Dipyridyl complexes of cobalt, rhodium, and iridium. Part I. Tervalent rhodium and iridium complexes. J. Chem. Soc., 4284-4288.
140. Kirch, M., Lehn, J.-M. and Sauvage, J.-P. (1979) Hydrogen generation by visible light irradiation of aqueous solutions of metal complexes. An approach to the photochemical conversion and storage of solar energy. Helv. Chim. Acta 62, 1345-1384.
141. Bhayat, I.I. and McWhinnie, W.R. (1972) An evaluation of the role of far infrared spectroscopy in the study of rhodium(III) halide complexes with nitrogen heterocyclic ligands. Spectrochim. Acta 28A, 743-751.
142. Frink, M. E., Sprouse, S.D., Goodwin, H.A., Watts, R.J. and Ford, P.C. (1988) Synthesis and excited-state properties of rhodium(III) terpyridine complexes. Inorg. Chem. 27, 1283-1286.
143. Eisenthal, R. and Danson, M.J. (1992) Enzyme Assays - A Practical Approach, IRL Press, Oxford.
144. Harrison, S.T.L. (1991) Bacterial cell disruption: A key unit operation in the recovery of intracellular products. Biotech. Adv. 9, 217-240.
145. Steckhan, E., Herrmann, S., Ruppert, R., Dietz, E., Frede, M. and Spika, E. (1991) Analytical study of a series of substituted (2,2′-bipyridyl) (pentamethylcyclopentadienyl) rhodium and iridium complexes. Organometallics 10, 1568-1577.
146. + cofactor - Application to the enzymatic reduction of pyruvate. J. Electroanal. Chem. 315, 307-312.
147. 3+. Chem. Lett. 3, 353-356.
148. +/NADH recycling. J. Organometallic Chem. 421, C16-C19.
149. Beley, M. and Collin, J-P. (1993) Electrochemical regeneration of nicotinamide cofactor using a polypyrrole rhodium bis-terpyridine modified electrode. J. Mol. Catalysis 79,133-140.
150. 2. Biochem. Bioenerg. 27, 495-500.
151. + reduction. Bioelectrochem. Bioenerg. 27, 475-486.
152. +. J. Mol. Catalysis 73, 371-380.
153. Schulz, M., Bayer, M., White, H., Gunther, H. and Simon, H. (1994) Application of high enzyme activities present in Clostridium thermoaceticum for the efficient regeneration of NADPH, NADP(+), NADH and NAD(+). Biocatalysis 10, 25-36.
154. Davies, S.G., Edwards, A.J., Skerlj, R.T., Sutton, K.H. and Whittaker, M. (1991) Chiral organometallic NADH mimics. J. Chem. Soc. Perkin Trans. I 5, 1027-1034.
155. Griffiths, D. and Hall, G. (1993) Biosensors - What real progress is being made. Trends Biotechnol. 11, 122-130.
156. Wilkins, E., Atanasov, P. and Muggenburg, B.A. (1995) Integrated implantable device for long-term glucose monitoring. Biosensors Bioelectronics 10, 485-494.