Perioperative Management of Drug Therapy: Clinical Considerations

Drugs

Volumn 51, Issue 2, 1996, Pages 238-259

  Smith, Mark Stafford ^a   Muir, Holly ^a   Hall, Richard ^a,b  

^a DALHOUSIE UNIVERSITY   (Canada)

^b QUEEN ELIZABETH II HEALTH SCIENCES CENTRE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; ANESTHETIC AGENT; ANTIANGINA PECTORIS AGENT; ANTIARRHYTHMIC AGENT; ANTICOAGULANT AGENT; ANTICONVULSIVE AGENT; ANTIHYPERTENSIVE AGENT; ANTIPARKINSON AGENT; ANXIOLYTIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM ANTAGONIST; DEXTROMETHORPHAN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; FIBRINOLYTIC AGENT; GLUCOCORTICOID; HEPARIN; LITHIUM; MONOAMINE OXIDASE INHIBITOR; NEUROLEPTIC AGENT; NONSTEROID ANTIINFLAMMATORY AGENT; PETHIDINE; TRICYCLIC ANTIDEPRESSANT AGENT; WARFARIN;

ANESTHESIA; CARDIOVASCULAR SYSTEM; CENTRAL NERVOUS SYSTEM; DRUG SAFETY; DRUG WITHDRAWAL; ENDOCRINE SYSTEM; EPIDURAL HEMATOMA; HEMOSTASIS; HUMAN; NERVE BLOCK; PARALYSIS; PERIOPERATIVE PERIOD; REVIEW; SPINAL CORD COMPRESSION; SPINAL CORD HEMORRHAGE; VASCULAR SURGERY;

ANIMALS; ANTICOAGULANTS; CARDIOVASCULAR AGENTS; CENTRAL NERVOUS SYSTEM AGENTS; DRUG THERAPY; GLUCOCORTICOIDS; HUMANS; INTRAOPERATIVE PERIOD;

EID: 0030030974     PISSN: 00126667     EISSN: None     Source Type: Journal    
DOI: 10.2165/00003495-199651020-00005     Document Type: Article

References (181)

1. Olsson GL, Hallen B, Hambraeus-Jonzon K. Aspiration during anesthesia: a computer-aided study of 185,358 anaesthetics. Acta Anaesthesiol Scand 1986; 30: 84-92
2. Tiret L, Nivoche Y, Hatton F, et al. Complications related to anaesthesia in infants and children: a prospective survey of 40240 anesthetics. Br J Anaesth 1988; 61: 263-9
3. Cheney FW, Posner KL, Caplan RA. Adverse respiratory events infrequently leading to malpractice suits: a closed claims analysis. Anesthesiology 1991; 75: 932-9
4. Warner MA, Warner ME, Weber JG. Clinical significance of pulmonary aspiration during the perioperative period. Anesthesiology 1993; 78: 56-62
5. Coté CJ. NPO after midnight for children - a reappraisal [editorial]. Anesthesiology 1990; 72: 589-92
6. Crawford M, Lerman J, Christensen S, et al. Effects of duration of fasting on gastric fluid pH and volume in healthy children. Anesth Analg 1990; 71: 400-3
7. Shevde K, Trivedi N. Effects of clear liquids on gastric volume and pH in healthy volunteers. Anesth Analg 1991; 72: 528-31
8. Schreiner MS, Triebwasser A, Keon TP. Ingestion of liquids compared with preoperative fasting in pediatric outpatients. Anesthesiology 1990; 72: 593-7
9. Maltby JR, Lewis P, Martin A, et al. Gastric fluid volume and pH in elective patients following unrestricted oral fluid until three hours before surgery. Can J Anaesth 1991; 38: 425-9
10. Phillips S, Hutchinson S, Davidson T. Preoperative drinking does not affect gastric contents. Br J Anaesth 1993; 70: 6-9
11. Søreide E, Holst-Larsen K, Reite K, et al. Effects of giving water 20-450 ml with oral diazepam premedication 1-2 h before operation. Br J Anaesth 1993; 71: 503-6
12. Goresby GV, Maltby JR. Fasting guidelines for elective surgical patients. Can J Anaesth 1990; 37: 493-5
13. Hjortsø E, Mandorf T. Does oral premedication increase the risk of gastric aspiration? Acta Anaesthesiol Scand 1982; 26: 505-6
14. McGrady EM, MacDonald AG. Effect of the preoperative administration of water on gastric volume and pH. Br J Anaesth 1988; 60: 803-5
15. Miller M, Wishart HY, Nimmo WS. Gastric contents at induction of anaesthesia: is a 4-hour fast necessary? Br J Anaesth 1983; 55: 1185-8
16. Sutherland AD, Maltby JR, Sale JP, et al. The effect of preoperative oral fluid and ranitidine on gastric fluid volume and pH. Can J Anaesth 1987; 34: 117-21
17. Maltby JR, Sutherland AD, Sale JP, et al. Preoperative oral fluids: is a five-hour fast justified prior to elective surgery? Anesth Analg 1986; 65: 1112-6
18. Brocks K, Jensen JS, Schmidt JF, et al. Gastric contents and pH after oral premedication. Acta Anaesthesiol Scand 1987; 31: 448
19. Splinter WM, Schaefer JD. Ingestion of clear fluids is safe for adolescents up to 3 h before anaesthesia. Br J Anaesth 1991; 66: 48-52
20. Splinter WM, Schaefer JD. Unlimited clear fluid ingestion two hours before surgery in children does not affect volume or pH of stomach contents. Anaesth Intens Care 1990; 18: 522-6
21. Pontén J, Biber B, Henriksson B-Å, et al. Beta-receptor blockade and neurolept anaesthesia: withdrawal vs continuation of long-term therapy in gall-bladder and carotid artery surgery. Acta Anaesthesiol Scand 1982; 26: 576-88
22. Berggren H, Ekroth R, Herlitz J, et al. Myocardial protective effect of maintained beta-blockade on aorto-coronary bypass surgery. Scand J Thor Cardiovasc Surg 1983; 17: 29-32
23. Prys-Roberts C, Meloche R, Foëx P. Studies of anaesthesia in relation to hypertension: I. cardiovascular responses of treated and untreated patients. Br J Anaesth 1971; 43: 122-37
24. Prys-Roberts C. Hypertension and anesthesia-fifty years on [editorial]. Anesthesiology 1979; 50: 281-4
25. Tarnow J, Müller RK. Cardiovascular effects of low-dose epinephrine infusions in relation to the extent of preoperative β-adrenoceptor blockade. Anesthesiology 1991; 74: 1035-43
26. Hart GR, Anderson RJ. Withdrawal syndromes and the cessation of antihypertensive therapy. Arch Intern Med 1981; 141: 1125-7
27. Nattel S, Rangno RE, Van Loon G. Mechanism of propranolol withdrawal phenomena. Circulation 1979; 59: 1158-64
28. Bruce DL, Croley TF, Lee JS, Preoperative clonidine withdrawal syndrome. Anesthesiology 1979: 51: 90-2
29. Kaukinen S, Kaukinen L, Eerola R. Preoperative and postoperative use of clonidine with neurolept anaesthesia. Acta Anaesthesiol Scand 1978; 23: 113-20
30. Quintin L, Cicala R, Kent M, et al. Effect of clonidine on mocardial ischaemia: a double-blind pilot trial. Can J Anaesth 1993; 40: 85-6
31. Fulgencio JP, Rimaniol JM, Catiore P, et al. Clonidine and postoperative myocardial ischaemia. Can J Anaesth 1994; 41: 550-1
32. Colson P, Médioni P, Saussine M, et al. Hemodymimic effect of calcium channel blockade during anesthesia for coronary artery surgery. J Cardiothorac Vase Anesth 1992; 6: 424-8
33. Schick Jr EC, Liang C, Heupler Jr FA, et al. Randomized withdrawal from nifedipine: placebo-controlled study in patients with coronary artery spasm. Am Heart J 1982; 104: 690-7
34. Subramanian VB, Bowles MJ, Khurmi NS, et al. Calcium antagonist withdrawal syndrome: objective demonstration with frequency-modulated ambulatory ST-segment monitoring. BMJ 1983; 286: 520-1
35. Larach DR, Hensley FAJ, Pae WE, et al. Diltiazem withdrawal before coronary artery bypass surgery. J Cardiothorac Vasc Anesth 1989; 3: 688-99
36. Chung F, Houston PL, Cheng DCH, et al. Calcium channel blockade does not offer adequate protection from perioperative myocardial ischemia. Anesthesiology 1988; 69: 343-7
37. Slogoff S, Keats AS. Does chronic treatment with calcium entry blockers reduce perioperative myocardial ischemia? Anesthesiology 1988; 68: 676-80
38. Yates AP, Hunter DN. Anaesthesia and angiotensin-converting enzyme inhibitors: the effect of enalapril on peri-operative cardiovascular stability. Anaesthesia 1988; 43: 935-8
39. Coriat P, Richer C, Douraki T, et al. Influence of chronic angiotensin-converting enzyme inhibition on anesthetic induction. Anesthesiology 1994; 81: 299-307
40. McCarthy GJ, Lindsay K, Wright JM, et al. Pressor response to tracheal intubation after sublingual captopril: a pilot study. Anaesthesia 1990; 45: 243-5
41. Sill JC, Nugent M, Moyer TP, et al. Influence of propranolol plasma levels on hemodynamics during coronary artery bypass surgery. Anesthesiology 1984; 60: 455-63
42. Hedberg A, Gerber JG, Nies AS, et al. Effects of pindolol and propranolol on beta adrenergic receptors on human lymphocytes. J Pharmacol Exp Ther 1986; 239: 117-23
43. Stone JG, Foëx P, Sear JW, et al. Myocardial ischemia in untreated hypertensive patients: effect of a single small oral dose of a beta-adrenergic blocking agent. Anesthesiology 1988; 68: 495-500
44. Roizen MF. Should we all have a sympathectomy at birth? Or at least preoperatively? [editorial]. Anesthesiology 1988; 68: 482-4
45. Kostis JB. Beta-blocker duration of action and implications for therapy. Am J Cardiol 1990; 66: 60G-2G
46. Gerber JG, Nies AS. Antihypertensive agents and the drug therapy of hypertension. In: Gilman AG, Rall TW, Nies AS, et al., editors. The pharmacological basis of therapeutics. New York: Pergamon, 1990: 784-813
47. 2 adrenoeeptor agonists and anaesthesia. Br J Anaesth 1993; 71: 108-18
48. Flacke JW, Bloor BC, Flacke WE, et al. Reduced narcotic requirement by clonidine with improved hemodynamic and adrenergic stability in patients undergoing coronary artery bypass surgery. Anesthesiology 1987; 67: 11-9
49. Reves JG, Kissin I, Lell WA, et al. Calcium entry blockers: uses and implications for anesthesiologists. Anesthesiology 1982; 57: 504-18
50. Schlanz KD, Myre SA, Bottorff MB. Pharmacokinetic interactions with calcium channel antagonists (part II). Clin Pharmacokinet 1991; 21: 448-60
51. Lehot JJ, Durand PG, Boulieu R, et al. Concentrations plasmatiques du diltiazem et de ses métabolites en chirurgie coronarienne: relation avec le traitement préopératoire. Ann Fr Anesth Rean 1993; 12: 452-6
52. Finegan BA, Hussain MD, Tam YK. Pharmacokinetics of diltiazem in patients undergoing coronary artery bypass grafting. Ther Drug Monitor 1992; 14: 485-92
53. Casson WR, Jones RM, Parsons RS. Nifedipine and cardiopulmonary bypass: post-bypass management alter continuation or withdrawal of therapy. Anaesthesia 1984; 39: 1197-201
54. Selby DG, Richards JD, Marshman JM. ACE inhibitors [letter]. Anaesth Intens Care 1989; 17: 110-1
55. Böttcher M, Behrens JK, Møller EA, et al. ACE inhibitor pre-medication attenuates sympathetic responses during surgery. Br J Anaesth 1994; 72: 633-7
56. Williams GH. Converting-enzyme inhibitors in the treatment of hypertension. N Engl J Med 1988; 319: 1517-25
57. Frishman WH. Comparative pharmacokinetic and clinical profiles of angiotensin-eonverting enzyme inhibitors and calcium antagonists in systemic hypertension. Am J Cardiol 1992; 69: 17C-25C
58. Pinaud M, Blanloeil Y. Operating on a cardiac patient: stopping or continuing preoperative treatment. Ann Fr Anesth Rean 1986; 5: 138-53
59. Vaughan Williams EM. A classification of antiarrhythmic actions reassessed after a decade of new drugs. J Clin in Pharmacol 1984; 24: 129-47
60. Liberman BA, Teasdale SJ. Anaesthesia and amiodarone. Can Anaesth Soc J 1985; 32: 629-38
61. Mason JW. Anuodarone. N Engl J Med 1987; 316: 455-66
62. Kupferschmid JP, Rosengart TK, McIntosh CL, et al. Amiodarone-induced complications after cardiac operation for obstructive hypertrophic cardiomyopathy. Ann Thorac Surg 1989; 48: 359-64
63. Teasdale S, Downar E. Amiodarone and anaesthesia [editorial]. Can J Anaesth 1990; 37: 151-5
64. Kannan R, Nademanee K, Hendrickson JA, et al. Amiodarone kinetics after oral doses. Clin Pharmacol Ther 1982; 31: 438-44
65. Puech P. Practical aspects of the use of amiodarone. Drugs 1991; 41 Suppl. 2: 67-73
66. Stoelting RK. Cardiac antidysrhythmic drugs In: Stoelting RK, editor. Pharmacology and physiology in anesthetic practice. Philadelphia (PA): JB Lippincott, 1987: 322-34
67. Colucci RD, Somberg JC. Treatment of cardiac arrhythmias. In: Chernow B, editor. Essentials of critical care pharmacology. Baltimore (MD): Williams and Wilkins, 1994: 313-37
68. Baldessarini RJ. Drugs in the treatment of psychiatric disorders. In: Gilman AG, Rall TW, Nies AS, et al., editors. The pharmacological basis of therapeutics. New York: Pergamon, 1990: 383-435
69. Elis J, Laurence DR, Mattie H, et al. Modification by monoamine oxidase inhibitors of the effect of some sympathomimetics on blood pressure. BMJ 1967; 2: 75-8
70. Stack CG, Rogers P, Linter SPK. Monoamine oxidase inhibitors and anaesthesia. Br J Anaesth 1988; 60: 222-7
71. Gevirtz C. Anesthesia and monoamine oxidase inhibitors. [letter]. JAMA 1989; 261: 3407
72. Mallinger AG, Smith E. Pharmacokinetics of monoamine oxidase inhibitors. Psychopharmacol Bull 1991; 27: 493-502
73. Boakes AJ, Laurence DR, Teoh PC, et al. Interactions between sympathetic amines and antidepressant agents in man. BMJ 1973; 1: 311-5
74. Ramanathan KB, Davidson C. Cardiac arrhythmia and imipramine therapy. BMJ 1975; 1: 661-2
75. Edwards RP, Miller RD, Roizen MF. et al. Cardiac responses to imipramine and pancuronium during anesthesia with halothane or enflurane. Anesthesiology 1979; 50: 421-5
76. Johnston RR, Eger EI, Wilson C. A comparative interaction of epinephrine with enflurane, isoflurane, and halothane in man. Anesth Analg 1976; 55: 709-12
77. Wong KC, Puerto AX, Puerto BA, et al. Influence of imipramine and pargyline on the arrhythmogenicity of epinephrine during halothane, enflurane or methoxyflurane anesthesia in dogs [abstract]. Anesthesiology 1980; 53: S25
78. Sprague DH, Wolf S. Enflurane seizures in patients taking amitriptyline. Anesth Analg 1982; 61: 67-8
79. Amsterdam J, Brunswick D, Mendels J. The clinical application of tricyclic antidepressant pharmacokinetics and plasma levels. Am J Psychiatry 1980; 137: 653-62
80. Hill GE, Wong KC, Hodges MR. Lithium carbonate and neuromuscular blocking agents. Anesthesiology 1977; 46: 122-6
81. Richelson E, El-Fakahany E. Changes in the sensitivity of receptors for neurotransmitters and the actions of some psychotherapeutic drugs. Mayo Clin Proc 1982; 57: 576-82
82. Whitwam JG, Russell WJ. The acute cardiovascular changes and adrenergic blockade by droperidol in man. Br J Anaesth 1971; 43: 581-91
83. Vohra SB. Convulsions after enflurane in a schizophrenic patient receiving neuroleptics. Can J Anaesth 1994; 41: 420-2
84. Mohler H, Richards JG. The benzodiazepine receptor: a pharmacological control element of brain function. Eur J Anesthesiol 1988; 2: 15-24
85. Perisho JA, Buechel DR, Miller Ronald D. The effect of diazepam (Valium) on minimum alveolar anaesthetic requirement (MAC) in man. Can Anaesth Soc J 1971; 18: 536-40
86. Gyermek L. Clinical effects of diazepam prior to and during general anesthesia. Curr Ther Res 1975; 17: 175-88
87. Torpey DJ, Ingram MD. Shock. In: Kirby RR, Gravenstein N, editors. Clinical anesthesia practice. Toronto: WB Saunders Co., 1994: 663-98
88. Haefely W. The preclinical pharmacology of flumazenil. Eur J Anesthesiol 1988; 2: 25-36
89. Stanski DR. Monitoring depth of anesthesia. In: Miller RD. editor. Anesthesia. New York (NY): Churchill Livingstone, 1990: 1001-30
90. Litt B, Krauss GL. Pharmacologic approach to acute seizures and antiepileptic drugs. In: Chernow B, editor. Essentials of critical care pharmacology. Baltimore (MD): Williams and Wilkins, 1994: 352-74
91. Rall TW, Schleifer LS. Drugs effective in the therapies of the epilepsies. In: Gilman AG, Rall TW, Nies AS, et al., editors. The pharmacological basis of therapeutics. 8th ed. New York (NY): McGraw-Hill Inc., 1990: 436-62
92. Cedarbaum JM, Schleifer LS. Drugs for Parkinson's disease, spasticity, and acute muscle spasms. In: Goodman AG, Rall TW, Nies AS, et al., editors. The pharmacological basis of therapeutics. New York (NY): Pergamon, 1990: 463-84
93. Friedman JH, Feinberg SS, Feldman RG. A neuroleptic malignantlike syndrome due to levodopa therapy withdrawal. JAMA 1985; 254: 2792-5
94. Stow PJ, Burrows FA. Anticoagulants in anaesthesia. Can J Anaesth 1987; 34: 632-49
95. Kakkar VV, Corrigan TP, Fossard DP. Prevention of fatal postoperative pulmonary embolism by low doses of heparin: an international multicenter trial. Lancet 1975; 2 (7924): 45-51
96. Majerus PW, Broze GJJ, Miletich JP, et al. Anticoagulant, thrombolytic, and antiplatelet drugs. In: Gilman AG, Rall TW, Nies AS, et al., editors. The pharmacological basis of therapeutics. New York (NY): Pergamon, 1990: 1311-31
97. Stoelting RK. Anticoagulants. In: Stoelting RK, editor. Pharmacology and physiology in anesthetic practice. Philadelphia (PA): Lippincott, 1991: 466-76
98. Bromage PR. Continuous epidural analgesia. In: Bromage PR, editor. Epidural analgesia. Toronto: WB Saunders Co, 1978: 215-57
99. Horlocker TT, Wedel DJ. Anticoagulants, antiplatelet therapy and neuraxis blockade. Anesthesiol Clin North Am 1992; 10 Suppl. 1: 1-11
100. Owens EL, Kasten GW, Hessel II EA. Spinal subarachnoid hematoma after lumbar puncture and heparinization: a case report, review of the literature, and discussion of anesthetic implications. Anesth Analg 1986; 65: 1201-7
101. Metzger G, Singbartl G. Spinal epidural hematoma following epidural anesthesia versus spontaneous spinal subdural hematoma: two case reports. Acta Anaesthesiol Scand 1991; 35: 105-7
102. Parnass SM, Rothenberg DM, Fischer RL, et al. Spinal anesthesia and mini-dose heparin [letter]. JAMA 1990; 263: 1496
103. Lowson SM, Goodchild CS. Low-dose heparin therapy and spinal anaesthesia [letter]. Anaesthesia 1989; 44: 67
104. Wille-Jørgensen P, Jørgensen LN, Rasmussen LS. Lumbar regional anaesthesia and prophylactic anticoagulant therapy: is the combination safe? Anaesthesia 1991; 46: 623-7
105. Eichhorn JH. Spinal anaesthesia and anticoagulant therapy [letter]. JAMA 1989; 262: 411
106. Vandermeulen EP, Van Aken H, Vermylen J. Anticoagulants and spinal-epidural anesthesia. Anesth Analg 1994; 79: 1165-77
107. Bergqvist D, Lindblad B, Mätzsch T. Risk of combining low molecular weight heparin for thromboprophylaxis and epidural or spinal anesthesia. Semin Thromb Hemost 1993; 19 Suppl. 1: 147-51
108. Bergqvist D, Lindblad B, Mätzsch T. Low molecular weight heparin for thromboprophylaxis and epidural/spinal anaesthesia - is there a risk? Acta Anaesthesiol Scand 1992; 36: 605-9
109. Wolf H. Experience with regional anesthesia in patients receiving low molecular weight heparins. Semin Thromb Hemost 1993; 19 Suppl. 1: 152-4
110. Odoom JA, Sih IL. Epidural analgesia and anticoagulant therapy: experience with one thousand cases of continuous epidurals. Anaesthesia 1983; 38: 254-9
111. Rao TLK, El-Etr AA. Anticoagulation following placement of epidural and subarachnoid catheters: an evaluation of neurologic sequelae. Anesthesiology 1981; 55: 618-20
112. Stevens DS. Epidural hematoma: was catheter removed during complete anticoagulation? [letter]. Anesth Analg 1992; 75: 863-4
113. Wildsmith JAW, McClure JH. Anticoagulant drugs and central nerve blockade [editorial]. Anaesthesia 1991; 46: 613-4
114. Tekkok IH, Cataltepe O, Tahta K, et al. Extradural haematoma after continuous extradural anaesthesia. Br J Anaesth 1991; 67: 112-5
115. Onishchuk JL, Carlsson C. Epidural hematoma associated with epidural anesthesia: complications of anticoagulant therapy. Anesthesiology 1992; 77: 1221-3
116. Dickman CA, Shedd SA, Spetzler RF, et al. Spinal epidural hematoma associated with epidural anesthesia: complications of systemic heparinization in patients receiving peripheral vascular thrombolytic therapy. Anesthesiology 1990; 72: 947-50
117. Dahlgren N, Törnebrandt K. Neurological complications after anesthesia. A follow-up of 18000 spinal and epidural anaesthetics performed over 3 years. Acta Anaesthesiol Scand 1995; 39: 872-80
118. Renck H. Neurological complications of central nerve blocks [editorial]. Acta Anaesthesiol Scand 1995; 39: 859-68
119. Breivik H. Safe perioperative spinal and epidural analgesia: importance of drug combinations, segmental site of injection, training and monitoring [editorial]. Acta Anaesthesiol Scand 1995; 39: 869-71
120. Horlocker TT, Wedel DJ, Schlichting JL. Postoperative epidural analgesia and oral anticoagulant therapy. Anesth Analg 1994; 79: 89-93
121. May JR, DiPiro JT, Sisley JF. Drug interactions in surgical patients. Am J Surg 1987; 153: 327-35
122. Verbeeck RK, Blackburn JL, Loewen GR. Clinical pharmacokinetics of non-steroidal anti-inflammalory drugs. Clin Pharmacokinet 1983; 8: 297-331
123. Denson DD, Katz JA. Nonsteroidal anti-inflammatory agents. In: Sinatra RS, Hord AH, Ginsberg B, et al., editors. Acute pain. Toronto: Mosby-Year Book Inc., 1992; 112-23
124. Patrono C, Ciabattoni G, Patrignani P, et al. Clinical pharmacology of platelet cyclooxygenase inhibition. Circulation 1985; 72: 1177-84
125. Rodgers RPC, Levin J. A critical reappraisal of the bleeding time. Semin Thromb Hemost 1990; 16: 1-20
126. MacDonald R. Aspirin and extradural blocks [editorial]. Br J Anaesth 1991; 66: 1-3
127. Williams HD, Howard R, O'Donnell N, et al. The effect of low dose aspirin on bleeding times. Anaesthesia 1993; 48: 331-3
128. Bromage PR. Bleeding time [letter]. Br J Anaesth 1992; 69: 330
129. Wildsmith JAW, McClure JH. Aspirin, bleeding time and central neural block [letter]. Br J Anaesth 1993; 70: 112
130. CLASP Collaborative Group. CLASP: a randomized trial of low-dose aspirin for the prevention and treatment of preeclampsia among 9364 pregnant women. Lancet 1994; 343: 619-29
131. Shnider SM, Levinson G. Anesthesia for cesarean section. In: Shnider SM, Levinson G, editors. Anesthesia for obstetrics. Philadelphia (PA): Williams and Wilkins, 1993: 211-45
132. deSwiet M, Redman CWG. Aspirin, extradural anaesthesia and the MRC collaborative low-dose aspirin study in pregnancy (CLASP) [letter]. Br J Anaesth 1992; 69: 109
133. Horlocker TT, Wedel DJ, Offord KP. Does preoperative anti-platelet therapy increase the risk of hemorrhagic complications associated with regional anesthesia? Anesth Analg 1990; 70: 631-4
134. Horlocker TT, Wedel DJ, Schroeder DR, et al. Preoperative anti-platelet therapy does not increase the risk of spinal hematoma associated with regional anesthesia. Anesth Analg 1995; 80: 303-9
135. Greensile FS, Katz J. Spinal subdural hematoma associated with attempted epidural anesthesia and subsequent continuous spinal anesthesia. Anesth Analg 1980; 59: 72-3
136. Smiter AJ, Fredman B, White PF. Controversies in the perioperative use of nonsteroidal antiinflammatory drugs. Anesth Analg 1994; 79: 1178-90
137. Woolf CJ, Chong Mun-S. Preemptive analgesia - treating postoperative pain by preventing the establishment of central sensituation. Anesth Analg 1993; 77: 362-79
138. Dahl JB, Kehlet H. Non-steroidal anti-inflammatory drugs: rationale for use in severe postoperative pain. Br J Anaesth 1991; 66: 703-12
139. Reilly IAG, Fitzgerald GA. Aspirin in cardiovascular disease. Drugs 1988; 35: 154-76
140. Habib GB. Current status of thrombolysis in acute myocardial infarction: I. Optimal selection and delivery of a thrombolytic drug. Chest 1995; 107: 225-32
141. Habib GB. Current status of thrombolysis in acute myocardial infarction: part II. Optimal utilization of thrombolysis in clinical subsets. Chest 1995; 107: 528-34
142. Skinner JR, Phillips SJ, Zeff RH, et al. Immediate coronary bypass following failed streplokinasc infusion in evolving myocardial infarction. J Thorac Cardiovasc Surg 1984; 87: 567-70
143. Harker LA, Malpass TW, Branson HE, et al. Mechanism of abnormal bleeding in patients undergoing cardiopulmonary bypass: acquired transient platelet dysfunction associated with selective α-granule release. Blood 1980; 56: 824-34
144. Woodman RC, Harker LA. Bleeding complications associated with cardiopulmonary bypass. Blood 1990; 76: 1680-97
145. Taggart DP, Siddiqui A, Wheatley DJ. Low-dose preoperative aspirin therapy, postoperative blood loss, and transfusion requirements. Ann Thorac Surg 1990; 50: 425-8
146. Ferraris VA, Ferraris SP, Lough FC, et al. Preoperative aspirin ingestion increases operative blood loss after coronary artery bypass grafting. Ann Thorac Surg 1988; 45: 71-4
147. van Oeveren W, Jansen NJG, Bidstrup BP, et al. Effects of aprotinin on hemostatic mechanisms during cardiopulmonary bypass. Ann Thorac Surg 1987; 44: 640-5
148. Emerson Jr TE. Pharmacology of aprotinin and efficacy during cardiopulmonary bypass. Cardiovasc Drug Rev 1989; 7: 127-40
149. Aoki N, Naito K, Yoshida N. Inhibition of platelet aggregation by protease inhibitors, possible involvement of proteases in platelet aggregation. Blood 1978; 51: 1-12
150. Dubber AHC, McNicol GP, Uttley D, et al. In vitro and In vivo studies with Trasylol, an anticoagulant and a fibrinolytic inhibitor. Br J Haematol 1968; 14: 31-49
151. Verstraete M. Clinical applications of inhibitors of fibrinolysis. Drugs 1985; 29: 236-61
152. Havel M, Teufelsbauer H, Knöbl P, et al. Effect of intraoperative aprotinin administration on postoperative bleeding in patients undergoing cardiopulmonary bypass operation. J Thorac Cardiovasc Surg 1991; 101: 968-72
153. Royston D, Bidstrup BP, Taylor KM, et al. Effect of aprotinin on need for blood transfusion after repeat open-heart surgery. Lancet 1987; 2 (8571): 1289-91
154. Bidstrup BP, Royston D, Sapsford RN, et al. Reduction in blood loss and blood use after cardiopulmonary bypass with high dose aprotinin (Trasylol). J Thorac Cardiovasc Surg 1989; 97: 364-72
155. Alajmo F, Calamai G, Perna A, et al. High-dose aprotinin: hemostatic effects in open heart operations. Ann Thorac Surg 1989; 48: 536-9
156. van Oeveren W, Harder MP, Roozendaal KJ, et al. Aprotinin protects platelets against the initial effect of cardiopulmonary bypass. J Thorac Cardiovasc Surg 1990; 99: 788-98
157. Lemmer Jr JH, Stanford W, Bonney SL, et al. Aprotinin for coronary bypass operations: efficacy, safety, and influence on early saphenous vein graft patency. J Thorac Cardiovasc Surg 1994; 107: 543-53
158. Murkin JM, Lux JoA, Shannon NA, et al. Aprotinin significantly decreases bleeding and transfusion requirements in patients receiving aspirin and undergoing cardiac operations, J Thorac Cardiovasc Surg 1994; 107: 554-61
159. Alajmo F, Calamai G. High-dose aprotinin in emergency coronary artery bypass after thrombolysis [letter]. Ann Thorac Surg 1992; 54: 1022
160. Akhtar TM, Goodchild CS, Boylan MKG. Reversal of streptokinase-induced bleeding with aprotinin for emergency cardiac surgery. Anaesthesia 1992; 47: 226-8
161. Efstratiadis T, Munsch C, Crossman D, et al. Aprotinin used in emergency coronary operation after streptokinase treatment. Ann Thorac Surg 1991; 52: 1320-1
162. van Doom CA, Munsch CM, Cowan JC. Cardiac rupture after thrombolytic therapy: the use of aprotinin to reduce blood loss after surgical repair. Br Heart J 1992; 67: 504-5
163. Horrow JC, DiGregorio GJ, Ruch E. The dose-plasma concentration relationship of tranexamic acid during surgery. Am J Ther 1994; 1: 206-9
164. Horrow JC, Hlavacek J, Strong MD et al. Prophylactic tranexamic acid decreases bleeding after cardiac operations. J Thorac Cardiovasc Surg 1990; 99: 70-4
165. Horrow JC, Van Riper DF, Strong MD, et al. Hemostatic effects of tranexamic acid and desmopressin during cardiac surgery. Circulation 1991; 84: 2063-70
166. DelRossi AJ, Cernaianu AC, Botros S, et al. Prophylactic treatment of postperfusion bleeding using EACA. Chest 1989; 96: 27-30
167. Lambert CJ, Marengo-Rowe AJ, Leveson JE, et al. The treatment of postperfusion bleeding using ε-aminocaproic acid, cryoprecipitate, fresh-frozen plasma, and protamine sulfate. Ann Thorac Surg 1979; 28: 440-4
168. Karski JM, Teasdale SJ, Norman PH, et al. Prevention of post-bypass bleeding with tranexamic acid and ε-aminocaproic acid. J Cardiothorac Vase Anesth 1993; 7: 431-5
169. Horrow JC, Van Riper DF, Strong MD, et al. The dose-response relationship of tranexamic acid. Anesthesiology 1995; 82: 383-92
170. Salem M, Tainsh Jr RE, Bromberg J, et al. Perioperative glucocorticoid coverage: a reassessment 42 years after emergence of a problem. Ann Surg 1994; 219: 416-25
171. Fraser CG, Preuss FS, Bigford WD. Adrenal atrophy and irreversible shock associated with cortisone therapy. JAMA 1952; 149: 1542-3
172. Lewis L, Robinson RF, Yee J, et al. Fatal adrenal cortical insufficiency precipitated by surgery during prolonged continuous cortisone treatment. Ann Intern Med 1953; 39: 116-26
173. Chernow B, Alexander HR, Smallridge RC, et al. Hormonal responses to graded surgical stress. Arch Intern Med 1987; 147: 1273-8
174. Udelsman R, Norton JA, Jelenich SE, et al. Responses of the hypothalamic-pituitary-adrenal and renin-angiotensin axes and the sympathetic system during controlled surgical and anesthetic stress. J Clin Endocrinol Metab 1987; 64: 986-94
175. Udelsman R, Goldstein DS, Loriaux DL, et al. Catecholamine-glucocorticoid interactions during surgical stress. J Surg Res 1987; 43: 539-45
176. Udelsman R, Ramp J, Gallucci WT, et al. Adaptation during surgical stress - a reevaluation of the role of glucocorticoids. J Clin Invest 1986; 77: 1377-81
177. Axelrod L. Glucocorticoid therapy. Medicine 1976; 55: 39-65
178. Dujovne CA, Azarnoff DL. Clinical complications of corticosteroid therapy: a selected review. Med Clin North Am 1973; 57: 1331-42
179. Schaffner A. Therapeutic concentrations of glucocorticoids suppress the antimicrobial activity of human macrophages without impairing their responsiveness to gamma interferon. J Clin Invest 1985; 76: 1755-64
180. Baltch AL, Hammer MC, Smith RP, et al. Comparison of the effect of three adrenal corticosteroids on human granulocyte function against Pseudomonas aeruginosa. J Trauma 1986; 26: 525-33
181. 4. J Clin Invest 1986; 77: 1244-50