The eve stripe 2 enhancer employs multiple modes of transcriptional synergy

Development

Volumn 122, Issue 1, 1996, Pages 205-214

  Arnosti, David N ^a   Barolo, Scott ^a   Levine, Michael ^a   Small, Stephen ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NEW YORK UNIVERSITY   (United States)

Author keywords

Bicoid; Drosophila embryo; Even skipped; Giant; Synergy; Transcription

Indexed keywords

CIS ACTING ELEMENT; HYBRID PROTEIN; TRANS ACTING FACTOR;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEVELOPMENTAL GENETICS; DROSOPHILA; EMBRYO; EMBRYO DEVELOPMENT; ENHANCER REGION; GENETIC COMPLEMENTATION; NONHUMAN; PRIORITY JOURNAL; TRANSCRIPTION REGULATION; TRANSGENIC ANIMAL;

ANIMALS; BACTERIAL PROTEINS; BASE SEQUENCE; BINDING SITES; DNA; DNA-BINDING PROTEINS; DROSOPHILA; DROSOPHILA PROTEINS; ENHANCER ELEMENTS (GENETICS); FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, INSECT; GENETIC COMPLEMENTATION TEST; HOMEODOMAIN PROTEINS; JUVENILE HORMONES; MALE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS;

ANIMALIA;

EID: 0030030902     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Capovilla, M., Eldon, E. D. and Pirrotta, V. (1992) The giant gene of Drosophila encodes a b-ZIP DNA-binding protein that regulates the expression of other segmentation gap genes. Development 114, 99-112.
2. Carey, M. S., Lin, Y. S., Green, M. R. and Ptashne, M. (1990) A mechanism for synergistic activation of a mammalian gene by GAL4 derivatives. Nature 345, 361-164.
3. Driever, W. and Nüsslein-Volhard, C. (1988) A gradient of bicoid protein in Drosophila embryos. Cell 54, 83-93.
4. Driever, W. and Nüsslein-Volhard, C. (1989) The bicoid protein is a positive regulator of hunchback transcription in the early Drosophila embyo. Nature 337, 138-143
5. Driever, W., Thoma, G. and Nüsslein-Volhard, C. (1989) Determination of spatial domains of zygotic gene expression in the Drosophila embryo by the affinity of binding sites for the bicoid morphogen. Nature 340, 363-367.
6. Du, W., Thanos, D. and Maniatis, T. (1993) Mechanisms of transcriptional synergism between distinct virus-inducible enhancer elements. Cell 74, 887-898.
7. Frasch, M. and Levine, M. (1987) Complementary patterns of even-skipped and fushi tarazu expression involve their differential regulation by a common set of segmentation genes in Drosophila. Genes Dev. 1, 981-995.
8. Frohnhofer, H. G. and Nüsslein-Volhard, C. (1986) Organization of anterior pattern in the Drosophila embryo by the maternal gene bicoid. Nature 324, 120-125.
9. Gaul, U. and Jackle, H. (1987) Pole region-dependent repression of the Drosophila gap gene Kruppel by maternal gene products. Cell 51, 549-555.
10. Goto, T., Macdonald, P. and Maniatis, T. (1989) Early and late periodic patterns of even-skipped expression are controlled by distinct regulatory elements that respond to different spatial cues. Cell 57, 413-422.
11. Gray, S., Szymanski, P. and Levine, M. (1994) Short-range repression permits multiple enhancers to function autonomously within a complex promoter. Genes Dev. 8. 1829-1838
12. Hanes, S. D., Riddihough, G., Ish-Horowiez, D. and Brent, R. (1994) Specific DNA recognition and intersite spacing are critical for action of the bicoid morphogen Mol. Cell Biol. 14, 3364-3375.
13. Harding, K., Hoey, T., Warrior, R. and Levine, M. (1989) Autoregulatory and gap sene response elements of the even-skipped promoter of Drosophila. EMBO J. 8, 1205-1212.
14. Hill, C. S. and Treisman, R. (1995) Transcriptional regulation by extracellular signals. mechanisms and specificity. Cell 80. 199-211.
15. Hope, I. A. and Struhl, K. (1986) Functional dissection of a eukaryotic transcriptional activator protein. GCN4 of yeast. Cell 46, 885-894.
16. Ip, T. T. and Levine, M. (1992) The role of the dorsal morphogen gradient in Drosophila embryogenesis. Semin. Dev. Biol. 3, 15-23.
17. Jiang, J., Kosman, D., Ip, Y. T. and Levine, M. (1991) The dorsal morphogen gradient regulates the mesoderm determinant twist in early Drosophila embryos Genes Dev. 5, 1881-1891.
18. Johnson, A. D. (1995) The price of repression. Cell 81, 655-658.
19. Kraut, R. and Levine, M. (1991) Spatial regulation of the gap gene giant during Drosophila development. Development 111, 601-609.
20. Levine, M. and Manley, J. (1989) Transcriptional repression of eukaryotic promoters. Cell 59, 405-408.
21. Lin, Y. S., Carey, M., Ptashne, M. and Green, M. (1990) How different eukaryotic transcriptional activators can cooperate promiscuously, Nature 345, 359-361.
22. Macdonald, P. M., Ingham, P. W. and Struhl, G. (1986) Isolation, structure, and expression of even-skipped: A second pair-rule gene of Drosophila containing a homeo box. Cell 47, 721-734
23. Mitchell, P. J. and Tjian, R. (1989) Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins. Science 245, 371-378.
24. Nüsslein-Volhard, C., Kluding, H. and Jurgens, G. (1985) Genes affecting the segmental subdivision of the Drosophila embryo. Cold Spring Harb. Symp. Quant. Biol. 50, 145-154.
25. Oliviero, S. and Struhl, K. (1991) Synergistic transcriptional activation does not depend on the number of acidic activation domains bound to the promoter. Proc. Natl. Acad. Sci USA 88, 224-228.
26. Ronchi, E., Treisman, J., Dostatni, N., Struhl, G. and Desplan, C. (1993) Down-regulation of the Drosophila morphogen bicoid by the torso receptor-mediated signal transduction cascade. Cell 74, 347-355.
27. Seipel, K., Georgiev, O. and Schaffner, W. (1992) Different activation domains stimulate transcription from remote ('enhancer') and proximal ('promoter') positions. EMBO J. 11, 4961-4968.
28. Simpson-Brose, M., Treisman, J. and Desplan, C. (1994) Synergy between two morphogens. bicoid and hunchback. is required for anterior patterning in Drosophila Cell 78, 855-865.
29. Small, S., Kraut, R., Hoey, T., Warrior, R. and Levine, M. (1991) Transcriptional regulation of a pair-rule stripe in Drosophila. Genes Dev. 5 827-839.
30. Small, S., Blair, A. and Levine, M. (1992) Regulation of even-skipped stripe 2 in the Drosophila embryo. EMBO J. 11, 4047-4057
31. Small, S., Arnosti, D. N. and Levine, M. (1993) Spacing ensures autonomous expression of different stripe enhancers in the even-skipped promoter. Development 119, 767-772.
32. Stanojevic, D., Hoey, T. and Levine, M. (1989) Sequence-specific DNA-binding activities of the gap proteins encoded by hunchback and Kruppel in Drosophila. Nature 341. 331-335.
33. Stanojevic, D., Small. S. and Levine, M. (1991) Regulation of a segmentation stripe by overlapping activators and repressors in the Drosophila embryo. Science 254, 1385-1387.
34. St. Johnston, D. and Nüsslein-Volhard, C. (1992) The origin of pattern and polarity in the Drosophila embryo. Cell 68, 201-219.
35. Struhl, G., Struhl, K. and Macdonald, P. (1989) The gradient morphogen bicoid is a concentration-dependent transcriptional activator. Cell 57. 1259-1273.
36. Szymanski, P. and Levine, M. (1995) Multiple modes of dorsal-bHLH transcriptional synergy in the Drosophila embryo. EMBO J. 14, 2229-2238
37. Thummel, C. S., Boulet, A. M. and Lipshitz, H. D. (1988) Vectors for Drosophila P element-mediated transformation and tissue culture transfection Gene 74, 445-456.
38. Xiao, H. and Lis, J. T. (1989) Heat shock and developmental regulation of the Drosophila melanogaster hsp83 gene. Mol. Cell Biol. 9, 1746-1753.