Pharmacokinetics of trovafloxacin (CP-99,219), a new quinolone, in rats, dogs, and monkeys

Antimicrobial Agents and Chemotherapy

Volumn 40, Issue 3, 1996, Pages 561-566

  Teng, Renli ^a   Girard, Dennis ^a   Gootz, Thomas D ^a   Foulds, George ^a   Liston, Theodore E ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALI; BETA GLUCURONIDASE; PLASMA PROTEIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; SULFATASE; TROVAFLOXACIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOG; DRUG BILE LEVEL; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG FECES LEVEL; DRUG PENETRATION; DRUG PROTEIN BINDING; DRUG URINE LEVEL; FEMALE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MALE; MONKEY; ORAL DRUG ADMINISTRATION; PHARMACOKINETICS; PRIORITY JOURNAL; RAT; SPECIES DIFFERENCE;

EID: 0030030864     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.40.3.561     Document Type: Article

References (16)

1. Boudinot, F. D., and W. J. Jusko. 1984. Fluid shifts and other factors affecting plasma protein binding of prednisolone by equilibrium dialysis. J. Pharm. Sci. 73:774-780.
2. Briggs-Gooding, B., and R. N. Johns. 1993. In vitro antimicrobial activity of CP-99,219, a novel 7-azabicyclo-naphthyridone. Antimicrob. Agents Chemother. 37:349-353.
3. Brighty, K. E., T. D. Gootz, A. Girard, R. Shanker, M. J. Castaldi, D. Girard, S. A. Miller, and J. Faiella. 1995. Prodrug of CP-99,219 for intravenous administration, synthesis and evaluation resulting in identification of CP-116,517, abstr. 730, p. 141. In Abstracts of the 7th European Congress of Clinical Microbiology and Infectious Diseases. CONIFER,™ Excerpta Media Medical Communications b.v.
4. Eliopoulos, G. M., K. Klimm, C. T. Eliopoulos, M. J. Ferraro, and R. C. Moellering, Jr. 1993. In vitro activity of CP-99,219, a new fluoroquinolone, against clinicat isolates of gram-positive bacteria. Antimicrob. Agents Chemother 37:366-370
5. Faed, E. M. 1984. Properties of acyl glucuronides implication for studies of the pharmacokinetics and metabolism of acidic drugs. Drug Metab. Rev 15:1213-1249.
6. Fitton, A. 1992. The quinolones: an overview of their pharmacology Clin Pharmacokinet. 22(Suppl. 1):1-11.
7. Gibaldi, M., and D. Perrier. Pharmacokinetics, 2nd ed. Maicel Dekker, Inc., New York.
8. Girard, A. E., J. A. Faiella, C. R. Cimochowski, and K. E. Brighty. 1993. In vivo oral activity of CP-99,219 in models of acute and localized infection, abstr. 1510, p 395. In Program and abstracts of the 33rd Interscience Conference on Antimicrobial Agents and Chemotherapy. American Society for Microbiology, Washington, D.C.
9. Girard, D., K. E. Brighty, and T. D. Gootz. 1993 CP-99,219, a novel 7-(3-azabicyclo[3.1.0]hexyl)naphthyridone: pharmacokinetics in animals. abstr. 1511, p. 395. In Program and abstracts of the 33rd Interscience Conference on Antimicrobial Agents and Chemotherapy. American Society for Microbiology, Washington, D.C.
10. Gootz, T. D., K. E. Brighty, M. R. Anderson, B. J. Schmieder, S. L. Haskell, J. A. Sutcliffe, M. J. Castaldi, and P. R. McGuirk. 1994. In vitro activity of CP-99,219, a novel 7-(3-azabicyclo[3.1 0]hexyl)naphthyridone Diagn. Microbiol. Infect Dis 19:235-243
11. Neu, H. C., and N. X. Chin. 1994. In vitro activity of the new fluoroquinolone CP-99,219. Antimicrob. Agents Chemother. 38:2615-2622.
12. Sinclair, K. A., and J. Caldwell. 1982. The formation of resistant glucuronides by intramolecular rearrangement of glucuronic acid conjugates at mild alkaline pH. Biochem. Pharmacol. 31:953-957.
13. Teng, R., D. R. Brennan, T. G. Tensfeldt, T. E. Liston, and G. Foulds. 1993. Determination of CP-99,219, a new oral quinolone antibiotic, in biological samples by reverse-phase high performance liquid chromatography, abstr. APQ 1183, p. S56. In Abstract book of the 8th American Association of Pharmaceutical Scientists Annual Meeting and Exposition. American Association of Pharmaceutical Scientists, Alexandria, Va.
14. Teng, R., S. C. Harris, G. Foulds, B. M. Silber, and T. E. Liston. 1993. Pharmacokinetics of CP-99,219, a new quinolone antibiotic, following single oral doses to healthy volunteers, abstr. 1512, p. 395. In Program and abstracts of the 33rd Interscience Conference on Antimicrobial Agents and Chemotherapy. American Society for Microbiology, Washington, D.C.
15. Teng, R., S. C. Harris, D. E. Nix, J. J. Schentag, G. Foulds, and T. E. Liston. 1995 Pharmacokinetics and safety of CP-99,219. a new quinolone antibiotic. following administration of single oral doses to healthy male volunteers. J. Antimicrob. Chemother 36:385-394.
16. Teng, R., N. B. Khosla, D. N. Renouf, D. Girard, B. M. Silber, G. Foulds, and T. E. Liston. 1993. Pharmacokinetics of CP-99,219, a new oral quinolone antibiotic, in Sprague-Dawley rats, beagle dogs and cynomolgus monkeys, abstr. PPDM 8151, p S336. In Abstract book of the 8th American Association of Pharmaceutical Scientists Annual Meeting and Exposition. American Association of Pharmaceutical Scientists. Alexandria, Va