Molecular scanning of candidate mitochondrial tRNA genes in type 2 (non-insulin dependent) diabetes mellitus

Journal of Medical Genetics

Volumn 33, Issue 3, 1996, Pages 253-255

  Thomas, A W ^a   Edwards, A ^a   Sherratt, E J ^a   Majid, A ^a   Gagg, J ^a   Alcolado, J C ^a  

^a UNIVERSITY HOSPITAL OF WALES   (United Kingdom)

Author keywords

Diabetes; MELAS; Mitochondrial DNA

Indexed keywords

MITOCHONDRIAL DNA; TRANSFER RNA;

ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; POINT MUTATION; PRIORITY JOURNAL; RNA GENE; SINGLE STRAND CONFORMATION POLYMORPHISM;

EID: 0030030748     PISSN: 00222593     EISSN: None     Source Type: Journal    
DOI: 10.1136/jmg.33.3.253     Document Type: Article

References (9)

1. Alcolado JC, Alcolado R. Importance of maternal history of non-insulin dependent diabetic patients. BMJ 1991;302:1178-80.
2. Alcolado JC, Majid A, Brockington M, et al. Mitochondrial gene defects in patients with NIDDM. Diabetologia 1994;37:372-6.
3. Ballinger SW, Shoffner JM, Gebhart S, Koontz DA, Wallace DC. Mitochondrial diabetes revisited. Nature Genet 1994;7:458-9.
4. Thomas AW, Morgan R, Sweeney M, Rees A, Alcolado JC. The detection of mitochondrial DNA mutations using single stranded conformational polymorphism (SSCP) analysis and heteroduplex analysis. Hum Genet 1994;94:621-3.
5. Brown MD, Voljavec AS, Lott MT, MacDonald I, Wallace DC. Leber's hereditary optic neuropathy: a model for mitochondrial neurodegenerative diseases. FASEB J 1992;6:2791-9.
6. Febrizi GM, Tiranti V, Mariotti G, et al. Sequence analysis of mtDNA in a new maternally inherited encephalomyopathy. J Neurol 1992;242:490-6.
7. Hattori Y, Goto Y, Sakuta R, Nonaka I, Mizuno Y, Horai S. Point mutations in mitochondrial tRNA genes: sequence analysis of chronic progressive external ophthalmoplegia (CPEO). J Neurol Sci 1994;125:50-5.
8. scr(UCN) gene. Hum Mol Genet 1995;4:1421-7.
9. Reid FM, Vernham GA, Jacobs HT. A novel mitochondrial point mutation in a maternal pedigree with sensorineural deafness. Hum Mutat 1995;3:243-7.