ras effector loop mutations that dissociate p120GAP and neurofibromin interactions

Molecular Carcinogenesis

Volumn 15, Issue 1, 1996, Pages 64-69

  Stang, Stacey ^a   Bottorff, Drell ^a   Stone, James C ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

GTPase activating proteins; Rat2 cells; Type 1 neurofibromatosis

Indexed keywords

EPIDERMAL GROWTH FACTOR; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; NEUROFIBROMIN; ONCOPROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; NEUROFIBROMATOSIS; NONHUMAN; ONCOGENE C H RAS; PLASMID; PRIORITY JOURNAL; RAT;

ANIMALS; CELL DIVISION; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; EPIDERMAL GROWTH FACTOR; GTP-BINDING PROTEINS; GTPASE-ACTIVATING PROTEINS; GUANINE NUCLEOTIDES; GUANOSINE TRIPHOSPHATE; HUMANS; NEUROFIBROMIN 1; POINT MUTATION; PROTEINS; PROTO-ONCOGENE PROTEINS P21(RAS); RAS GTPASE-ACTIVATING PROTEINS; RATS; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA; ESCHERICHIA COLI; MAMMALIA;

EID: 0030030704     PISSN: 08991987     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2744(199601)15:1<64::AID-MC9>3.0.CO;2-S     Document Type: Article

References (38)

1. Boguski MS, and McCormick F. Proteins regulating Ras and its relatives. Nature 366:643-654, 1993.
2. Avruch J, Zhang X, Kyriakis JM. Raf meets ras: Completing the framework of a signal transduction pathway Trends Biochem Sci 19:279-283, 1994.
3. Rodriguez-Viciana P, Warne PH, Dhand R, et al. Phosphatidylinositol-3-OH kinase as a direct target of Ras. Nature 370:527-532, 1994
4. Bos JL. ras Oncogenes in human cancer: A review Cancer Res 49:4682-4689, 1989
5. Trahey M, McCormick F A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants. Science 238:542-545, 1987.
6. Xu G, Lin B, Tanaka K, et al. The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae. Cell 63:835-841, 1990.
7. Knudson AJ. Genetics of human cancer. Annu Rev Genet 20 231-251, 1986
8. Legius E, Marchuk DA, Collins FS, Glover TW Somatic deletion of the neurofibromatosis type 1 gene in a neurofibrosarcoma supports a tumour suppressor gene hypothesis Nat Genet 3 122-126, 1993
9. Sigal IS, Gibbs JB, D'Alonzo JS, Scolnick EM. Identification of effector residues and a neutralizing epitope of Ha-ras-encoded p21. Proc Natl Acad Sci USA 83:4725-4729, 1986.
10. Willumsen BM, Papageorge AG, Rung H-F, et al Mutational analysis of a ras catalytic domain. Mol Cell Biol 6:2646-2654, 1986.
11. Calés C, Hancock JF, Marshall CJ, Hall A The cytoplasmic protein GAP is implicated as the target for regulation by the ras gene product. Nature 332:548-550, 1988.
12. Adari H, Lowy DR, Willumsen BM, Der CJ, McCormick F. Guanosine triphosphatase activating protein (GAP) interacts with the p21 ras effector binding domain. Science 240:518-521, 1988.
13. Bollag G, McCormick F. Differential regulation of rasGAP and neurofibromatosis gene product activities. Nature 351:576-579, 1991.
14. Dominguez I, Marshall MS, Gibbs JB, García de Herreros A, et al. Role of GTPase activating protein in mitogenic signalling through phosphatidylcholine-hydrolysing phospholipase C EMBO J 10:3215-3220, 1991
15. Schweighoffer F, Barlat I, Chevallier-Multon M-C, Tocque B. Implication of GAP in ras-dependent transactivation of a polyoma enhancer sequence. Science 256:825-827, 1992
16. + channels Cell 61:769-776, 1990.
17. DeClue JE, Stone JC, Blanchard RA, et al. A ras effector domain mutant which is temperature sensitive for cellular transformation: Interactions with GTPase-activating protein and NF-1 Mol Cell Biol 11:3132-3138, 1991.
18. ras effector function and GTPase-activating protein interaction. Mol Cell Biol 13:7311-7320, 1993
19. Zhang K, DeClue JE, Vass WC, Papageorge AG, McCormick F, Lowy DR. Suppression of c-ras transformation by GTPase-activating protein. Nature 346:754-756, 1990.
20. Morgenstern JP, Land H. Advanced mammalian gene transfer: High titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line Nucleic Acids Res 18:3587-3596, 1990.
21. Mann R, Mulligan RC, Baltimore D. Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus Cell 33:153-159, 1983
22. Topp WC. Normal rat cell lines deficient in nuclear thymidine kinase. Virology 113:408-411, 1981
23. Stone JC, Blanchard RA. Genetic definition of ras effector elements. Mol Cell Biol 11:6158-6165, 1991
24. Furth ME, Davis LJ, Fleurdelys B, Scolnick EM Monoclonal antibodies to the p21 products of the transforming gene of Harvey murine sarcoma virus and of the cellular ras gene family. J Virol 43 294-304, 1982.
25. Zhang K, Noda M, Vass WC, Papageorge AG, Lowy DR. Identification of small dusters of divergent amino acids that mediate the opposing effects of ras and Krev-1. Science 249 162-165, 1990
26. Zhang JC, Papageorge AG, Martin P, et al. Heterogeneous amino acids in ras and rap1A specifying sensitivity to GAP proteins. Science 254:1630-1634, 1991.
27. Pizon V, Chardin P, Lerosey I, Olofsson B, Tavitian A. Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region. Oncogene 3:201-204, 1988.
28. Gideon P, John J, Frech M, et al. Mutational and kinetic analyses of the GTPase-activating protein (GAP)-p21 interaction: The C-terminal domain of GAP is not sufficient for full activity Mol Cell Biol 12:2050-2056, 1992.
29. Martin GA, Viskochil D, Bollag G, et al. The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21 Cell 63:843-849, 1990.
30. Mistou M-Y, Jacquet E, Poullet P, et al. Mutations of Ha-ras p21 that define important regions for the molecular mechanism of the SDC25 C-domain a guanine nucleotide dissociation stimulator EMBO J 11 2391-2397, 1992
31. ras in fibroblasts Mol Cell Biol 13:1903-1910, 1993.
32. Li B-Q, Kaplan D, Kung H, Kamata T. Nerve growth factor stimulation of the ras-guanine nucleotide exchange factor and GAP functions. Science 256:1456-1459, 1992.
33. Pawson T, Gish GD. SH2 and SH3 domains: From structure to function. Cell 71:359-362, 1992.
34. Ellis C, Moran M, McCormick F, Pawson T. Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases. Nature 343:377-380, 1990.
35. Al-Alawi N, Xu G, White R, Clark R, McCormick F, Feramisco JR. Differential regulation of cellular activities by GTPase-activating protein and NF1 Mol Cell Biol 13:2497-2503, 1993
36. Basu TN, Gutmann DH, Fletcher JA, Glover TW, Collins FS, Downward J. Aberrant regulation of ras proteins in malignant tumor cells from type 1 neurofibromatosis patients Nature 356:713-715, 1992
37. ras contributes to malignant tumor growth m von Recklinghausen (Type 1) neurofibromatosis. Cell 69:265-273, 1992
38. Johnson MR, DeClue JE, Felzmann S, et al Neurofibromin can inhibit ras-dependent growth by a mechanism independent of its GTPase-accelerating function Mol Cell Biol 14:641-645, 1994.