Interaction between cell wall model of vancomycin resistant strain and aglucovancomycin synthetic analogs

Tetrahedron Letters

Volumn 37, Issue 2, 1996, Pages 191-192

  Nakamura, Kazuhiko ^a   Nishiyama, Shigeru ^a   Yamamura, Shosuke ^a  

^a KEIO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

VANCOMYCIN DERIVATIVE;

ARTICLE; CELL WALL; DRUG BINDING; MEMBRANE MODEL; NUCLEAR MAGNETIC RESONANCE;

BACTERIA (MICROORGANISMS); SAN ANGELO VIRUS;

EID: 0030030207     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/0040-4039(95)02112-4     Document Type: Article

References (13)

1. (a) Williams, D. H.; Waltho, J. P. Molecular Recognition: Chemical and Biological Problems (S. M. Roberts Ed.), The Royal Society of Chemistry (Cambridge) 1989, 16.
2. (b) Searle, M. S.; Williams, D. H.; Gerhard, U. J. Am. Chem. Soc. 1992, 114, 10697.
3. (c) Pearce, C. P.; Gerhard U.; Williams, D. H. J. Chem. Soc. Perkin Trans. 2 1995, 159.
4. Nakamura, K.; Nishiyama, S.; Yamamura, S. Tetrahedron Lett. in press.
5. (a) Yamamura, S.; Nishiyama, S. Studies in Natural Products Chemistry (Atta-ur-Rahman Ed.), Elsevier (Amsterdam) 1992, 629.
6. (b) Noda, H.; Niwa, M.; Yamamura, S; Tetrahedron Lett. 1981, 22, 3274.
7. (a) Bugg, T. D. H.; Malen, S.; Arthur, M.; Couvalin, P.; Walsh, C. T. Biochemistry 1991, 30, 2017.
8. (b) Wright, G. D.; Walsh, C. T. Acc. Chem. Res. 1992, 25, 468.
9. (c) Bugg, T. D. H.; Walsh, C. T.; Nat. Prod. Rep. 1992, 9, 199.
10. 2O, TSP = 0 ppm) 1.42 (3H, d, J= 7.3 Hz), 1.51 (3H, d, J= 7.0 Hz), 2.01 (3H, s), 4.42 (1H, q, J= 7.3 Hz), 5.03 (1H, q, J= 7.0 Hz).
11. d is now under way.
12. Brooks, B. R.; Bruccoleri, R. E.; Olafson, B. D.; States, D. J.; Swaminathan, S.; Karplus, M. J. Comp. Chem. 1983, 4, 187.
13. When the ligand was brought from the lower site of the molecule, consistent hydrogen bonds were achieved (see ref. 2).