Aging and immune function: A possible role for growth hormone

Hormone Research in Paediatrics

Volumn 45, Issue 1-2, 1996, Pages 46-49

  Gelato, M C ^a  

^a STONY BROOK UNIVERSITY   (United States)

Author keywords

Aging; Growth hormone; Immune function; Insulin like growth factor 1; Secretion; Treatment

Indexed keywords

GERET; GROWTH HORMONE; GROWTH HORMONE RELEASING FACTOR; SOMATOMEDIN C; UNCLASSIFIED DRUG;

AGING; CANCER; CELLULAR IMMUNITY; CLINICAL TRIAL; CONFERENCE PAPER; DRUG EFFECT; FATALITY; GROWTH HORMONE DEFICIENCY; GROWTH HORMONE RELEASE; HERPES ZOSTER; HUMAN; HUMORAL IMMUNITY; IMMUNE DEFICIENCY; IMMUNE RESPONSE; NONHUMAN; PNEUMONIA; PRIMATE; PRIORITY JOURNAL; TUBERCULOSIS;

ADULT; AGED; AGING; ANIMALS; ANTIBODY FORMATION; B-LYMPHOCYTES; GROWTH HORMONE; HERPES ZOSTER; HUMANS; IMMUNITY, CELLULAR; INSULIN-LIKE GROWTH FACTOR I; MIDDLE AGED; NEOPLASMS; PNEUMONIA; PRIMATES; T-LYMPHOCYTES;

EID: 0030030163     PISSN: 16632818     EISSN: 16632826     Source Type: Journal    
DOI: 10.1159/000184758     Document Type: Article

References (25)

1. Rudman D, Kutner MH, Rogers CM: Impaired growth hormone secretion in the adult population: Relation to age and adiposity, J Clin Invest 1981:67:1361-1366.
2. Ho KY, Evans WS, Blizzard RM, Veldhuis J, Merriam GR, Samojlik E, Furlanetto R, Rogol AD, Kaiser DL, Thomer MO: Effects of sex and age on the 24-hour profile of growth hormone secretion in man: Importance of endogenous estradiol concentrations, J Clin Endocrinol Metab 1987:64:51-58.
3. Corpas E, Harman SM, Pineyro MA, Roberson R, Blackman MR: Growth hormone (GH)-releasing hormone-(l-29) twice daily reverses the decreased GH and insulin-like growth I'ac-lor-1 levels in old men, J Clin Endocrinol Metab 1992:75:530-535.
4. Corpas E, Harman SM, Blackman MR: Human growth hormone and human aging, Endocr Rev 1993:14:20-39.
5. Johanson AJ, Blizzard RM: Low somato-medin-C levels in older men rise in response to growth hormone administration, Johns Hopkins Med J 1981:149:115-120.
6. Frost R, Lang CH, Bercket A, Wilson T, Gelato MC: Insulin-like growth factor (IGF)-binding protein (BP)-1 is phosphorylatcd in serum of catabolic patients, J Clin Endocrinol Metab 1994:78:1533-1535.
7. Clemmons DR, Camacho-Hubner C, Jones J I, McCusker RH, Busby WH: Insulin-like growth factor binding proteins: Mechanisms of action at the cellular level: in Spencer EM (ed): Modem Concepts of Insulin-Like Growth Factors, New York, Elsevier, 1991. pp 475-486.
8. Geokas MC, Lakatta EG, Makinodan T, Tim-iras PS: The aging process, Ann Intern Med 1990;113:455-466.
9. Saltzman RL, Peterson PK: Immunodeficiency of the elderly, Rev Infect Dis 1987:9: 1127-1139.
10. Mackay IR: Aging and immunological function in man, Geronlologia 1972:18:285-304.
11. Toh BH, Roberts-Thomson IC, Matthews JD, Whiltingham S, Mackay IR: Depression of cell mediated immunity in old age and the immuno-pathic diseases, lupus erythematosus, chronic hepatitis and rhematoid arthritis, Clin Exp Immunol 1973:14:193-202.
12. Currie MS: Imniunosenescence, Compr Ther 1992:18:26-34.
13. Shapiro ED, Berg AT, Austrian R, Schroeder D, Parcells V, Margolis A, Adair RK, Clemens JD: The protective efficacy of polyvalent pneumococcal polysaccharide vaccine, N Engl J Med 1991;325:1453-1460.
14. Howells CHL, Vesselinova-Jenkins CK, Evans AD, James J: Influenza vaccination and mortality from bronchopneumonia in the elderly, Lancet 1975;i:381-383.
15. Kishimoto S, Tomino S, Mitsuya H, Nishimura H: Age-related decrease in frequencies of B-cell precursors and specific helper T-cells involved in the IgG anti-tetanus toxoid antibody production in humans, Clin Immunol Immuno-pathol 1982:25:1-10.
16. Gardner P, Schaffner W: Immunization of adults, N Engl J Med 1993:328:1252-1258.
17. Goodwin JS, Searles RP, Tung KSK: Immunological responses of a healthy elderly population, Clin Exp Immunol 1982:48:403-410.
18. Matthews JD, Hooper BM, Whiltingham S, Mackay IK, Stcnhouse NS: Association of auloahtibodics with smoking, cardiovascular morbidity and death in the Busselton population, Lancet 1973:ii:754-758.
19. Matthews JD, Whiltingham S, Mackay IK: Autoimmunity and human vascular disease -hypothesis, Lancet 1974:ii: 1423-1427.
20. Corberand J, Nguyen F, Laharrogue P, Fon-tanillcs AM, Glcizes B, Gyrard E, Senegas C: Polymorphonuclear functions and aging in humans, J Am Geriatr Soc 1981:29:39l-397.
21. Kelley K W: The role of growth hormone in the modulation of the immune response, Ann NY Acad Sci 1990:594:95-103.
22. Gelato M: Growth hormone-insulin-like growth factor I and immune function, TEM 1993:4:106-110.
23. Hooghe K, Delhase M, Vcrgani P, Malur A, Hooghe-Petcrs EL: Growth hormone and prolactin are paracrine growth and differentiation factors in the homeopoietic system, Immunol Today 1993:14:212-214.
24. Wiederman CJ, Niedermuhlbichler M, Beim-pold H, Braunstciner H: In vitro activation of neutrophils of the aged by recombinant human growth hormone, J Infect Dis 1991:164: 1017-1020.
25. Petersen BH, Steimel LS, Baum LL, Kudman D: Measurement of immune parameters following long-term in vivo treatment with recombinant human growth hormone (abstract 707), 75th Annual Meeting of Endocrine Society, Las Vegas, 1993. p 227.