Mechanism of early tumor anorexia

Journal of Surgical Research

Volumn 60, Issue 2, 1996, Pages 389-397

  Muscaritoli, Maurizio ^b   Meguid, Michael M ^a   Beverly, J Lee ^a   Yang, Zhong Jin ^a   Cangiano, Carlo ^b   Rossi Fanelli, Filippo ^b  

^a State University of New York Upstate Medical University: College of Medicine   (United States)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

5 HYDROXYINDOLEACETIC ACID; ALBUMIN; AMINO ACID; FATTY ACID; ISOLEUCINE; LEUCINE; PHENYLALANINE; SEROTONIN; TRYPTOPHAN; TYROSINE; VALINE;

AMINO ACID BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANOREXIA; CONFERENCE PAPER; CONTROLLED STUDY; EARLY CANCER; FOOD INTAKE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SARCOMA; SEROTONIN BLOOD LEVEL;

EID: 0030029926     PISSN: 00224804     EISSN: None     Source Type: Journal    
DOI: 10.1006/jsre.1996.0064     Document Type: Conference Paper

References (30)

1. Heber, D., Byerley, L. O., and Chlebowski, R. T. Metabolic abnormalities in the cancer patient. Cancer 55: 225-229, 1985.
2. Garattini, S., Bizzi, A., Donelli, M. G., Guaitani, A., Samanin, R., and Spreafico, F. Anorexia and cancer in animals and man. Cancer Treat. Rev. 7: 115-140, 1980.
3. Rudman, D., Vogler, W. R., Howard, C. R., and Gerron, G. G. Observations on the plasma amino acids of patients with acute leukemia. Cancer Res. 31: 1159-1165, 1971.
4. Clarke, E. F., Lewis, A. M., and Waterhouse, C. Peripheral amino acid levels in patients with cancer. Cancer 42: 2909-2913, 1978.
5. Norton, J. A., Gorschboth, C. M., Wesley, R. A., Burt, M. E., and Brennan, M. F. Fasting plasma amino acid levels in cancer patients. Cancer 56: 1181-1186, 1985.
6. Watanabe, A., Higashi, T., Sakata, T., and Nigashima, H. Serum amino acid levels in patients with hepatocellular carcinoma. Cancer 54: 1875-1882, 1984.
7. Cascino, A., Cangiano, C., Franchi, F., Menichetti, E. T., Muscaritoli, M., and Rossi Fanelli, F. Plasma amino acids in human cancer: The individual role of tumor, malnutrition and glucose tolerance. Clin. Nutr. 7: 213-218, 1988.
8. Kubota, A., Meguid, M. M., and Hitch, D. C. Amino acid profiles correlate diagnostically with organ site in three kinds of malignant tumors. Cancer 69: 2343-2348, 1992.
9. Kurzer, M., Janiszewski, J., and Meguid, M. M. Amino acid profiles in tumor bearing and non-tumor bearing malnourished rats. Cancer 62: 1492-1496, 1988.
10. Chance, W. T., Cao, L., Nelson, J. L., Foley-Nelson, T., and Fischer, J. E. Reversal of neurochemical aberrations after tumor resection in rats. Am. J. Surg. 155: 124-129, 1988.
11. Rossi-Fanelli, F., and Cangiano, C. Increased availability of tryptophan in brain as a common pathogenic mechanism for anorexia associated with different diseases. Nutrition 7: 364-367, 1991.
12. Rossi-Fanelli, F., Cangiano, C., Ceci, F., Cellerino, R., Franchi, F., Menichetti, E. T., Muscaritoli, M., and Cascino, A. Plasma tryptophan and anorexia in human cancer. Eur. J. Cancer Clin. Oncol. 22: 89-95, 1986.
13. Meguid, M. M., Muscaritoli, M., Beverly, J. L., Yang, Z.-J., Cangiano, C., and Rossi Fanelli, F. The early cancer anorexia paradigm: Changes in plasma free tryptophan and feeding indexes. J. Parenter. Enteral Nutr. 16: 56S-59S, 1992.
14. Madden, R. E., and Burke, D. Production of viable single cell suspension from solid tumors. J. Natl. Cancer Inst. 27: 841-861, 1961.
15. Meguid, M. M., Landel, A. M., Lo, C.-C., and Rivera, D. Effect of tumor and tumor removal on DNA, RNA, protein tissue content and survival of methylcholanthrene sarcoma-bearing rats. Surg. Res. Commun. 1: 261-271, 1987.
16. Landel, A. M., Lo, C.-C., Meguid, M. M., and Rivera, D. Effect of methylcholanthrene-induced sarcoma and its removal on plasma and intracellular free amino acid content. Surg. Res. Commun. 1: 273-287, 1987.
17. Wolf, W. A., and Kuhn, D. M. Simultaneous determination of 5-hydroxytryptamine, its amino acid precursor and acid metabolite in discrete brain regions by high-performance liquid chromatography with fluorescence detection. J. Chromatogr. 275: 1-9, 1983.
18. Meguid, M. M., Chen, T.-Y., Yang, Z.-J., Campos, A. C. L., Hitch, D. C., and Gleason, J. R. Effects of continuous graded total parenteral nutrition on feeding indexes and metabolic concomitants in rats. Am. J. Physiol. 260: E126-E140, 1991.
19. Orosco, M., and Nicolaidis, S. Spontaneous feeding-related monoaminergic changes in the rostromedial hypothalamus revealed by microdialysis. Physiol. Behav. 52: 1015-1019, 1992.
20. Perez-Cruet, J., Chase, T. N., and Murphy, D. L. Dietary regulation of brain tryptophan metabolism by plasma ratio of free tryptophan and neutral amino acids in humans. Nature (London) 248: 693, 1974.
21. Dunn, A. J. Endotoxin-induced activation of cerebral catecholamine and serotonin metabolism: Comparison with interleukin-1. J. Pharmacol. Exp. Ther. 261: 964-969, 1992.
22. Cascino, A., Cangiano, C., Ceci, F., Franchi, F., Mineo, T., Mulieri, M., Muscaritoli, M., and Rossi-Fanelli, F. Increased plasma free tryptophan levels in human cancer: A tumor related effect? Anticancer Res. 11: 1313-1316, 1991.
23. Cangiano, C., Testa, U., Muscaritoli, M., Meguid, M. M., Mulieri, M., Laviano, A., Cascino, A., Preziosa, I., Conversano, L., and Rossi Fanelli, F. Cytokines, tryptophan and anorexia in cancer patients before and after surgical tumor ablation. Anticancer Res. 14: 1451-1456, 1994.
24. Cangiano, C., Cascino, A., Ceci, F., Laviano, A., Mulieri, M., Muscaritoli, M., and Rossi Fanelli, F. Plasma and CSF tryptophan in cancer anorexia. J. Neural Transm. 81: 225-233, 1990.
25. Cangiano, C., Ceci, F., Riggio, O., Cascino, A., Laviano, A., Muscaritoli, M., and Rossi Fanelli, F. Plasma tryptophan (TRP) levels and anorexia in liver cirrhosis. Clin. Res. 40: 409A, 1992. [Abstract]
26. Chance, W. T., Zhang, F. S., Foley-Nelson, T., and Fischer, J. E. Hyperammonemia and anorexia in Morris hepatoma-bearing rats. Physiol. Behav. 50: 397-401, 1991.
27. Yang, Z-J., Koseki, M., Meguid, M. M., Gleason, J. R., and Debonis, D. Synergistic effect of rhTNF-α and rhIL-1α in inducing anorexia in rats. Am. J. Physiol. 267: R1056-R1064, 1994.
28. Dunn, A. J. Endotoxin-induced activation of cerebral catecholamine and serotonin metabolism: Comparison with IL-1. J. Pharmacol. Exp. Ther. 261: 964-969, 1992.
29. Opara, E. I., Laviano, A., Meguid, M. M., and Yang, Z-J. Correlation between food intake and CSF IL-1α in anorectic tumour bearing rats. NeuroReport 6: 750-752, 1995.
30. Chance, W. T., Cao, L., Fischer, J. E. Tumor-induced alterations in brain neurotransmitter and plasma ammonia concentrations are normalized twenty-four hours after tumor resection. Life Sci. 48: 425-432, 1991.