Correlational patterns of cerebral glucose metabolism in never-medicated schizophrenics

Neuropsychobiology

Volumn 33, Issue 1, 1996, Pages 1-11

  Katz, Mark ^b   Buchsbaum, Monte S ^a   Siegel, Benjamin V ^a   Wu, Joseph ^b   Haier, Richard J ^b   Bunney, William E ^b  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

18F deoxyglucose; Cerebral metabolic rate; Frontal lobe; Glucose; Neural circuits; Positron emission tomography; Thalamus

Indexed keywords

FLUORODEOXYGLUCOSE F 18;

ADOLESCENT; ADULT; ARTICLE; BRAIN METABOLISM; CLINICAL ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; FRONTAL LOBE; GLUCOSE METABOLISM; HUMAN; LEFT HEMISPHERE; MALE; METABOLIC RATE; NERVE TRACT; OCCIPITAL CORTEX; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RIGHT HEMISPHERE; SCHIZOPHRENIA; TEMPORAL CORTEX; THALAMOCORTICAL TRACT; THALAMUS;

ADULT; BLOOD GLUCOSE; BRAIN; BRAIN MAPPING; DEOXYGLUCOSE; DOMINANCE, CEREBRAL; FLUORODEOXYGLUCOSE F18; FRONTAL LOBE; HUMANS; MALE; NERVE NET; NEURAL PATHWAYS; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; THALAMUS; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0030029330     PISSN: 0302282X     EISSN: 14230224     Source Type: Journal    
DOI: 10.1159/000119241     Document Type: Article

References (65)

1. Ingvar DU, Franzen G: Abnormalities of cerebral blood flow distribution in patients with chronic schizophrenia, Acta Psychiatr Scand 1974:50:425-462.
2. Buchsbaum MS: The frontal lobes, basal ganglia and temporal lobes as sites for schizophrenia, Schizophr Bull 1990; 16:377-387.
3. Andreasen NC, Rezai K, Alliger R, Swayze VW, Flaum M, Kirchner P, Cohen G, O’Leary DS: Hypofrontalitv in neuroleptic-naive patients and in patients with chronic schizophrenia, Arch Gen Psychiatry 1992:49:943-958.
4. Crosson B, Hughes CW: Role of the thalamus in language: Is it related to thought disorder’? Schizophr Bull 1987:13:605-621.
5. Oke AF, Adams RN: Elevated thalamic dopamine: Possible link to sensory dysfunctions in schizophrenia, Schizophr Bull 1987; 13:589-604.
6. Oke AF, Putz C, Adams RN, Bird ED: Neuroleptic treatment is an unlikely cause of elevated dopamine in thalamus of schizophrenic subjects, Psychiatry Res 1992:45:203-208.
7. Penney JB, Young AB: Speculations on the functional anatomy of basal ganglia dysfunction, Annu Rev Neurosci 1983:6:73-94.
8. Alexander GE, DeLong MR, Strick PI.: Parallel organization of functionally segregated circuits linking basal ganglia and cortex, Annu Rev Neurosci 1986:9:357-381.
9. Swerdlow NR, Koob GF: Dopamine, schizophrenia, mania, and depression: Toward a unified hypothesis of cortico-striato-pallido-tha-lamic function, Behav Brain Sci 1987; 10:197-245.
10. Bunney WE: PCP receptor ionophore complex: Basic mechanisms and possible relevance to schizophrenia (abstract No, 20), 21st Annu Winter Conf Brain Res, Steamboat Springs, 1988.
11. Bunney WE: Schizophrenia - new hypotheses and treatments: in Stefanis CN, Soldatos CR, Rabavilas AD (eds): Psychiatry: A World Perspective, Amsterdam, Elsevier, 1990, vol 2, pp 37-44.
12. Carlsson A: The current status of the dopamine hypothesis of schizophrenia, Neuro psychopharmacology 1988:1:179-186.
13. Carlsson M, Carlsson A: Schizophrenia: A sub-cortical neurotransmitter imbalance syndrome? Schizophr Bull 1990:16:425-432.
14. Kim JS, Komhuber HH, Schmid-Burgk W, Ilolzmullcr B: Low cerebrospinal fluid glutamate in schizophrenic patients and a new hypothesis of schizophrenia, Neurosci Lett 1980; 20:179-182.
15. Clark CM, Kessler R, Buchsbaum MS, Margolin RA, Holcomb HH: Correlational methods for determining regional coupling of cerebral glucose metabolism: A pilot study, Biol Psychiatry 1984:19:663-678.
16. Kessler RM, Clark CM, Buchsbaum MS, Holcomb H, Margolin RA, Cappcletti J, Channing M, Manning RG, Van Kammen DP, King AC, Johnson J: Regional correlations in patterns of glucose use in patients with schizophrenia and normal subjects during mild pain stimulation: in I leiss WD, Phelps MD (eds): Positron Emis-sion Tomography of the Brain, Berlin, Springer, 1983, pp 196-200.
17. Horwitz B: Simulating functional interactions in the brain: A model for examining correlations between regional cerebral metabolic rates, Int J Biomed Comput 1990:26:149-170.
18. Horwitz B, Swedo SE, Grady CL, Pietrini P, Schapiro MB, Rapoport JL, Rapoport SI: Cerebral metabolic pattern in obsessive-compulsive disorder: Altered intercorrelations between regional rates of glucose utilization, Psychiatry Res 1991:40:221-237.
19. Metter J, Riege WH, Hanson WR, Jackson CA, Kempler D, Lancker DV: Subcortical structures in aphasia: An analysis based on (F-18)-fluorodeoxyglucose, positron emission tomography, and computed tomography, Arch Neurol 1988;45:1229-1234.
20. Wicsel FA, Wik G, Sjogren I, Blomqvist G, Greitz T: Altered relationships between metabolic rates of glucose in brain regions of schizophrenic patients, Acta Psychiatr Scand 1987: 76:642-647.
21. Wu JC, Siegel BV, Haicr RJ, Buchsbaum MS: Testing the Swcrdlow/Koob model of schizophrenia pathophysiology using positron emission tomography, Behav Brain Sci 1990:13: 169-170.
22. Volkow ND, Wolf AP, Brodie JD, Cancro R, Overall JF., Rhoades H, Gelder PV: Brain interactions in chronic schizophrenics under resting and activation conditions, Schizophr Res 1988;1:47-53.
23. Venables PH: Input dysfunction in schizophrenia; in Maher BA (ed): Progress in Experimental Personality Research, New York, Academic Press, 1964, vol 16.
24. Zubin J: Problem of attention in schizophrenia, in Kietzman ML, Sutton S, Zubin J (eds); Exp Approaches to Psychopathology, Orlando, Academic Press, 1975, pp 139-166.
25. Holzman PS: Recent studies of psychophysiology in schizophrenia, Schizophr Bull 1987:13: 49-75.
26. Rosvold HE, Mirskv AF, Sarason I, Bransome ED, Beck LH: A continuous performance test of brain damage, J Consult Psychol 1956;20: 343-350.
27. Orzack MIL Kornetsky C, Freeman H: The effects of daily administration of carphenazine on attention in the schizophrenic patient, Psv-chopharmacology 1967:11:31-38.
28. Nuechterlein KII, Buchsbaum MS, Dawson ME: Neuropsychological vulnerability to schizophrenia; in Davids A, Cutting J (eds): The Neuropsychology of Schizophrenia, London, Erlbaum 1994, pp 53-73.
29. Buchsbaum MS, Haier RJ, Polkin SG, Nuechterlein K, Bracha S, Katz M, Lohr J, Wu J, Lottenberg S, Jerabek PA, Trenary M, Tafalla R, Reynolds C, Bunncy WE: Fronto-striatal disorder of cerebral metabolism in never-medicated schizophrenics, Arch Gen Psychiatry 1992:49: 935-942.
30. Walker E, Shave J: Familial schizophrenia: A predictor of ncuromotor and atientional abnormalities in schizophrenia, Arch Gen Psychiatry 1982:39:1153-1156.
31. Comblatt BA, Lenzenweger MF, Erlenmeyer-Kimling L: The Continuous Performance test, Identical Pairs version (CPT-IP), II, Contrasting attenlional profiles in schizophrenic and depressed patients, Psvchiatrv Res 1989:29: 65-85.
32. Comblatt B, Winters L, Erlenmayer-Kimling L: Attcntional markers of schizophrenia: Evidence from the New York high-risk study: in Schulz CS, Tamminga CA (eds): Schizophrenia: Scientific Progress, New York, Oxford University Press, 1989, pp 83-91.
33. Wohlberg GW, Kometsky C: Sustained attcn-dion in remitted schizophrenics, Arch Gen Psychiatry 1973;28:533-537.
34. Asarnow RF, MacCrimmon DJ: Residual performance deficit in clinically remitted schizophrenics: A marker of schizophrenia, J Abnorm Psychol 1978:87:597-608.
35. Cohen RM, Semple WE, Gross M, Nordahl TE, DeLisi LE, Holcomb HH, King AC, Mori-hisa JM, Pickar D: Dysfunction in a prefronlal substrate of sustained attention in schizophrenia, Life Sci 1987:40:2031-2039.
36. Nuechterlein KI I: Signal detection in vigilance tasks and behavioral attributes among offspring of schizophrenic mothers and among hyperactive children, J Abnorm Psvchol 1983; 92:4-28.
37. Rutschmann J, Comblatt B, Erlcnmeycr-Kim-ling L: Sustained attention in children at risk for schizophrenia, Arch Gen Psychiatry 1977; 34:571-575.
38. Erlenmeyer-Kimling L, Comblatt B: Attenlional measures in a study of children at high risk for schizophrenia, J Psychiatr Res 1978:14:93-98.
39. Wing JK, Cooper JE, Sartorius N: Measurement and Classification of Psychiatric Symptoms, London, Cambridge University Press, 1974.
40. Overall JE, Gorham DR: The brief psychiatric rating scale, Psychol Rep 1962:10:799-812.
41. Lukoff D, Nuechterlein KH, Ventura J; Manual for expanded Brief Psychiatric Rating Scale (BPRS), Schizophr Bull 1986:12:594-602.
42. Andersen NC: Negative symptoms in schizophrenia: Definition and reliability, Arch Gen Psychiatry 1982:39:784-788.
43. Siegel BV, Buchsbaum MS, Bunney WE, Gotl-schalk LA, Haier RJ, Lohr JB, Lottenberg S, Najafi A, Nuechterlein KH, Potkin SG, Wu JC: Cortico-striatal-thalamic circuits and brain glucose metabolic activity in 70 unmedicated male schizophrenics, Am J Psychiatry 1993: 150:1325-1336.
44. Nuechterlein KH, Parasuraman R, Jiang Q: Visual sustained attention: Image degradation produces rapid decrement over time, Science 1983;220:327-329.
45. Buchsbaum MS, Nuechterlein KH, Haier RJ, Wu J, Sicolte N, Hazlett E, Asarnow R, Potkin S, Guich S, Lagunas-Solar M: Glucose metabolic rate in normals and schizophrenics during the continuous performance test assessed by positron emission tomography, Br J Psychiatry 1990:156:216-227.
46. 18F]-lluoro-2-deoxy-glucose using polyether supported nucleophilic substitution, J NuclMed 1986:27:235-238.
47. Buchsbaum MS, Gillin JC, Wu J, Hazlett E, Sicotte N, DuPont RM: Regional cerebral glucose metabolic rate in human sleep assessed by positron emission tomography, Life Sci 1989; 45:1349-1356.
48. Matsui T, Hirano A: An Atlas of the Human Brain for Computerized Tomography, Tokyo, Igaku-Shoin, 1978.
49. Siegel BV, Asarnow R, Tanguay P, Call JD, Abel L, Ho A, Lott I, Buchsbaum MS: Regional cerebral glucose metabolism and attention in adults with a history of childhood autism, J Neuropsychiatry 1992:4:406-414.
50. Buchsbaum MS, Wu JC, DeLisi LE, Holcomb HH, Hazlett E, Cooper-Langston K, Kessler R: Positron emission tomography studies of basal ganglia and somatosensory cortex neuroleptic drug effects: Differences between normal controls and schizophrenic patients, Biol Psychiatry 1987;22:479-494.
51. Buchsbaum MS, DeLisi LE, Holcomb HH, Cappelletti J, King AC, Johnson J, Hazlett E, Dowling-Zimmerman S, Post RM, Morihisa J, Carpenter W, Cohen R, Pickar D, Weinberger DR, Margolin R, Kessler RM: Anteroposterior gradients in cerebral glucose use in schizophrenia and affective disorders, Arch Gen Psychiatry 1984:41:1159-1166.
52. Ford I: Confounded correlations: Statistical limitations in the analysis of interregional relationships of cerebral metabolic activity, J Cereb Blood Flow Metab 1986:6:385-388.
53. Bartlett EJ, Barouche F, Brodie JD, Wolkin A, Angrist B, Rotrosen J, Wolf AF: Stability of resting deoxyglucosc metabolic values in PE I' studies of schizophrenia, Psychiatry Res 1991: 40:11-20.
54. Kullback S: On testing correlation matrices, Appl Stat 1967:16:80-85.
55. Sokolof TL: The radioactive deoxyglucose method theory, procedures, and applications for the measurement of local glucose utilization in the central nervous system, Adv Neurochem 1982:4:1-82.
56. Buchsbaum MS, Ingvar DH, Kessler R, Waters RN, Cappelletti J, van Kammen DP, King AC, Johnson JJ, Manning RG, Flynn RM, Mann LS, Bunney WE, Sokoloff L: Cerebral glucogra-phy with positron tomography in normals and in patients with schizophrenia, Arch Gen Psychiatry 1982;39:251-259.
57. Weinberger DR, Berman KF, Zee RF: Physiological dysfunction of dorsolateral prefrontal cortex in schizophrenia I: Regional cerebral blood flow evidence, Arch Gen Psychiatry 1986:43:114-124.
58. Hoffman RE, Buchsbaum MS, Escobar MD, Makuch RW, Nuechlerlein KH, Guich SM: EF.G coherence of prefrontal areas in normal and schizophrenic males during perceptual activation, J Neuropsychiatry 1991:3:169-175.
59. Cleghorn JM, Garnett ES, Nahmias C, Fimau G, Brown GM, Kaplan R, Szechtman II, Szechlman B: Increased frontal and reduced parietal glucose metabolism in acute untreated schizophrenia, Psychiatry Res 1989:28:119-133.
60. Benes FM, Majocha R, Bird ED, Marotta C.A: Increased vertical axon numbers in cingulate cortex of schizophrenia, Arch Gen Psychiatry 1987;44:1017-1021.
61. Drevets WC, Videen TO, MacLeod AK, et al: PET images of blood flow changes during anxiety: Correction, Science 1992:256:1696.
62. Harris GJ, Links JM, Pearlson GD, Camargo EE: Cortical circumferential profile of SPECT cerebral perfusion in Alzheimer’s disease, Psychiatry Res 1991:40:167-180.
63. Hennerici U, Halsband T, Kuwert H, Steinmetz H, Herzog H, Aulich A, Feinendegen LE: PET and neuropsychology in thalamic infarction: Evidence for associated cortical dysfunction, Psychiatry Res 1989:29:363-365.
64. l3NHj, Ann Neurol 1980:8:47-60.
65. Baron JC: Depression of energy metabolism in distant brain structures: Studies with positron emission tomography in stroke patients, Semin Neurol 1989:9:281-285.