Growth inhibition of Cryptococcus neoformans by 2-(1-piperazinyl)-5-(1,2-diarylethyl)-4,6-dichloropyrimidines: Synthesis and in vitro studies

European Journal of Medicinal Chemistry

Volumn 31, Issue 1, 1996, Pages 77-81

  Fellahi, Y ^a   Mandin, D ^b   Dubois, P ^a   Ombetta Goka, J E ^a   Guenzet, J ^a   Chaumont, J P ^b   Frangin, Y ^a  

^a UNIVERSITÉ DE TOURS   (France)

^b UNIVERSITÉ DE FRANCHE COMTÉ   (France)

Author keywords

Crytococcus neoformans; Pyrimidine derivative

Indexed keywords

4,6 DICHLORO 5 [1 (4 CHLOROPHENYL) 2 (3 CHLOROPHENYL)ETHYL] 2 (1 PIPERAZINYL)PYRIMIDINE; 4,6 DICHLORO 5 [1 (4 CHLOROPHENYL) 2 PHENYLETHYL] 2 (1 PIPERAZINYL)PYRIMIDINE; ANTIFUNGAL AGENT; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CRYPTOCOCCUS NEOFORMANS; DRUG SYNTHESIS; FUNGUS; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; REACTION ANALYSIS;

EID: 0030028828     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(96)80010-9     Document Type: Article

References (16)

1. Eilam Y, Polacheck I, Ben-Gigi G, Chernichovsky D (1987) Antimicrob Agents Chemother 31, 834-836
2. Allerberger F, Reisinger EC, Söldner B, Dierich MP (1989) Mycoses 32, 527-530
3. Liu S, Oguntimein B, Hufford CD, Clark AM (1990) Antimicrob Agents Chemother 34, 529-533
4. Pfaller MA, Riley J, Gerarden T (1990) Mycopathol 112, 27-32
5. Oki T, Kakushima M, Hirano et al (1992) J Antibiotics 45, 1512-1517
6. Wright KA, Perfect JR, Ritter W (1990) J Antimicrob Chemother 26, 387-397
7. Allendoerfer R, Yates RR, Marquis AJ, Loebenberg D, Rinaldi MG, Graybill JR (1992) Antimicrob Agents Chemother 36, 217-219
8. Peng T, Galgiani JN ( 1993) Antimicrob Agents Chemother 37, 2126-2131
9. Kinsman OS, Livermore DG, Smith C (1993) Antimicrob Agents Chemother 37, 1243-1246
10. Takesako K, Kuroda H, Inoue T et al (1993) J Antibiotics 46, 1414-1420
11. Stansell JD (1993) Semin Respir Infect 8, 116-123
12. Speer H, Dabovich TC (1955) Org Synth Coll III, 39-41
13. Frangin Y, Guimbal C, Wissocq F, Zamarlik H (1986) Synthesis 12, 1046-1050
14. Gaudemar M (1962) Bull Soc Chim Fr 974-979
15. Gershon H, Braun R, Scala A, Rodin R (1964) J Med Chem 7, 808-811
16. Viollon C (1993) Thesis, Besançon, France