Carbon-13 nuclear magnetic resonance spectra of some 4-substituted analogues of phencyclidine and thienylcyclidine

Saudi Pharmaceutical Journal

Volumn 4, Issue 2, 1996, Pages 84-91

  Al Deeb, Omar A ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

2D NMR; 13C NMR; Phencyclidine; Thienylcyclidine

Indexed keywords

CARBON 13; PHENCYCLIDINE; PIPERIDINE DERIVATIVE; TENOCYCLIDINE;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG STRUCTURE;

EID: 0030028609     PISSN: 13190164     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Petercon RC, and Stillman RC. An overview in phencyclidine abuse. National institute on drug abuse, Washington, DC, 1978, pp. 1-17.
2. Bailey K, and Legault D. The identification of the analogues of the hallucinogen cyclohexamine. J Assoc Off Anal Chem 1979; 62: 1124.
3. Brine GA, Williams EE, Bold KG, and Carroll FI. Carbon-13 nuclear magnetic resonance spectra of phencyclidine analogues. J Heterocyclic Chem 1979; 16:1425.
4. Bailey K, and Legault D. Identification of phencyclidine and simple analogues by carbon-13 nuclear magnetic resonance. Anal Chim Acta 1980; 113: 375.
5. Itzhak Y, Kalir A, Weissman B, and Cohen S. New analgesics derived from phencyclidine. J Med Chem 1981; 24: 496.
6. Al-Deeb OA. Synthesis and analgesic activity of new phencyclidine derivatives. Arzneium.-Forsch/Drug Res 1994; 44(11), 10: 1141.
7. Al-Deeb OA. New analgesics derived from the phencyclidine analogue TCP. Arzneium.-Forsch/Drug Res 1996; 46(5).
8. Geneste P and Kamenka JM. Etude par Résonance Magnétique Nucléaire du 13C des chlorhydrates de-N-(phényl-1 cyclohexyl) piperidines. Org Magn Res 1975;7: 579.
9. Pehk T and Lippmaa E. Carbon-13 chemical shifts of monosubstituted cyclohexanes. Org Magn Res 1971; 3: 679.
10. Kosugi T and Motozato Y. 13C-NMR of piperidine-cyclodextrin inclusion compounds. Nippon Kagaku Kaishi 1983; 2: 202.
11. Jones AJ, Casy AF and McErlane MJ. Carbon-13 magnetic resonance: the stereochemistry of 1,2- and 1,3-dimethyl-4-phenylpiperidine derivatives. Can J Chem 1973; 51: 1782.
12. Levy GC, Lichter RL and Nelson GL. Magnetic Resonance Spectroscopy, 2nd Ed, Wiley-Interscience, New York, N.Y., 1980, pp 111-112.
13. Casy AF, Iorio MA and Podo F. 13C-NMR studies of isomeric piperidine derivative with opiate properties and related compounds. Org Magn Res 1981; 15(3): 275.
14. Couperus PA, Claque ADH and van Dongen JPCM. Carbon-13 chemical shifts of some model carboxylic acids and esters. Org Magn Res 1978; 11(12): 590.
15. Casy AF. PMR Spectroscopy in Medicinal and Biological Chemistry. Chaps. 3 and 4, Academic Press, London, 1971.
16. Eaton AT, Houk KN, Watkins SF and Fronczek FR. Geometries and conformational processes in phencyclidine and a rigid admantyl analogue : Variable-temperature NMR, X-ray crystallographic and molecular mechanics studies. J Med Chem 1983; 26: 479.
17. Silverstein RM, Bassler GC and Morrill TC. Spectrometric Identification of Organic Compounds. Fourth Ed., John Willy and Sons, Singapore, 1981, p. 226.