The efficient resolution of protected diols and hydroxy aldehydes by lipases: Steric auxiliary approach and synthetic applications

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 1, 1996, Pages 71-76

  Kim, Mahn Joo ^a   Lim, In Taek ^a   Choi, Gil Bae ^a   Whang, Sang Yeul ^a   Ku, Bon Cheol ^a   Choi, Jin Young ^a  

^a Pohang University of Science and Technology (POSTECH)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

PSEUDOMONAS;

ALDEHYDE; ALKANEDIOL DERIVATIVE; TRIACYLGLYCEROL LIPASE;

ARTICLE; DRUG PURIFICATION; DRUG SYNTHESIS; ENANTIOMER; ENZYME ACTIVITY; PSEUDOMONAS;

EID: 0030028475     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0960-894X(95)00550-D     Document Type: Article

References (23)

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12. For previous examples of lipase-mediated resolution of hydroxy aldehyde acetals, see Pederson, R. L.; Liu, K. K.-C.; Rutan, J. E.; Chen, L.; Wong, C.-H. J. Org. Chem. 1990, 55, 4897; Bianchi, D.; Cesti, P.; Golini, P. Tetrahedron 1989, 45, 869.
13. For previous examples of lipase-mediated resolution of hydroxy aldehyde acetals, see Pederson, R. L.; Liu, K. K.-C.; Rutan, J. E.; Chen, L.; Wong, C.-H. J. Org. Chem. 1990, 55, 4897; Bianchi, D.; Cesti, P.; Golini, P. Tetrahedron 1989, 45, 869.
14. 3, ppm) 73.0, 71.5, 64.0, 44.6, 27.4.
15. 18-10.8° (c 0.98, EtOH) for (S)-enantiomer].
16. 3, ppm) 73.3, 70.5, 65.8, 60.9, 35.3, 27.5.
17. 3, ppm) 137.7, 129.3, 128.7, 128.3, 126.6, 73.0, 60.1, 39.8.
18. 3, ppm,) 134.9, 130.1, 129.1, 126.8, 69.9, 65.2, 37.7.
19. 21 m.p. 73°C].
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