Hyperinsulinemia in nondiabetic Asian subjects using specific assays for insulin, intact proinsulin, and des-31,32-proinsulin

Diabetes Care

Volumn 19, Issue 1, 1996, Pages 39-42

  Nagi, Dinesh K ^a,b   Ali, Vidya Mohamed ^a   Walji, Shahenaz ^a   Jain, Sachin K ^a   Yudkin, John S ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; PROINSULIN;

ADULT; ARTICLE; CAUCASIAN; CONTROLLED STUDY; FEMALE; HUMAN; HYPERINSULINEMIA; IMPAIRED GLUCOSE TOLERANCE; INSULIN BLOOD LEVEL; INSULIN RELEASE; MAJOR CLINICAL STUDY; MALE; MONGOLOID RACE; RACE DIFFERENCE;

EID: 0030027984     PISSN: 01495992     EISSN: None     Source Type: Journal    
DOI: 10.2337/diacare.19.1.39     Document Type: Article

References (16)

1. McKeigue PM, Shah B, Marmot MG: Relation of central obesity and insulin resistance with high diabetes prevalence and cardiovascular risk in South Asians. Lancet 337:382-386, 1991
2. McKeigue PM, Pierpoint T, Ferrie JE, Marmot MG: Relationship of glucose intolerance and hyperinsulinaemia to body fat pattern in South Asians and Europeans. Diabetologia 35:785-791, 1992
3. Temple RC, Clark P, Schneider A, Nagi DK, Hendra TJ, Yudkin JS, Hales CN: Radioimmunoassay may overestimate insulin in non-insulin-dependent diabetics. Clin Endocrinol 32:689-693, 1990
4. World Health Organization: Diabetes Mellitus: Report of a WHO Study Group. Geneva, World Health Org , 1985 (Tech Rep Ser , no. 727)
5. Sobey WJ, Beer SF, Carrington CA, Clark PMS, Frank BH, Gray IP, Luzio SD, Owens DR. Schneider AE, Siddle K, Temple RC, Hales CN. Sensitive and specific two-site immunoradiometric assays to human insulin, proinsulin, 65-66 split and 32-33 split proinsulin Biochem J 260: 535-541. 1989
6. Mohamed-Ali V, Yudkin JS: An end-point amplified enzymoimmunoassay (IEMA) specific for human insulin. Clin Sci 82 (Suppl. 27):4P, 1992
7. Mohamed-Ali V, Yudkin JS: Simple and highly sensitive microplate assays (IR-MAs) for intact proinsulin and des 31,32 proinsulin. Diabetic Med 10 (Suppl. 1): p67, 1993
8. Phillips DIW, Clark PM, Hales CN, Osmond C: Understanding oral glucose tolerance: comparison of glucose or insulin measurements during oral glucose tolerance test with specific measurements of insulin resistance and insulin secretion. Diabetic Med 11:286-293, 1994
9. Mitrakou A, Kelley D, Mokan M, Veneman T, Pangburn T, Reilly J, Gerich J: Role of reduced suppression of glucose production and diminished early insulin release in impaired glucose tolerance. N Engl J Med 326:22-29, 1992
10. Hollenbeck C, Reaven GM: Variations in insulin stimulated glucose uptake in individuals with normal glucose tolerance. J Clin Endocrinol Metab 64:1169-1173, 1987
11. Knight TM, Smith Z, Whittles A, Sahota P, Lockton JA, Hogg G, Bedford A, Toop M, Kernohan HEM, Baker MR: Insulin resistance, diabetes, and risk markers for ischaemic heart disease in Asian men and non-Asian men in Bradford Br Heart J 67: 343-350, 1992
12. Aronoff SL, Bennett PH, Gorden P, Rushforth N, Miller M: Unexplained hyperinsulinemia in normal and "prediabetic" Pima Indians compared with normal Caucasians. Diabetes, 26:827-840, 1977
13. Zimmet P, Whitehouse S, Kies J: Ethnic variability in glucose tolerance in Polynesian and Micronesian subjects. Diabetes 28:624-628, 1979
14. Lillioja S, Mott D, Spraul M, Ferraro R, Foley J, Ravussin E, Knowler WC, Bennett PH, Bogardus C: Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. prospective studies of Pima Indians. N Engl J Med 329:1988-1992, 1993
15. Polonsky KS, Rubenstein AH: C-peptide as a measure of the secretion and hepatic extraction of insulin: pitfalls and limitations. Diabetes 33:486-494, 1984
16. Despres JP, Tremblay A, Nadeau A, Bouchard C: Physical training and changes in regional adipose tissue distribution Acta Med Scand 723 (Suppl.):205-212, 1988