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Volumn 30, Issue 2, 1996, Pages 107-140

The use of therapeutic drug monitoring to optimise immunosuppressive therapy

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; AZATHIOPRINE; CD3 ANTIGEN; CYCLOSPORIN; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; NUCLEOTIDE; OKT 3; RAPAMYCIN; TACROLIMUS;

EID: 0030027698     PISSN: 03125963     EISSN: None     Source Type: Journal    
DOI: 10.2165/00003088-199630020-00003     Document Type: Review
Times cited : (65)

References (310)
  • 1
    • 0345183785 scopus 로고
    • The reversal of rejection in human renal homografts with subsequent development of homog raft tolerance
    • Starzl TE, Marchioro TL, Waddell WR. The reversal of rejection in human renal homografts with subsequent development of homog raft tolerance. Surg Gynecol Obstet 1963; 117: 385-95
    • (1963) Surg Gynecol Obstet , vol.117 , pp. 385-395
    • Starzl, T.E.1    Marchioro, T.L.2    Waddell, W.R.3
  • 2
    • 84943984371 scopus 로고
    • Current results and expectations of renal transplantation
    • Standards Committee of American Society of Transplant Surgeons. Current results and expectations of renal transplantation. JAMA 1981; 246: 1330-1
    • (1981) JAMA , vol.246 , pp. 1330-1331
  • 3
    • 0021720922 scopus 로고
    • Experience with cyclosporine and steroids in clinical renal transplantation
    • Tilney NL, Milford EL, Araujo JL, et al. Experience with cyclosporine and steroids in clinical renal transplantation. Ann Surg 1984; 200: 605-13
    • (1984) Ann Surg , vol.200 , pp. 605-613
    • Tilney, N.L.1    Milford, E.L.2    Araujo, J.L.3
  • 4
    • 0027791704 scopus 로고
    • The UNOS Scientific Renal Transplant Registry
    • Terasaki PI, Cecka JM, editors. Los Angeles: UCLA Tissue Typing Laboratory
    • Cecka JM, Terasaki PI. The UNOS Scientific Renal Transplant Registry. In: Terasaki PI, Cecka JM, editors. Clinical transplants 1992. Los Angeles: UCLA Tissue Typing Laboratory, 1993: 1-16
    • (1993) Clinical Transplants 1992 , pp. 1-16
    • Cecka, J.M.1    Terasaki, P.I.2
  • 5
    • 0026575932 scopus 로고
    • The mechanism of action of cyclosporine and FK506
    • Schreiber SL, Crabtree IR. The mechanism of action of cyclosporine and FK506. Immunol Today 1992; 13: 136-42
    • (1992) Immunol Today , vol.13 , pp. 136-142
    • Schreiber, S.L.1    Crabtree, I.R.2
  • 6
    • 0028878220 scopus 로고
    • The synergistic effects of cyclosporine, sirolimus, and brequinar on heart allograft survival in mice
    • Tu Y, Stepkowski SM, Chou TC, et al. The synergistic effects of cyclosporine, sirolimus, and brequinar on heart allograft survival in mice. Transplantation 1995; 59: 177-83
    • (1995) Transplantation , vol.59 , pp. 177-183
    • Tu, Y.1    Stepkowski, S.M.2    Chou, T.C.3
  • 7
    • 0027973619 scopus 로고
    • Synergistic effects of cyclosporin analogs - A, D, G, 1MM-125 - with rapamycin and/or brequinar
    • Kahan BD, Chou T, Teipal N, et al. Synergistic effects of cyclosporin analogs - A, D, G, 1MM-125 - with rapamycin and/or brequinar. Transplant Proc 1994; 26: 3021-4
    • (1994) Transplant Proc , vol.26 , pp. 3021-3024
    • Kahan, B.D.1    Chou, T.2    Teipal, N.3
  • 8
    • 0026081972 scopus 로고
    • Synergistic interactions of cyclosporine and rapamycin to inhibit immune performances of normal human peripheral blood lymphocytes in vitro
    • Kahan BD, Gibbons S, Tejpal N, et al. Synergistic interactions of cyclosporine and rapamycin to inhibit immune performances of normal human peripheral blood lymphocytes in vitro. Transplantation 1991; 51: 232-9
    • (1991) Transplantation , vol.51 , pp. 232-239
    • Kahan, B.D.1    Gibbons, S.2    Tejpal, N.3
  • 9
    • 0026668330 scopus 로고
    • Therapeutic monitoring of cyclosporine, FK-506, and rapamycin
    • Yatscoff RW, Shaw LM. Therapeutic monitoring of cyclosporine, FK-506, and rapamycin. Ther Drug Monit 1992; 14: 267-8
    • (1992) Ther Drug Monit , vol.14 , pp. 267-268
    • Yatscoff, R.W.1    Shaw, L.M.2
  • 10
    • 0027170712 scopus 로고
    • Cyclosporin: A review of pharmacodynamic and pharmacokinetic properties, and therapeutic use in immunoregulatory disorders
    • Faulds D, Goa KL, Benfield P. Cyclosporin: a review of pharmacodynamic and pharmacokinetic properties, and therapeutic use in immunoregulatory disorders. Drugs 1993; 45: 953-1040
    • (1993) Drugs , vol.45 , pp. 953-1040
    • Faulds, D.1    Goa, K.L.2    Benfield, P.3
  • 11
    • 0017157814 scopus 로고
    • Biological effects of cyclosporine A: A new antilymphocyte agent
    • Borel JF, Feurer C, Gubler HU, et al. Biological effects of cyclosporine A: a new antilymphocyte agent. Agents Actions 1976; 6: 468-75
    • (1976) Agents Actions , vol.6 , pp. 468-475
    • Borel, J.F.1    Feurer, C.2    Gubler, H.U.3
  • 12
    • 0021159379 scopus 로고
    • Cyclophilin: A specific cytosolic binding protein for cyclosporin A
    • Handschumacher RE, Harding MW, Rice J, et al. Cyclophilin: a specific cytosolic binding protein for cyclosporin A. Science 1984; 226: 544-7
    • (1984) Science , vol.226 , pp. 544-547
    • Handschumacher, R.E.1    Harding, M.W.2    Rice, J.3
  • 13
    • 0021704746 scopus 로고
    • Induction of interleukin-2 messenger RNA inhibited by cyclosporine A
    • Elliot JF, Lin Y, Mizel SB, et al. Induction of interleukin-2 messenger RNA inhibited by cyclosporine A. Science 1984; 226: 1439-41
    • (1984) Science , vol.226 , pp. 1439-1441
    • Elliot, J.F.1    Lin, Y.2    Mizel, S.B.3
  • 14
    • 0021994249 scopus 로고
    • Cyclosporine inhibits antigen and lectin-induced but not constitutive production of interleukin 3
    • Palacios R. Cyclosporine inhibits antigen and lectin-induced but not constitutive production of interleukin 3. Eur J Immunol 1985; 15: 204-6
    • (1985) Eur J Immunol , vol.15 , pp. 204-206
    • Palacios, R.1
  • 15
    • 0025372608 scopus 로고
    • Cyclosporin A rapidly inhibits mediator release from human basophils presumably by interacting with cyclophilin
    • Cirillo R, Triggiani M, Siri L. Cyclosporin A rapidly inhibits mediator release from human basophils presumably by interacting with cyclophilin. J Immunol 1990; 144: 3891-7
    • (1990) J Immunol , vol.144 , pp. 3891-3897
    • Cirillo, R.1    Triggiani, M.2    Siri, L.3
  • 16
    • 0024262991 scopus 로고
    • Production of tumor necrosis factor/cachectin by human B cell lines and tonsillar B cells
    • Sung SS, Jung LK, Walters JA, et al. Production of tumor necrosis factor/cachectin by human B cell lines and tonsillar B cells. J Exp Med 1988; 168: 1539-51
    • (1988) J Exp Med , vol.168 , pp. 1539-1551
    • Sung, S.S.1    Jung, L.K.2    Walters, J.A.3
  • 17
    • 0020579924 scopus 로고
    • Gamma interferon synthesis by human thymocytes and T lymphocytes inhibited by cyclosporine A
    • Reem GH, Cook LA, Vilcek J. Gamma interferon synthesis by human thymocytes and T lymphocytes inhibited by cyclosporine A. Science 1983; 221: 63-4
    • (1983) Science , vol.221 , pp. 63-64
    • Reem, G.H.1    Cook, L.A.2    Vilcek, J.3
  • 18
    • 0027155059 scopus 로고
    • Cyclosporin metabolism in transplant patients
    • Christians U, Sewing KF. Cyclosporin metabolism in transplant patients. Pharmacol Ther 1993; 57: 291-345
    • (1993) Pharmacol Ther , vol.57 , pp. 291-345
    • Christians, U.1    Sewing, K.F.2
  • 19
    • 0026090248 scopus 로고
    • The clinical significance of cyclosporine metabolites
    • Yatscoff RW, Rosano TG, Bowers LD. The clinical significance of cyclosporine metabolites. Clin Biochem 1991; 24: 23-35
    • (1991) Clin Biochem , vol.24 , pp. 23-35
    • Yatscoff, R.W.1    Rosano, T.G.2    Bowers, L.D.3
  • 20
    • 0026969409 scopus 로고
    • Relationship between the dose and whole blood level of cyclosporine after liver and kidney transplantation
    • Kahn D, Cervio G, Mazzaferro V, et al. Relationship between the dose and whole blood level of cyclosporine after liver and kidney transplantation. J Clin Lab Immunol 1992; 37: 163-71
    • (1992) J Clin Lab Immunol , vol.37 , pp. 163-171
    • Kahn, D.1    Cervio, G.2    Mazzaferro, V.3
  • 21
    • 0025194435 scopus 로고
    • 125I-tracer selective monoclonal antibody levels on whole blood matrix to predict rejection or nephrotoxic episodes in renal transplant patients under antilymphocyte globulin and prednisone therapy
    • 125I-tracer selective monoclonal antibody levels on whole blood matrix to predict rejection or nephrotoxic episodes in renal transplant patients under antilymphocyte globulin and prednisone therapy. Transplant Proc 1990; 22: 1253-4
    • (1990) Transplant Proc , vol.22 , pp. 1253-1254
    • Stiller, C.1    Keown, P.2
  • 22
    • 0023928004 scopus 로고
    • Minimal low dosage of cyclosporine therapy in renal transplantation by careful monitoring of high-performance liquid chromatography whole blood trough levels
    • Uchida K, Yamada N, Orihara A, et al. Minimal low dosage of cyclosporine therapy in renal transplantation by careful monitoring of high-performance liquid chromatography whole blood trough levels. Transplant Proc 1988; 20 (2 Suppl. 2): 394-401
    • (1988) Transplant Proc , vol.20 , Issue.2 SUPPL. 2 , pp. 394-401
    • Uchida, K.1    Yamada, N.2    Orihara, A.3
  • 23
    • 0023832079 scopus 로고
    • Serum cyclosporine kinetic profile. Failure to correlate with nephrotoxicity or rejection episodes following sequential immunotherapy for renal transplantation
    • Sommer BG, Sing DE, Henry ML, et al. Serum cyclosporine kinetic profile. Failure to correlate with nephrotoxicity or rejection episodes following sequential immunotherapy for renal transplantation. Transplantation 1988; 45: 86-90
    • (1988) Transplantation , vol.45 , pp. 86-90
    • Sommer, B.G.1    Sing, D.E.2    Henry, M.L.3
  • 24
    • 0021953181 scopus 로고
    • Cyclosporine plasma levels in renal transplant patients
    • Klintmalm G, Sawe J, Fingden O, et al. Cyclosporine plasma levels in renal transplant patients. Transplantation 1985; 39: 132-7
    • (1985) Transplantation , vol.39 , pp. 132-137
    • Klintmalm, G.1    Sawe, J.2    Fingden, O.3
  • 25
    • 0023951425 scopus 로고
    • Cyclosporine levels are not helpful
    • Henry ML, Bowers VD, Fanning WJ, et al. Cyclosporine levels are not helpful. Transplant Proc 1988; 20 (2 Suppl. 2): 419-21
    • (1988) Transplant Proc , vol.20 , Issue.2 SUPPL. 2 , pp. 419-421
    • Henry, M.L.1    Bowers, V.D.2    Fanning, W.J.3
  • 26
    • 0024605129 scopus 로고
    • Monitoring of cyclosporine blood levels with polyclonal and monoclonal assays during episodes of renal graft dysfunction
    • Martinez L, Foradori A, Vaccarezza A, et al. Monitoring of cyclosporine blood levels with polyclonal and monoclonal assays during episodes of renal graft dysfunction. Transplant Proc 1989; 21: 1490-1
    • (1989) Transplant Proc , vol.21 , pp. 1490-1491
    • Martinez, L.1    Foradori, A.2    Vaccarezza, A.3
  • 27
    • 0021635362 scopus 로고
    • The value of serial serum trough cyclosporine levels in human renal transplantation
    • Kahan BD, Wideman CA, Reid M, et al. The value of serial serum trough cyclosporine levels in human renal transplantation. Transplant Proc 1984; 16: 1195-9
    • (1984) Transplant Proc , vol.16 , pp. 1195-1199
    • Kahan, B.D.1    Wideman, C.A.2    Reid, M.3
  • 28
    • 0021177239 scopus 로고
    • Cyclosporine blood levels do correlate with clinical complications
    • Irschik E, Tilg H, Niederwieser D, et al. Cyclosporine blood levels do correlate with clinical complications. Lancet 1984; 2: 692-3
    • (1984) Lancet , vol.2 , pp. 692-693
    • Irschik, E.1    Tilg, H.2    Niederwieser, D.3
  • 29
    • 0024514747 scopus 로고
    • Cyclosporine monitoring with polyclonal and specific monoclonal antibodies during episodes of renal allograft dysfunction
    • Holt DW, Marsden JT, Johnston A, et al. Cyclosporine monitoring with polyclonal and specific monoclonal antibodies during episodes of renal allograft dysfunction. Transplant Proc 1989; 21: 1482-4
    • (1989) Transplant Proc , vol.21 , pp. 1482-1484
    • Holt, D.W.1    Marsden, J.T.2    Johnston, A.3
  • 30
    • 0022913273 scopus 로고
    • Studies of cyclosporine blood levels: Analysis, clinical utility, pharmacokinetics. metabolites, and chronopharmacology
    • Bowers LD, Canafax DM, Singh J, et al. Studies of cyclosporine blood levels: analysis, clinical utility, pharmacokinetics. metabolites, and chronopharmacology. Transplant Proc 1986; 28 (6 Suppl. 5): 137-43
    • (1986) Transplant Proc , vol.28 , Issue.6 SUPPL. 5 , pp. 137-143
    • Bowers, L.D.1    Canafax, D.M.2    Singh, J.3
  • 31
    • 0023914860 scopus 로고
    • Cyclosporine nepllrotoxicity is minimized by adjusting dosage on the basis of drug concentration in blood
    • Moyer TP, Post GR, Sterioff S, et al. Cyclosporine nepllrotoxicity is minimized by adjusting dosage on the basis of drug concentration in blood. Mayo Clin Proc 1988; 63: 241-7
    • (1988) Mayo Clin Proc , vol.63 , pp. 241-247
    • Moyer, T.P.1    Post, G.R.2    Sterioff, S.3
  • 32
    • 0025230677 scopus 로고
    • Rejection and infection after pediatric cardiac transplantation
    • Braunlin EA, Canter CE, Olivari MT, et al. Rejection and infection after pediatric cardiac transplantation. Ann Thorac Surg 1990; 49: 385-90
    • (1990) Ann Thorac Surg , vol.49 , pp. 385-390
    • Braunlin, E.A.1    Canter, C.E.2    Olivari, M.T.3
  • 33
    • 0025364494 scopus 로고
    • Liver transplantation in Birmingham - Use of cyclosporine - clinical correlations with drug measurements
    • Gunson BK, Jones SR, Buckels JAC, et al. Liver transplantation in Birmingham - use of cyclosporine - clinical correlations with drug measurements. Transplant Proc 1990; 22: 1312-8
    • (1990) Transplant Proc , vol.22 , pp. 1312-1318
    • Gunson, B.K.1    Jones, S.R.2    Buckels, J.A.C.3
  • 34
    • 0025374371 scopus 로고
    • A prospective study of cyclosporine monitoring in renal transplantation
    • Lindholm A. A prospective study of cyclosporine monitoring in renal transplantation. Transplantion 1990; 22: 1260-3
    • (1990) Transplantion , vol.22 , pp. 1260-1263
    • Lindholm, A.1
  • 35
    • 0025050489 scopus 로고
    • A prospective study of cyclosporine concentration in relation to its therapeutic effect and toxicity after renal transplantation
    • Lindholm A, Dahlqvist J, Groth GG, et al. A prospective study of cyclosporine concentration in relation to its therapeutic effect and toxicity after renal transplantation. Br J Clin Pharmacol 1990; 30: 443-52
    • (1990) Br J Clin Pharmacol , vol.30 , pp. 443-452
    • Lindholm, A.1    Dahlqvist, J.2    Groth, G.G.3
  • 36
    • 0025281690 scopus 로고
    • Adjustment of cyclosporine dosage in renal transplant patients based on concentration measured specifically in whole blood: Clinical outcome results and diagnostic utility
    • Shaw LM, Audet PR, Grossman RA, et al. Adjustment of cyclosporine dosage in renal transplant patients based on concentration measured specifically in whole blood: clinical outcome results and diagnostic utility. Transplant Proc 1990; 22: 1267-73
    • (1990) Transplant Proc , vol.22 , pp. 1267-1273
    • Shaw, L.M.1    Audet, P.R.2    Grossman, R.A.3
  • 37
    • 0025284227 scopus 로고
    • Clinical correlations of cyclosporine HPLC and FPIA levels in renal transplant recipients
    • Sridhar N, Schroeder TJ, Pesce AJ, et al. Clinical correlations of cyclosporine HPLC and FPIA levels in renal transplant recipients. Transplant Proc 1990; 22: 1257-9
    • (1990) Transplant Proc , vol.22 , pp. 1257-1259
    • Sridhar, N.1    Schroeder, T.J.2    Pesce, A.J.3
  • 38
    • 0025312599 scopus 로고
    • Value of cyclosporine measurements in renal transplant recipients irmmunosuppressed with triple therapy
    • Taube D, Marsden J, Palmer A, et al. Value of cyclosporine measurements in renal transplant recipients irmmunosuppressed with triple therapy. Transplant Proc 1990; 22: 1251-2
    • (1990) Transplant Proc , vol.22 , pp. 1251-1252
    • Taube, D.1    Marsden, J.2    Palmer, A.3
  • 39
    • 0028297145 scopus 로고
    • Cyclosporine monitoring improves graft-versus-host disease prophylaxis after bone marrow transplantation
    • Ghalie R, Fitzsimmons WE, Weinstein A, et al. Cyclosporine monitoring improves graft-versus-host disease prophylaxis after bone marrow transplantation. Ann Pharmacother 1994; 28: 379-82
    • (1994) Ann Pharmacother , vol.28 , pp. 379-382
    • Ghalie, R.1    Fitzsimmons, W.E.2    Weinstein, A.3
  • 40
    • 0028052168 scopus 로고
    • Diagnostic, utility of whole blood cyclosporine measurements in renal transplantation using triple therapy
    • Nankivell BJ, Hibbins M, Chapman JR. Diagnostic, utility of whole blood cyclosporine measurements in renal transplantation using triple therapy. Transplantation 1994; 58: 989-96
    • (1994) Transplantation , vol.58 , pp. 989-996
    • Nankivell, B.J.1    Hibbins, M.2    Chapman, J.R.3
  • 41
    • 0022997421 scopus 로고
    • Blood cyclosporine concentrations and renal allograft dysfunction
    • Holt DW, Marsden JT, Johnston A, et al. Blood cyclosporine concentrations and renal allograft dysfunction. BMJ 1986; 293: 1057-9
    • (1986) BMJ , vol.293 , pp. 1057-1059
    • Holt, D.W.1    Marsden, J.T.2    Johnston, A.3
  • 42
    • 0022625328 scopus 로고
    • Cyclosporine blood concentrations in the management of renal transplant recipients
    • Rogerson ME, Marsden JT, Reid KE, et al. Cyclosporine blood concentrations in the management of renal transplant recipients. Transplantation 1986; 41: 276-8
    • (1986) Transplantation , vol.41 , pp. 276-278
    • Rogerson, M.E.1    Marsden, J.T.2    Reid, K.E.3
  • 43
    • 0023912721 scopus 로고
    • Influence of early cyclosporine dosage and plasma and whole blood levels on acute rejections in cadaveric renal allograft recipients
    • Lindholm A, Lundgren G, Fehrman I, et al. Influence of early cyclosporine dosage and plasma and whole blood levels on acute rejections in cadaveric renal allograft recipients. Transplant Proc 1988; 20: 444-6
    • (1988) Transplant Proc , vol.20 , pp. 444-446
    • Lindholm, A.1    Lundgren, G.2    Fehrman, I.3
  • 44
    • 0023879731 scopus 로고
    • Serum cyclosporine concentration and risk of acute graft-versus-host disease after allogeneic marrow transplantation
    • Yee GC, Self SG, McGuire TR, et al. Serum cyclosporine concentration and risk of acute graft-versus-host disease after allogeneic marrow transplantation. N Engl J Med 1988; 319: 65-70
    • (1988) N Engl J Med , vol.319 , pp. 65-70
    • Yee, G.C.1    Self, S.G.2    McGuire, T.R.3
  • 45
    • 0026467096 scopus 로고
    • Blood cyclosporin concentrations and the short-term risk of lung rejection following heart-lung transplantation
    • Best NG, Trull AK, Kan KKC, et al. Blood cyclosporin concentrations and the short-term risk of lung rejection following heart-lung transplantation. Br J Clin Pharmacol 1992; 34: 513-20
    • (1992) Br J Clin Pharmacol , vol.34 , pp. 513-520
    • Best, N.G.1    Trull, A.K.2    Kan, K.K.C.3
  • 46
    • 0023940854 scopus 로고
    • Failure of whole blood cyclosporine levels to provide a reliable measure of immunosuppression in clinical heart and heart/lung transplantation
    • White D, Rose M, Wright L, et al. Failure of whole blood cyclosporine levels to provide a reliable measure of immunosuppression in clinical heart and heart/lung transplantation. Transplant Proc 1988; 20 (2 Suppl. 2): 422-5
    • (1988) Transplant Proc , vol.20 , Issue.2 SUPPL. 2 , pp. 422-425
    • White, D.1    Rose, M.2    Wright, L.3
  • 47
    • 0025374373 scopus 로고
    • Cyclosporine monitoring in liver allograft recipients: Two distinct patterns of blood level derangement associated with nephrotoxicity
    • Wonigeit K, Kohlhaw K, Winkler M, et al. Cyclosporine monitoring in liver allograft recipients: two distinct patterns of blood level derangement associated with nephrotoxicity. Transplant Proc 1990; 22: 1305-11
    • (1990) Transplant Proc , vol.22 , pp. 1305-1311
    • Wonigeit, K.1    Kohlhaw, K.2    Winkler, M.3
  • 48
    • 0018186018 scopus 로고
    • Cyclosporin A in patients receiving renal allografts from cadaver donors
    • Calne RY, White DJG, Thiru S, et al. Cyclosporin A in patients receiving renal allografts from cadaver donors. Lancet 1978; 2: 1323-7
    • (1978) Lancet , vol.2 , pp. 1323-1327
    • Calne, R.Y.1    White, D.J.G.2    Thiru, S.3
  • 49
    • 0023118989 scopus 로고
    • Involvement of cyclosporine metabolites in therapeutic monitoring and immunosuppression
    • Rosano TG, Freed BM, Pell MA, et al. Involvement of cyclosporine metabolites in therapeutic monitoring and immunosuppression. Transplant Proc 1987; 19: 1699-703
    • (1987) Transplant Proc , vol.19 , pp. 1699-1703
    • Rosano, T.G.1    Freed, B.M.2    Pell, M.A.3
  • 50
    • 0025194439 scopus 로고
    • 1H-based specific monoclonal antibody assay on whole blood samples with the fluorescence polarization nonspecific immunoassay on serum samples for diagnosis of adverse events in renal transplant patients
    • 1H-based specific monoclonal antibody assay on whole blood samples with the fluorescence polarization nonspecific immunoassay on serum samples for diagnosis of adverse events in renal transplant patients. Transplant Proc 1990; 22: 1274-9
    • (1990) Transplant Proc , vol.22 , pp. 1274-1279
    • Kahan, B.D.1    Napoli, K.2    Welsh, M.3
  • 51
    • 0027954542 scopus 로고
    • Therapeutic monitoring of cyclosporine
    • Woo J Therapeutic monitoring of cyclosporine. Ann Clin Lab Sci 1994; 24: 60-8
    • (1994) Ann Clin Lab Sci , vol.24 , pp. 60-68
    • Woo, J.1
  • 52
    • 0025148248 scopus 로고
    • Consensus document: Hawk's Cay meeting on therapeutic drug monitoring of cyclosporine
    • Kahan BD, Shaw LM, Holt D, et al. Consensus document: Hawk's Cay meeting on therapeutic drug monitoring of cyclosporine. Clin Chem 1990; 36: 1510-6
    • (1990) Clin Chem , vol.36 , pp. 1510-1516
    • Kahan, B.D.1    Shaw, L.M.2    Holt, D.3
  • 53
    • 0025821379 scopus 로고
    • I Considerations for monitoring cyclosporine in transplant recipients
    • Napoli KL, Kahan BD. I Considerations for monitoring cyclosporine in transplant recipients. Clin Lab Med 1991; 11: 671-91
    • (1991) Clin Lab Med , vol.11 , pp. 671-691
    • Napoli, K.L.1    Kahan, B.D.2
  • 54
    • 0027509073 scopus 로고
    • A reliable high-performance liquid chromatography assay for high-throughput routine cyclosporin A monitoring in whole blood
    • Salm P, Norris RLG, Taylor PJ, et al. A reliable high-performance liquid chromatography assay for high-throughput routine cyclosporin A monitoring in whole blood. Ther Drug Monit 1993; 15: 65-9
    • (1993) Ther Drug Monit , vol.15 , pp. 65-69
    • Salm, P.1    Norris, R.L.G.2    Taylor, P.J.3
  • 55
    • 0028237990 scopus 로고
    • Cyclosporine in whole blood: Drug monitoring difficulties and presentation of a reliable normal-phase liquid chromatographic assay
    • Poirier J-M, Lebot M, Cheymol G. Cyclosporine in whole blood: drug monitoring difficulties and presentation of a reliable normal-phase liquid chromatographic assay. Ther Drug Monit 1994; 16: 388-9
    • (1994) Ther Drug Monit , vol.16 , pp. 388-389
    • Poirier, J.-M.1    Lebot, M.2    Cheymol, G.3
  • 56
    • 0026742361 scopus 로고
    • Specific monoclonal radioimmunoassay and fluorescence polarization immunoassay for trough concentration and area-under-the-curve monitoring of cyclosporine in renal transplantation
    • Lindholm A, Napoli K, Rutzy L, et al. Specific monoclonal radioimmunoassay and fluorescence polarization immunoassay for trough concentration and area-under-the-curve monitoring of cyclosporine in renal transplantation. Ther Drug Monit 1992; 14: 292-300
    • (1992) Ther Drug Monit , vol.14 , pp. 292-300
    • Lindholm, A.1    Napoli, K.2    Rutzy, L.3
  • 57
    • 0025759262 scopus 로고
    • Monitoring cyclosporine: Is it still important?
    • Holt DW, Fashola TOA, Johnston A. Monitoring cyclosporine: is it still important? Immunol Lett 1991; 29: 99-104
    • (1991) Immunol Lett , vol.29 , pp. 99-104
    • Holt, D.W.1    Fashola, T.O.A.2    Johnston, A.3
  • 58
    • 0025098508 scopus 로고
    • Comparison of cyclosporin A measurement in whole blood by six different methods
    • Tjandra-Maga B, Verbsselt R, Scharpe S, et al. Comparison of cyclosporin A measurement in whole blood by six different methods. J Clin Chem Clin Biochem 1990; 28: 53-7
    • (1990) J Clin Chem Clin Biochem , vol.28 , pp. 53-57
    • Tjandra-Maga, B.1    Verbsselt, R.2    Scharpe, S.3
  • 59
    • 0025328819 scopus 로고
    • Therapeutic cyclosporine monitoring: Comparison of radioimmunoassay and high-performance liquid chromatography methods in organ transplant recipients
    • Hirvisalo E-L, Kivisto KT, Neuvonen PJ. Therapeutic cyclosporine monitoring: comparison of radioimmunoassay and high-performance liquid chromatography methods in organ transplant recipients. Ther Drug Monit 1990; 12; 353-8
    • (1990) Ther Drug Monit , vol.12 , pp. 353-358
    • Hirvisalo, E.-L.1    Kivisto, K.T.2    Neuvonen, P.J.3
  • 60
    • 0026686214 scopus 로고
    • Is the monoclonal fluorescence palarization immunoassay for cyclosporine specific? Comparison with specific radioimmunoassay
    • Armijo JA, Navarro FA, de Cos MA. Is the monoclonal fluorescence palarization immunoassay for cyclosporine specific? Comparison with specific radioimmunoassay. Ther Drug Monit 1992; 14: 333-8
    • (1992) Ther Drug Monit , vol.14 , pp. 333-338
    • Armijo, J.A.1    Navarro, F.A.2    De Cos, M.A.3
  • 61
    • 0026669486 scopus 로고
    • 125, and fluorescence polarization: Comparison of accuracy, cost, reproducibility and percent recovery
    • 125, and fluorescence polarization: comparison of accuracy, cost, reproducibility and percent recovery. Transplant Proc 1992; 241: 1716-7
    • (1992) Transplant Proc , vol.241 , pp. 1716-1717
    • Masri, M.A.1
  • 63
    • 0025374363 scopus 로고
    • Specific and nonspecific monoclonal /25I-Incstar assays
    • Wong PY, Ma,. Specific and nonspecific monoclonal /25I-Incstar assays Transplant Proc 1990; 22: 1166-70
    • (1990) Transplant Proc , vol.22 , pp. 1166-1170
    • Wong, P.Y.1    Ma2
  • 64
    • 0026447540 scopus 로고
    • Measurement of cyclosporine by liquid chromatography and three immunoassays in blood from liver, cardiac, and renal transplant recipients
    • McBride JH, Kim SS, Rodgerson DO, et al. Measurement of cyclosporine by liquid chromatography and three immunoassays in blood from liver, cardiac, and renal transplant recipients. Clin Chem 1992; 38; 2300-6
    • (1992) Clin Chem , vol.38 , pp. 2300-2306
    • McBride, J.H.1    Kim, S.S.2    Rodgerson, D.O.3
  • 65
    • 0028293422 scopus 로고
    • A comparison of cyclosporine assays using sequential samples from selected transplant patients
    • LeGatt DF, Coates JE, Simpson AI, et al. A comparison of cyclosporine assays using sequential samples from selected transplant patients. Clin Biochem 1994; 27: 43-8
    • (1994) Clin Biochem , vol.27 , pp. 43-48
    • LeGatt, D.F.1    Coates, J.E.2    Simpson, A.I.3
  • 66
    • 0025288061 scopus 로고
    • Performance of the Sandoz radioimmunoassays for cyclosporine
    • Holt DW, Marsden JT, Fashola TOA, et al. Performance of the Sandoz radioimmunoassays for cyclosporine. Transplant Proc 1990; 22: 1155-9
    • (1990) Transplant Proc , vol.22 , pp. 1155-1159
    • Holt, D.W.1    Marsden, J.T.2    Fashola, T.O.A.3
  • 67
    • 0028824489 scopus 로고
    • Lake Louise consensus conference on cyclosporin monitoring in organ transplantation: Report of the consensus panel
    • Oellerich M, Armstrong IVW, Kahan B, et al. Lake Louise consensus conference on cyclosporin monitoring in organ transplantation: report of the consensus panel. Ther Drug Monit 1995; 17: 642-54
    • (1995) Ther Drug Monit , vol.17 , pp. 642-654
    • Oellerich, M.1    Armstrong, I.V.W.2    Kahan, B.3
  • 68
    • 0026077434 scopus 로고
    • Abbott TDx 'selective' assay overestimates cyclosporin in whole blood
    • Kyne F, Maguire S, O'Broin S, et al. Abbott TDx 'selective' assay overestimates cyclosporin in whole blood. Clin Chem 1991; 37: 1657-8
    • (1991) Clin Chem , vol.37 , pp. 1657-1658
    • Kyne, F.1    Maguire, S.2    O'Broin, S.3
  • 69
    • 0027703377 scopus 로고
    • Evaluations of EMIT cyclosporine assay for use with whole blood
    • Beresini MH, Davalian D, Alexander S, et al. Evaluations of EMIT cyclosporine assay for use with whole blood. Clin Chem 1993; 39: 2235-41
    • (1993) Clin Chem , vol.39 , pp. 2235-2241
    • Beresini, M.H.1    Davalian, D.2    Alexander, S.3
  • 70
    • 0026322276 scopus 로고
    • Analytical performance of EMIT cyclosporine assay evaluates
    • Dasgupta A, Saldana S, Desai M. Analytical performance of EMIT cyclosporine assay evaluates. Clin Chem 1991; 37: 2130-3
    • (1991) Clin Chem , vol.37 , pp. 2130-2133
    • Dasgupta, A.1    Saldana, S.2    Desai, M.3
  • 71
    • 84946376557 scopus 로고
    • Monitoring cyclosporin A (ciclosporin, INN) concentrations in whole blood: Evaluation of the EMIT assay in comparison with HPLC and RIA
    • Schumann G, Petersen D, Hoyer PF, et al. Monitoring cyclosporin A (ciclosporin, INN) concentrations in whole blood: evaluation of the EMIT assay in comparison with HPLC and RIA. Eur J Clin Chem Clin Biochem 1993; 31: 381-8
    • (1993) Eur J Clin Chem Clin Biochem , vol.31 , pp. 381-388
    • Schumann, G.1    Petersen, D.2    Hoyer, P.F.3
  • 72
    • 0023952367 scopus 로고
    • Cyclosporine and metabolites inblood from renal allograft recipients with nephrotoxicity, rejection, or good renal function: Comparative high-performance liquid chromatography and monoclonal radiomimunoassay studies
    • Rosano TG, Pell MA, Freed BM, et al. Cyclosporine and metabolites inblood from renal allograft recipients with nephrotoxicity, rejection, or good renal function: comparative high-performance liquid chromatography and monoclonal radiomimunoassay studies. Transplant Proc 1988; 20 (2 Suppl. 2): 330-8
    • (1988) Transplant Proc , vol.20 , Issue.2 SUPPL. 2 , pp. 330-338
    • Rosano, T.G.1    Pell, M.A.2    Freed, B.M.3
  • 73
    • 0025276859 scopus 로고
    • French multicentre study: Comparison of two specific and four nonspecific methods for Sandimmune (cyclosporine) blood and plasma (separated at 37 C or at 22 C) monitoring
    • Vernillet L, Humbert H, Aupetit B, et al. French multicentre study: comparison of two specific and four nonspecific methods for Sandimmune (cyclosporine) blood and plasma (separated at 37 C or at 22 C) monitoring. Transplant Proc 1990; 22: 1218-23
    • (1990) Transplant Proc , vol.22 , pp. 1218-1223
    • Vernillet, L.1    Humbert, H.2    Aupetit, B.3
  • 74
    • 0025291737 scopus 로고
    • Comparative analyses of cyclosporine in whole blood and plasma by radioimmunoassay, fluorescence polarization immunoassay, and high-performance liquid chromatography
    • Lindholm A, Henricsson S. Comparative analyses of cyclosporine in whole blood and plasma by radioimmunoassay, fluorescence polarization immunoassay, and high-performance liquid chromatography. Ther Drug Monit 1990; 12: 344-52
    • (1990) Ther Drug Monit , vol.12 , pp. 344-352
    • Lindholm, A.1    Henricsson, S.2
  • 75
    • 0022337265 scopus 로고
    • Derivatives of cyclosporin compatible with antibody-based assays. I: The generation of /25I-labeled cyclosporin
    • Mahoney WC, Orf JW. Derivatives of cyclosporin compatible with antibody-based assays. I: The generation of /25I-labeled cyclosporin. Clin Chem 1985; 31: 959-61
    • (1985) Clin Chem , vol.31 , pp. 959-961
    • Mahoney, W.C.1    Orf, J.W.2
  • 77
    • 0025323734 scopus 로고
    • Clinical evaluation and therapeutic range of cyclosporine A as monitored by FPIA in kidney transplantation
    • Nattermann U, Steimer W, Gokel JM, et al. Clinical evaluation and therapeutic range of cyclosporine A as monitored by FPIA in kidney transplantation. Transplant Proc 1990; 22: 1284-6
    • (1990) Transplant Proc , vol.22 , pp. 1284-1286
    • Nattermann, U.1    Steimer, W.2    Gokel, J.M.3
  • 78
    • 0023232859 scopus 로고
    • Critical issues in cyclosporine monitoring: Report of the task force on cyclosporine monitoring
    • Shaw LM, Bowers L, Demers L, et al. Critical issues in cyclosporine monitoring: report of the task force on cyclosporine monitoring. Clin Chem 1987; 33: 1269-88
    • (1987) Clin Chem , vol.33 , pp. 1269-1288
    • Shaw, L.M.1    Bowers, L.2    Demers, L.3
  • 79
    • 0025284219 scopus 로고
    • Cyclosporine analysis by high-performance liquid chromatography: Precision, accuracy, and minimum detectable quantity
    • Bowers LD. Cyclosporine analysis by high-performance liquid chromatography: precision, accuracy, and minimum detectable quantity. Transplant Proc 1990; 22: 1150-4
    • (1990) Transplant Proc , vol.22 , pp. 1150-1154
    • Bowers, L.D.1
  • 80
    • 0025286754 scopus 로고
    • Quality assessment of cyclosporine measurements: Comparison of current methods
    • Holt DW, Marsden JT, Johnston A. Quality assessment of cyclosporine measurements: comparison of current methods. Transplant Proc 1990; 22: 1234-9
    • (1990) Transplant Proc , vol.22 , pp. 1234-1239
    • Holt, D.W.1    Marsden, J.T.2    Johnston, A.3
  • 81
    • 0025286752 scopus 로고
    • Comment on cyclosporine assay techniques: An attempt for recommendations
    • Rosenthaler J, Keller HP. Comment on cyclosporine assay techniques: an attempt for recommendations. Transplant Proc 1990; 22: 1160-5
    • (1990) Transplant Proc , vol.22 , pp. 1160-1165
    • Rosenthaler, J.1    Keller, H.P.2
  • 82
    • 0026012166 scopus 로고
    • Monoclonal antibody technology for cyclosporine monitoring
    • Quesniaux VFJ. Monoclonal antibody technology for cyclosporine monitoring. Clin Biochem 1991; 24: 37-42
    • (1991) Clin Biochem , vol.24 , pp. 37-42
    • Quesniaux, V.F.J.1
  • 83
    • 0024413542 scopus 로고
    • Sensitivity of CYCLO-Trac-SP (specific monoclonal immunoassay for cyclosporin A)
    • Lee SC, Johanson N, Lee J. Sensitivity of CYCLO-Trac-SP (specific monoclonal immunoassay for cyclosporin A) [letter]. Clin Chem 1989; 35: 1164
    • (1989) Clin Chem , vol.35 , pp. 1164
    • Lee, S.C.1    Johanson, N.2    Lee, J.3
  • 84
    • 0023944443 scopus 로고
    • Cyclosporine monitoring in kidney and liver transplant patients: Comparison between radioimmunoassay (37 C plasma) and high-performance liquid chromatography (whole blood) measurements
    • Mojaverian P, Green PI. Cyclosporine monitoring in kidney and liver transplant patients: comparison between radioimmunoassay (37 C plasma) and high-performance liquid chromatography (whole blood) measurements. Transplant Proc 1988; 20: 4148
    • (1988) Transplant Proc , vol.20 , pp. 4148
    • Mojaverian, P.1    Green, P.I.2
  • 85
    • 0026761409 scopus 로고
    • A review of assay methods for cyclosporin
    • Kivisto KT. A review of assay methods for cyclosporin. Clin Pharmacokinet 1992; 23: 173-90
    • (1992) Clin Pharmacokinet , vol.23 , pp. 173-190
    • Kivisto, K.T.1
  • 86
    • 0026071894 scopus 로고
    • Monitoring of blood levels of cyclosporine in renal and cardiac transplant recipients - Comparison of HPLC to Incstar CYCLO-Trac SP RIA
    • Loo JCK, Gallicano KD, McGilveray IJ, et al. Monitoring of blood levels of cyclosporine in renal and cardiac transplant recipients - comparison of HPLC to Incstar CYCLO-Trac SP RIA. Clin Biochem 1991; 24: 49-53
    • (1991) Clin Biochem , vol.24 , pp. 49-53
    • Loo, J.C.K.1    Gallicano, K.D.2    McGilveray, I.J.3
  • 87
    • 0023818445 scopus 로고
    • 3H radioimmunoassay with a monoclonal antibody for monitoring cyclosporine in blood
    • 3H radioimmunoassay with a monoclonal antibody for monitoring cyclosporine in blood. Clin Chem 1988; 34: 357-60
    • (1988) Clin Chem , vol.34 , pp. 357-360
    • Ball, P.E.1    Munzer, H.2    Keller, H.P.3
  • 88
    • 0023476218 scopus 로고
    • Determination of cyclosporine concentrations with monoclonal antibodies
    • Schran HF, Rosano TG, Hassell AE, et al. Determination of cyclosporine concentrations with monoclonal antibodies. Clin Chem 1987; 33: 2225-9
    • (1987) Clin Chem , vol.33 , pp. 2225-2229
    • Schran, H.F.1    Rosano, T.G.2    Hassell, A.E.3
  • 89
    • 0023900159 scopus 로고
    • Comparison of Abbott TDx fluorescence polarization immunoassay, Sandoz radioimmunoassay, and high-performance liquid chromatagraphy methods for the assay of serum cyclosporine
    • Schroeder TJ, Pesce J, Hassan FM, et al. Comparison of Abbott TDx fluorescence polarization immunoassay, Sandoz radioimmunoassay, and high-performance liquid chromatagraphy methods for the assay of serum cyclosporine. Transplant Proc 1988; 20 (2 Suppl. 2): 345-7
    • (1988) Transplant Proc , vol.20 , Issue.2 SUPPL. 2 , pp. 345-347
    • Schroeder, T.J.1    Pesce, J.2    Hassan, F.M.3
  • 90
    • 0025156893 scopus 로고
    • Measurement of cyclosporine in plasma of cardiac allograft recipients by fluorescence polarization immunoassay
    • Rondanelli R, Regazzi MB, Gastaldi L, et al. Measurement of cyclosporine in plasma of cardiac allograft recipients by fluorescence polarization immunoassay. Ther Drug Monit 1990; 12: 182-6
    • (1990) Ther Drug Monit , vol.12 , pp. 182-186
    • Rondanelli, R.1    Regazzi, M.B.2    Gastaldi, L.3
  • 91
    • 0026022626 scopus 로고
    • Cyclosporine monitoring by fluorescence polarization immunoassay
    • Wang PP, Simpson E, Meucci V, et al. Cyclosporine monitoring by fluorescence polarization immunoassay. Clin Biochem 1991; 24: 55-8
    • (1991) Clin Biochem , vol.24 , pp. 55-58
    • Wang, P.P.1    Simpson, E.2    Meucci, V.3
  • 92
    • 0025923365 scopus 로고
    • Evaluation of Abbott TDx monoclonal assay of cyclosporine in whole blood
    • Moyer TP, Winkels J, Krom R, et al. Evaluation of Abbott TDx monoclonal assay of cyclosporine in whole blood. Clin Chem 1991; 37: 1120-1
    • (1991) Clin Chem , vol.37 , pp. 1120-1121
    • Moyer, T.P.1    Winkels, J.2    Krom, R.3
  • 93
    • 0026700839 scopus 로고
    • Comparison of cyclosporine measurement in whole blood by high-performance liquid chromatography, monoclonal fluorescence polarization immunoassay, and monoclonal enzyme-multiplied immunoassay
    • Dusci LJ, Hackett LP, Chiswell GM, et al. Comparison of cyclosporine measurement in whole blood by high-performance liquid chromatography, monoclonal fluorescence polarization immunoassay, and monoclonal enzyme-multiplied immunoassay. Ther Drug Monit 1992; 14: 327-32
    • (1992) Ther Drug Monit , vol.14 , pp. 327-332
    • Dusci, L.J.1    Hackett, L.P.2    Chiswell, G.M.3
  • 94
    • 0001109435 scopus 로고
    • Evaluation of the Abbott TDx monoclonal cyclosporine A assay in pediatric cardiac transplant patients
    • Rogers LC, Smith FA, Jamero A. Evaluation of the Abbott TDx monoclonal cyclosporine A assay in pediatric cardiac transplant patients [abstract]. Clin Chem 1991; 37: 1014
    • (1991) Clin Chem , vol.37 , pp. 1014
    • Rogers, L.C.1    Smith, F.A.2    Jamero, A.3
  • 95
    • 0013525020 scopus 로고
    • Evaluation of the new cyclosporine monoclonal antibody fluorescent polarization immunoassay in cardiac and renal transplants
    • Schroeder T, Vine W, Ruckrigi D, et al. Evaluation of the new cyclosporine monoclonal antibody fluorescent polarization immunoassay in cardiac and renal transplants [abstract]. Clin Chem 1991; 37: 990
    • (1991) Clin Chem , vol.37 , pp. 990
    • Schroeder, T.1    Vine, W.2    Ruckrigi, D.3
  • 96
    • 0025221317 scopus 로고
    • Abbott TDx monoclonal antibody assay evaluated for measuring cyclosporin in whole blood
    • Yatscoff RW, Copeland KR, Faraci CJ. Abbott TDx monoclonal antibody assay evaluated for measuring cyclosporin in whole blood. Clin Chem 1990; 36: 1969-73
    • (1990) Clin Chem , vol.36 , pp. 1969-1973
    • Yatscoff, R.W.1    Copeland, K.R.2    Faraci, C.J.3
  • 97
    • 0026545650 scopus 로고
    • Monoclonal fluorescence polarization immunoassay evaluated for monitoring cyclosporine in whole blood after kidney, heart, and liver transplantation
    • Winkler M, Schumann G, Petersen D, et al. Monoclonal fluorescence polarization immunoassay evaluated for monitoring cyclosporine in whole blood after kidney, heart, and liver transplantation. Clin Chem 1992; 38: 123-6
    • (1992) Clin Chem , vol.38 , pp. 123-126
    • Winkler, M.1    Schumann, G.2    Petersen, D.3
  • 98
    • 0026871159 scopus 로고
    • Comparison of cyclosporine blood concentrations measured by radioimmunoassay and two nonisotopic immunoassays using monoclonal antibodies
    • Sabate I, Gracia S, Diez O, et al. Comparison of cyclosporine blood concentrations measured by radioimmunoassay and two nonisotopic immunoassays using monoclonal antibodies. Clin Chem 1992; 38: 1187-8
    • (1992) Clin Chem , vol.38 , pp. 1187-1188
    • Sabate, I.1    Gracia, S.2    Diez, O.3
  • 99
    • 0026676244 scopus 로고
    • Measurement of cyclosporin a in whole blood by RIA, EMIT and FPIA: A comparative study
    • Wacke R, Drewelow B, Hehl E-M, et al. Measurement of cyclosporin A in whole blood by RIA, EMIT and FPIA: a comparative study. Int J Clin Pharmacol Ther Tox 1992; 30: 502-3
    • (1992) Int J Clin Pharmacol Ther Tox , vol.30 , pp. 502-503
    • Wacke, R.1    Drewelow, B.2    Hehl, E.-M.3
  • 100
    • 0027283631 scopus 로고
    • Cyclosporine A monitoring in patients with renal, cardiac, and liver transplants: A comparison between fluorescence polarization immunoassay and two different RIA methods
    • Bergan S, Rugstad HE, Stokke O, et al. Cyclosporine A monitoring in patients with renal, cardiac, and liver transplants: a comparison between fluorescence polarization immunoassay and two different RIA methods. Scand J Clin Lab Invest 1993; 53: 471-7
    • (1993) Scand J Clin Lab Invest , vol.53 , pp. 471-477
    • Bergan, S.1    Rugstad, H.E.2    Stokke, O.3
  • 101
    • 0026779583 scopus 로고
    • Evaluation of instrumental, nonisotopic immunoassays (fluorescence polarization immunoassay and enzyme-multiplied immunoassay technique) for cyclosporine monitoring in whole blood after kidney and liver transplantation
    • Beutler D, Molteni S, Zeugin T, et al. Evaluation of instrumental, nonisotopic immunoassays (fluorescence polarization immunoassay and enzyme-multiplied immunoassay technique) for cyclosporine monitoring in whole blood after kidney and liver transplantation. Ther Drug Monit 1992; 14: 424-32
    • (1992) Ther Drug Monit , vol.14 , pp. 424-432
    • Beutler, D.1    Molteni, S.2    Zeugin, T.3
  • 103
    • 0027497226 scopus 로고
    • Experiences with the enzyme-multiplied immunoassay cyclosporine specific assay in a therapeutic drug monitoring laboratory
    • Morris RG, Saccoia NC, Sallustio BC, et al. Experiences with the enzyme-multiplied immunoassay cyclosporine specific assay in a therapeutic drug monitoring laboratory. Ther Drug Monit 1993; 15; 11-3
    • (1993) Ther Drug Monit , vol.15 , pp. 11-13
    • Morris, R.G.1    Saccoia, N.C.2    Sallustio, B.C.3
  • 104
    • 0028019874 scopus 로고
    • Cyclosporin A monitoring in Australia: Consensus recommendations
    • Morris RG, Tett SE, Ray JE. Cyclosporin A monitoring in Australia: consensus recommendations. Ther Drug Monit 1994; 16: 570-6
    • (1994) Ther Drug Monit , vol.16 , pp. 570-576
    • Morris, R.G.1    Tett, S.E.2    Ray, J.E.3
  • 105
    • 0025291565 scopus 로고
    • Chemiluminescence immunoassay of cyclosporine in whole blood
    • Stabler TV, Siegel AL. Chemiluminescence immunoassay of cyclosporine in whole blood. Clin Chem 1990; 36: 906-8
    • (1990) Clin Chem , vol.36 , pp. 906-908
    • Stabler, T.V.1    Siegel, A.L.2
  • 106
    • 0024318981 scopus 로고
    • Advances in cyclosporine pharmacology, measurement, and therapeutic monitoring
    • Shaw L. Advances in cyclosporine pharmacology, measurement, and therapeutic monitoring. Clin Chem 1989; 35: 1299-308
    • (1989) Clin Chem , vol.35 , pp. 1299-1308
    • Shaw, L.1
  • 107
    • 0021073402 scopus 로고
    • Distribution and binding of cyclosporine in blood and tissues
    • Niederberger W, LeMarie M, Maurer G, et al. Distribution and binding of cyclosporine in blood and tissues. Transplant Proc 1983; 15: 2419-21
    • (1983) Transplant Proc , vol.15 , pp. 2419-2421
    • Niederberger, W.1    LeMarie, M.2    Maurer, G.3
  • 109
    • 0023508097 scopus 로고
    • Cyclosporine: Structure, pharmacokinetics, and therapeutic drug monitoring
    • Vine W, Bowers LD. Cyclosporine: structure, pharmacokinetics, and therapeutic drug monitoring. Crit Rev Clin Lab Sci 1987; 25: 275-311
    • (1987) Crit Rev Clin Lab Sci , vol.25 , pp. 275-311
    • Vine, W.1    Bowers, L.D.2
  • 110
    • 0022641242 scopus 로고
    • Routine monitoring of cyclosporine in whole blood and in kidney tissue using high performance liquid chromatography
    • Kahn GC, Shaw LM, Kane MD. Routine monitoring of cyclosporine in whole blood and in kidney tissue using high performance liquid chromatography. J Anal Toxicol 1986; 10: 28-34
    • (1986) J Anal Toxicol , vol.10 , pp. 28-34
    • Kahn, G.C.1    Shaw, L.M.2    Kane, M.D.3
  • 111
    • 0025892101 scopus 로고
    • Concentrations of cyclosporine-A and its metabolites in transplanted human kidney tissue during rejection and stable graft function
    • Hanas E, Tufveson G, Lindgren P-G, et al. Concentrations of cyclosporine-A and its metabolites in transplanted human kidney tissue during rejection and stable graft function. Clin Transplant 1991; 5: 107-11
    • (1991) Clin Transplant , vol.5 , pp. 107-111
    • Hanas, E.1    Tufveson, G.2    Lindgren, P.-G.3
  • 112
    • 0020701791 scopus 로고
    • Cyclosporine A tissue levels in a cadaveric renal allograft recipient
    • Kahan BD, Van Buren CT, Boileau M, et al. Cyclosporine A tissue levels in a cadaveric renal allograft recipient. Transplantation 1983; 35: 96-9
    • (1983) Transplantation , vol.35 , pp. 96-99
    • Kahan, B.D.1    Van Buren, C.T.2    Boileau, M.3
  • 113
    • 0025892034 scopus 로고
    • Con entrations of cyclosporin A and its metabolites in human tissues postmortem
    • Lensmeyer GL, Wiebe DA, Carlson IH, et al. Con entrations of cyclosporin A and its metabolites in human tissues postmortem. J Anal Toxicol 1991; 15: 110-5
    • (1991) J Anal Toxicol , vol.15 , pp. 110-115
    • Lensmeyer, G.L.1    Wiebe, D.A.2    Carlson, I.H.3
  • 114
    • 0027174992 scopus 로고
    • Cyclosporin clinical pharmacokinetics
    • Fahr A. Cyclosporin clinical pharmacokinetics. Clin Pharmacokinet 1993; 24: 472-95
    • (1993) Clin Pharmacokinet , vol.24 , pp. 472-495
    • Fahr, A.1
  • 115
    • 0025887582 scopus 로고
    • Factors influencing the pharmacokinetics of cyclosporine in man
    • Lindholm A. Factors influencing the pharmacokinetics of cyclosporine in man. Ther Drug Monit 1991; 13: 465-77
    • (1991) Ther Drug Monit , vol.13 , pp. 465-477
    • Lindholm, A.1
  • 116
    • 0024499019 scopus 로고
    • Therapeutic drug monitoring of cyclosporin: Practical applications and limitations
    • Rodighiero V. Therapeutic drug monitoring of cyclosporin: practical applications and limitations. Clin Pharmacokinet 1989; 16: 27-37
    • (1989) Clin Pharmacokinet , vol.16 , pp. 27-37
    • Rodighiero, V.1
  • 117
    • 0022651554 scopus 로고
    • Demographic factors affecting the pharmacokinetics of cyclosporine estimated by radioimmunoassay
    • Kahan BD, Kramer WG, Wideman C, et al Demographic factors affecting the pharmacokinetics of cyclosporine estimated by radioimmunoassay. Transplantation 1986; 41: 459-64
    • (1986) Transplantation , vol.41 , pp. 459-464
    • Kahan, B.D.1    Kramer, W.G.2    Wideman, C.3
  • 118
    • 0024541256 scopus 로고
    • Long 3-term cyclosporine pharmacokinetic changes in renal transplant recipients: Effects of binding and metabolism
    • Awni WM, Kasiske BL, Heim-Duthoy K, et al. Long 3-term cyclosporine pharmacokinetic changes in renal transplant recipients: effects of binding and metabolism. Clin Pharmacol Ther 1989; 45: 41-8
    • (1989) Clin Pharmacol Ther , vol.45 , pp. 41-48
    • Awni, W.M.1    Kasiske, B.L.2    Heim-Duthoy, K.3
  • 119
    • 0021220236 scopus 로고
    • Distribution and concentration of cyclosporine in human blood
    • Atkinson K, Briton K, Riggs J. Distribution and concentration of cyclosporine in human blood. J Clin Pathol 1984; 37: 1167-71
    • (1984) J Clin Pathol , vol.37 , pp. 1167-1171
    • Atkinson, K.1    Briton, K.2    Riggs, J.3
  • 120
    • 0025337223 scopus 로고
    • Effect of food on the pharmacokinetics of cyclosporine in healthy subjects following oral and intravenous administration
    • Gupta SK, Manfro RC, Tomlanovich SJ, et al. Effect of food on the pharmacokinetics of cyclosporine in healthy subjects following oral and intravenous administration. J Clin Pharmacol 1990; 30: 643-53
    • (1990) J Clin Pharmacol , vol.30 , pp. 643-653
    • Gupta, S.K.1    Manfro, R.C.2    Tomlanovich, S.J.3
  • 121
    • 0024510403 scopus 로고
    • Cyclosporin A pharmacokinetics in liver transplant recipients in relation to biliary T-tube clamping and liver dysfunction
    • Naoumov NV, Tredger JM, Steward CM, et al. Cyclosporin A pharmacokinetics in liver transplant recipients in relation to biliary T-tube clamping and liver dysfunction. Gut 1989; 30: 391-6
    • (1989) Gut , vol.30 , pp. 391-396
    • Naoumov, N.V.1    Tredger, J.M.2    Steward, C.M.3
  • 123
    • 0021966569 scopus 로고
    • Cyclosporine monitoring and pharmacokinetics in pediatric liver transplant patients
    • Burckart G, Starzl T, Williams L, et al. Cyclosporine monitoring and pharmacokinetics in pediatric liver transplant patients. Transplant Proc 1985; 17: 1172-5
    • (1985) Transplant Proc , vol.17 , pp. 1172-1175
    • Burckart, G.1    Starzl, T.2    Williams, L.3
  • 124
    • 0022490203 scopus 로고
    • Cyclosporine pharmacokinetics in children following cadaveric renal transplantation
    • Ptachcinski RJ, Burckart GJ, Rosenthal JT, et al. Cyclosporine pharmacokinetics in children following cadaveric renal transplantation. Transplant Proc 1986; 18: 766-77
    • (1986) Transplant Proc , vol.18 , pp. 766-777
    • Ptachcinski, R.J.1    Burckart, G.J.2    Rosenthal, J.T.3
  • 125
    • 0025268692 scopus 로고
    • Small-bowel length and the dose of cyclosporine in children after liver transplantation
    • Whitington PF, Emond JC, Whitington SH, et al. Small-bowel length and the dose of cyclosporine in children after liver transplantation. N Engl J Med 1990;; 322: 733-8
    • (1990) N Engl J Med , vol.322 , pp. 733-738
    • Whitington, P.F.1    Emond, J.C.2    Whitington, S.H.3
  • 126
    • 0023921505 scopus 로고
    • Cyclosporine metabolism in human liver: Identification of cytochrome p-450 III gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs
    • Kronbach T, Fischer V, Meyers UA. Cyclosporine metabolism in human liver: identification of cytochrome p-450 III gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs. Clin Pharmacol Ther 1988; 43: 630-5
    • (1988) Clin Pharmacol Ther , vol.43 , pp. 630-635
    • Kronbach, T.1    Fischer, V.2    Meyers, U.A.3
  • 127
    • 0023588109 scopus 로고
    • Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man
    • Watkins PB, Wrightorh SA, Schuetz EG, et al. Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man. J Clin Invest 1987; 80: 1029-36
    • (1987) J Clin Invest , vol.80 , pp. 1029-1036
    • Watkins, P.B.1    Wrightorh, S.A.2    Schuetz, E.G.3
  • 128
    • 0026457407 scopus 로고
    • Bionavailability of cyclosporine with concomitant rifampin administration is markedly less than predicted by hepatic enzyme induction
    • Hebert MF, Roberts JP, Prueksaritanont T, et al. Bionavailability of cyclosporine with concomitant rifampin administration is markedly less than predicted by hepatic enzyme induction. Clin Pharmacol Ther 1992; 52: 453-7
    • (1992) Clin Pharmacol Ther , vol.52 , pp. 453-457
    • Hebert, M.F.1    Roberts, J.P.2    Prueksaritanont, T.3
  • 129
    • 0029123393 scopus 로고
    • The effects of ketoconazole on the intestinal metabolism and bioavailability of cyclosporine
    • Gomez DY, Wacher VJ, Tomlanovich SJ, et al. The effects of ketoconazole on the intestinal metabolism and bioavailability of cyclosporine. Clin Pharmacol Ther 1995; 58: 15-9
    • (1995) Clin Pharmacol Ther , vol.58 , pp. 15-19
    • Gomez, D.Y.1    Wacher, V.J.2    Tomlanovich, S.J.3
  • 130
    • 0028071759 scopus 로고
    • Noninvasive tests of CYP3A enzymes
    • Watkins PB. Noninvasive tests of CYP3A enzymes. Pharmacogenetics 1994; 4: 171-84
    • (1994) Pharmacogenetics , vol.4 , pp. 171-184
    • Watkins, P.B.1
  • 131
    • 9044244404 scopus 로고
    • Ethnic differences in cyclosporine pharmacokinetics
    • Tsunoda SM, Chang T, Hebert MF, et al. Ethnic differences in cyclosporine pharmacokinetics [abstract]. Pharmacotherapy 1995; 15: 388
    • (1995) Pharmacotherapy , vol.15 , pp. 388
    • Tsunoda, S.M.1    Chang, T.2    Hebert, M.F.3
  • 132
    • 85035157436 scopus 로고    scopus 로고
    • The effects of menopause and hormone replacement therapies on predrisolone and erythromycin pharmacokinetics
    • In press
    • Harris RZ, Tsunoda SM, Mroczkowski P, et al. The effects of menopause and hormone replacement therapies on predrisolone and erythromycin pharmacokinetics. Clin Pharmacol Ther. In press
    • Clin Pharmacol Ther.
    • Harris, R.Z.1    Tsunoda, S.M.2    Mroczkowski, P.3
  • 133
    • 0024589575 scopus 로고
    • Cyclosporine monitoring in renal transplantation: Area under the curve monitoring is superior to trough-level monitoring
    • Grevel J, Welsh MS, Kahan BD. Cyclosporine monitoring in renal transplantation: area under the curve monitoring is superior to trough-level monitoring. Ther Drug Monit 1989; 11: 246-8
    • (1989) Ther Drug Monit , vol.11 , pp. 246-248
    • Grevel, J.1    Welsh, M.S.2    Kahan, B.D.3
  • 134
    • 0025793712 scopus 로고
    • Area under the curve monitoring of cyclosporine therapy: The early posttransplant period
    • Grevel J, Kahan BD. Area under the curve monitoring of cyclosporine therapy: the early posttransplant period. Ther Drug Monit 1991; 13: 89-95
    • (1991) Ther Drug Monit , vol.13 , pp. 89-95
    • Grevel, J.1    Kahan, B.D.2
  • 135
    • 0027443897 scopus 로고
    • Area-under-the-curve versus trough level monitoring of cyclosporine concentration: Critical assessment of dosage adjustment practices and measurement of clinical outcome
    • Grevel J. Area-under-the-curve versus trough level monitoring of cyclosporine concentration: critical assessment of dosage adjustment practices and measurement of clinical outcome. Ther Drug Monit 1993; 15: 488-91
    • (1993) Ther Drug Monit , vol.15 , pp. 488-491
    • Grevel, J.1
  • 137
    • 0028215663 scopus 로고
    • Utility of pretransplantation cyclosporine pharmacokinetic studies
    • Cooney GF, Heifetsv I, Bell A, et al. Utility of pretransplantation cyclosporine pharmacokinetic studies. Ther Drug Monit 1994; 16: 151-4
    • (1994) Ther Drug Monit , vol.16 , pp. 151-154
    • Cooney, G.F.1    Heifetsv, I.2    Bell, A.3
  • 138
    • 0027298674 scopus 로고
    • Michaelis-Menten kinetics determine cyclosporine steady-state concentrations: A population analysis in renal transplant patients
    • Grevel J, Post BK, Kahan BD. Michaelis-Menten kinetics determine cyclosporine steady-state concentrations: a population analysis in renal transplant patients. Clin Pharmacol Ther 1993; 53: 651-60
    • (1993) Clin Pharmacol Ther , vol.53 , pp. 651-660
    • Grevel, J.1    Post, B.K.2    Kahan, B.D.3
  • 139
    • 0022859377 scopus 로고
    • Relationship of cyclosporine pharmacokinetic parameters to clinical events in human renal transplantation
    • Savoldi S, Kahan BD. Relationship of cyclosporine pharmacokinetic parameters to clinical events in human renal transplantation. Transplant Proc 1986; 18 (Suppl. 5): 120-8
    • (1986) Transplant Proc , vol.18 , Issue.5 SUPPL. , pp. 120-128
    • Savoldi, S.1    Kahan, B.D.2
  • 140
    • 0027226147 scopus 로고
    • Influence of cyclosporine pharmacokinetics, trough concentrations, and AUC monitoring on outcome after kidney transplantation
    • Lindholm A, Kahan BD. Influence of cyclosporine pharmacokinetics, trough concentrations, and AUC monitoring on outcome after kidney transplantation. Clin Pharmacol Ther 1993; 54: 205-18
    • (1993) Clin Pharmacol Ther , vol.54 , pp. 205-218
    • Lindholm, A.1    Kahan, B.D.2
  • 141
    • 0022864074 scopus 로고
    • Analysis of pharnacokinetic profiles in 232 renal and 87 cardiac allograft recipients treated with cyclosporine
    • Kalian BD, Kramer WG, Wideman CA, et al. Analysis of pharnacokinetic profiles in 232 renal and 87 cardiac allograft recipients treated with cyclosporine. Transplant Proc 1986; 18 Suppl. 5: 115-9
    • (1986) Transplant Proc , vol.18 , Issue.5 SUPPL. , pp. 115-119
    • Kalian, B.D.1    Kramer, W.G.2    Wideman, C.A.3
  • 142
    • 0025348673 scopus 로고
    • Monitoring of cyclosporine by serial posttransplant pharmacokinetic studies in renal transplant patients
    • Awni WM, Heim-Duthoy K, Kasiske BL. Monitoring of cyclosporine by serial posttransplant pharmacokinetic studies in renal transplant patients. Transplant Proc 1940; 22: 1343-4
    • (1940) Transplant Proc , vol.22 , pp. 1343-1344
    • Awni, W.M.1    Heim-Duthoy, K.2    Kasiske, B.L.3
  • 143
    • 0026325755 scopus 로고
    • Abbreviated kinetic profiles in area-under-the-curve monitoring of cyclosporine therapy
    • Grevel J, Kahan BD. Abbreviated kinetic profiles in area-under-the-curve monitoring of cyclosporine therapy. Clin Them 1991; 37: 1905-8
    • (1991) Clin Them , vol.37 , pp. 1905-1908
    • Grevel, J.1    Kahan, B.D.2
  • 144
    • 0025194442 scopus 로고
    • A limited sampling strategy for the measurement of cyclosporine AUC
    • Johnston A, Sketris I, Marsden JT, et al. A limited sampling strategy for the measurement of cyclosporine AUC. Transplant Proc 1990; 22: 1345-6
    • (1990) Transplant Proc , vol.22 , pp. 1345-1346
    • Johnston, A.1    Sketris, I.2    Marsden, J.T.3
  • 145
    • 0023867580 scopus 로고
    • Cyclosporine plasma levels six hours after oral administration. A useful tool for monitoring therapy
    • Cantarovich F, Bizollen C, Cantarovich D, et al. Cyclosporine plasma levels six hours after oral administration. A useful tool for monitoring therapy. Transplantation 1988; 45: 389-94
    • (1988) Transplantation , vol.45 , pp. 389-394
    • Cantarovich, F.1    Bizollen, C.2    Cantarovich, D.3
  • 146
    • 0026495392 scopus 로고
    • Optimization of sampling time for cyclosporine monitoring in transplant patients
    • Regazzi MB, Ronadanelli R, Gastaldi L, et al. Optimization of sampling time for cyclosporine monitoring in transplant patients. J Clin Pharmacol 1992; 32: 978-81
    • (1992) J Clin Pharmacol , vol.32 , pp. 978-981
    • Regazzi, M.B.1    Ronadanelli, R.2    Gastaldi, L.3
  • 147
    • 0027239821 scopus 로고
    • Failure to predict cyclosporine area under the curve using a limited sampling strategy
    • Gaspari F, Ruggenenti P, Toree L, et al. Failure to predict cyclosporine area under the curve using a limited sampling strategy. Kidney Int 1993; 44: 436-9
    • (1993) Kidney Int , vol.44 , pp. 436-439
    • Gaspari, F.1    Ruggenenti, P.2    Toree, L.3
  • 148
    • 0024556650 scopus 로고
    • Erythromycin breath test as an assay of glucocorticoid-inducible liver cytochromes P-450
    • Watkins PB, Murray SA, Winkelman LG, et al. Erythromycin breath test as an assay of glucocorticoid-inducible liver cytochromes P-450. J Clin Invest 1989; 83: 688-97
    • (1989) J Clin Invest , vol.83 , pp. 688-697
    • Watkins, P.B.1    Murray, S.A.2    Winkelman, L.G.3
  • 149
    • 0026545245 scopus 로고
    • The erythromycin breath test selectively measures P450IIIA in patients with severe liver disease
    • Lown K, Kolars J, Turgeon K, et al. The erythromycin breath test selectively measures P450IIIA in patients with severe liver disease. Clin Pharmacol Ther 1992; 51: 229-38
    • (1992) Clin Pharmacol Ther , vol.51 , pp. 229-238
    • Lown, K.1    Kolars, J.2    Turgeon, K.3
  • 150
    • 0025063782 scopus 로고
    • The erythromycin breath test as a predictor of cyclosporine blood levels
    • Watkins PB, Hamilton TA, Annesley TM, et al. The erythromycin breath test as a predictor of cyclosporine blood levels. Clin Pharmacol Ther 1990; 48: 120-9
    • (1990) Clin Pharmacol Ther , vol.48 , pp. 120-129
    • Watkins, P.B.1    Hamilton, T.A.2    Annesley, T.M.3
  • 151
    • 0028149595 scopus 로고
    • P450 3A activity and cyclosporine dosing in kidney and heart transplant recipients
    • Turgeon DK, Leichtman AB, Lown KS, et al. P450 3A activity and cyclosporine dosing in kidney and heart transplant recipients. Clin Pharmacol Ther 1994; 56: 253-60
    • (1994) Clin Pharmacol Ther , vol.56 , pp. 253-260
    • Turgeon, D.K.1    Leichtman, A.B.2    Lown, K.S.3
  • 152
    • 45149139153 scopus 로고
    • Metabolites of cyclosporine: Blood and tissue levels. Biological activity?
    • Humbert H. Metabolites of cyclosporine: blood and tissue levels. Biological activity? Int J Radiat Appl Instrum B 1990; 17: 723-7
    • (1990) Int J Radiat Appl Instrum B , vol.17 , pp. 723-727
    • Humbert, H.1
  • 153
    • 0025997099 scopus 로고
    • Ciclosporin metabolite pattern in blood and urine of liver graft recipients. I: Association of ciclosporin metabolites with nephrotoxicity
    • Christians U, Kohlhaw K, Budniak J, et al. Ciclosporin metabolite pattern in blood and urine of liver graft recipients. I: Association of ciclosporin metabolites with nephrotoxicity. Eur J Clin Pharmacol 1991; 41: 285-90
    • (1991) Eur J Clin Pharmacol , vol.41 , pp. 285-290
    • Christians, U.1    Kohlhaw, K.2    Budniak, J.3
  • 154
    • 0025058297 scopus 로고
    • Cyclosporine toxicity at therapeutic blood levels and cytochrome P-450111A
    • Lucey MR, Kolars JC, Merion RM, et al. Cyclosporine toxicity at therapeutic blood levels and cytochrome P-450111A. Lancet 1990; 335: 11-5
    • (1990) Lancet , vol.335 , pp. 11-15
    • Lucey, M.R.1    Kolars, J.C.2    Merion, R.M.3
  • 155
    • 0026475120 scopus 로고
    • Pharmacodynamic monitoring of cyclosporine
    • Awni WM. Pharmacodynamic monitoring of cyclosporine. Clin Pharmacokinet 1992; 23: 428-48
    • (1992) Clin Pharmacokinet , vol.23 , pp. 428-448
    • Awni, W.M.1
  • 156
    • 85035156524 scopus 로고    scopus 로고
    • Immunopharmacodynamic studies of cyclosporine in pre-kidney transplant patients
    • In press
    • d'Uscio CH, Aweeka FT, Prueksaritanont T, et al. Immunopharmacodynamic studies of cyclosporine in pre-kidney transplant patients. J Clin Pharmacol. In press
    • J Clin Pharmacol.
    • D'Uscio, C.H.1    Aweeka, F.T.2    Prueksaritanont, T.3
  • 157
    • 0024467411 scopus 로고
    • A radioreceptor assay for the measurement of cyclosporine activity: A preliminary report
    • Donnelly JG, Soldin SJ. A radioreceptor assay for the measurement of cyclosporine activity: a preliminary report. Ther Drug Monit 1989; 11: 696-700
    • (1989) Ther Drug Monit , vol.11 , pp. 696-700
    • Donnelly, J.G.1    Soldin, S.J.2
  • 158
    • 0025972415 scopus 로고
    • A preliminary study to evaluate an in vitro assay for determining patient whole blood immunosuppressive cyclosporine A and metabolite activity: A comparison with cytosolic binding assays using cyclophilin or a 50-kDa binding protein, and the Abbott TDx cyclosporine A parent, and parent and metabolites assays
    • Russell RL, Donnelly JG, Palaszynski EW, et al. A preliminary study to evaluate an in vitro assay for determining patient whole blood immunosuppressive cyclosporine A and metabolite activity: a comparison with cytosolic binding assays using cyclophilin or a 50-kDa binding protein, and the Abbott TDx cyclosporine A parent, and parent and metabolites assays. Ther Drug Monit 1991; 13: 32-6
    • (1991) Ther Drug Monit , vol.13 , pp. 32-36
    • Russell, R.L.1    Donnelly, J.G.2    Palaszynski, E.W.3
  • 159
    • 0023099905 scopus 로고
    • Pharmacodynamic assays of the immunosuppressive action of cyclosporine therapy in transplant recipients
    • Kahan BD, Pellis NR, Leinikki P, et al. Pharmacodynamic assays of the immunosuppressive action of cyclosporine therapy in transplant recipients. Transplant Proc 1987; 19: 1695-8
    • (1987) Transplant Proc , vol.19 , pp. 1695-1698
    • Kahan, B.D.1    Pellis, N.R.2    Leinikki, P.3
  • 160
    • 0023919435 scopus 로고
    • Interleukin-2 production in plasma and urine, plasma interleukin-2 receptor levels, and urine cytology as a means of monitoring renal allogratt recipients
    • Cornaby A, Simpson MA, Vann Rice R, et al. Interleukin-2 production in plasma and urine, plasma interleukin-2 receptor levels, and urine cytology as a means of monitoring renal allogratt recipients. Transplant Proc 1988; 20: 108-10
    • (1988) Transplant Proc , vol.20 , pp. 108-110
    • Cornaby, A.1    Simpson, M.A.2    Vann Rice, R.3
  • 161
    • 0025898789 scopus 로고
    • Sequential inlerleukin 2 and interleukin 2 receptor levels distinguish rejection from cyclosporine toxicity in liver allogratt recipients
    • Simpson MA, Young-Fadok TM, Madras PN, et al. Sequential inlerleukin 2 and interleukin 2 receptor levels distinguish rejection from cyclosporine toxicity in liver allogratt recipients. Arch Surg 1991; 126: 717-20
    • (1991) Arch Surg , vol.126 , pp. 717-720
    • Simpson, M.A.1    Young-Fadok, T.M.2    Madras, P.N.3
  • 162
    • 0021914597 scopus 로고
    • Immunologic monitoring: Utility and limitations
    • Kahan BD. Immunologic monitoring: utility and limitations. Transplant Proc 1985; 17: 1537-45
    • (1985) Transplant Proc , vol.17 , pp. 1537-1545
    • Kahan, B.D.1
  • 163
    • 0022590679 scopus 로고
    • Effect of cyclosporin A and dexamethasone on interleukin-2 receptor gene expression
    • Reed JC, Abidi AH, Alpers JD, et al. Effect of cyclosporin A and dexamethasone on interleukin-2 receptor gene expression. J Immunol 1986; 137: 150-4
    • (1986) J Immunol , vol.137 , pp. 150-154
    • Reed, J.C.1    Abidi, A.H.2    Alpers, J.D.3
  • 164
    • 0024558951 scopus 로고
    • Cyclosporin A mediated immunosuppression in vitro: Effect on high affinity interleukin-2 receptor expression and turnover
    • Povlsen JV, Moller BK, Christiansen BS, et al. Cyclosporin A mediated immunosuppression in vitro: effect on high affinity interleukin-2 receptor expression and turnover. Tissue Antigens 1989; 33: 4-14
    • (1989) Tissue Antigens , vol.33 , pp. 4-14
    • Povlsen, J.V.1    Moller, B.K.2    Christiansen, B.S.3
  • 165
    • 0025973284 scopus 로고
    • Immunological monitoring in cyclosporine-treated patients
    • McKenna RM, Schroeder TJ. immunological monitoring in cyclosporine-treated patients. Clin Biochem 1991; 24: 75-80
    • (1991) Clin Biochem , vol.24 , pp. 75-80
    • McKenna, R.M.1    Schroeder, T.J.2
  • 166
    • 0025943649 scopus 로고
    • Cell free serum interleukin-2 receptor levels after heart transplantation
    • McNally CM, Luckhurst E, Penny R. Cell free serum interleukin-2 receptor levels after heart transplantation. J Heart Lung Transplant 1991; 10 (5 Pt 1): 769-74
    • (1991) J Heart Lung Transplant , vol.10 , Issue.5 PART 1 , pp. 769-774
    • McNally, C.M.1    Luckhurst, E.2    Penny, R.3
  • 167
    • 0027949262 scopus 로고
    • Soluble interleukin-2 receptor monitoring during bacterial and viral infections in liver transplant recipients: A comparative evaluation
    • Rossi SJ, Schroeder TJ, Muth KL, et al. Soluble interleukin-2 receptor monitoring during bacterial and viral infections in liver transplant recipients: a comparative evaluation. Clin Transplant 1994; 8: 479-84
    • (1994) Clin Transplant , vol.8 , pp. 479-484
    • Rossi, S.J.1    Schroeder, T.J.2    Muth, K.L.3
  • 168
    • 0025937767 scopus 로고
    • Soluble interleukin-2 receptor (s IL-2R) in renal and pancreatic transplantation
    • Touraine F, Malcus C, Pouteil-Noble C, et al. Soluble interleukin-2 receptor (s IL-2R) in renal and pancreatic transplantation. Eur Cytokine Netw 1991; 2: 47-50
    • (1991) Eur Cytokine Netw , vol.2 , pp. 47-50
    • Touraine, F.1    Malcus, C.2    Pouteil-Noble, C.3
  • 169
    • 0028335905 scopus 로고
    • Reduced inter-and intraindividual variability in cyclosporine pharmacokinetics from a microemulsion formulation
    • Kovarik JM, Mueller EA, van Bree JB, et al. Reduced inter-and intraindividual variability in cyclosporine pharmacokinetics from a microemulsion formulation. J Pharm Sci 1994; 83: 444-6
    • (1994) J Pharm Sci , vol.83 , pp. 444-446
    • Kovarik, J.M.1    Mueller, E.A.2    Van Bree, J.B.3
  • 170
    • 0027988313 scopus 로고
    • Cyclosporine pharmacokinetics and variablility from a microemulsion formulation - A multicenter investigation in kidney transplant patients
    • Kovarik JM, Mueller EA, van Bree JB, et al. Cyclosporine pharmacokinetics and variablility from a microemulsion formulation - a multicenter investigation in kidney transplant patients. Transplantation 1994; 58: 658-63
    • (1994) Transplantation , vol.58 , pp. 658-663
    • Kovarik, J.M.1    Mueller, E.A.2    Van Bree, J.B.3
  • 171
    • 0028000098 scopus 로고
    • Comparison of the pharmacokinetics of cyclosporine Sandimmune with Sandimmune Neoral in stable renal transplant patients
    • Sketris IS, Lawen JG, Beauregard-Zollinger L, et al. Comparison of the pharmacokinetics of cyclosporine Sandimmune with Sandimmune Neoral in stable renal transplant patients. Transplant Proc 1994; 26: 2961-3
    • (1994) Transplant Proc , vol.26 , pp. 2961-2963
    • Sketris, I.S.1    Lawen, J.G.2    Beauregard-Zollinger, L.3
  • 172
    • 0028130374 scopus 로고
    • Blood cyclosporin A and metabolite kinetic profiles after administration of Sandimmune soft gelatin capsules and Neoral in transplant recipients
    • Vernillet L, Kovarik J, Freiburghaus R, et al. Blood cyclosporin A and metabolite kinetic profiles after administration of Sandimmune soft gelatin capsules and Neoral in transplant recipients. Transplant Proc 1994; 26: 2964-8
    • (1994) Transplant Proc , vol.26 , pp. 2964-2968
    • Vernillet, L.1    Kovarik, J.2    Freiburghaus, R.3
  • 173
    • 0028007304 scopus 로고
    • The Neoral formulation: Improved correlation between cyclosporine trough levels and exposure in stable renal transplant recipients
    • Kahan BD, Dunn J, Fitts C, et al. The Neoral formulation: improved correlation between cyclosporine trough levels and exposure in stable renal transplant recipients. Transplant Proc 1994; 26: 2940-3
    • (1994) Transplant Proc , vol.26 , pp. 2940-2943
    • Kahan, B.D.1    Dunn, J.2    Fitts, C.3
  • 174
    • 0028222162 scopus 로고
    • Pharmacokinetics and tolerability of a microemulsion formulation of cyclosporine in renal allograft recipients - A concentrator-controlled comparison with the commercial formulation
    • Mueller EA, Kovarik JM, van Bree JB, et al. Pharmacokinetics and tolerability of a microemulsion formulation of cyclosporine in renal allograft recipients - a concentrator-controlled comparison with the commercial formulation. Transplantation 1994; 57: 1178-82
    • (1994) Transplantation , vol.57 , pp. 1178-1182
    • Mueller, E.A.1    Kovarik, J.M.2    Van Bree, J.B.3
  • 175
    • 9044250735 scopus 로고
    • Influence of a fat-rich meal on the pharmacokinetics of a new oral formulation of cyclosporine in a crossover comparison with the market formulation
    • Mueller EA, Kovarik JM, van Bree JB, et al. Influence of a fat-rich meal on the pharmacokinetics of a new oral formulation of cyclosporine in a crossover comparison with the market formulation. Pharm Res 1991; 11: 1151-5
    • (1991) Pharm Res , vol.11 , pp. 1151-1155
    • Mueller, E.A.1    Kovarik, J.M.2    Van Bree, J.B.3
  • 176
    • 0028577660 scopus 로고
    • Sandimmun Neoral, a new oral formulation of cyclosporin A with improved pharmacokinetic characteristics: Safety and tolerability in renal transplant patients
    • Taesch S, Niese D, Mueller EA. Sandimmun Neoral, a new oral formulation of cyclosporin A with improved pharmacokinetic characteristics: safety and tolerability in renal transplant patients. Transplant Proc 1994; 26: 3147-9
    • (1994) Transplant Proc , vol.26 , pp. 3147-3149
    • Taesch, S.1    Niese, D.2    Mueller, E.A.3
  • 177
    • 0028986969 scopus 로고
    • Economic analysis of Sandimmune Neoral in Canada in stable renal transplant patients
    • Keown P, Lawen JG, Landsberg D, et al. Economic analysis of Sandimmune Neoral in Canada in stable renal transplant patients. Transplant Proc 1995; 27: 1845-8
    • (1995) Transplant Proc , vol.27 , pp. 1845-1848
    • Keown, P.1    Lawen, J.G.2    Landsberg, D.3
  • 178
    • 0027485716 scopus 로고
    • Tacrolimus: A review of its pharmacology and therapeutic potential in hepatic and renal transplantation
    • Peters DH, Fitlon A, Plosker GL, et al. Tacrolimus: a review of its pharmacology and therapeutic potential in hepatic and renal transplantation. Drugs 1993; 46: 746-94
    • (1993) Drugs , vol.46 , pp. 746-794
    • Peters, D.H.1    Fitlon, A.2    Plosker, G.L.3
  • 179
    • 0026662551 scopus 로고
    • Cytochrome P-450 3A enzymes are responsible for biotransformation of FK506. and rapamycin in man and rat
    • Sattler M, Guengerich FP, Yun C-H, et al. Cytochrome P-450 3A enzymes are responsible for biotransformation of FK506. and rapamycin in man and rat. Drug Metab Dispos 1992; 20: 753-61
    • (1992) Drug Metab Dispos , vol.20 , pp. 753-761
    • Sattler, M.1    Guengerich, F.P.2    Yun, C.-H.3
  • 180
    • 0028124324 scopus 로고
    • Randomised trial comparing tacrolimus (FK506) and cyclosporin in prevention of liver allograft rejection
    • European FK506 Multicentre Liver Study Group. Randomised trial comparing tacrolimus (FK506) and cyclosporin in prevention of liver allograft rejection. Lancet 1994; 344: 423-8
    • (1994) Lancet , vol.344 , pp. 423-428
  • 181
    • 0027994850 scopus 로고
    • A comparison of tacrolimus (FK 506) and cyclosporine for immunosuppression in liver transplantation
    • US Multicenter FK506 Liver Study Group. A comparison of tacrolimus (FK 506) and cyclosporine for immunosuppression in liver transplantation. N Engl J Med 1994; 331: 1110-5
    • (1994) N Engl J Med , vol.331 , pp. 1110-1115
  • 182
    • 0027413458 scopus 로고
    • Japanese study of FK 506 on kidney transplantation: Results of a late phase 11 study
    • Japanese FK 506 Study Group. Japanese study of FK 506 on kidney transplantation: results of a late phase 11 study. Transplant Proc 1993; 25: 649-54
    • (1993) Transplant Proc , vol.25 , pp. 649-654
  • 183
    • 0026354689 scopus 로고
    • Japanese study of FK 506 on kidney transplantation: The benefit of monitoring the whole blood FK 506 concentration
    • Japanese FK 506 Study Group. Japanese study of FK 506 on kidney transplantation: the benefit of monitoring the whole blood FK 506 concentration. Transplant Proc 1991; 23: 3085-8
    • (1991) Transplant Proc , vol.23 , pp. 3085-3088
  • 184
    • 0027971287 scopus 로고
    • Monitoring of FK 506 blood levels in kidney transplant recipients
    • Takahara S, Kokado, Kameoka H, et al. Monitoring of FK 506 blood levels in kidney transplant recipients. Transplant Proc 1994; 26: 2106-8
    • (1994) Transplant Proc , vol.26 , pp. 2106-2108
    • Takahara, S.1    Kokado2    Kameoka, H.3
  • 185
    • 0028213126 scopus 로고
    • FK506 trough levels in whole blood and plasma in liver transplant recipients
    • Backman L, Nicar M, Levy M, et al. FK506 trough levels in whole blood and plasma in liver transplant recipients. Transplantation 1994; 57: 519-25
    • (1994) Transplantation , vol.57 , pp. 519-525
    • Backman, L.1    Nicar, M.2    Levy, M.3
  • 186
    • 0028064531 scopus 로고
    • Plasma FK506 levels in patients with histopathologically documented renal allograft rejection
    • Erden E, Warty V, Magnone M, et al. Plasma FK506 levels in patients with histopathologically documented renal allograft rejection. Transplantation 1994; 58: 397-8
    • (1994) Transplantation , vol.58 , pp. 397-398
    • Erden, E.1    Warty, V.2    Magnone, M.3
  • 187
    • 0026355193 scopus 로고
    • Correlation of rejection episodes with FK 506 dosage. FK 506 level, and steroids following primary orthotopic liver transplant
    • Jain AB, Todo S, Fung JJ, et al. Correlation of rejection episodes with FK 506 dosage. FK 506 level, and steroids following primary orthotopic liver transplant. Transplant Proc 1991; 23: 3023-5
    • (1991) Transplant Proc , vol.23 , pp. 3023-3025
    • Jain, A.B.1    Todo, S.2    Fung, J.J.3
  • 188
    • 0028872550 scopus 로고
    • Comparison of plasma vs whole blood as matrix for FK 506 drug level monitoring
    • Winkler M, Wonigeit K, Undre N, et al. Comparison of plasma vs whole blood as matrix for FK 506 drug level monitoring. Transplant Proc 1995; 27: 822-5
    • (1995) Transplant Proc , vol.27 , pp. 822-825
    • Winkler, M.1    Wonigeit, K.2    Undre, N.3
  • 189
    • 0028284542 scopus 로고
    • Comparison of different assays for the quantitation of FK 506 levels in blood or plasma
    • Winkler M, Christians U, Stoll K, et al. Comparison of different assays for the quantitation of FK 506 levels in blood or plasma. Ther Drug Monit 1994; 16: 281-6
    • (1994) Ther Drug Monit , vol.16 , pp. 281-286
    • Winkler, M.1    Christians, U.2    Stoll, K.3
  • 190
    • 0028810418 scopus 로고
    • Consensus document: Therapeutic monitoring of tacrolimus (FK506)
    • Jusko WJ, Thomson W, Fung J, et al. Consensus document: therapeutic monitoring of tacrolimus (FK506). Ther Drug Monit 1995; 17: 606-14
    • (1995) Ther Drug Monit , vol.17 , pp. 606-614
    • Jusko, W.J.1    Thomson, W.2    Fung, J.3
  • 191
    • 0026343366 scopus 로고
    • Association of elevated FK 506 plasma levels with nephrotoxicity in liver-grafted patients
    • Winkler M, Jost U, Ringe B, et al. Association of elevated FK 506 plasma levels with nephrotoxicity in liver-grafted patients. Transplant Proc 1991; 23: 3153-5
    • (1991) Transplant Proc , vol.23 , pp. 3153-3155
    • Winkler, M.1    Jost, U.2    Ringe, B.3
  • 192
    • 0025879435 scopus 로고
    • The effect of graft function on FK506 plasma levels, dosages, and renal function, with particular reference to the liver
    • Abu-Elmagd K, Fung JJ, Alessiani M, et al. The effect of graft function on FK506 plasma levels, dosages, and renal function, with particular reference to the liver. Transplantation 1991; 52: 71-7
    • (1991) Transplantation , vol.52 , pp. 71-77
    • Abu-Elmagd, K.1    Fung, J.J.2    Alessiani, M.3
  • 193
    • 0028813323 scopus 로고
    • Early cellular rejection after orthotopic liver transplantation correlates with low concentrations of FK506 in hepatic tissue
    • Sandborn WJ, Lawson GM, Cody TJ, et al. Early cellular rejection after orthotopic liver transplantation correlates with low concentrations of FK506 in hepatic tissue. Hepatology 1995; 21: 70-6
    • (1995) Hepatology , vol.21 , pp. 70-76
    • Sandborn, W.J.1    Lawson, G.M.2    Cody, T.J.3
  • 194
    • 0027996814 scopus 로고
    • FK 506 renal toxicity and lack of detectable cytochrome P-450 3A in the liver graft of a patient undergoing liver transplantation
    • Lemoine A, Azoulay D, Dennison A, et al. FK 506 renal toxicity and lack of detectable cytochrome P-450 3A in the liver graft of a patient undergoing liver transplantation. Hepatology 1994; 20: 1472-7
    • (1994) Hepatology , vol.20 , pp. 1472-1477
    • Lemoine, A.1    Azoulay, D.2    Dennison, A.3
  • 195
    • 0026318003 scopus 로고
    • FK 516 assay past and present-characteristics of FK 506 ELISA
    • Kobayashi M, Tamura K, Katayama N, et al. FK 516 assay past and present-characteristics of FK 506 ELISA. Transplant Proc 1991; 23: 2725-9
    • (1991) Transplant Proc , vol.23 , pp. 2725-2729
    • Kobayashi, M.1    Tamura, K.2    Katayama, N.3
  • 196
    • 0026343345 scopus 로고
    • High performance liquid chromatography/mass spectrometry of FK 506 and its metabolites in blood, bile, and urine of liver grafted patients
    • Christians U, Braun F, Kosian N, et al. High performance liquid chromatography/mass spectrometry of FK 506 and its metabolites in blood, bile, and urine of liver grafted patients. Transplant Proc 1991; 23: 2741-4
    • (1991) Transplant Proc , vol.23 , pp. 2741-2744
    • Christians, U.1    Braun, F.2    Kosian, N.3
  • 197
    • 0023205091 scopus 로고
    • A highly sensitive method to assay FK 506 levels in plasma
    • Tamura K, Kobayashi M, Hashimoto K, et al. A highly sensitive method to assay FK 506 levels in plasma. Transplant Proc 1987; 19: 23-5
    • (1987) Transplant Proc , vol.19 , pp. 23-25
    • Tamura, K.1    Kobayashi, M.2    Hashimoto, K.3
  • 198
    • 0026349506 scopus 로고
    • Monitoring FK 506 concentrations in plasma and whole blood
    • Jusko WJ, D'Ambrosio R. Monitoring FK 506 concentrations in plasma and whole blood. Transplant Proc 1991; 23: 2732-5
    • (1991) Transplant Proc , vol.23 , pp. 2732-2735
    • Jusko, W.J.1    D'Ambrosio, R.2
  • 200
    • 0027230926 scopus 로고
    • Improvement and assessment of enzyme-linked immunosorbent assay to detect low FK506 concentrations in plasma or whole blood within 6 hours
    • Wallemacq PE, Firdaous I, Hassoun A. Improvement and assessment of enzyme-linked immunosorbent assay to detect low FK506 concentrations in plasma or whole blood within 6 hours. Clin Chem 1943; 39: 1045-9
    • (1943) Clin Chem , vol.39 , pp. 1045-1049
    • Wallemacq, P.E.1    Firdaous, I.2    Hassoun, A.3
  • 201
  • 202
    • 0026090249 scopus 로고
    • Correlation of cyclosporine and metabolite binding to cyclosporine and a 50-kDa binding protein with in vitto immunosuppression: A preliminary report
    • Donrelly JG, Russell RL, Palaszynski EW, et al. Correlation of cyclosporine and metabolite binding to cyclosporine and a 50-kDa binding protein with in vitto immunosuppression: a preliminary report. Clin Biochem 1991; 24: 71-4
    • (1991) Clin Biochem , vol.24 , pp. 71-74
    • Donrelly, J.G.1    Russell, R.L.2    Palaszynski, E.W.3
  • 203
    • 0026784428 scopus 로고
    • Radioreceptor assay for quantifying FK-506 immunosuppressant in whole blood
    • Murtny JN, Chen Y, Warty VS, et al. Radioreceptor assay for quantifying FK-506 immunosuppressant in whole blood. Clin Chem 1992; 18: 1307-10
    • (1992) Clin Chem , vol.18 , pp. 1307-1310
    • Murtny, J.N.1    Chen, Y.2    Warty, V.S.3
  • 204
    • 0026327395 scopus 로고
    • Pharmacokinetics of FK 506 in transplant patients
    • Venkataramanan R, Jain A, Warty VS, et al. Pharmacokinetics of FK 506 in transplant patients. Transplant Proc 1991; 23: 2736-40
    • (1991) Transplant Proc , vol.23 , pp. 2736-2740
    • Venkataramanan, R.1    Jain, A.2    Warty, V.S.3
  • 205
    • 0028606438 scopus 로고
    • Pharmacokinetics, dosing principles, and blood level monitoring of FK506
    • Sewing K-F. Pharmacokinetics, dosing principles, and blood level monitoring of FK506. Transplant Proc 1994; 26: 3267-9
    • (1994) Transplant Proc , vol.26 , pp. 3267-3269
    • Sewing, K.-F.1
  • 206
    • 0026322986 scopus 로고
    • Effect of temperature and hematocrit on plasma concentration of FK 506
    • Machida M, Takahara S, Ishibashi M, et al. Effect of temperature and hematocrit on plasma concentration of FK 506. Transplant Proc 1991; 23: 2753-4
    • (1991) Transplant Proc , vol.23 , pp. 2753-2754
    • Machida, M.1    Takahara, S.2    Ishibashi, M.3
  • 207
  • 208
    • 4243547604 scopus 로고
    • Blood protein binding (BPB) of FK-506 (F) in various species
    • Habucky K, Flowers J, Warty VJ, et al. Blood protein binding (BPB) of FK-506 (F) in various species [abstract]. Pharm Res 1992; 9 Suppl.: S-334
    • (1992) Pharm Res , vol.9 , Issue.SUPPL.
    • Habucky, K.1    Flowers, J.2    Warty, V.J.3
  • 210
    • 0025327284 scopus 로고
    • Effect of hepatic dysfunction and T tube clamping on FK 506 pharmacokinetics and trough concentrations
    • Jain AB, Venkataramanan R, Cadoff E, et al. Effect of hepatic dysfunction and T tube clamping on FK 506 pharmacokinetics and trough concentrations. Transplant Proc 1990; 22 Suppl. 1: 57-9
    • (1990) Transplant Proc , vol.22 , Issue.1 SUPPL. , pp. 57-59
    • Jain, A.B.1    Venkataramanan, R.2    Cadoff, E.3
  • 211
    • 0025964226 scopus 로고
    • Measurement of FK 506 by HPLC and isolation and characterization of its metabolites
    • Christians U, Kruse C, Kownatzki R, et al. Measurement of FK 506 by HPLC and isolation and characterization of its metabolites. Transplant Proc 1991; 23: 940-1
    • (1991) Transplant Proc , vol.23 , pp. 940-941
    • Christians, U.1    Kruse, C.2    Kownatzki, R.3
  • 212
    • 0027518214 scopus 로고
    • Isolation, identification, and biological activities of oxidation metabolites of FK506, a potent immunosuppressive macrolide lactone
    • Iwasaki K, Shiraga T, Nagase K, et al. Isolation, identification, and biological activities of oxidation metabolites of FK506, a potent immunosuppressive macrolide lactone. Drug Metah Dispos 1993; 21: 971-7
    • (1993) Drug Metah Dispos , vol.21 , pp. 971-977
    • Iwasaki, K.1    Shiraga, T.2    Nagase, K.3
  • 213
    • 0025267572 scopus 로고
    • Bioassay of plasma specimens from liver transplant patients on FK 506 immunosuppression
    • Zeevi A, Eiras G, Burckart G, et al. Bioassay of plasma specimens from liver transplant patients on FK 506 immunosuppression. Transplant Proc 1990; 22 Suppl. 1: 60-3
    • (1990) Transplant Proc , vol.22 , Issue.1 SUPPL. , pp. 60-63
    • Zeevi, A.1    Eiras, G.2    Burckart, G.3
  • 214
    • 0026322604 scopus 로고
    • In vitro assessment of FK 506 immunosuppressive activity in transplant patients
    • Zeevi A, Venkataramanan R, Warty V, et al. In vitro assessment of FK 506 immunosuppressive activity in transplant patients. Trarsplant Proc 1991; 23: 2897-9
    • (1991) Trarsplant Proc , vol.23 , pp. 2897-2899
    • Zeevi, A.1    Venkataramanan, R.2    Warty, V.3
  • 215
    • 0024676035 scopus 로고
    • Muromonab CD3: A review of its pharmacology and therapeutic potential
    • Todd PA, Brogden RN, Muromonab CD3: a review of its pharmacology and therapeutic potential. Drugs 1989; 37: 871-99
    • (1989) Drugs , vol.37 , pp. 871-899
    • Todd, P.A.1    Brogden, R.N.2
  • 216
    • 0021816056 scopus 로고
    • A randomized clinical rial of OKT3 monoclonal antibody for acute rejection of cadaveric renal transplants
    • Ortho Multicenter Transplant Study Group. A randomized clinical rial of OKT3 monoclonal antibody for acute rejection of cadaveric renal transplants. N Engl J Med 1985; 313: 337-42
    • (1985) N Engl J Med , vol.313 , pp. 337-342
  • 217
    • 0027202152 scopus 로고
    • OKT3: Immunology, production, purification, and pharmacokinetics
    • Roitt M. OKT3: immunology, production, purification, and pharmacokinetics. Clin Transplant 1993; 7: 367-73
    • (1993) Clin Transplant , vol.7 , pp. 367-373
    • Roitt, M.1
  • 218
    • 0023779923 scopus 로고
    • Infections with cytomegalov rus and other herpesviruses in 121 liver transplant recipients: Transmission by donated organ and the effects of OKT3 antibodies
    • Singh N, Dummer JS, Kusne S, et al. Infections with cytomegalov rus and other herpesviruses in 121 liver transplant recipients: transmission by donated organ and the effects of OKT3 antibodies. J Infect Dis 1988; 158: 124-31
    • (1988) J Infect Dis , vol.158 , pp. 124-131
    • Singh, N.1    Dummer, J.S.2    Kusne, S.3
  • 219
    • 0027185299 scopus 로고
    • Immunologic monitoring during OKT3 therapy
    • Chatenoud L. Immunologic monitoring during OKT3 therapy. Clin Transplant 1993; 7: 422-30
    • (1993) Clin Transplant , vol.7 , pp. 422-430
    • Chatenoud, L.1
  • 220
    • 0023038734 scopus 로고
    • OKT3 monoclonal antibody plasma levels during therapy and the subsequent development of host antibodies to OKT3
    • Goldstein G, Fuccello AJ, Norman DJ, et al. OKT3 monoclonal antibody plasma levels during therapy and the subsequent development of host antibodies to OKT3. Transplantation 1986; 42: 507-10
    • (1986) Transplantation , vol.42 , pp. 507-510
    • Goldstein, G.1    Fuccello, A.J.2    Norman, D.J.3
  • 221
    • 0019851727 scopus 로고
    • Treatment of acute renal allograft rejection with OKT3 monoclonal antibody
    • Cosimi AB, Burton RC, Colvin RB, et al. Treatment of acute renal allograft rejection with OKT3 monoclonal antibody Transplantation 1981; 32: 535-9
    • (1981) Transplantation , vol.32 , pp. 535-539
    • Cosimi, A.B.1    Burton, R.C.2    Colvin, R.B.3
  • 222
    • 0025895959 scopus 로고
    • Laboratory monitoring of therapy with OKT3 and other murine monoclonal antibodies
    • Colvin RB, Preffer FI. Laboratory monitoring of therapy with OKT3 and other murine monoclonal antibodies. Clin Lab Med 1991; 11: 693-715
    • (1991) Clin Lab Med , vol.11 , pp. 693-715
    • Colvin, R.B.1    Preffer, F.I.2
  • 223
    • 0023755784 scopus 로고
    • Pharmacokinetic study of orthoclone OKT3 serum levels during treatment of acute renal allograft rejection
    • Goldstein G, Norman DJ, Henell KR, et al. Pharmacokinetic study of orthoclone OKT3 serum levels during treatment of acute renal allograft rejection. Transplantation 1988; 46: 587-9
    • (1988) Transplantation , vol.46 , pp. 587-589
    • Goldstein, G.1    Norman, D.J.2    Henell, K.R.3
  • 224
    • 0027994043 scopus 로고
    • The pharmacokinetic profile of standard and low-dose OKT3 induction immunosuppression in renal transplant recipients
    • Alloway R, Kolb M, Hathaway D, et al. The pharmacokinetic profile of standard and low-dose OKT3 induction immunosuppression in renal transplant recipients. Transplantation 1994; 58: 249-53
    • (1994) Transplantation , vol.58 , pp. 249-253
    • Alloway, R.1    Kolb, M.2    Hathaway, D.3
  • 225
    • 0027479185 scopus 로고
    • Monitoring OKT3 treatment: Pharmacodynamic and pharmacokinetic measures
    • Henell KR, Norman DJ. Monitoring OKT3 treatment: pharmacodynamic and pharmacokinetic measures. Transplant Proc 1993; 25 Suppl. 1: 83-5
    • (1993) Transplant Proc , vol.25 , Issue.1 SUPPL. , pp. 83-85
    • Henell, K.R.1    Norman, D.J.2
  • 226
    • 0028236071 scopus 로고
    • Variations in serum OKT3 concentration based upon age, sez, transplanted organ, treatment regimen, and anti-OKT3 antibody status
    • Schroeder TJ, Michael AT, First MK, et al. Variations in serum OKT3 concentration based upon age, sez, transplanted organ, treatment regimen, and anti-OKT3 antibody status. Ther Drug Monit 1994; 16: 361-7
    • (1994) Ther Drug Monit , vol.16 , pp. 361-367
    • Schroeder, T.J.1    Michael, A.T.2    First, M.K.3
  • 227
    • 0023871413 scopus 로고
    • Immunologic monitoring during and after OKT3 therapy
    • Shield CF, Norman DJ. Immunologic monitoring during and after OKT3 therapy. Am J Kidney Dis 1988; 11: 120-4
    • (1988) Am J Kidney Dis , vol.11 , pp. 120-124
    • Shield, C.F.1    Norman, D.J.2
  • 229
    • 0024995504 scopus 로고
    • Prolonged and repeated courses of OKT3 after liver transplantation
    • Colledan M, Gridelli B, Rossi G, et al. Prolonged and repeated courses of OKT3 after liver transplantation. Transplant Proc 1990; 22: 1769-71
    • (1990) Transplant Proc , vol.22 , pp. 1769-1771
    • Colledan, M.1    Gridelli, B.2    Rossi, G.3
  • 230
    • 0024340140 scopus 로고
    • Efficacy of OKT3 retreatment for refractory cardiac allograft rejection
    • O'Connell JB, Renlund DG, Gay WAJ, et al. Efficacy of OKT3 retreatment for refractory cardiac allograft rejection. Transplantation 1989; 47: 788-92
    • (1989) Transplantation , vol.47 , pp. 788-792
    • O'Connell, J.B.1    Renlund, D.G.2    Gay, W.A.J.3
  • 231
    • 0025764957 scopus 로고
    • Prognostic significance of T cell associated surface antigen density changes during OKT3 therapy of renal allograft rejection
    • Shabtai M, Walter WC, Dominguez-Rafer C, et al. Prognostic significance of T cell associated surface antigen density changes during OKT3 therapy of renal allograft rejection. J Urol 1991; 145: 928-31
    • (1991) J Urol , vol.145 , pp. 928-931
    • Shabtai, M.1    Walter, W.C.2    Dominguez-Rafer, C.3
  • 232
    • 0020538297 scopus 로고
    • Immunologic follow-up of renal allograft recipients treated prophylactically by OKT3 alone
    • Chatenoud L, Baudrihaye MF, Chkoff N, et al. Immunologic follow-up of renal allograft recipients treated prophylactically by OKT3 alone. Transplant Proc 1983; 15: 643-5
    • (1983) Transplant Proc , vol.15 , pp. 643-645
    • Chatenoud, L.1    Baudrihaye, M.F.2    Chkoff, N.3
  • 233
    • 0023836973 scopus 로고
    • One-month prophylactic use of OKT3 in cadaver kidney transplant recipients
    • Debure A, Chkoff N, Chatenoud L. One-month prophylactic use of OKT3 in cadaver kidney transplant recipients. Transplantation 1988; 45: 546-53
    • (1988) Transplantation , vol.45 , pp. 546-553
    • Debure, A.1    Chkoff, N.2    Chatenoud, L.3
  • 235
    • 0024440911 scopus 로고
    • The quantitative flow cytometric plasma OKT3 assay. Its potential application in cardiac transplantation
    • Wittwer CT, Knape WA, Bristow MR. The quantitative flow cytometric plasma OKT3 assay. Its potential application in cardiac transplantation. Transplantation 1989; 48: 533-5
    • (1989) Transplantation , vol.48 , pp. 533-535
    • Wittwer, C.T.1    Knape, W.A.2    Bristow, M.R.3
  • 236
    • 0027196980 scopus 로고
    • Prevention of adverse clinical outcome by monitoring of cardiac transplant patients for murine monoclonal CD3 antibody (OKT3) sensilization
    • Hammond FA, Yowell RL, Greenwood J, et al. Prevention of adverse clinical outcome by monitoring of cardiac transplant patients for murine monoclonal CD3 antibody (OKT3) sensilization. Transplantation 1993; 55: 1061-3
    • (1993) Transplantation , vol.55 , pp. 1061-1063
    • Hammond, F.A.1    Yowell, R.L.2    Greenwood, J.3
  • 237
    • 9044234272 scopus 로고
    • Monitoring of OKT3 serum concentrations using a cartridge-based immunoassay system
    • Schleuter KT, Pouletty C, Schroeder TJ, et al. Monitoring of OKT3 serum concentrations using a cartridge-based immunoassay system [abstract]. Ther Drug Monit 1993; 15: 151
    • (1993) Ther Drug Monit , vol.15 , pp. 151
    • Schleuter, K.T.1    Pouletty, C.2    Schroeder, T.J.3
  • 238
    • 0024995028 scopus 로고
    • Low serum OKT3 levels correlate with failure to prevent rejection in ortholopic liver transplant patients
    • McDiarmid SV, Millis M, Terashita G, et al. Low serum OKT3 levels correlate with failure to prevent rejection in ortholopic liver transplant patients. Transplant Proc 1990; 22: 1774-6
    • (1990) Transplant Proc , vol.22 , pp. 1774-1776
    • McDiarmid, S.V.1    Millis, M.2    Terashita, G.3
  • 240
    • 0025907721 scopus 로고
    • OKT3 therapy for hepatic allograft rejection. Differential response in adults and children
    • Woodle ES, Thistlethwaite JR, Emond JC, et al. OKT3 therapy for hepatic allograft rejection. Differential response in adults and children. Transplantation 1991; 51: 1207-12
    • (1991) Transplantation , vol.51 , pp. 1207-1212
    • Woodle, E.S.1    Thistlethwaite, J.R.2    Emond, J.C.3
  • 241
    • 0025203368 scopus 로고
    • Relationship of OKT3 sensitization and vascular rejection in cardiac transplant patients receiving OKT3 for rejection prophylaxis
    • Hammond EH, Wittwer CT, Greenwood J, et al. Relationship of OKT3 sensitization and vascular rejection in cardiac transplant patients receiving OKT3 for rejection prophylaxis. Transplantation 1990; 50: 776-82
    • (1990) Transplantation , vol.50 , pp. 776-782
    • Hammond, E.H.1    Wittwer, C.T.2    Greenwood, J.3
  • 242
    • 0024989346 scopus 로고
    • Immunologic monitoring in OKT3-treated kidney graft recipients
    • Zlabinger GJ, Maurer D, Ulrich W, et al. Immunologic monitoring in OKT3-treated kidney graft recipients. Transplant Proc 1990; 22: 1777-8
    • (1990) Transplant Proc , vol.22 , pp. 1777-1778
    • Zlabinger, G.J.1    Maurer, D.2    Ulrich, W.3
  • 243
    • 0029080326 scopus 로고
    • The incidence of antibody formation to OKT3 consequent to its use in organ transplantation
    • Carey G, Lisi PJ, Schroeder TJ. The incidence of antibody formation to OKT3 consequent to its use in organ transplantation. Transplantation 1995; 60: 151-8
    • (1995) Transplantation , vol.60 , pp. 151-158
    • Carey, G.1    Lisi, P.J.2    Schroeder, T.J.3
  • 244
    • 0022541673 scopus 로고
    • Restriction of the human in vivo immune response against the mouse monoclonal antibody OKT3
    • Chatenoud L, Baudrih aye MF, Chkoff N, et al. Restriction of the human in vivo immune response against the mouse monoclonal antibody OKT3. J Immunol 1986; 137: 830-8
    • (1986) J Immunol , vol.137 , pp. 830-838
    • Chatenoud, L.1    Baudrih Aye, M.F.2    Chkoff, N.3
  • 245
    • 0023791604 scopus 로고
    • Effectiveness of a second course of OKT3 monoclonal anti-T cell antibody for treatment of renal allograft rejection
    • Norman DJ, Shield CF, Henell KR, et al. Effectiveness of a second course of OKT3 monoclonal anti-T cell antibody for treatment of renal allograft rejection. Transplantation 1988; 46: 523-9
    • (1988) Transplantation , vol.46 , pp. 523-529
    • Norman, D.J.1    Shield, C.F.2    Henell, K.R.3
  • 246
    • 0024559024 scopus 로고
    • Successful retreatment of allograft rejection with OKT3
    • First MR, Schroeder TJ, Hurtubise PE, et al. Successful retreatment of allograft rejection with OKT3. Transplantation 1989; 47: 83-91
    • (1989) Transplantation , vol.47 , pp. 83-91
    • First, M.R.1    Schroeder, T.J.2    Hurtubise, P.E.3
  • 247
    • 0025976427 scopus 로고
    • Anti-murine antibody to OKT3 in cardiac transplantation: Implications tor prophylaxis and retreatment of rejection
    • O'Connell JB, Bristow MR, Hammond EH, et al. Anti-murine antibody to OKT3 in cardiac transplantation: implications tor prophylaxis and retreatment of rejection. Transplant Proc 1991; 23: 1157-9
    • (1991) Transplant Proc , vol.23 , pp. 1157-1159
    • O'Connell, J.B.1    Bristow, M.R.2    Hammond, E.H.3
  • 249
    • 0027398182 scopus 로고
    • Rapid detection of anti-OKT3 antibodies with the Transtat assay
    • Schroeder TJ, First MR, Pouletty C, et al. Rapid detection of anti-OKT3 antibodies with the Transtat assay. Transplantation 1993; 55: 297-9
    • (1993) Transplantation , vol.55 , pp. 297-299
    • Schroeder, T.J.1    First, M.R.2    Pouletty, C.3
  • 250
    • 0023845862 scopus 로고
    • Summary: Monitoring and complications of monoclonal therapy
    • Shield CF. Summary: monitoring and complications of monoclonal therapy. Am J Kidney Dis 1988; 11: 125
    • (1988) Am J Kidney Dis , vol.11 , pp. 125
    • Shield, C.F.1
  • 251
    • 0025639047 scopus 로고
    • In vivo use of OKT3: Main issues for the monitoring of treated patients
    • Chatenoud L, Ferran C, Bach J-F. In vivo use of OKT3: main issues for the monitoring of treated patients. Transplant Proc 1990; 22: 26O5-8
    • (1990) Transplant Proc , vol.22
    • Chatenoud, L.1    Ferran, C.2    Bach, J.-F.3
  • 252
    • 0023215605 scopus 로고
    • Comparison of antimouse and antihorse antibody production during the treatment of allograft rejection with OKT3 or antithymocyte globlin
    • Shield CF, Norman DJ, Marlett P, et al. Comparison of antimouse and antihorse antibody production during the treatment of allograft rejection with OKT3 or antithymocyte globlin. Nephron 1987; 46 Suppl. 1: 48-51
    • (1987) Nephron , vol.46 , Issue.1 SUPPL. , pp. 48-51
    • Shield, C.F.1    Norman, D.J.2    Marlett, P.3
  • 253
    • 0025046880 scopus 로고
    • Inhibition of anti-OKT3 antibody generation by cyclosporine - Results of a prospective randomised trial
    • Hricik DE, Mayes JT, Schulak JA. Inhibition of anti-OKT3 antibody generation by cyclosporine - results of a prospective randomised trial. Transplantation 1990; 50: 237-40
    • (1990) Transplantation , vol.50 , pp. 237-240
    • Hricik, D.E.1    Mayes, J.T.2    Schulak, J.A.3
  • 254
    • 0023199132 scopus 로고
    • Clinical development of orthoclone OKT3
    • Cosimi A. Clinical development of orthoclone OKT3. Transplant Proc 1987; 19 (2 Suppl. 1): 7-16
    • (1987) Transplant Proc , vol.19 , Issue.2 SUPPL. 1 , pp. 7-16
    • Cosimi, A.1
  • 255
    • 0024509310 scopus 로고
    • Randomised prospective trial of OKT3 for early prophylaxis of rejection after liver transplanation
    • Millis JM, McDiarmid SV, Hiatt JR, et al. Randomised prospective trial of OKT3 for early prophylaxis of rejection after liver transplanation. Transplantation 1989; 47: 82-8
    • (1989) Transplantation , vol.47 , pp. 82-88
    • Millis, J.M.1    McDiarmid, S.V.2    Hiatt, J.R.3
  • 256
    • 0026027150 scopus 로고
    • OKT3 for induction immunosuppression in renal transplantation: A comparative study of high versus low doses
    • Norman DJ, Barry JM, Bennet WM, et al. OKT3 for induction immunosuppression in renal transplantation: a comparative study of high versus low doses. Transplant Proc 1991; 23: 1052-4
    • (1991) Transplant Proc , vol.23 , pp. 1052-1054
    • Norman, D.J.1    Barry, J.M.2    Bennet, W.M.3
  • 257
    • 0027416629 scopus 로고
    • Results of a prospective, randomized double-blind study comparing standard vs low-dose OKT3 induction therapy
    • Alloway R, Kotb M, Hathaway DK, et al. Results of a prospective, randomized double-blind study comparing standard vs low-dose OKT3 induction therapy. Transplant Proc 1993; 25: 550-2
    • (1993) Transplant Proc , vol.25 , pp. 550-552
    • Alloway, R.1    Kotb, M.2    Hathaway, D.K.3
  • 258
    • 0027216244 scopus 로고
    • Randomized double-blind study of standard versus low-dose OKT3 induction therapy in renal allograft recipients
    • Alloway R, Kotb M, Hathaway DK, et al. Randomized double-blind study of standard versus low-dose OKT3 induction therapy in renal allograft recipients. Am J Kidney Dis 1993; 22: 36-43
    • (1993) Am J Kidney Dis , vol.22 , pp. 36-43
    • Alloway, R.1    Kotb, M.2    Hathaway, D.K.3
  • 259
    • 0028961582 scopus 로고
    • Efficacy of low-dose OKT3 as cytolytic induction therapy in heart transplantation
    • Alonso-Pulpon L, Serrano-Fiz S, Rubio JA, et al. Efficacy of low-dose OKT3 as cytolytic induction therapy in heart transplantation. J Heart Lung Transplant 1995; 14: 136-42
    • (1995) J Heart Lung Transplant , vol.14 , pp. 136-142
    • Alonso-Pulpon, L.1    Serrano-Fiz, S.2    Rubio, J.A.3
  • 260
    • 0028815315 scopus 로고
    • Azathioprine myelotoxicity related to elevated 6-thioguanine nucleotides in heart transplantantion
    • Schutz E, Gummert J, Mohr FW, et al. Azathioprine myelotoxicity related to elevated 6-thioguanine nucleotides in heart transplantantion. Transplant Proc 1995; 27: 1298-300
    • (1995) Transplant Proc , vol.27 , pp. 1298-1300
    • Schutz, E.1    Gummert, J.2    Mohr, F.W.3
  • 261
    • 0014218597 scopus 로고
    • Immunosuppressive therapy. The relation between clinical response and immnunologic competence
    • Swanson MA, Schwartz RS. Immunosuppressive therapy. The relation between clinical response and immnunologic competence. N Engl J Med 1967; 277: 163-70
    • (1967) N Engl J Med , vol.277 , pp. 163-170
    • Swanson, M.A.1    Schwartz, R.S.2
  • 262
    • 84907114780 scopus 로고
    • The effects of azathioprine and 6-mercaptopurine on immunity
    • Winkelstein A. The effects of azathioprine and 6-mercaptopurine on immunity. J Immunopharmacol 1979; 1: 429-54
    • (1979) J Immunopharmacol , vol.1 , pp. 429-454
    • Winkelstein, A.1
  • 263
    • 0015606968 scopus 로고
    • Studies on the xanthine oxidase activity of mammalian cells
    • Brunschede H, Krooth RS. Studies on the xanthine oxidase activity of mammalian cells. Biochem Genet 1973; 8: 341-50
    • (1973) Biochem Genet , vol.8 , pp. 341-350
    • Brunschede, H.1    Krooth, R.S.2
  • 264
    • 0021148310 scopus 로고
    • 6-thioguanine induced DNA damage as a determinant of cytotoxicity in cultured Chinese hamster ovary cells
    • Christie NT, Drake S, Meyn RE, et al. 6-thioguanine induced DNA damage as a determinant of cytotoxicity in cultured Chinese hamster ovary cells. Cancer Res 1984; 44: 3665-71
    • (1984) Cancer Res , vol.44 , pp. 3665-3671
    • Christie, N.T.1    Drake, S.2    Meyn, R.E.3
  • 265
    • 0016053706 scopus 로고
    • A biochemical mechanism for the delayed cytotoxic reaction of 6-mercaptopurine
    • Tidd DM, Paterson ARP. A biochemical mechanism for the delayed cytotoxic reaction of 6-mercaptopurine. Cancer Res 1974; 34: 738-46
    • (1974) Cancer Res , vol.34 , pp. 738-746
    • Tidd, D.M.1    Paterson, A.R.P.2
  • 266
    • 0020677815 scopus 로고
    • Assay of 6-thioguanine nucleotide a major metabolite of azathioprine, 6-mercaptopurine and 6-thioguanine, in human red cells
    • Lennard L, Maddocks JL. Assay of 6-thioguanine nucleotide a major metabolite of azathioprine, 6-mercaptopurine and 6-thioguanine, in human red cells. J Pharm Pharmacol 1983; 35: 15-8
    • (1983) J Pharm Pharmacol , vol.35 , pp. 15-18
    • Lennard, L.1    Maddocks, J.L.2
  • 267
    • 0028130337 scopus 로고
    • Monitoring of azathioprine treatment by determination of 6-thioguanine nucleotide concentrations in erythrocytes
    • Bergan S, Rugstad HE, Bentdal Ø, et al. Monitoring of azathioprine treatment by determination of 6-thioguanine nucleotide concentrations in erythrocytes. Transplantation 1994; 58: 803-8
    • (1994) Transplantation , vol.58 , pp. 803-808
    • Bergan, S.1    Rugstad, H.E.2    Bentdal, Ø.3
  • 268
    • 0024451147 scopus 로고
    • Pharmacogenetics of acute azathioprine toxicity: Relationship to thiopurine methyltransferase genetic polymorphism
    • Lennard L, Van Loon JA, Weinshilboum RM. Pharmacogenetics of acute azathioprine toxicity: relationship to thiopurine methyltransferase genetic polymorphism. Clin Pharmacol Ther 1989; 46: 149-54
    • (1989) Clin Pharmacol Ther , vol.46 , pp. 149-154
    • Lennard, L.1    Van Loon, J.A.2    Weinshilboum, R.M.3
  • 269
    • 9044251480 scopus 로고
    • The role of genetic variation in thiopurine methyltransferase activity and the efficacy and/or side effects of azathioprine therapy in dermatologic patients
    • Snow JL, Gibson LE. The role of genetic variation in thiopurine methyltransferase activity and the efficacy and/or side effects of azathioprine therapy in dermatologic patients. Arch Dermatol 1994; 130: 1-6
    • (1994) Arch Dermatol , vol.130 , pp. 1-6
    • Snow, J.L.1    Gibson, L.E.2
  • 270
    • 0028843129 scopus 로고
    • Azathioprine-related bone marrow toxicity and low activities of purine enzymes in patients with rheumatoid arthritis
    • Kerstens PJSM, Stolk JN, De Abrue RA, et al. Azathioprine-related bone marrow toxicity and low activities of purine enzymes in patients with rheumatoid arthritis. Arthritis Rheum 1995; 38: 142-5
    • (1995) Arthritis Rheum , vol.38 , pp. 142-145
    • Kerstens, P.J.S.M.1    Stolk, J.N.2    De Abrue, R.A.3
  • 271
    • 0027419990 scopus 로고
    • Large interindividual variability in bioavailability of azathioprine in renal transplant recipients
    • Ohlman S, Lafolie P, Lindholm A, et al. Large interindividual variability in bioavailability of azathioprine in renal transplant recipients. Clin Transplant 1993; 7: 65-70
    • (1993) Clin Transplant , vol.7 , pp. 65-70
    • Ohlman, S.1    Lafolie, P.2    Lindholm, A.3
  • 272
    • 0018860249 scopus 로고
    • Quantitation of plasma azathioprine and 6-mercaptopurine levels in renal transplant patients
    • Lin S-N, Jessup K, Floyd M, et al. Quantitation of plasma azathioprine and 6-mercaptopurine levels in renal transplant patients. Transplantation 1980; 29: 290-4
    • (1980) Transplantation , vol.29 , pp. 290-294
    • Lin, S.-N.1    Jessup, K.2    Floyd, M.3
  • 273
    • 0022648037 scopus 로고
    • Serum azathioprine and 6-mercaptopurine levels and immunosuppressive activity after azathioprine in uremic patients
    • Odlind B, Hartvig P, Lindstrom B, et al. Serum azathioprine and 6-mercaptopurine levels and immunosuppressive activity after azathioprine in uremic patients. Int J Immunopharmacol 1986; 8: 1-11
    • (1986) Int J Immunopharmacol , vol.8 , pp. 1-11
    • Odlind, B.1    Hartvig, P.2    Lindstrom, B.3
  • 274
    • 0021675990 scopus 로고
    • Azathioprine metabolism in kidney transplant recipients
    • Lennard L, Brown CB, Fox M, et al. Azathioprine metabolism in kidney transplant recipients. Br J Clin Pharmacol 1984; 18: 693-701
    • (1984) Br J Clin Pharmacol , vol.18 , pp. 693-701
    • Lennard, L.1    Brown, C.B.2    Fox, M.3
  • 275
    • 0022551875 scopus 로고
    • Oral 6-mercaptopurine in childhood leukaemia: Parent drug pharmacokinetics and active metabolite concentrations
    • Lennard L, Keen D, Lilleyman JS. Oral 6-mercaptopurine in childhood leukaemia: parent drug pharmacokinetics and active metabolite concentrations. Clin Pharmacol Ther 1986; 40: 287-92
    • (1986) Clin Pharmacol Ther , vol.40 , pp. 287-292
    • Lennard, L.1    Keen, D.2    Lilleyman, J.S.3
  • 276
    • 0025148411 scopus 로고
    • A reversed phase high performance liquid chromatography approach to determining total red blood cell concentrations of 6-thioguanine, 6-mercaptopurine, methylthioguanine and methylmercaptopurine in a patient receiving thiopurine therapy
    • Erdmann GR, France LA, Bostrom BC, et al. A reversed phase high performance liquid chromatography approach to determining total red blood cell concentrations of 6-thioguanine, 6-mercaptopurine, methylthioguanine and methylmercaptopurine in a patient receiving thiopurine therapy. Biomed Chromatogr 1990; 4: 47-51
    • (1990) Biomed Chromatogr , vol.4 , pp. 47-51
    • Erdmann, G.R.1    France, L.A.2    Bostrom, B.C.3
  • 277
    • 0023588197 scopus 로고
    • Assay of 6-thioinosinic acid and 6-thioguanine nucleotides, active metabolites of 6-mercaptopurine in human red blood cells
    • Lennard L. Assay of 6-thioinosinic acid and 6-thioguanine nucleotides, active metabolites of 6-mercaptopurine in human red blood cells. J Chromatogr 1987; 423: 169-78
    • (1987) J Chromatogr , vol.423 , pp. 169-178
    • Lennard, L.1
  • 278
    • 0026758498 scopus 로고
    • The clinical pharmacology of 6-mercaptopurine
    • Lennard L. The clinical pharmacology of 6-mercaptopurine. Eur J Clin Pharmacol 1992; 43: 329-39
    • (1992) Eur J Clin Pharmacol , vol.43 , pp. 329-339
    • Lennard, L.1
  • 279
    • 0017880983 scopus 로고
    • Human erythrocyte thiopurine methyltransferase radiochemical microassay and biochemical properties
    • Weinshilboum RM, Raymond FA, Pazmino PA. Human erythrocyte thiopurine methyltransferase radiochemical microassay and biochemical properties. Clin Chem Acta 1987; 85: 323-33
    • (1987) Clin Chem Acta , vol.85 , pp. 323-333
    • Weinshilboum, R.M.1    Raymond, F.A.2    Pazmino, P.A.3
  • 280
    • 0026907122 scopus 로고
    • Human user thiopurine methyltransferase pharmacogenetics: Biochemical properties, liver-erythrocyte correlation and presence of isozynes
    • Szumlanski CL, Honchel R, Scott MC, et al. Human user thiopurine methyltransferase pharmacogenetics: biochemical properties, liver-erythrocyte correlation and presence of isozynes. Pharmacogenetics 1992; 2: 148-59
    • (1992) Pharmacogenetics , vol.2 , pp. 148-159
    • Szumlanski, C.L.1    Honchel, R.2    Scott, M.C.3
  • 281
    • 0018822866 scopus 로고
    • Mercaptupurine pharmacogenetics: Monogenic inheritance of erythrocyte thiopurine methyltransferase activity
    • Weinshilboum RM, Sladek SL. Mercaptupurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity. Am J Hum Genet 1980; 32: 651-62
    • (1980) Am J Hum Genet , vol.32 , pp. 651-662
    • Weinshilboum, R.M.1    Sladek, S.L.2
  • 282
    • 0025331198 scopus 로고
    • Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia
    • Lennard L, Lilleyman JS, Van Loon JA, et al. Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia. Lancet 1990; 336: 225-9
    • (1990) Lancet , vol.336 , pp. 225-229
    • Lennard, L.1    Lilleyman, J.S.2    Van Loon, J.A.3
  • 283
    • 9044239524 scopus 로고
    • The importance of thiopurine methyltransferase activity for the use of azathioprine in transplant recipients
    • Chocair P, Duley JA, Simmonds HA, et al. The importance of thiopurine methyltransferase activity for the use of azathioprine in transplant recipients. Transplantation 1992; 3: 105-6
    • (1992) Transplantation , vol.3 , pp. 105-106
    • Chocair, P.1    Duley, J.A.2    Simmonds, H.A.3
  • 284
    • 0027786826 scopus 로고
    • Immunosuppressive and other effects of mycophenolic acid and an ester prodrug, mycophenolate mofetil
    • Allison AC, Eugui EM. Immunosuppressive and other effects of mycophenolic acid and an ester prodrug, mycophenolate mofetil. Immunol Rev 1993; 136: 5-28
    • (1993) Immunol Rev , vol.136 , pp. 5-28
    • Allison, A.C.1    Eugui, E.M.2
  • 285
    • 0029058395 scopus 로고
    • Lycophenolic acid binding to human serum albumin: Characterization and relationship to pharmacodynamics
    • Nowak I, Shaw LM. Lycophenolic acid binding to human serum albumin: characterization and relationship to pharmacodynamics. Clin Chem 1995; 41: 1011-7
    • (1995) Clin Chem , vol.41 , pp. 1011-1017
    • Nowak, I.1    Shaw, L.M.2
  • 286
    • 0344027270 scopus 로고
    • Subcommittee on Immunosuppressant Drugs. March 30, Rockville (MD): Food and Drug Administration
    • Report of the Antiviral Drug Advisory Committee, Subcommittee on Immunosuppressant Drugs. March 30, 1995. Rockville (MD): Food and Drug Administration
    • (1995) Report of the Antiviral Drug Advisory Committee
  • 287
    • 0028815323 scopus 로고
    • Pilot study of mycophenolate mofetil (RS-61443) in the prevention of acute rejection following renal transplantation in Japanese patients
    • Japan RS-61443 Investigation Committee. Pilot study of mycophenolate mofetil (RS-61443) in the prevention of acute rejection following renal transplantation in Japanese patients. Transplant Proc 1995; 27: 1421-4
    • (1995) Transplant Proc , vol.27 , pp. 1421-1424
  • 288
    • 0006344719 scopus 로고
    • RS-61443: A phase I clinical trial and pilot rescue study
    • Sollinger HW, Deierhoi MH, Belzer FO, et al. RS-61443: a phase I clinical trial and pilot rescue study. Transplantation 1992; 51: 27-31
    • (1992) Transplantation , vol.51 , pp. 27-31
    • Sollinger, H.W.1    Deierhoi, M.H.2    Belzer, F.O.3
  • 289
    • 0029115531 scopus 로고
    • Mycophenolate mofetil for the prevention of acute rejection in primary cadaveric renal allograft recipients
    • Sollinger, HW, for the US Renal Transplant Mycophenolate Mofetil Study Group. Mycophenolate mofetil for the prevention of acute rejection in primary cadaveric renal allograft recipients. Transplantation 1995; 60: 225-32
    • (1995) Transplantation , vol.60 , pp. 225-232
    • Sollinger, H.W.1
  • 290
    • 0029006409 scopus 로고
    • Placebo-controlled study of mycophenolate mofetil combined with cyclosporin and corticosteroids for prevention of acute rejection
    • European Mycophenolate Mofetil Cooperative Study Group. Placebo-controlled study of mycophenolate mofetil combined with cyclosporin and corticosteroids for prevention of acute rejection. Lancet 1995; 345: 1321-5
    • (1995) Lancet , vol.345 , pp. 1321-1325
  • 291
    • 0027154959 scopus 로고
    • Maintenance immunosuppression with prednisone and RS-61443 alone following liver transplantation
    • Freise CE, Hebert M, Osorio RW, et al. Maintenance immunosuppression with prednisone and RS-61443 alone following liver transplantation. Transplant Proc 1993; 25: 1758-9
    • (1993) Transplant Proc , vol.25 , pp. 1758-1759
    • Freise, C.E.1    Hebert, M.2    Osorio, R.W.3
  • 292
    • 0027317348 scopus 로고
    • The use of mycophenolate mofetil (RS-61443) in human heart transplant recipients
    • Ensley RD, Bristow MR, Olsen SL, et al. The use of mycophenolate mofetil (RS-61443) in human heart transplant recipients. Transplantation 1993; 56: 75-82
    • (1993) Transplantation , vol.56 , pp. 75-82
    • Ensley, R.D.1    Bristow, M.R.2    Olsen, S.L.3
  • 293
    • 0028342882 scopus 로고
    • Treatment of recurrent heart rejection with mycophenolate mofetil (RS-61443): Initial clinical experience
    • Kirklin JK, Bourge RC, Naftel DC, et al. Treatment of recurrent heart rejection with mycophenolate mofetil (RS-61443): initial clinical experience. J Heart Lung Transplant 1994; 13: 444-50
    • (1994) J Heart Lung Transplant , vol.13 , pp. 444-450
    • Kirklin, J.K.1    Bourge, R.C.2    Naftel, D.C.3
  • 294
    • 0028331709 scopus 로고
    • Determination of a new immunosuppressant, mycophenolate mofetil, and its active metabolite, mycophenolic acid, in rat and human body fluids by high-performance liquid chromatography
    • Sugioka N, Odani H, Ohta T, et al. Determination of a new immunosuppressant, mycophenolate mofetil, and its active metabolite, mycophenolic acid, in rat and human body fluids by high-performance liquid chromatography. J Chromatgr B 1994; 654: 249-56
    • (1994) J Chromatgr B , vol.654 , pp. 249-256
    • Sugioka, N.1    Odani, H.2    Ohta, T.3
  • 295
    • 0027281537 scopus 로고
    • Therapeutic drug monitoring (immunosuppressive drugs)
    • Chou D. Therapeutic drug monitoring (immunosuppressive drugs). Anal Chem 1993; 65: 412R-415R
    • (1993) Anal Chem , vol.65
    • Chou, D.1
  • 296
    • 0001167612 scopus 로고
    • Pharmacokinetic drug interaction study of mycophenolate mofetil and intravenous ganciclovir in renal transplant patients
    • Wolfe EJ, Mathur V, Tomlanovich S, et al. Pharmacokinetic drug interaction study of mycophenolate mofetil and intravenous ganciclovir in renal transplant patients [abstract]. Clin Pharmacol Ther 1995; 57: 148
    • (1995) Clin Pharmacol Ther , vol.57 , pp. 148
    • Wolfe, E.J.1    Mathur, V.2    Tomlanovich, S.3
  • 297
    • 0028895151 scopus 로고
    • Mycophenolate mofetil: A report of the consensus panel
    • Shaw LM, Sollinger HW, Halloran P, et al, Mycophenolate mofetil: a report of the consensus panel. Ther Drug Monit 1995; 17: 690-9
    • (1995) Ther Drug Monit , vol.17 , pp. 690-699
    • Shaw, L.M.1    Sollinger, H.W.2    Halloran, P.3
  • 298
    • 0016713286 scopus 로고
    • Rapamycin (AY-22,989) a new antifungal antibiotic. II: Fermentation, isolation and characterization
    • Sehgal SN, Baker H, Vezina C. Rapamycin (AY-22,989) a new antifungal antibiotic. II: Fermentation, isolation and characterization. J Antibiot 1975; 28: 727-32
    • (1975) J Antibiot , vol.28 , pp. 727-732
    • Sehgal, S.N.1    Baker, H.2    Vezina, C.3
  • 299
    • 0027786832 scopus 로고
    • Rapamycin inhibits p34cdc2 expression and arrests T lymphocyte proliferation at the GI/S transition
    • Flanagan WM, Crahtree GR. Rapamycin inhibits p34cdc2 expression and arrests T lymphocyte proliferation at the GI/S transition. Ann NY Acad Sci 1993; 696: 31-7
    • (1993) Ann NY Acad Sci , vol.696 , pp. 31-37
    • Flanagan, W.M.1    Crahtree, G.R.2
  • 300
    • 0026102058 scopus 로고
    • Production of synerergistic, but non-identical mechanisms of imnuisuppression by rapamycin and cyclosporine
    • Kimball PM, Kerman RH, Kahan BD. Production of synerergistic, but non-identical mechanisms of imnuisuppression by rapamycin and cyclosporine. Transplantation 1991; 51: 486-90
    • (1991) Transplantation , vol.51 , pp. 486-490
    • Kimball, P.M.1    Kerman, R.H.2    Kahan, B.D.3
  • 301
    • 0025228926 scopus 로고
    • Cyclosporine, FK 506 and rapamycin: Some effects on early activation events in serum-free, mitogen-stimulated mouse spleen cells
    • Metcalfe SM, Richards FM. Cyclosporine, FK 506 and rapamycin: some effects on early activation events in serum-free, mitogen-stimulated mouse spleen cells. Transplantation 1990; 49: 798-802
    • (1990) Transplantation , vol.49 , pp. 798-802
    • Metcalfe, S.M.1    Richards, F.M.2
  • 302
    • 0025099697 scopus 로고
    • Distinct mechanisms of suppression of murine T-cell activation by the related macrolides FK 506 and rapamycin
    • Dumont FJ, Staruch MJ, Koprak SL, et al. Distinct mechanisms of suppression of murine T-cell activation by the related macrolides FK 506 and rapamycin. J Immunol 1990; 144: 251-8
    • (1990) J Immunol , vol.144 , pp. 251-258
    • Dumont, F.J.1    Staruch, M.J.2    Koprak, S.L.3
  • 303
    • 0027430173 scopus 로고
    • Therapeutic monitoring of rapamycin: A new immunosuppressive drug
    • Yatscoff RW, LeGatt F, Kneteman NM. Therapeutic monitoring of rapamycin: a new immunosuppressive drug. Ther Drug Monit 1993; 15: 478-82
    • (1993) Ther Drug Monit , vol.15 , pp. 478-482
    • Yatscoff, R.W.1    LeGatt, F.2    Kneteman, N.M.3
  • 304
    • 0025971270 scopus 로고
    • Cyclosporine monitoring in autoimmune and other diseases
    • Ludwin D. Cyclosporine monitoring in autoimmune and other diseases. Clin Biochem 1991; 24: 47-9
    • (1991) Clin Biochem , vol.24 , pp. 47-49
    • Ludwin, D.1
  • 305
    • 0026547953 scopus 로고
    • Cyclosporine monitoring: Its role in autoimmune indications
    • Holt DW, Johnston A. Cyclosporine monitoring: its role in autoimmune indications. J Autoimmun 1992; 5 Suppl. A: 177-82
    • (1992) J Autoimmun , vol.5 , Issue.SUPPL. A , pp. 177-182
    • Holt, D.W.1    Johnston, A.2
  • 306
    • 0026560491 scopus 로고
    • The optimal use of cyclosporin A in autoimmunue diseases
    • Feutren G. The optimal use of cyclosporin A in autoimmunue diseases. J Autoimmun 1992; 5 Suppl. A: 183-95
    • (1992) J Autoimmun , vol.5 , Issue.SUPPL. A , pp. 183-195
    • Feutren, G.1
  • 307
    • 0029024492 scopus 로고
    • Tacrolimus: A potential neu treatment for autoimmune chronic active hepatitis: results of an open-label preliminary trial
    • Van Thiel DH, Wright H, Carroll P, et al. Tacrolimus: a potential neu treatment for autoimmune chronic active hepatitis: results of an open-label preliminary trial. Am J Gastroenterol 1995; 90: 771-6
    • (1995) Am J Gastroenterol , vol.90 , pp. 771-776
    • Van Thiel, D.H.1    Wright, H.2    Carroll, P.3
  • 308
    • 0027192249 scopus 로고
    • FK 506: A novel immunosuppressant for the treatment of autoimmune disease. Rationale and preliminary clinical experience at the University of Pittsburgh
    • Thomson AW, Carroll PB, McCauley J, et al. FK 506: a novel immunosuppressant for the treatment of autoimmune disease. Rationale and preliminary clinical experience at the University of Pittsburgh. Springer Semin Immunopathol 1993; 14: 323-14
    • (1993) Springer Semin Immunopathol , vol.14 , pp. 323-414
    • Thomson, A.W.1    Carroll, P.B.2    McCauley, J.3
  • 309
    • 0027368695 scopus 로고
    • Computer-guided concentration-controlled trials in autoimmune disorders
    • McMichael J, Lieberman R, Doyle H, et al. Computer-guided concentration-controlled trials in autoimmune disorders. Ther Drug Monit 1993; 15: 510-3
    • (1993) Ther Drug Monit , vol.15 , pp. 510-513
    • McMichael, J.1    Lieberman, R.2    Doyle, H.3
  • 310
    • 0002422233 scopus 로고
    • New DMARD. mycophenolate mofetil, effectively treats refractory rheumatoid arthritis patients for one year
    • Schiff MH, Goldblum R, Rees MMC. New DMARD. mycophenolate mofetil, effectively treats refractory rheumatoid arthritis patients for one year [abstract]. Arthritis Rheum 1991; 34 Suppl.: S89
    • (1991) Arthritis Rheum , vol.34 , Issue.SUPPL.
    • Schiff, M.H.1    Goldblum, R.2    Rees, M.M.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.