Highly efficient diastereoselective exo Diels-Alder reactions of homochiral 2-(N-acylamino)-1-thia-1,3-dienes: A powerful entry into optically pure thiopyrans

Tetrahedron Letters

Volumn 37, Issue 1, 1996, Pages 123-126

  Bell, Andrew S ^b   Fishwick, Colin W G ^a   Reed, Jessica E ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

THIOPYRAN DERIVATIVE;

ARTICLE; CHIRALITY; DRUG SYNTHESIS; REACTION ANALYSIS; STEREOCHEMISTRY; X RAY ANALYSIS;

BETULACEAE; THIA;

EID: 0030027156     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/0040-4039(95)02089-6     Document Type: Article

References (27)

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27. Molecular models were constructed on a Silicon Graphics Indigo using MacroModel v3.0, developed by Professor W.C. Still. All models were fully optimised using AMI Hamiltonian in MOPAC v6.0 which was optimised for parallel computation using a Silicon Graphics Challenge eight processor parallel computer. Transition structures were located via the SADDLE routine in MOPAC and optimised via the TS routine. Transition structures were characterised using FORCE within MOPAC.