Effects of MCI-727 on pancreatic exocrine secretion and acute pancreatitis in two experimental rat models

Pancreas

Volumn 12, Issue 2, 1996, Pages 165-172

  Tachibana, Issei ^a   Watanabe, Nobuaki ^a   Shirohara, Hisashi ^a   Akiyama, Toshiharu ^a   Nakano, Shigekazu ^a   Otsuki, Makoto ^a  

^a UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

Author keywords

Acute pancreatitis; Cholecystokinin; MCI 727; Pancreatic exocrine secretion; Secretin

Indexed keywords

2 (4 METHYL 1 PIPERAZINYL) 1 (4 PHENETHYLPHENYL)ETHANONE OXIME; AMYLASE; ANTIULCER AGENT; ATROPINE; CERULETIDE; CHOLECYSTOKININ; LOXIGLUMIDE; SECRETIN; TAUROCHOLIC ACID; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG;

ACUTE PANCREATITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHOLECYSTOKININ BLOOD LEVEL; CONTROLLED STUDY; EXOCRINE SECRETION; EXPERIMENTAL MODEL; HORMONAL REGULATION; MALE; NONHUMAN; PANCREAS JUICE; PRIORITY JOURNAL; RAT; SECRETIN BLOOD LEVEL;

EID: 0030026951     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006676-199603000-00010     Document Type: Article

References (25)

1. Steinberg WM, Schlesselman SE. Treatment of acute pancreatitis. Comparison of animal and human studies. Gastroenterology 1987;93:1420-7.
2. Renner IG, Wisner JR Jr. Protective effects of exogenous secretin on caeruletide-induced acute pancreatitis in the rat. J Clin Invest 1983;72:1081-92.
3. Niederau C, Ferrell LD, Grendell JH. Caerulem-mduced acute necrotizing pancreatitis in mice: protective effects of proglumide, benzotript, and secretin. Gastroenterology 1985;88:1192-204.
4. Renner IG, Wisner JR Jr, Bradford CL. Partial restoration of pancreatic function by exogenous secretin in rats with caeruletide-induced acute pancreatitis. Dig Dis Sci 1986;31:305-13.
5. Renner IG, Wisner JR Jr. Caeruletide-induced acute pancreatitis in the dog and its amelioration by exogenous secretin. Int J Pancreatol 1986;1:39-49.
6. Tachibana I, Watanabe N, Shirohara H, Akiyama T, Nakano S, Otsuki M. Effects of tetraprenylacetone on pancreatic exocrine secretion and acute pancreatitis in two experimental models in rats. Int J Pancreatol 1995;17:147-54.
7. Evander A, Ihse I, Lundquist I. Influence of hormonal stimulation on acute experimental pancreatitis in the rat. Eur Surg Res 1981;13:257-68.
8. Niederau C, Liddle RA, Ferrell LD, Grendell JH. Beneficial effects of cholecystokinin receptor blockade and inhibition of proteolytic enzyme activity in mice. Evidence for cholecystokinin as a major factor in the development of acute pancreatitis. J Clin Invest 1986;78:1056-63.
9. Fujimoto M, Yamanaka T, Bessho M, Igarashi T. Effects of geranylgeranylacetone on gastrointestinal secretion in rats. Eur J Pharmacol 1982;77:113-8.
10. Debas HT, Goto Y, Pappas TN, Chey WY. Geranyl-geranyl acetone: a novel stimulant of secretin release in the dog. Pancreas 1990;5:555-8.
11. Yamazaki S, Kawamura M, Kitsukawa M, et al. Effects of MCI-727, a new antiulcer agent, on various gastric and duodenal lesions in experimental animals. Japan J Pharmacol 1991;55:415-24.
12. Niederau M, Niederau C, Strohmeyer G, Grendell JH. Comparative effects of CCK receptor antagonists on rat pancreatic secretion in vivo. Am J Physiol 1989;256:G150-7.
13. Miyasaka K, Green GM. Effect of atropine on rat basal pancreatic secretion during return or diversion of bile-pancreatic juice. Proc Soc Exp Biol Med 1983;174:187-92.
14. Tani S, Otsuki M, Itoh H, et al. Histologic and biochemical alterations in experimental acute pancreatitis induced by supramaximal caerulein stimulation. Int J Pancreatol 1987;2: 337-48.
15. Aho HJ, Koskensalo SML, Navalainen TJ. Experimental pancreatitis in the rat. Sodium taurocholate-induced acute hemorrhagic pancreatitis. Scand J Gastroenterol 1980;15: 411-6.
16. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951;193:265-75.
17. Ceska M, Birath K, Brown B. A new and rapid method for the clinical determination of α-amylase activities in human serum and urine. Clin Chim Acta 1969;26:437-44.
18. Whitaker JP. A rapid and specific method for the determination of pancreatic lipase in serum and urine. Clin Chim Acta 1973;44:133-8.
19. Chang J, Watanabe S, Shiratori K, Moriyoshi Y, Takeuchi T. Plaunotol stimulates endogenous secretin release and exocrine pancreatic secretion in rats. Digestion 1989;44: 142-7.
20. Saluja A, Hashimoto S, Saluja M, Powers RE, Meldolesi J, Steer ML. Subcellular redistribution of lysosomal enzymes during caerulein-induced pancreatitis. Am J Physiol 1987; 253:G508-16.
21. Koike H, Steer ML, Meldolesi J. Pancreatic effects on ethionine: blockage of exocytosis and appearance of crinophagy and autophagy precede cellular necrosis. Am J Physiol 1982; 242:G297-307.
22. Hirano T, Manabe T, Imanishi K, Tobe T. Protective effect of a cephalosporin, Shiomarin, plus a new potent protease inhibitor, E3123, on rat taurocholate-induced pancreatitis. J Gastroenterol Hepatol 1993;8:52-9.
23. Evander A, Lundquist I, Ihse I. Influence of gastrointestinal hormones on the course of acute experimental pancreatitis. Hepato-Gastroenterology 1982;29:161-6.
24. Lankisch PG, Göke B, Fölsch UR, Winkler K, Otto J, Creutzfeldt W. Influence of secretin on the course of acute experimental pancreatitis in rats. Digestion 1983;26:187-91.
25. Infantino A, Dodi G, Basso D, et al. Failure of secretin to exert an ameliorative effect on acute reflux pancreatitis in the rat. Res Exp Med 1990;190:89-93.