Mitochondrial glycerol-3-phosphate dehydrogenase: Cloning of an alternatively spliced human islet-cell cDNA, tissue distribution, physical mapping, and identification of a polymorphic genetic marker

Diabetes

Volumn 45, Issue 2, 1996, Pages 262-266

  Ferrer, Jorge ^a   Aoki, Minoru ^a   Behn, Philip ^a   Nestorowicz, Ann ^a   Riggs, Andrew ^a   Permutt, M Alan ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; GLYCEROL 3 PHOSPHATE DEHYDROGENASE; MESSENGER RNA; MITOCHONDRIAL ENZYME;

ALTERNATIVE RNA SPLICING; ANIMAL CELL; ARTICLE; CHROMOSOME 2Q; CHROMOSOME POLYMORPHISM; CONTROLLED STUDY; ENZYME ANALYSIS; GENE MAPPING; GENETIC MARKER; HUMAN; HUMAN CELL; HUMAN TISSUE; INSULINOMA; MOLECULAR CLONING; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RAT; TISSUE DISTRIBUTION;

EID: 0030026367     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diab.45.2.262     Document Type: Article

References (17)

1. Meglasson MD, Matschinsky FM: Pancreatic islet glucose metabolism and regulation of insulin secretion. Diabetes Metab Rev 2:163-214, 1986
2. Malaisse W, Sener A, Herchuelz A, Hutton J: Insulin release: the fuel hypothesis. Metabolism 28:373-386, 1979
3. Dukes ID, McIntyre MS, Mertz RJ, Philipson LH, Roe MW, Spencer B, Worley JF: Dependence on NADH produced during glycolysis for beta-cell glucose signaling. J Biol Cliem 269:10979-10982, 1994
4. MacDonald MJ. Elusive proximal signals of beta-cells for insulin secretion Diabetes 39:1461-1466, 1990
5. Stryer L: Biochemistry. 4th ed. New York, WH Freeman, 1995
6. MacDonald MJ: High content of mitochondrial glycerol-3-phosphate dehydrogenase in pancreatic islets and its inhibition by diazoxide. J Biol Cliem 256:8287-8290, 1981
7. Ostenson CG, Abdel HS, Rasschaert J, Malaisse LF, Meuris S, Sener A, Efendic S, Malaisse WJ: Deficient activity of FAD-linked glycerophosphate dehydrogenase in islets of GK rats. Diabetologia 36:722-726, 1993
8. Giroix MH, Rasschaert J, Bailbe D, Leclercq MV, Sener A, Portha B, Malaisse WJ: Impairment of glycerol phosphate shuttle in islets from rats with diabetes induced by neonatal streptozocin. Diabetes 40:227-232, 1991
9. Fernandez AJ, Conget I, Rasschaert J, Sener A, Gomis R, Malaisse WJ: Enzymatic, metabolic and secretory patterns in human islets of type 2 (non-insulin-dependent) diabetic patients. Diabetologia 37:177-181, 1994
10. Lehn DA, Brown LJ, Simonson GD, Moran SM, Macdonald MJ: The sequence of a human mitochondrial glycerol-3-phosphate dehydrogenase-encoding cDNA. Gene 150:417-418, 1994
11. Muller S, Seitz HJ: Cloning of a cDNA for the FAD-linked glycerol-3-phosphate dehydrogenase from rat liver and its regulation by thyroid hormones. Proc Natl Acad Sci USA 91:10581-10585, 1994
12. Brown LJ, MacDonald MJ, Lehn DA, Moran SM: Sequence of rat mitochondrial glycerol-3-phosphate dehydrogenase cDNA evidence for EF-hand calcium-binding domains. J Biol Chem 269:14363-14360, 1994
13. Macdonald MJ, Moran SM, Simonson GD: The amino acid sequence of the pancreatic islet mitochondrial glycerol phosphate dehydrogenase is not unique and the enzyme is not thyroid or glucose responsive. Arch Biochem Biophys 319:305-308, 1995
14. Ferrer J, Nichols CG, Makhina EN, Salkoff L, Bernstein J, Gerhard D, Wasson J, Ramanadham S, Permutt MA. Pancreatic islet cells express a family of inwardly rectifying K+ channel subunits which interact to form G-protein activated channels. J Biol Chem 270.26086-26092, 1995
15. McDaniel ML, Colca JK, Kotagal N, Lacy PE: A subcellular fractionation approach for studying insulin release mechanisms and calcium metabolism in islets of Langerhans. Methods Enzymol 98:182-200, 1983
16. Cuhen D, Chumakov I, Weissenbach J: A first-generation physical map of the human genome. Nature 366:698-701, 1993
17. Copeman JB, Cucca F, Hearne CM, Cornall RJ, Reed PW, Ronningen KS, Undlien DE, Nistico L, Buzzetti R, Tosi R, Pociot F, Nerup J, Cornelis F, Barnett AH, Bain SC, Todd JA: Linkage disequilibrium mapping of a type 1 diabetes susceptibility gene (IDDM7) to chromosome 2q31-q3.3. Nature Genet 9:80-85, 1995