α-Tocopherol ameliorates oxidant injury in isolated copper-overloaded rat hepatocytes

Pediatric Research

Volumn 39, Issue 2, 1996, Pages 259-263

  Sokol, Ronald J ^a,b   Mckim Jr , James M ^a   Devereaux, Michael W ^a  

^a Children's Hospital Colorado   (United States)

^b CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; CHELATING AGENT; COPPER; N,N' BIS(2 AMINOETHYL) 1,3 PROPANEDIAMINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DAMAGE; CELL VIABILITY; CONTROLLED STUDY; LIPID PEROXIDATION; LIVER CELL CULTURE; LIVER TOXICITY; MALE; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; RAT; WILSON DISEASE;

EID: 0030026203     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/00006450-199602000-00012     Document Type: Article

References (27)

1. Sokol RJ 1994 Wilson's disease and Indian childhood cirrhosis. In: Suchy FJ (ed) Liver Disease in Children. CV Mosby, St. Louis, pp 747-772
2. Scheinberg IH, Sternlieb I 1984 Wilson's Disease. WB Saunders, Philadelphia
3. Bull PC, Thomas GR, Mommens JM, Forbes JR, Cox D 1993 The Wilson disease gene is a putative copper transporting P-type ATPase similar to the Menkes gene. Nature Genet 5:327-337
4. Petrukhin K, Fischer SG, Pirastu M, Tanzi RE, Chernov I, et al 1993 Mapping, cloning and genetic characterization of the region containing the Wilson disease gene. Nature Genet 5:338-343
5. Popper H, Goldfischer S, Sternlieb I, Nayak NB, Madhaven TV 1979 Cytoplasmic copper and its toxic effects - studies in Indian childhood cirrhosis. Lancet 1:1205-1208
6. Lefkowitch JH, Honig CL, King ME, Hagstrom JWC 1982 Hepatic copper overload and features of Indian childhood cirrhosis in an American sibship. N Engl J Med 307:271-277
7. O'Neill NC, Tanner MS 1989 Uptake of copper from brass vessels by bovine milk and its relevance to Indian childhood cirrhosis. J Pediatr Gastroenterol Nutr 9:167-172
8. Yuzbasiyan-Gurkan V, Grider A, Nostrant T, Cousins RJ, Brewer GJ 1992 Treatment of Wilson's disease with zinc. X. Intestinal metallothionein induction. J Lab Clin Med 120:380-386
9. Sternlieb I, Scheinberg IH 1968 Prevention of Wilson's disease in asymptomatic patients. N Engl J Med 278:352-354
10. Sternlieb I 1984 Wilson's disease: indications for liver transplantation. Hepatology 4:15s-17s
11. Schilsky ML, Scheinberg IH, Sternlieb I 1994 Liver transplantation for Wilson's disease: indications and outcome. Hepatology 19:583-587
12. Tanner MS, Bhave SA, Pradham AM, Pandit AN 1987 Clinical trials of penicillamine in Indian childhood cirrhosis. Arch Dis Child 62:1118-1124
13. Sokol RJ, Francis PO, Gold SH, Ford DM, Lum GM, Ambruso DR 1985 Orthotopic liver transplantation for acute fulminant Wilson disease. J Pediatr 107:549-552
14. Sokol RJ, Devereaux M, Mierau GW, Hambidge KM, Shikes RH 1990 Oxidant injury to hepatic mitochondrial lipids in rats with dietary copper overload. Modification by vitamin E deficiency. Gastroenterology 99:1061-1071
15. Sokol RJ, Devereaux MW, O'Brien K, Khandwala RA, Loehr JP 1993 Abnormal hepatic mitochondrial respiration and cytochrome c oxidase activity in rats with long-term copper overload. Gastroenterology 105:178-187
16. Sokol RJ, Twedt D, McKim Jr JM, Devereaux MW, Karrer FM, Kam I, Von Steigman G, Narkewicz MR, Bacon BR, Britton RS, Neuschwander-Tetri BA 1994 Oxidant injury to hepatic mitochondria in patients with Wilson's disease and Bedlington terriers with copper toxicosis. Gastroenterology 107:1788-1798
17. Sokol RJ, Devereaux MW, Traber MG, Shikes RH 1989 Copper toxicity and lipid peroxidation in isolated rat hepatocytes: effect of vitamin E. Pediatr Res 25:55-62
18. Hill KE, Burk RF 1982 Effect of selenium deficiency and vitamin E deficiency on glutathione metabolism in isolated rat hepatocytes. J Biol Chem 257:10668-10672
19. Twedt DC, Hunzaker HA, Allen KGD 1988 2,3,2-Tetramine as a hepatic copper chelator in the treatment of copper hepatotoxicity in Bedlington terrier dogs. Am J Vet Res 192:52-56
20. Evenson MA, Warren BL 1975 Determination of serum copper by atomic absorption, with the use of the graphite cuvette. Clin Chem 21:619-625
21. Southorn PA, Powis G 1988 Free radicals in Medicine. I. Chemical nature and biologic reactions. Mayo Clin Proc 63:381-389
22. Sokol RJ, Devereaux M, Khandwala R, O'Brien K 1993 Evidence for involvement of oxygen free radicals in bile acid toxicity to isolated rat hepatocytes. Hepatology 17:869-881
23. McKim Jr JM, Devereaux MW, Petersen DR, Hambidge KM, Ruyle SZ, Schilsky ML, Sternlieb I, Sokol RJ 1994 Mitochondrial oxidant injury in Long-Evans Cinnamon (LEC) rat liver containing high copper. Gastroenterology 106:A941
24. Sokol RJ 1994 At long last - an animal model for Wilson's disease. Hepatology 20:533-535
25. Twedt DC, Sternlieb I, Gilbertson SR 1979 Clinical, morphologic, and chemical studies on copper toxicosis of Bedlington terriers. J Am Vet Med Assoc 175:269-275
26. Blomstrand R, Forsgren L 1968 Labelled tocopherols in man. Int J Vitam Nutr Res 38:328-344
27. Traber M, Rudel L, Burton G, Hughes L, Ingold K, Kayden H 1990 Nascent VLDL from liver perfusions of cynomolgus monkeys are preferentially enriched in RRR-compared with SRR-α tocopherol. Studies using deuterated tocopherols. J Lipid Res 31:687-694