Kinetics of the block by intracellular Mg2+ of the NMDA-activated channel in cultured rat neurons

Journal of Physiology

Volumn 491, Issue 1, 1996, Pages 121-135

  Li Smerin, Yingying ^a   Johnson, Jon W ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ION CHANNEL; MAGNESIUM ION; N METHYL DEXTRO ASPARTIC ACID;

ANIMAL CELL; ARTICLE; BINDING SITE; BRAIN NERVE CELL; CELL MEMBRANE DEPOLARIZATION; DISSOCIATION CONSTANT; ION CURRENT; NERVE CELL CULTURE; NERVE CELL MEMBRANE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CELLS, CULTURED; CEREBRAL CORTEX; ELECTROPHYSIOLOGY; ION CHANNELS; KINETICS; MAGNESIUM; MEMBRANE POTENTIALS; N-METHYLASPARTATE; NEURONS; PATCH-CLAMP TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0030026193     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.1996.sp021201     Document Type: Article

References (39)

1. ANTONOV, S. M. & JOHNSON, J. W. (1994). Ion flow contributes to the voltage dependence of open channel block of the NMDA-activated channel. Society for Neuroscience Abstracts 20, 212.
2. ASCHER, P. & NOWAK, L. (1988). The role of divalent cations in the N-methyl-D-aspartate responses of mouse central neurones in culture. Journal of Physiology 399, 247-266.
3. CHRISTINE, C. W. & CHOI, D. W. (1990). Effect of zinc on NMDA receptor-mediated channel currents in cortical neurons. Journal of Neuroscience 10, 108-116.
4. COLLINGRIDGE, G. L. & LESTER, R. A. (1989). Excitatory amino acid receptors in the vertebrate central nervous system. Pharmacological Reviews 40, 143-210.
5. COOPER, K. E., GATES, P. Y & EISENBERG, R. S. (1988). Diffusion theory and discrete rate constants in ion permeation. Journal of Membrane Biology 106, 95-105.
6. CROUCHER, M. J., COLLINS, J. F. & MELDRUM, B. S. (1982). Anticonvulsant action of excitatory amino acid antagonists. Science 21, 899-901.
7. DICHTER, M. A. (1978). Rat cortical neurons in cell culture: culture methods, cell morphology, electrophysiology, and synapse formation. Brain Research 149, 279-293.
8. FITZHUGH, R (1983) Statistical properties of the asymmetric random telegraph signal, with applications to single-channel analysis. Mathematical Biosciences 64, 75-89.
9. GILL, R., FOSTER, A. C. & WOODRUFF, G. H. (1988). MK-801 is neuroprotective in gerbils when administered during the post-ischemic period. Neuroscience 25, 847-856.
10. HAMILL, O. P., MARTY, A., NEHER, E., SAKMANN, B. & SIGWORTH, F. J. (1981). Improved patch-clamp techniques for high resolution current recording from cells and cell-free membrane patches. Pflügers Archiv 391, 85-100.
11. HILLE, B. (1992). Ionic Channels of Excitable Membranes. Sinauer Associates, Sunderland, MA, USA.
12. JAHR, C. E. & STEVENS, C. F. (1990). A quantitative description of NMDA receptor-channel kinetic behavior. Journal of Neuroscience 10, 1830-1837.
13. JAHR, C. E. & STEVENS, C. F. (1993). Calcium permeability of the N-methyl-D-aspartate receptor channel in hippocampal neurons in culture. Proceedings of the National Academy of Sciences of the USA 90, 11573-11577.
14. 2+ of N-methyl-D-aspartate-activated channels. Biophysical Journal 57, 1085-1090.
15. 2+ and Excitable Membranes, ed. STRATA, P. & CARBONE, E., pp. 105-118. Springer-Verlag, New York.
16. 2+ channel in rat phaeochromocytoma cells: two sets of ion binding sites in the pore. Journal of Physiology 466, 629-655.
17. 2+ in rat phaeochromocytoma cells. Journal of Physiology 466, 683-706.
18. LÄUGER, P. (1973). Ion transport through pores: A rate-theory analysis. Biochimica et Biophysica Acta 311, 423-441.
19. LEVITT, D. G. (1986). Interpretation of biological ion channel flux data: Reaction-rate versus continuum theory. Annual Review of Biophysics and Biophysical Chemistry 15, 29-57.
20. 2+ of the NMDA response in whole-cell and outside-out patch recordings. Society for Neuroscience Abstracts 18, 652.
21. 2+ of the NMDA-activated channel. Society for Neuroscience Abstracts 19, 467.
22. 2+ on channel gating and steady-state responses of the NMDA receptor in cultured rat neurons Journal of Physiology 491, 137-150.
23. 2+ can carry current through the NMDA-activated channel. Society for Neuroscience Abstracts 21, 1104.
24. MARCHAIS, D. & MARTY, A. (1979). Interaction of permeant ions with channels activated by acetylcholine in Aplysia neurones. Journal of Physiology 297, 9-45.
25. MARTELL, A. E. & SMITH, R. M. (1974). Critical Stability Constants. Amino Acids, vol. 1. Plenum Press, New York.
26. MATSUDA, H. (1988). Open-state substructure of inwardly rectifying potassium channels revealed by magnesium block in guinea-pig heart cells. Journal of Physiology 397, 237-258.
27. MAYER, M. L. & WESTBROOK, G. L. (1987a). Permeation and block of N-methyl-D-aspartic acid receptor channels by divalent cations in mouse cultured central neurones. Journal of Physiology 394, 501-527.
28. MAYER, M. L. & WESTBROOK, G. L. (1987b). The physiology of excitatory amino acids in the vertebrate central nervous system. Progress in Neurobiology 28, 197-276.
29. 2+ of NMDA receptors in spinal cord neurones. Nature 309, 262-263.
30. MORRIS, R. G. M., DAVIS, S. & BUTCHER, S. P. (1991). Hippocampal synaptic plasticity and N-methyl-D-aspartate receptors: a role in information storage? In Long-Term Potentiation: A Debate of Current Issues, ed. BAUDRY, M. & DAVIS, J. L., pp. 27-300. MIT Press, Cambridge, MA, USA.
31. NEHER, E. & STEINBACH, J. H. (1978). Local anaesthetics transiently block currents through single acetylcholine-receptor channels. Journal of Physiology 277, 153-176.
32. NOWAK, L., BREGESTOVSKI, P., ASCHER, P., HERBET, A. & PROCHIANTZ, A. (1984). Magnesium gates glutamate-activated channels in mouse central neurones. Nature 307, 462-465.
33. + as permeant ions. Journal of General Physiology 94, 1-21.
34. PORTZEHL, H., CALDWELL, P. C. & RÜEGG, J. C. (1964). The dependence of contraction and relaxation of muscle fibres from the crab Maia squinado on the internal concentration of free calcium ions. Biochimica et Biophysica Acta 79, 581-591.
35. RUPPERSBERG, J. P., KITZING, E. V. & SCHOEPFER, R. (1994). The mechanism of magnesium block of NMDA receptors. Seminars in the Neurosciences 6, 87-96.
36. WOODHULL, A. M. (1973). Ionic blockage of sodium channels in nerve. Journal of General Physiology 61, 687-708.
37. + channels of bovine chromaffin cells. Journal of General Physiology 84, 157-186.
38. ZAREI, M. M. & DANI, J. A. (1994). Ionic permeability characteristics of the N-methyl-D-aspartate receptor channel. Journal of General Physiology 103, 231-248,
39. ZAREI, M. M. & DANI, J. A. (1995). Structural basis for explaining open-channel blockade of the NMDA receptor. Journal of Neuroscience 15, 1446-1454.