Azole endothelin antagonists. 2. Structure-activity studies

Journal of Medicinal Chemistry

Volumn 39, Issue 4, 1996, Pages 968-981

  Von Geldern, Thomas W ^a   Kester, Jeffrey A ^a   Bal, Radhika ^a   Wu Wong, Jinshyun R ^a   Chiou, William ^a   Dixon, Douglas B ^a   Opgenorth, Terry J ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [[2 [[2 [[(HEXAHYDRO 1H AZEPIN 1 YL)CARBONYL]AMINO] 4 METHYLPENTANOYL]AMINO] 3 (1 METHYL 1H INDOL 3 YL)PROPIONYL]AMINO] 3 (2 PYRIDYL)PROPIONIC ACID; ENDOTHELIN RECEPTOR ANTAGONIST; PYRROLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DRUG CONFORMATION; DRUG EFFECT; DRUG POTENCY; DRUG SYNTHESIS; ENZYME MODIFICATION; METHYLATION; NONHUMAN; PROTEIN ASSEMBLY; RAT; RECEPTOR AFFINITY; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION;

ANIMALS; AZOLES; CELL LINE; CELL MEMBRANE; CEREBELLUM; DRUG DESIGN; ENDOTHELINS; KINETICS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PHOSPHATIDYLINOSITOLS; RATS; RECEPTOR, ENDOTHELIN A; RECEPTORS, ENDOTHELIN; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE;

EID: 0030026167     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm950592+     Document Type: Article

References (13)

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