Uptake of azithromycin by various cells and its intracellular activity under in vivo conditions

Antimicrobial Agents and Chemotherapy

Volumn 40, Issue 1, 1996, Pages 75-79

  Wildfeuer, A ^a   Laufen, H ^a   Zimmermann, T ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZITHROMYCIN;

ANTIBACTERIAL ACTIVITY; ARTICLE; CELL LEVEL; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG UPTAKE; ERYTHROCYTE; HUMAN; HUMAN EXPERIMENT; INTRACELLULAR TRANSPORT; MALE; MONOCYTE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PHAGOCYTOSIS; POLYMORPHONUCLEAR CELL; PRIORITY JOURNAL; STAPHYLOCOCCUS;

EID: 0030025942     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.40.1.75     Document Type: Article

References (15)

1. Bonnet, M., and P. Van der Auwera. 1992. In vitro and in vivo intraleukocytic accumulation of azithromycin (CP-62, 993) and its influence on ex vivo leukocytc chemiluminescence. Antimicrob. Agents Chemother. 36:1302-1309.
2. Deuticke, B. 1977. Properties and structural basis of simple diffusion pathways in the erythrocyte membrane. Rev. Physiol Biochem. Pharmacol. 78: 1-97.
3. Gladue, R. P., G. M. Bright, R. E. Isaacson, and M. F. Newborg. 1989. In vitro and in vivo uptake of azithromycin (CP-62,993) by phagocytic cells: possible mechanism of delivery and release at sites of infection. Antimicrob. Agents Chemother. 33:277-282.
4. Hand, W. L., and N. L. King-Thompson. 1982. Membrane transport of clindamycin in alveolar macrophages Antimicrob. Agents Chemother. 21: 241-247
5. Hand, W. L., and N. L. King-Thompson. 1990 Uptake of antibiotics by human polymorphonuclear leukocyte cytoplasts. Antimicrob. Agents Chemother. 34:1189-1193.
6. Hof, H. 1991. Intracellular microorganisms: a particular problem for chemotherapy. Infection 19(Suppl. 4): 193-194.
7. Kinasewitz, G., and R. G. Wood. 1991. Azithromycin versus cefaclor in the treatment of acute bacterial pneumonia Eur. J. Clin. Miciobiol Infect. Dis 10:872-877.
8. Laufen, H., and A. Wildfeuer. 1989. Kinetics of the uptake of antimicrobial agents by human polymorphonuclear leucocytes. Arzneim Forsch. 39:233-235.
9. Laufen, H., A. Wildfener, and P. Lach. 1990 Mechanisms of azithromycin uptake in human polymorphonuclear leucocytes. Arzneim. Forsch. 40:686-689.
10. Laufen, H., A. Wildfeuer, and K. Räder. 1985. Uptake of antimicrobial agents by human polymorphonuclear leucocytes. Arzneim. Forsch. 35:1097-1099.
11. Riedel, K.-D., A. Wildfeuer, H. Laufen, and T. Zimmermann. 1992 Equivalence of a high-performance liquid chromatographic assay and a bioassay of azithromycin in human serum samples. J. Chromatogr. 576:358-362.
12. Sachs, L. 1992. Angewandte Statistik, p. 626-643. Springer, Berlin.
13. Wildfeuer, A., H. Laufen, D. Müller-Wening, and O. Haferkamp. 1989 Interaction of azithromycin and human phagocytic cells. Arzneim. Forsch. 39:755-758.
14. Wildfeuer, A., H. Laufen, and T. Zimmermann. 1994 Distribution of orally administered azithromycin in various blood compartments. Int. J. Clin. Pharmacol. Ther. 32:356-360.
15. Zuckerman, S. H., and S. D. Douglas. 1979. Dynamics of the macrophage plasma membrane. Annu. Rev. Microbiol. 33:267-307.