Insoluble complex formation between LDL and arterial proteoglycans in relation to serum lipid levels and effects of lipid lowering drugs

Atherosclerosis

Volumn 119, Issue 1, 1996, Pages 57-67

  Wiklund, Olov ^a   Bondjers, Göran ^b   Wright, Irma ^a   Camejo, German ^a,c  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b VOLVO AERO CORPORATION   (Sweden)

^c ASTRAZENECA R AND D   (Sweden)

Author keywords

Atherosclerosis; Hyperlipidemia; Lipoproteins; Proteoglycans

Indexed keywords

ANTILIPEMIC AGENT; GEMFIBROZIL; HIGH DENSITY LIPOPROTEIN; LIPID; LIPOPROTEIN A; LOW DENSITY LIPOPROTEIN; PLACEBO; PRAVASTATIN; PROTEOGLYCAN;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; COMPLEX FORMATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG MECHANISM; FEMALE; HUMAN; HYPERCHOLESTEROLEMIA; MAJOR CLINICAL STUDY; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

EID: 0030025740     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/0021-9150(95)05628-9     Document Type: Article

References (25)

1. Camejo G. The interaction of lipids and lipoproteins with the intercellular matrix of arterial tissue: its possible role in atherogenesis. Adv Lipid Res 1982;19:1.
2. Camejo G, Hurt E, Bondjers G. Effects of proteoglycans on lipoprotein-cell interactions: possible contribution to atherogenesis. Curr Opin Lipidol 1990;1:431.
3. Steele RH, Wagner WD, Rowe HA, Edwards IJ. Artery wall-derived proteoglycan-plasma lipoprotein interaction: lipoprotein binding properties of extracted proteoglycans. Atherosclerosis 1987;65:51.
4. Srinivasan SR, Radhakrishnamurthy B, Vijayagopal P Berenson GS. Proteoglycans, Lipoproteins and Atherosclerosis in Hypercholesterolemia, Hypocholesterolemia, Hypertriglyceridemia. Malmendier CL (ed). Plenum Press, New York, 1990;378.
5. Camejo G, Olofsson S-O, Lopez F, Carlsson P, Bondjers G. Identification of apo B-100 segments mediating the interaction of low density lipoproteins with arterial proteoglycans. Arteriosclerosis 1988;8:368.
6. Wiklund O, Camejo G, Mattsson L, Lopez F, Bondjers G. Cationic polypeptides modulate in vitro association of low density lipoprotein with arterial proteoglycans, fibroblasts and arterial tissue. Arteriosclerosis 1990;10: 695.
7. Hurt-Camejo E, Camejo G, Rosengren B, Lopez F, Wiklund O, Bondjers G. Differential uptake of protoglycanselected subfractions of low density lipoprotein by human macrophages. J Lipid Res 1990;31:1387.
8. Lindén T, Bondjers G, Camejo G, Bergstrand R Wilhelmsen L, Wiklund O. Affinity of LDL to a human arterial proteoglycan among male survivors of myocardial infarction. Eur J Clin Invest 1989; 19:38.
9. Camejo G, Lindén T, Olsson U, Wiklund O, Lopez F Bondjers G. Binding parameters and concentration control the formation of complexes between LDL and arterial proteoglycans in serum. Atherosclerosis 1989;79:121.
10. Camejo G, Hurt-Camejo E, Rosengren B, Wiklund O, López F, Bondjers G. Modification of copper-catalyzed oxidation of low density lipoprotein by proteoglycans and glycosaminoglycans. J Lipid Res 1991;32:1983.
11. Wiklund O, Angelin B, Bergman M, Berglund L, Bondjers G, Carlsson A, Lindén T, Mettinen T, Ödman B, Olofsson S-O Saarinen I, Sipilä R, Sjöström P, Kron B, Vanhanen H, Wright I. Pravastatin and gemfibrozil alone and in combination for the treatment of hypercholesterolemia. Am J Med 1992; in press.
12. Wiklund O, Fager G, Craig IH, Wilhelmsson C-E, Vedin A, Olofsson S-O, Bondjers G, Wilhelmsen L. Alphalipoprotein cholesterol levels in relation to acute myocardial infarction and its risk factors. Scand J Clin Lab Invest 1980;40:239.
13. Carlsson K. Lipoprotein fractionation. J Clin Pathol 1973;26(5):32.
14. Fager G, Wiklund O, Olofsson S-O, Wilhelmsen L Bondjers G. Multivariate analyses of serum apolipoproteins and risk factors in relation to acute myocardial infarction. Arteriosclerosis 1981;1:273.
15. Camejo G, Lopez A, Lopez F, Quinones J. Interaction of low density lipoproteins with arterial proteoglycans. The role of charge and sialic acid content. Atherosclerosis 1985;55:93.
16. Auerbach BJ, Parks JS, Aplebaum-Bowden D. A rapid and sensitive microassay for the enzymatic determination of plasma lipoprotein cholesterol. J Lipid Res 1990;30: 738.
17. Camejo G, Lalaguna F, Lopez F, Starosta R. Characterization and properties of a lipoprotein-complexing proteoglycan from human aorta. Atherosclerosis 1980;35:307.
18. Frank JS, Fogelman AM. Ultrastructure of the intima in WHHL and cholesterol-fed rabbit aortas prepared by ultra-rapid freezing and freeze-etching. J Lipid Res 1989; 30:967.
19. Austin MA, Breslow JL, Hennekes JE, Wilett WC, Krauss RM. Low density lipoprotein subclass patterns and risk of myocardial infarction. J Am Med Assoc 1988; 260:1917.
20. Deckelbaum RJ, Granot E, Oschrg Y, Rose L, Eisenberg S. Plasma triglycerides determine structure and composition in low and high density lipoproteins. Arteriosclerosis 1984;4:225.
21. Eisenberg S, Gavish D, Oschry Y, Fainaru M, Deckelbaum RJ. Abnormalities in very low, low and high density lipoproteins in hypertriglyceridemia. Reversal toward normal with bezafibrate treatment. J Clin Invest 1984; 74:470.
22. Bihari-Varga M, Gruber E, Rotheneder M, Zechner R Kostner GM. Interaction of lipoprotein(a) and low density lipoprotein with glycosaminoglycans from human aorta. Arteriosclerosis 1988;8:851.
23. Tsai MY, Yuan J, Hunninghake DB. Effect of gemfibrozil on composition of lipoproteins and distribution of LDL subspecies. Atherosclerosis 1992;95:35.
24. Franceschini G, Cassinotti M, Vecchio G, Gianfranceschi G, Pazzucconi F, Murakami T, Sirtori M, D'Acuquarica AL, Sirtori CR. Pravastatin effectively lowers LDL cholesterol in familial combined hyperlipidemia without changing LDL subclass pattern. Arterioscler Thromb 1994;14:1569.
25. Lindén T, Camejo G, Wiklund O, Warnold I, Olofsson S-O, Bondjers G. Effect of short term beta-blockade on serum lipid levels and on the interaction of LDL with human arterial proteoglycans. J Clin Pharmacol 1990;30: 124.