Glucocorticoid-lnduced modulation of cytokine secretion from normal and leukemic human myelomonocytic cells

International Archives of Allergy and Immunology

Volumn 109, Issue 2, 1996, Pages 110-115

  Welker, Pia ^a   Lippert, Undine ^a   Nürnberg, Wolf ^a   Krüger Krasagakes, Sabine ^a   Möller, Annelie ^a   Czarnetzki, Beate M ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Glucocorticoids; Interleukin 1 and beta; Interleukin 8; Monocytes; Myelomonocytic cells; Tumor necrosis factor and alpha;

Indexed keywords

BETAMETHASONE VALERATE; CALCIMYCIN; CYTOKINE; GLUCOCORTICOID; INTERLEUKIN 1BETA; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; METHYLPREDNISOLONE; METHYLPREDNISOLONE ACEPONATE; PHORBOL 13 ACETATE 12 MYRISTATE; PREDNICARBATE; TUMOR NECROSIS FACTOR ALPHA;

ALLERGY; ARTICLE; CELL LINE; CELL SECRETION; CELL STRAIN HL 60; CELL TYPE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG POTENCY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; INFLAMMATION; LEUKEMIA CELL; MONOCYTE; MONONUCLEAR CELL; NORTHERN BLOTTING; PRIORITY JOURNAL;

ADMINISTRATION, TOPICAL; ANTI-INFLAMMATORY AGENTS; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUCOCORTICOIDS; HUMANS; LEUKEMIA, MYELOMONOCYTIC, ACUTE; LEUKEMIA, MYELOMONOCYTIC, CHRONIC; LEUKOCYTES, MONONUCLEAR; LIPOPOLYSACCHARIDES; METHYLPREDNISOLONE; TUMOR CELLS, CULTURED;

EID: 0030025711     PISSN: 10182438     EISSN: 14230097     Source Type: Journal    
DOI: 10.1159/000237208     Document Type: Article

References (17)

1. Arai K, Lee F, Miyajima A, Miyalakc S, Arai N, Yokota T: Cytokines: Coordinators of immune and inflammatory responses, Annu Rev Bio-chern 1990:59:783-836.
2. Barnes PJ, Adcock I: Anti-inflammatory actions of steroids: Molecular mechanisms, Trends Pharmacol Sci 1993:14:436-441.
3. Sambrock J, Fritsch EF, Maniatis T: Extraction, purification and analysis of m-RNA from eukaryotic cells: in Molecular Cloning, Cold Spring Harbor, Laboratory Press, 1989; p 7.1.
4. Kirkland TN, Finley F, Lcturcq D, Moriarty A, Lee JD, Ulcvich RJ, Tobias PS: Analysis of lipopolysaccharide binding by CD 14., J Biol Chent 1993:268:24818-24823.
5. Abrink M, Gobi AF„ Huang R, Nilsson K, Hell-mann L: Human cell lines U-937. THP-I and Mono Mac 6 represent relatively immature cells of the monocyte-macrophagc cell lineage, Leukemia 1994:8:1579-1584.
6. Barton BE, Jakvvay JP, Smith SR, Siegel MI: Cytokine inhibition by a novel steroid mometa-sonfuoroatc, Immunopharmacol Immunotoxi-col 1991:13:251-261.
7. Tobler A, Meier R, Seitz M, Devvald B, Baggio-lini M, Frey MF: Glucocorticoids downregulate gene expression of GM-CSF, NAP-l IL-8. and IL-6. but not of M-CSF in human fibroblasts, Blood 1991:79:45-51.
8. Barber AF„ Coyle SM, Marano MA, Fischer E, Calvano SE, Fong Y, Moldawer LL, Lowry SF: Glucocorticoid therapy alters hormonal and cytokine response to endotoxin in man, J Immunol 1993;150:1999-2006.
9. Zcincr M, Gehring U: Glucocorticoid receptor expression during differentiation of human pro-mycloic leukemia cells, Cancer Res 1993:53: 3513-3520.
10. Hass R, Brach M, Gunji H, Kharbanda S, Kufc D: Inhibition of EGR-I and NF-kappa B gene expression by dexamethasone during phorbol ester-induced human monocytic differentiation, Biochem Pharmacol 1992;20:1569-1576.
11. Dinarello CA: Interleukin-1 and interleukin-l antagonism, Blood 1991:77:1627-1652.
12. Perez C, Albert I, DeFay K, Zachariadcs N, Gooding L, Kriegler M: A nonsccretable cell surface mutant of tumor necrosis factor (TNF) kills by cell contact, Cell 1990:63:251-258.
13. Zesch A: Lokaltherapie mit Kortikosteroiden Grenzen der Anwendungsdauer, Hautarzt 1990; 41:119-125.
14. Täuber U: Dermatoeortieosteroids: Structure, activity, pharmacokinetics, EurJ Dermatol 1994: 4:419-429.
15. Albrecht G: Clinical comparison of methyl-prednisolone accponatc and predniearbate in cronic eczema, J Eur Acad Dermatol Vencro l994;3(suppl 1):42-48.
16. Hein R, Körting I IC, Mehring T: Differential effect of medium potent nonhalogcnatcd double-cster-type and conventional glucocorticostc-roids on proliferation and chemotaxis of fibroblasts in vitro, Skin Pharmacol 1994:7:300-306.
17. Kccskes A, Hcgcr-Mahn D, Kleine Kuhlmann R, Utngc I: Comparison of the local and systemic side effects of mcthylprednisolone acep-onatc and momctasone furoate applied as ointments with equal antiinflammatory activity, J Am Acad Dermatol 1993:29:576-580.