Three-dimensional gated EPR imaging of the beating heart: Time-resolved measurements of free radical distribution during the cardiac contractile cycle

Magnetic Resonance in Medicine

Volumn 35, Issue 3, 1996, Pages 323-328

  Kuppusamy, Periannan ^a   Chzhan, Michael ^a   Wang, Penghai ^a   Zweier, Jay L ^a,b  

^a DEPARTMENT OF PATHOLOGY   (United States)

^b JOHNS HOPKINS ASTHMA AND ALLERGY CENTER   (United States)

Author keywords

free radicals; gated EPR; imaging; nitroxide; rat heart

Indexed keywords

ELECTRON SPIN RESONANCE SPECTROSCOPY; FREE RADICALS; HISTOLOGY; IMAGING TECHNIQUES; PARAMAGNETIC RESONANCE; RATS; TISSUE;

ANATOMICAL STRUCTURES; NITROXIDE SPIN LABELS; NITROXIDES; PARAMAGNETIC SPECIES; RADICAL DISTRIBUTIONS; RAT HEART; TEMPORAL AND SPATIAL; TIME RESOLVED MEASUREMENT;

HEART;

FREE RADICAL; NITROXIDE;

ACCURACY; ARTICLE; ELECTRON SPIN RESONANCE; HEART CONTRACTION; IMAGE PROCESSING; IMAGE RECONSTRUCTION; SIGNAL PROCESSING;

EID: 0030025704     PISSN: 07403194     EISSN: None     Source Type: Journal    
DOI: 10.1002/mrm.1910350309     Document Type: Article

References (24)

1. W. Fronsicz, J. S. Hyde, The loop-gap resonator, a new microwave lumped circuit ESR sample structure. J. Magn. Reson. 47, 515-521 (1982).
2. S. J. Lukiewicz, S. G. Lukiewicz, In vivo ESR spectroscopy of large biological objects. Magn. Reson. Med. 1, 297-298 (1984).
3. A. Sotgiu, Resonator design for in vivo ESR spectroscopy. J. Magn. Reson. 65, 206-214 (1985).
4. J. L. Zweier, P. Kuppusamy, Electron paramagnetic resonance measurements of free radicals in the intact beating heart: A technique for detection and characterization of free radicals in whole biological tissues. Proc. Natl. Acad. Sci. USA 85, 5703-5707 (1988).
5. H. J. Halpern, D. P. Spencer, J. V. Polen, M. K. Bowman, A. C. Nelson, E. M. Dowey, E A. Teicher, Imaging radio frequency electron spin resonance spectrometer with high resolution and sensitivity for in vivo measurements. Rev. Sci. Instrum. 60, 1040-1050 (1989).
6. M. Chzhan, M. Shteynbuk, P. Kuppusamy, J. L. Zweier. An optimized L-band resonator for EPR imaging of biological samples. J. Magn. Reson. A 105, 49-53 (1993).
7. S. Ishida, H. Kumashiro, N. Tsuchihashi, T. Ogata, M. Ono, H. Kamada, E. Yoshida, In vivo analysis of nitroxide radicals injected into small animals bv L-band ESR technique. Phys. Med. Biol. 34, 1317-1323 (1989).
8. L. J. Berliner, X. Wan. In vivo pharmacokinetics by electron paramagnetic resonance spectroscopy. Magn. Reson. Med. 9, 430-434 (1989).
9. M. Alecci, S. Colacicchi, P. L. Indovina, F. Momo, P. Pavone, A. Sotgiu, Three-dimensional in vivo BSR imaging in rats. Magn. Reson. Imaging 8, 59-63 (1990).
10. K. Takeshita, H. Utsumi, A. Hamada, ESR measurement of radical clearance in lung of whole mouse. Biophys. Res. Commun. 177, 874-880 (1991).
11. P. Kuppusamy, M. Chzhan, K. Vij, M. Shteynbuk, D. J. Lefer, E. Giannella, J. L. Zweier, 3-D spectral-spatial EPR imaging of free radicals in the heart: A technique for imaging tissue metabolism and oxygenation. Proc. Natl. Acad. Sci. USA 91, 3388-3392 (1994).
12. M. Alecci, M. Ferrari, V. Quaresima, A. Sotgiu, C. L. Ursini, Simultaneous 280 MHz EPR imaging of rat organs during nitroxide free radical clearance. Biophys. J. 67, 1274-1279 (1994).
13. H. J. Halpern, C. Yu, E. Barth, M. Peric, G. M. Rosen, In situ detection, by spin trapping, of hydroxyl radical markers produced from ionizing radiation in the tumor of a living mouse. Proc. Natl. Acad. Sci. USA 92, 796-800 (1995).
14. P. Kuppusamy, P. Wang, J. L. Zweier, Three-dimensional spatial imaging of rat hearts. Magn. Reson. Med. 34, 99-105(1995).
15. L. J. Berliner, H. Fujii, X. Wan, S. J. Lukiewicz, Feasibility study of imaging a living murine tumor by electron paramagnetic resonance. Magn. Reson. Med. 4, 380-384 (1987).
16. G. Bacic, M. Nilges, R. Magin, T. Walczak, H. M. Swartz, In vivo localized ESR spectroscopy reflecting metabolism. Magn. Reson. Med. 10, 266-272 (1989).
17. S. Colacicchi, M. Ferrari, G. Gualtieri, M. T. Santini, A. Sotgiu. Saptial localization and oximetry of EPR signal in mice. Phys. Med. 2-4, 297-305 (1989).
18. P. Kuppusamy, M. Chzhan, A. Samouilov, P. Wang, J. L. Zweier, Mapping the spin density and lineshape distribution of free radicals using 4D spectral-spatial EPR imaging. J. Magn. Reson. B 107, 116-125 (1995).
19. J. L. Zweier, S. Thomson-Gorman, P. Kuppusamy, Measurement of oxygen concentrations in the intact beating heart using electron paramagnetic resonance spectroscopy: A technique for measuring oxygen concentrations in situ. J. Bioenerg. Biomembr. 23, 855-871 (1991).
20. L. Testa, G. Gualtieri, A. Sotgiu. Electron paramagnetic resonance imaging of a model of a beating heart, Phys. Med. Biol. 38, 259-266 (1993).
21. P. Kuppusamy, M. Chzhan, J. L. Zweier, Development and optimization of three-dimensional spatial EPR imaging for biological samples and tissues. J. Magn. Reson. B 106, 122-130 (1995).
22. U. Ewert, K-U. Thiessenhusen, Deconvolution for the stationary-gradient method, in "EPR Imaging and In Vivo EPR" (G. R. Eaton, S. S. Eaton, K. Ohno, Eds.), pp. 119-126, CRC Press. Boca Raton, 1991.
23. R. B. Marr, C. N. Chen, P. C. Lauterbur, On two approaches to 3D reconstruction in NMR zeugmatography, in "Mathematical Aspects of Computerized Tomography" (G. T. Herman, F. Natterer, Eds.), Vol. 8, p. 225, Springer-Verlag, New York/Berlin, 1981.
24. R. K. Woods, W. B. Hyslop, R. B. Maar, P. C. Lauterbur, Image reconstruction, in "EPR Imaging and In Vivo EPR" (G. R. Eaton. S. S Eaton. K. Ohno. Eds.), pp. 91-117, CRC Press, Boca Raton. 1991.