Hormone-dependent and -independent transcriptional activation by thyroid hormone receptors are mediated by different mechanisms

Endocrinology

Volumn 137, Issue 2, 1996, Pages 390-399

  Helmer, Elizabeth B ^a,b   Raaka, Bruce M ^a   Samuels, Herbert H ^a  

^a NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^b GEOPHYSICAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; ONCOPROTEIN; RETINOID X RECEPTOR; THYROID HORMONE RECEPTOR;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENE MUTATION; HORMONAL REGULATION; HORMONE RECEPTOR INTERACTION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RAT; RECEPTOR UPREGULATION; REGULATORY MECHANISM; TRANSACTIVATION; TRANSCRIPTION REGULATION;

EID: 0030024894     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.137.2.8593781     Document Type: Article

References (55)

1. Samuels HH, Forman BM, Horowitz ZD, Ye Z-S 1988 Regulation of gene expression by thyroid hormone. J Clin Invest 81:957-967
2. Evans RM 1988 The steroid and thyroid hormone receptor superfamily. Science 240:889-895
3. Forman BM, Samuels HH 1990 Interactions among a subfamily of nuclear hormone receptors: the regulatory zipper model. Mol Endocrinol 4:1293-1301
4. McDonnell DP, Mangelsdorf DJ, Pike JW, Haussler MR, O'Malley BW 1987 Molecular cloning of complementary DNA encoding the avian receptor for vitamin D. Science 235:1214-1217
5. Giguere V, Tini M, Flock G, Ong E, Evans RM, Otulakowski G 1994 Isoform-specific amino-terminal domains dictate DNA-binding properties of RORα, a novel family of orphan hormone nuclear receptors. Genes Dev 8:538-553
6. Koenig RJ, Warne RL, Brent GA, Harney JW, Larsen PR, Moore DD 1988 Isolation of a cDNA clone encoding a biologically active thyroid hormone receptor. Proc Natl Acad Sci USA 85:5031-5035
7. Mitsuhashi NT, Tennyson GE, Nikodem VM 1988 Alternative splicing generates messages encoding rat c-erbA proteins that do not bind thyroid hormone. Proc Natl Acad Sci USA 85:5804-5808
8. Sap J, Munoz A, Damm K, Goldberg Y, Ghysdael J, Leutz A, Beug H, Vennstrom B 1986 The c-erb-A protein is a high-affinity receptor for thyroid hormone. Nature 324:635-640
9. Selmi S, Samuels HH 1991 Thyroid hormone receptor/c-erbA and v-erbA: a single amino acid difference in the C-terminal region influences dominant negative activity and receptor dimer formation. J Biol Chem 266:11589-11593
10. Forman BM, Casanova J, Raaka BM, Ghysdael J, Samuels HH 1992 Half-site spacing and orientation determines whether thyroid hormone and retinoic acid receptors and related factors bind to DNA response elements as monomers, homodimers, or heterodimers. Mol Endocrinol 6:429-442
11. Leid M, Kastner P, Lyons R, Nakshatri H, Saunders M, Zacharewski T, Chen J-Y, Staub A, Gamier J-M, Mader S, Chambon P 1992 Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently. Cell 68:377-395
12. Glass CK, Lipkin SM, Devary OV, Rosenfeld MG 1989 Positive and negative regulation of gene transcription by a retinoic acid-thyroid hormone receptor heterodimer. Cell 59:697-708
13. Lazar MA, Berrodin TJ 1990 Thyroid hormone receptors form distinct nuclear protein-dependent and independent complexes with a thyroid hormone response element. Mol Endocrinol 4:1627-1635
14. Yu VC, Delsert C, Andersen B, Holloway JM, Devary OV, Naar AM, Kim SY, Boutin J-M, Glass CK, Rosenfeld MG 1991 RXRβ: a coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements. Cell 67:1251-1266
15. Berrodin TJ, Marks MS, Ozato K, Linney E, Lazar MA 1992 Heterodimerization among thyroid hormone receptor, retinoic acid receptor, retinoid X receptor, chicken ovalbumin upstream promoter transcription factor, and an endogenous liver protein. Mol Endocrinol 6:1468-1478
16. Marks MS, Hallenbeck PL, Nagata T, Segars JH, Appella E, Nikodem VM, Ozato K 1992 H-2RIIBP (RXR-β) heterodimerization provides a mechanism for combinatorial diversity in the regulation of retinoic acid and thyroid hormone responsive genes. EMBO J 11:1419-1435
17. Damm K, Thompson CC, Evans RM 1989 Protein encoded by v-erbA functions as a thyroid hormone receptor antagonist. Nature 339:593-597
18. Brent GA, Dunn MK, Harney JW, Gulick T, Larsen PR, Moore DD 1989 Thyroid hormone aporeceptor represses T3-inducible promoters and blocks activity of the retinoic acid receptor. New Biol 1:329-336
19. Baniahmad A, Steiner C, Kohne AC, Renkawitz R 1990 Modular structure of a chicken lysozyme silencer: involvement of an unusual thyroid hormone receptor binding site. Cell 61:505-514
20. Baniahmad A, Kohne CA, Renkawitz R 1992 A transferable silencing domain is present in the thyroid hormone receptor, in the v-erbA oncogene product and in the retinoic acid receptor. EMBO J 11: 1015-1023
21. Au-Fliegner M, Helmer E, Casanova J, Raaka BM, Samuels HH 1993 The conserved ninth C-terminal heptad in thyroid hormone and retinoic acid receptors mediates diverse responses by affecting heterodimer but not homodimer formation. Mol Cell Biol 13:5725-5737
22. Forman BM, Yang C-R, Stanley F, Casanova J, Samuels HH 1988 c-erbA protooncogenes mediate thyroid hormone-dependent and independent regulation of the rat growth hormone and prolactin genes. Mol Endocrinol 2:902-911
23. Forman BM, Yang C-R, Au M, Casanova J, Ghysdael J, Samuels HH 1989 A domain containing leucine zipper like motifs mediate novel in vivo interactions between the thyroid hormone and retinoic acid receptors. Mol Endocrinol 3:1610-1626
24. Baniahmad A, Leng X, Burris TP, Tsai SY, Tsai M-J, O'Malley BW 1995 The τ4 activation domain of the thyroid hormone receptor is required for release of a putative corepressor(s) necessary for transcriptional silencing. Mol Cell Biol 15:76-86
25. Qi J-S, Desai-Yajnik V, Greene ME, Raaka BM, Samuels HH 1995 The ligand binding domains of the thyroid hormone/retinoid receptor gene subfamily function in vivo to mediate heterodimerization, gene silencing, and transactivation. Mol Cell Biol 15:1817-1825
26. Saatcioglu F, Deng T, Karin M 1993 A novel cis element mediating ligand-independent activation by c-erbA: implications for hormonal regulation. Cell 75:1095-1105
27. Ways DK, Qin W, Cook P, Parker PJ, Menke JB, Hao E, Smith AM, Jones C, Hershman JM, Geffner ME, Su F, Samuels HH, Usala SJ 1993 Dominant and non-dominant negative c-erbAβ1 receptors associated with thyroid hormone resistance syndromes augment TPA-induction of the collagenase promoter and exhibit defective T3-mediated repression. Mol Endocrinol 7:1112-1120
28. Tomic M, Jiang C-K, Epstein HS, Freedberg IM, Samuels HH, Blumenberg M 1990 Nuclear receptors for retinoic acid and thyroid hormone regulate transcription of keratin genes. Cell Regul 1:965-973
29. Casanova J, Helmer E, Selmi-Ruby S, Qi J-S, Au-Fliegner M, Desai-Yajnik V, Koudinova N, Yarm F, Raaka BM, Samuels HH 1994 Functional evidence for ligand-dependent dissociation of thyroid hormone and retinoic acid receptors from an inhibitory cellular factor. Mol Cell Biol 14:5756-5765
30. Saatcioglu F, Bartunek P, Deng T, Zenke M, Karin M 1993 A conserved C-terminal sequence that is deleted in v-erbA is essential for the biological activities of c-erbA (the thyroid hormone receptor). Mol Cell Biol 13:3675-3685
31. Barettino D, Ruiz MdMV, Stunnenberg HG 1994 Characterization of the ligand-dependent transactivation domain of thyroid hormone receptor. EMBO J 13:3039-3049
32. Toney JH, Wu L, Summerfield AE, Sanyal G, Forman BM, Zhu J, Samuels HH 1993 Conformational changes in chicken thyroid hormone receptor α1 induced by binding to ligand or to DNA. Biochemistry 32:2-6
33. Rosen ED, Beninghof EG, Koenig RJ 1993 Dimerization interfaces of thyroid hormone, retinoic acid, vitamin D, and retinoid X receptors. J Biol Chem 268:11534-11541
34. Hadzic E, Desai-Yajnik V, Helmer E, Guo S, Casanova J, Raaka BM, Samuels HH 1995 A ten amino acid sequence in the N-terminal "A/B" domain of T3Rα is essential for transcriptional activation and interaction with the general transcription factor TFIIB. Mol Cell Biol 15:4507-4517
35. Umesono K, Evans RM 1989 Determinants of target gene specificity for steroid/thyroid hormone receptors. Cell 57:1139-1146
36. Umesono K, Murakami KK, Thompson CC, Evans RM 1991 Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D receptors. Cell 65:1255-1266
37. Marks MS, Levi B-Z, Segars JH, Driggers PH, Hirschfeld S, Nagata T, Appella E, Ozato K 1992 H-2RIIBP expressed from a baculovirus vector binds to multiple hormone response elements. Mol Endocrinol 6:219-230
38. Horowitz ZD, Yang C-R, Forman BM, Casanova J, Samuels HH 1989 Characterization of the domain structure of chick c-erbA by deletion mutation: in vitro translation and cell transfection studies. Mol Endocrinol 3:148-156
39. Flug F, Copp RP, Casanova J, Horowitz ZD, Janocko L, Plotnick M, Samuels H 1987 cis-acting elements of the rat growth hormone gene which mediate basal and regulated expression by thyroid hormone. J Biol Chem 262:6373-6382
40. Fox SR, Jong MTC, Casanova J, Ye Z-S, Stanley F, Samuels HH 1990 The homeodomain protein Pit-1/GHF-1 is capable of binding to and activating cell-specific elements of both the growth hormone and prolactin gene promoters. Mol Endocrinol 4:1069-1080
41. Crone DE, Kim H-S, Spindler SR 1990 Alpha and beta thyroid hormone receptors bind immediately adjacent to the rat growth hormone gene TATA box in a negatively hormone-responsive region. J Biol Chem 265:10851-10856
42. Drust DS, Troccoli NM, Jameson JL 1991 Binding specificity of cyclic adenosine 3′,5′-monophosphate-responsive element (CRE)-binding proteins and activating transcription factors to naturally occurring CRE sequence variants. Mol Endocrinol 5:1541-1551
43. Lee JW, Gulick T, Moore DD 1992 Thyroid hormone receptor dimerization function maps to a conserved subregion of the ligand binding domain. Mol Endocrinol 6:1867-1873
44. O'Donnell AL, Koenig RJ 1990 Mutational analysis identifies a new functional domain of the thyroid hormone receptor. Mol Endocrinol 4:715-720
45. O'Donnell AL, Rosen ED, Darling DS, Koenig RJ 1991 Thyroid hormone receptor mutations that interfere with transcriptional activation also interfere with receptor interaction with a nuclear protein. Mol Endocrinol 5:94-99
46. Munoz A, Zenke M, Gehring U, Sap J, Beug H, Vennstrom B 1988 Characterization of the hormone-binding domain of the chicken c-erbA/thyroid hormone receptor protein. EMBO J 7:155-159
47. Sap J, Munoz A, Schmitt J, Stunnenberg H, Vennstrom B 1989 Repression of transcription mediated at a thyroid hormone response element by the v-erb-A oncogene product. Nature 340:242-244
48. Sharif M, Privalsky ML 1991 v-erbA oncogene function in neoplasia correlates with its ability to repress retinoic acid receptor action. Cell 66:885-893
49. Privalsky ML, Sharif M, Yamamoto KR 1990 The viral erbA oncogene protein, a constitutive repressor in animal cells, is a hormone-regulated activator in yeast. Cell 63:1277-1286
50. Banker DE, Bigler J, Eisenman RN 1991 The thyroid hormone receptor gene (c-erbA) is expressed in advance of thyroid gland maturation during the early embryonic development of Xenopus laevis. Mol Cell Biol 11:5079-5089
51. Lezoualc'h F, Hassan AHS, Giraud P, Loeffler J-P, Lee SL, Demeneix BA 1992 Assignment of the β-thyroid hormone receptor to 3,5,3′-triiodothyronine-dependent inhibition of transcription from the thyrotropin-releasing hormone promoter in chick hypothalamic neurons. Mol Endocrinol 6:1797-1804
52. Schaufele F, West BL, Baxter J 1992 Synergistic activation of the rat growth hormone promoter by Pit-1 and the thyroid hormone receptor. Mol Endocrinol 6:656-665
53. Tung L, Mohamed MK, Hoeffler JP, Takimoto GS, Horwitz KB 1993 Antagonist-occupied human progesterone B receptors activate transcription without binding to progesterone response elements and are dominantly inhibited by A receptors. Mol Endocrinol 7:1256-1263
54. Naar AM, Boutin J-M, Lipkin SM, Yu VC, Holloway JM, Glass CK, Rosenfeld MG 1991 The orientation and spacing of core DNA-binding motifs dictate selective transcriptional responses to three nuclear receptors. Cell 65:1267-1279
55. Zenke M, Munoz A, Sap J, Vennstrom B, Beug H 1990 v-erbA oncogene activation entails the loss of hormone-dependent regulator activity of c-erbA. Cell 61:1035-1049