Lazaroid U-74389G for 48-hour canine liver preservation

Transplantation

Volumn 61, Issue 2, 1996, Pages 189-194

  Todo, Satoru ^a   Hamada, Nobuo ^b   Zhu, Yue ^b   Zhang, Shimin ^b   Subbotin, Vladimir ^b   Nemoto, Akiyoshi ^b   Takeyoshi, Izumi ^b   Starzl, Thomas E ^b  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

21 [4 [2,6 BIS(1 PYRROLIDINYL) 4 PYRIMIDINYL] 1 PIPERAZINYL]PREGNA 1,4,9(11) TRIENE 3,20 DIONE; LAZAROID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; FEMALE; GRAFT SURVIVAL; INTRAVENOUS DRUG ADMINISTRATION; LIVER BLOOD FLOW; LIVER FAILURE; LIVER PRESERVATION; LIVER TRANSPLANTATION; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIOXIDANTS; DOGS; FEMALE; INJECTIONS, INTRAVENOUS; LIVER TRANSPLANTATION; ORGAN PRESERVATION; PREGNATRIENES;

EID: 0030024352     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199601270-00004     Document Type: Article

References (36)

1. Braughler JM, Pregenzer JF, Chase RL, Duncan LA, Jacobsen EJ, McCall JM. Novel 21-amino steroids as potent inhibitors of iron-dependent lipid peroxidation. J Biol Chem 1987; 262: 10, 438.
2. Shenkar R, Abraham E. Effects of treatment with the 21-aminosteroid, U7438F, on pulmonary cytokine expression following hemorrhage and resuscitation. Crit Care Med 1995; 23: 132.
3. Meyer RJ, Juarez RA, Holden WE. 21-aminosteroids protect endothelial cells against injury by neutrophils. Am Rev Respir Dis 1992; 145: A571.
4. Gadaleta D, Verma M, Davis JM. Inhibition of neutrophil leukotriene generation by the 21-aminosteroid, U-74389F. J Surg Res 1994; 57: 233.
5. Hall ED, Pazara KE, Braughler JM. 21-aminosteroid lipid peroxidation inhibitor U74006F protects against cerebral ischemia in gerbils. Stroke 1988; 19: 997.
6. Park CK, Hall ED. Dose-response analysis of the effect of 21-aminosteroid tirilazad mesylate (U-74006F) upon neurological outcome and ischemic brain damage in permanent focal cerebral ischemia. Brain Res 1994; 645: 157.
7. Perkins WJ, Milde LN, Milde JH, Michenfelder JD. Pretreatment with U74006F improves neurologic outcome following complete cerebral ischemia in dogs. Stroke 1991; 22: 902.
8. Holzgrefe HH, Buchanan LV, Gibson JK. Effects of U74006F, a novel inhibitor of lipid peroxidation, in stunned reperfused canine myocardium. J Cardiovasc Pharmacol 1990; 15: 239.
9. Hendry PJ, Anstadt MP, Plunkett MD, Amato MT, Menius JA Jr, Lowe JE. Improved donor myocardial recovery with a new lazaroid lipid antiperoxidant in the isolated canine heart. J Heart Lung Transplant 1992; 11: 636.
10. Aeba R, Killinger WA, Keenan RJ, et al. Lazaroid U74500A as an additive to University of Wisconsin solution for pulmonary grafts in the rat transplant model. J Thorac Cardiovasc Surg 1992; 104: 1333.
11. Killinger WA Jr, Dorofi DB, Keagy BA, Johnson G Jr. Improvement of endothelial cell viability at 4 degrees C by addition of lazaroid U74500A to preservation solutions. Transplantation 1992; 53: 983.
12. Cosenza CA, Cramer DV, Cunneen SA, Tuso PJ, Wang HK, Makowka L. Protective effect of the lazaroid U74006F in cold ischemia-reperfusion injury of the liver. Hepatology 1994; 19: 418.
13. Katz SM, Sun S, Schechner RS, Tellis VA, Alt ER, Greenstein SM. Improved small intestinal preservation after lazaroid U74389G treatment and cold storage in University of Wisconsin solution. Transplantation 1995; 59: 694.
14. Stanley JJ, Goldblum JR, Frank TS, Zelenock GB, D'Alecy LG. Attenuation of renal reperfusion injury in rats by the 21-aminosteroid U74006F. J Vasc Surg 1993; 17: 685.
15. Shackleton CR, Ettinger SL, Scudamore CH, Toleikis PF, Keown PA. Effect of a 21-aminosteroid, U74006F, on lipid peroxidation and glomerulotubular function following experimental renal ischemia. J Surg Res 1994; 57: 433.
16. Todo S, Kam I, Lynch S, Starzl TE. Animal research in liver transplantation - with special reference to the dog. Semin Liver Dis 1985; 5: 309.
17. Todo S, Podesta L, Ueda Y, et al. A comparison of UW with other solutions for liver preservation in dogs. Clin Transplant 1989; 3: 253.
18. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72: 248.
19. Wynants J, Van Belle H. Single-run high performance liquid chromatography of nucleotides, nucleosides, and major purine bases and its application to different tissue extracts. Anal Biochem 1985; 144: 258.
20. Hamamoto I, Takaya S, Todo S, et al. Can adenine nucleotides predict primary nonfunction of the human liver homograft? Transplant International 1994; 7: 89.
21. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979; 95: 351.
22. Krawisz JE, Sharon P, Stenson WR. Quantitative assay for acute intestinal inflammation based on myeloperoxidse activity. Gastroenterology 1984; 87: 1334.
23. Furukawa H, Wu YM, Zhu Y, Suzuki T, Todo S, Starzl TE. Disturbance of microcirculation associated with prolonged preservation of dog livers under UW solution. Transplant Proc 1993; 25: 1591.
24. Zhu Y, Zeng Q, Suzuki T, et al. Successful 48-hour preservation of the canine liver by modified simple hypothermic storage with UW solution. Transplant Proc 1995; 27: 732.
25. Belzer FO, Southard JH. Principles of solid organ preservation by cold storage. Transplantation 1988; 45: 673.
26. Todo S, Nery J, Yanaga K, Podesta L, Gordon RD, Starzl TE. Extended preservation of human liver grafts with UW solution. JAMA 1989; 261: 711.
27. Jamieson NV, Sundberg R, Lindell S, et al. Preservation of the canine liver for 24-48 hours using simple cold storage with UW solution. Transplantation 1988; 46: 517.
28. Sumimoto R, Lindell SL, Southard JH, Belzer FO. A comparison of histidine-lactobionate and UW solution in 48-hour dog liver preservation. Transplantation 1992; 54: 610.
29. Boudjema K, Van Gulik TM, Lindell SL, Vreugdenhil PS, Southard JH, Belzer FO. Effect of oxidized and reduced glutathione in liver preservation. Transplantation 1990; 50: 948.
30. McCord JM. Oxygen-derived free radicals in postischemic tissue injury. N Engl J Med 1985; 312: 159.
31. Clavien PA, Harvey PRC, Strasberg SM. Preservation and reperfusion injuries in liver allografts. Transplantation 1992; 53: 957.
32. Goode HF, Webster NR, Howdle PD, et al. Reperfusion injury, antioxidants and hemodynamics during orthotopic liver transplantation. Hepatology 1994; 19: 354.
33. Haley EC Jr, Kassell NF, Alves WM, et al. Phase II trial of tirilazad in aneurysmal subarachnoid hemorrhage: a report of the cooperative aneurysm study. J Neurosurg 1995; 82: 786.
34. Ferguson DM, Gores GJ, Ludwig J, Krom RAF. UW solution protects against reperfusion injury by inhibiting lipid peroxidation. Transplant Proc 1991; 23: 1552.
35. Furukawa H, Todo S, Imventarza O, et al. Effect of cold ischemia time on the early outcome of human heptic allografts preserved with UW solution. Transplantation 1991; 51: 1000.
36. Hulst LK, Fleishaker JC, Peters GR, Harry JD, Wright M, Ward P. Effect of age and gender on tirilazad pharmacokinetics in humans. Clin Pharmacol Ther 1994; 55: 378.