Nortriptyline-induced hepatic failure

Therapeutic Drug Monitoring

Volumn 18, Issue 1, 1996, Pages 100-102

  Pedersen, Anne Marie Bisgaard ^a,b   Enevoldsen, Henriette Køhler ^a  

^a AMAGER HOSPITAL   (Denmark)

^b NONE   (Denmark)

Author keywords

Hepatitis; Nortriptyline; Toxic

Indexed keywords

ALANINE AMINOTRANSFERASE; AMITRIPTYLINE; ASPARTATE AMINOTRANSFERASE; IMIPRAMINE; LACTATE DEHYDROGENASE; NORTRIPTYLINE; TRICYCLIC ANTIDEPRESSANT AGENT;

ADULT; ARTICLE; CASE REPORT; CLINICAL FEATURE; DEPRESSION; DISEASE COURSE; DOSE LIVER FUNCTION RELATION; DRUG INDUCED DISEASE; FEMALE; HEPATITIS; HUMAN; LIVER FAILURE; PRIORITY JOURNAL;

ALANINE TRANSAMINASE; ALKALINE PHOSPHATASE; ANTIDEPRESSIVE AGENTS, TRICYCLIC; FEMALE; HUMANS; LIVER FAILURE; MIDDLE AGED; NORTRIPTYLINE; PROTHROMBIN TIME;

EID: 0030024290     PISSN: 01634356     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007691-199602000-00017     Document Type: Article

References (11)

1. Holmberg MB, Jansson B. A study of blood count and serum transaminase in prolonged treatment with amitriptyline. J New Drugs 1962;2:361-5.
2. Klerman GL, Cole JO. Clinical pharmacology of imipramine and related antidepressant compounds. Pharmacol Rev 1965;17:101-41.
3. Zimmerman HJ. Hepatotoxicity: the adverse effects of drugs and other chemicals on the liver. New York: Appleton-Century-Crofts, 1978:407.
4. Kragh-Sørensen P. Monitoring plasma concentration of nortriptyline: methodological, pharmacokinetic, and clinical aspects. Dan Med Bull 1985;32:29-53.
5. Brøsen K, Otton SV, Gram LF. Sparteine oxidation polymorphism in Denmark. Acta Pharmacol Toxicol 1985;57: 357-60.
6. Brøsen K. Isozyme specific drug oxidation: genetic polymorphism and drug-drug interactions. Nord J Psychiatry 1993;47(suppl 30):21-6.
7. Hammer W, Sjöqvist F. Plasma levels of monomethylated tricyclic antidepressants during treatment with imipramine-like compounds. Life Sci 1967;6:1895-903.
8. Alexanderson B, Evans DAP, Sjöqvist F. Steady-state plasma levels of nortriptyline in twins: influence of genetic factors and drug therapy. Br Med J 1969;4:764-8.
9. Mellström B, Bertilsson L, Säve J, Schulz HU, Sjöqvist F. E- and Z-10-hydroxylation of nortriptyline: relationship to polymorphic debrisoquine hydroxylation. Clin Pharmacol Ther 1981;30:189-93.
10. Danan G, Bernau J, Moullot X, et al. Amitriptyline-induced fulminant hepatitis. Digestion 1984;30:179-84.
11. Abernathy CO, Lukacs L, Zimmermann HJ. Toxicity of tricyclic antidepressants to isolated rat hepatocytes. Biochem Pharmacol 1975;24:347-50.