Design of immunogens as components of a new generation of molecular vaccines

Journal of Biotechnology

Volumn 44, Issue 1-3, 1996, Pages 129-137

  Loktev, V B ^a   Ilyichev, A A ^a   Eroshkin, A M ^a   Karpenko, L I ^a   Pokrovsky, A G ^a   Pereboev, A V ^a   Svyatchenko, V A ^a   Ignat'ev, G M ^a   Smolina, M I ^a   Melamed, N V ^a   Lebedeva, C D ^a   Sandakhchiev, L S ^a  

^a STATE RESEARCH CENTER OF VIROLOGY AND BIOTECHNOLOGY VECTOR   (Russian Federation)

Author keywords

Artificial protein; Epitope; HIV 1; Immunogenicity; Phage; Vaccine; VEE; Virus

Indexed keywords

ANTIGEN-ANTIBODY REACTIONS; BACTERIOPHAGES; COLIFORM BACTERIA; IMMUNOLOGY; VIRUSES;

ARTIFICIAL PROTEIN; CELLULAR IMMUNE RESPONSE; EPITOPES; HUMORAL IMMUNE RESPONSE; IMMUNOGENICITY; IMMUNOGENS; MOLECULAR VACCINES;

VACCINES;

ANTIGEN; EPITOPE; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; VACCINE;

CONFERENCE PAPER; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOGENICITY; MOLECULAR CLONING; MOLECULAR GENETICS; NONHUMAN; PRIORITY JOURNAL; SAFETY;

EID: 0030023740     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/0168-1656(95)00089-5     Document Type: Conference Paper

References (25)

1. Agapov, E.V., Razumov, I.A., Frolov, I.V., Kolykhalov, A.A., Netesov, S.V. and Loktev, V.B. (1994) Localization of four antigenic sites involved in Venezuelan equine encephalomyelitis virus protection. Arch. Virol. 139, 173-181.
2. Ahlers, J.D., Pendleton, C.D., Dunlop, N., Minassian, A., Nara, P.L. and Berzofsky, J.A, (1993) Construction of an HIV-1 peptide vaccine containing a multideterminant helper peptide linked to a V3 loop peptide 18 inducing strong neutralizing antibody responses in mice of multiple MHC haplotypes after two immunizations. J. Immunol. 150, 5647-5665.
3. Borisova, G., Arya, B., Dislers, A., Borschukova, O., Tsibinogin, V., Skrastina, D., Eldarov, M.A., Pumpens, P., Skryabin, K.G. and Gren E. (1993) Hybrid hepatitis B virus nucleocapsid bearing an immunodominant region from hepatitis B virus surface antigen. J. Virol. 67, 3696-3701.
4. Borras-Cuesta, F., Petit-Camurdon, A. and Fedon, Y. (1987) Engineering of immunogenic peptides by co-linear synthesis of determinants recognized by B and T cells. Eur. J. Immunol. 17, 1213-1215.
5. Broekhuijsen, M.P., Van Rijn, J.M.M., Pouwels, P.H., Enger-Valk, B.E., Brown, F. and Francis, M.J. (1987) Fusion protein and multiple copies of major antigenic determinant of foot-and-month disease virus protect both the natural host and laboratory animal. J. Gen. Virol. 68, 3137-3143.
6. Brown, J.H., Jardetzky, T.S., Gorga, J.C., Stern, L.J., Urban, R.G., Strominger, J.L. and Wiley, D.C. (1993) Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1. Nature (Lond.) 364, 33-39.
7. Clerici, M., Stocks, N.I., Zajac, R.A., Boswell, R.N., Bernstein, D.C., Mann, D.L., Shearer, G.M. and Berzofsky, J.A.(1989) Interleukin-2 production used to detect antigenic peptide recognition by T-helper lymphocytes from asymptomatic HIV-seropositive individuals. Nature (Lond.) 339, 883-385.
8. Copelan, E.A., Rinehardt, J.J. and Lewis, M. (1983) The mechanism of retrovirus suppression of human T cell proliferation in vitro. J. Immunol. 131, 2017-2020.
9. DeGrado, W.F., Wasserman, Z.R. and Lear, J.D. (1989) Protein design, a minimalist approach. Science 243, 622-628.
10. Delpeyroux, F., Chenciner, N., Lim, A., Malpiece, Y., Blondel, B., Graime, R., Van der Werf, S. and Streeck, R.E. (1986) A poliovirus neutralization epitope expressed on hybrid Hepatitis B surface antigen particles. Science 233, 472-474.
11. Douillard, J.Y. and Hoffmann, T. (1984) Enzyme-linked immunosorbent assay for screening monoclonal antibody production using enzyme-labelled second antibody. In: Langone, J.J. and Vunakis, H.P. (Eds.), Methods of Enzymology 92, pp. 168-174.
12. Eroshkin, A.M., Zhilkin, P.A., Shamin, V.V., Korolev, S.V. and Fedorov, B.B. (1993) Artificial protein vaccines with predetermined tertiary structure: application to anti-HIV-1 vaccine design. Protein Eng. 6, 997-1001.
13. Eroshkin, A.M., Karginova, E.A., Gileva ,I.P., Lomakin, A.S., Lebedev, L.R., Kamyinina, T.P., Pereboev, A.V. and Ignat'ev, G.M. (1995) Design of four-helix bunble protein as a candidate for HIV-1 vaccine. Protein Eng. 8, 167-173.
14. Fritz, H.I. (1988) In: Glover, D. (Ed.), DNA Cloning Methods. Mir, Moscow, pp. 191-229 (in Russian).
15. Ilyichev, A.A., Minenkova, O.O., Kishchenko, G.P., Tat'kov, S.I., Kapryshev, N.N., Eroshkin, A.M., Ofizerov, V.I., Akimenko, V.A., Petrenko, V.A. and Sandakhchiev, L.S. (1992) Inserting foreign peptides into the major coat protein of bacteriophage M13. FEBS Lett. 301, 322-324.
16. Margalit, H., Spouge, J.L., Cornette, J.L., Cease, K.B., Delisi, C. and Berzofsky, J.A. (1987) Prediction of immunodominant helper T cell antigenic sites from the primary sequence. J. Immunol. 138, 2213-2229.
17. Minenkova, O.O., Ilyichev, A.A., Kishchenko, G.P. and Petrenko, V.A. (1993) Design of spesific immunogens using filamentous phage as carrier. Gene 128, 85-88.
18. Palker, T.J.J. (1989) Polyvalent human immunodeficiency virus synthetic immunogen comprised of envelope gp120 T helper cell sites and B cell neutralization epitopes. Immunology 142, 3612-3619.
19. Papsidero, L.D., Sheu, M. and Ruscetti, F.M. (1989) HIV-1 type 1-neutralizing antibodies which react with p17 core protein: characterization and epitope mapping. J. Virol. 63, 267-272.
20. Parmley, S.F. and Smith, G.P. (1988) Antibody-selected filamentous fd phage vectors: affinity purification of target genes. Gene 73, 305-318.
21. Pereboev, A.V., Agapov, E.V., Svyatchenko, V.A., Razumov, I.A., Protopopova, E.V. and Loktev, V.B. (1993) Investigation of antigenic structure of eastern equine encephalomyelitis virus by means of monoclonal antibodies. Vopr. Virusol. 38, 117-122 (in Russian).
22. Razumov, I.A., Agapov, E.V., Pereboev, A.V., Protopopova, E.V., Lebedeva, S.D. and Loktev, V.B. (1991) Study of the antigenic structure of Venezuelan equine encephalomyelitis virus glycoprotein E2 using rat monoclonal antibodies. Vopr. Virusol. 36, 34-37 (in Russian).
23. Richardson, J.S. and Richardson, D.C. (1989) The de novo design of protein structures. Trends Biochem. Sci. 14, 304-309.
24. Steward, M.W. and Howard, C.R. (1985) The potential of synthetic peptides for vaccines. Med. Lab. Sci. 42, 376-387.
25. Tindle, R.W., Herd, K., Londono, P., Fernando, G.J.P., Chatfield, S.N., Malcolm, K. and Dougan, G. (1994) Chimeric hepatitis B core antigen particles containing B- and T-epitopes of human papilloma virus type 16 E7 protein induce specific antibody and T-helper responses in immunised mice. Virology 200, 547-557.