Dietary cholesterol enhances impaired endothelium-dependent relaxations in aortas of salt-induced hypertensive Dahl rats

European Journal of Pharmacology

Volumn 297, Issue 1-2, 1996, Pages 71-76

  Kitagawa, Satomi ^a   Yamaguchi, Yu ^a   Shinozuka, Kazumasa ^a   Kwon, Young Mi ^a   Kunitomo, Masaru ^a  

^a Mukogawa Women's University   (Japan)

Author keywords

Dahl salt sensitive rat; Endothelium dependent relaxation; High cholesterol diet; Hypercholesterolemia; Hypertension

Indexed keywords

ACETYLCHOLINE; CALCIMYCIN; CHOLESTEROL; CHOLESTEROL ESTER; NITROPRUSSIDE SODIUM; NORADRENALIN; PAPAVERINE; SODIUM CHLORIDE; VASOACTIVE AGENT;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL REACTIVITY; CHOLESTEROL DIET; CONCENTRATION RESPONSE; CONTROLLED STUDY; HYPERCHOLESTEROLEMIA; HYPERTENSION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE RELAXATION; THORACIC AORTA; VASCULAR ENDOTHELIUM;

EID: 0030023698     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(95)00729-6     Document Type: Article

References (27)

1. Boegehold, M.A., 1992, Reduced influence of nitric oxide on arteriolar tone in hypertensive Dahl rats, Hypertension 19, 290.
2. Dahl, L.K., K.D. Knudsen, M.A. Heine and G.J. Leitl, 1968, Effects of chronic excess salt ingestion. Modification of experimental hypertension in the rat by variations in the diet, Circ. Res. 22, 11.
3. Freiman, P.C., G.G. Mitchell, D.D. Heistad, M.L. Armstrong and D.G. Harrison, 1986, Atherosclerosis impairs endothelium-dependent vascular relaxation to acetylcholine and thrombin in primates, Circ. Res. 58, 783.
4. Fukushima, H., S. Aono and H. Nakatani, 1968, Effect of N-(α-methylbenzyl)linoleamide on lipid levels of plasma and liver in cholesterol-fed rats, J. Nutr. 96, 15.
5. Hayashi, T., T. Ishikawa, M. Naito, M. Kuzuya, C. Funaki, K. Asai, H. Hidaka and F. Kuzuya, 1991, Low level hyperlipidemia impairs endothelium-dependent relaxation of porcine coronary arteries by two mechanisms. Functional change in endothelium and impairment of endothelium-dependent relaxation by two mediators, Atherosclerosis 87, 23.
6. Hogan, J.C., M.J. Lewis and A.H. Henderson, 1988, In vivo EDRF activity influences platelet function, Br. J. Pharmacol. 94, 1020.
7. Jayakody, R.L., M.P.J. Senaratne, A.B.R. Thomson and C.T. Kappagoda, 1985, Cholesterol feeding impairs endothelium-dependent relaxation of rabbit aorta, Can. J. Physiol. Pharmacol. 63, 1206.
8. 2 may be the endothelium-derived contracting factor released by acetylcholine in the aorta of the rat, Hypertension 15, 475.
9. Kitagawa, S., Y. Yamaguchi, M. Kunitomo, N. Imaizumi and M. Fujiwara, 1992, Impairment of endothelium-dependent relaxation in aorta from rats with arteriosclerosis induced by excess vitamin D and a high-cholesterol diet, Jpn. J. Pharmacol. 59, 339.
10. Konishi, M. and C. Su, 1983, Role of endothelium in dilator responses of spontaneously hypertensive rat arteries, Hypertension 5, 881.
11. Kubes, P., M. Suzuki and D.N. Granger, 1991, Nitric oxide: An endogenous modulator of leukocyte adhesion, Proc. Natl. Acad. Sci. USA 88, 4651.
12. Kunitomo, M., Y. Yamaguchi, K. Matsushima and Y. Bando, 1984, Cholesterol metabolism in serum and aorta of inbred mice fed a high-cholesterol diet, Jpn. J. Pharmacol. 34, 153.
13. Kunitomo, M., Y. Yamaguchi, K. Matsushima, Y. Futagawa and Y. Bando, 1985, Hyperlipidemic effects of adriamycin in rats, Jpn. J. Pharmacol. 39, 323.
14. Limas, C., B. Westrum, C.J. Limas and J.N. Cohn, 1980, Effect of salt on vascular lesions of spontaneously hypertensive rats, Hypertension 2, 477.
15. Limas, C., B. Westrum, J. Iwai and C.J. Limas, 1982, Aortic morphology in salt-dependent genetic hypertension, Am. J. Pathol. 107, 378.
16. Lüscher, T.F. and P.M. Vanhoutte, 1986, Endothelium-dependent contractions to acetylcholine in the aorta of the spontaneously hypertensive rat, Hypertension 8, 344.
17. Lüscher, T.F., L. Raij and P.M. Vanhoutte, 1987, Endothelium-dependent vascular responses in normotensive and hypertensive Dahl rats, Hypertension 9, 157.
18. Mori, H., K. Ishiguro and H. Okuyama, 1993, Hypertension in rats does not potentiate hypercholesterolemia and aortic cholesterol deposition induced by a hypercholesterolemic diet, Lipids 28, 109.
19. Nicholls, M.G., 1984, Reduction of dietary sodium in Western society, Hypertension 6, 795.
20. O'Donnell, M.P., B.L. Kasiske and W.F. Keane, 1989, Risk factors for glomerular injury in rats with genetic hypertension, Am. J. Hypertens. 2, 9.
21. Scott-Burden, T., V.B. Schini, E. Elizondo, D.C. Junquero and P.M. Vanhoutte, 1992, Platelet-derived growth factor suppresses and fibroblast growth factor enhances cytokine-induced production of nitric oxide by cultured smooth muscle cells. Effects on cell proliferation, Circ. Res. 71, 1088.
22. Van de Voorde, J. and I. Leusen, 1986, Endothelium-dependent and independent relaxation of aortic rings from hypertensive rats, Am. J. Physiol. 250, H711.
23. Vanhoutte, P.M., 1989, Endothelium and control of vascular function. State of the art lecture, Hypertension 13, 658.
24. Verbeuren, T.J., F.H. Jordaens, L.L. Zonnekeyn, C.E. Van Hove, M.-C. Coene and A.G. Herman, 1986, Effect of hypercholesterolemia on vascular reactivity in the rabbit. I. Endothelium-dependent and endothelium-independent contractions and relaxations in isolated arteries of control and hypercholesterolemic rabbits, Circ. Res. 58, 552.
25. Verbeuren, T.J., F.H. Jordaens, C.E. Van Hove, A.-E. Van Hoydonck and A.G. Herman, 1990, Release and vascular activity of endothelium-derived relaxing factor in atherosclerotic rabbit aorta, Eur. J. Pharmacol. 191, 173.
26. Yamaguchi, Y., S. Kitagawa, Y. Kwon, K. Shinozuka and M. Kunitomo, 1995, Different cholesterol deposition in aorta of Dahl salt-sensitive rats and spontaneously hypertensive rats fed a high-cholesterol diet, Clin. Exp. Pharmacol. Physiol. (in press).
27. Yu, S.-M., Z.-S. Huang, C.-Y. Wang and C.-M. Teng, 1993, Effects of hyperlipidemia on the vascular reactivity in the Wistar-Kyoto and spontaneously hypertensive rats, Eur. J. Pharmacol. 248, 289.