Influence of administration of long-chain polyunsaturated fatty acids on process of histological recovery in liver cirrhosis produced by oral intake of thioacetamide

Digestive Diseases and Sciences

Volumn 41, Issue 1, 1996, Pages 197-207

  Fernández, Isabel ^a   Torres, Isabel ^b   Moreira, Eliane ^b   Fontana, Luis ^b   Gil, Angel ^b   Rios, Antonio ^b  

^a UNIVERSITY OF GRANADA   (Spain)

^b NONE

Author keywords

Dietary supplementation; Liver cirrhosis; PUFAs; Thioacetamide

Indexed keywords

POLYUNSATURATED FATTY ACID; THIOACETAMIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; ELECTRON MICROSCOPY; FEMALE; HISTOLOGY; LIVER CIRRHOSIS; LIVER REGENERATION; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT;

ANIMALS; DIETARY FATS, UNSATURATED; FATTY ACIDS, OMEGA-3; FATTY ACIDS, OMEGA-6; FATTY ACIDS, UNSATURATED; FEMALE; LIPIDS; LIVER; LIVER CIRRHOSIS, EXPERIMENTAL; RATS; RATS, WISTAR; THIOACETAMIDE;

EID: 0030022511     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02208605     Document Type: Article

References (38)

1. Arias MA, Boyer JL, Fausto N, Jakoby WB, Schachter DA, Shafritz DA: The Liver: Biology and Pathobiology. New York, Raven Press, 1994
2. Kretzschmar M, Machnik G, Müller A, Splinter F-K, Zimmermann T, Klinger W: Experimental treatment of thioacetamide-induced liver cirrhosis by metenolone acetate. A morphological and biochemical study. Exp Pathol 42:37-46, 1991
3. Bergasa NV, Borque MJ, Wahl LM, Rabin L, Jones EA: Modulation on thioacetamide-induced hepatocellular necrosis by prostaglandins is associated with novel histologic changes. Liver 12:168-174. 1992
4. Dyrotf MC, Neal RA: Identification of the major protein adduct formed in rat liver after thioacetamide administration. Cancer Res 41:3430-3435, 1981
5. Trennery PN, Waring RH: Early changes in thioacetamide-induced liver damage. Toxicol Lett 19:299-307, 1983
6. Anghileri LJ, Heidbreder M, Weiler G, Dermietzel R: Hepatocarcinogenesis by thioacetamide: Correlations of histological and biochemical changes, and possible role of cell injury. Exp Cell Biol 45:34-47, 1977
7. Becker FF: Thioacetamide hepatocarcinogenesis. J Natl Cancer Inst 71:553-558, 1983
8. Dasgupta A, Chatterjee R, Chowdhury JR: Thioacetamide-induced hepatocarcinoma in rats. Oncology 38:249-253, 1981
9. Gupta DN: Production of cancer of the bile ducts with thioacetamide. Nature 175:257, 1955
10. Müller D, Sommer M, Kretzschmar M, Zimmermann T, Buko VU, Lukivskaya OJ, Dargel R: Lipids peroxidation in thioacetamide-induced macronodular rat liver cirrhosis. Arch Toxicol 65:199-203, 1991
11. Nozu F, Takeyama N, Tanaka T: Changes of hepatic fatty acid metabolism produced by chronic thioacetamide administration in rats. Hepatology 15:1099-1106, 1992
12. Zimmermann T, Franke H, Dargel R: Studies on lipid and lipoprotein metabolism in rat liver cirrhosis induced by different regimens of thioacetamide administration. Exp Pathol 30:109-117, 1986
13. Zimmermann T, Müller A, Machnik G, Franke H, Schubert H, Dargel R: Biochemical and morphological studies on production and regression of experimental liver cirrhosis induced by thioacetamide in Uje: WIST rats. Z Versuchstierkd 30:165-180, 1987
14. Cabré E, Periago JL, Abad-Lacruz A, Gil A, González-Huix F, Sánchez de Medina F, Gassull MA: Polyunsaturated fatty acid deficiency in liver cirrhosis: Its relation to associated protein-energy malnutrition (preliminary report). Am J Gastroenterol 83:712-717, 1988
15. Cabré E, Periago JL, Abad-Lacruz A, et al: Plasma fatty acid profile in advanced cirrhosis: Unsaturation deficit of lipid fractions. Am J Gastroenterol 85:1597-1604, 1990
16. Cabré E, Periago JL, González J, González-Huix F, Abad-Lacruz A, Gil A, Sánchez-Medina F, Esteve-Comas M, Fernández-Bañares F, Planas R, Gassull MA: Plasma polyunsaturated fatty acids in liver cirrhosis with or without chronic hepatic encephalopathy: A preliminary study. JPEN 16:359-363, 1992
17. Latifi R, Killam RW, Dudrick SJ: Nutritional support in liver failure. Surg Clin North Am 1991:71:567-578, 1991
18. Müller MJ, Rieger A, Willmann O: Metabolic responses to lipid infusions in patients with liver cirrhosis. Clin Nutr 11: 193-206, 1992
19. Christon R, Fernandez Y, Linard A, Périquet A, Deltour P, Mitjavila S: Diet-induced structural and functional modifications in the pig liver endoplasmic reticulum membrane: effect of polyunsaturated fatty acid deficiency. J Nutr Biochem 3:510-518, 1992
20. Moreira E, Fontana L, Periago JL, Sánchez de Medina F, Gil A: Changes in fatty acid composition of plasma, liver microsomes and erythrocytes in liver cirrhosis induced by microsomes and erythrocytes in liver cirrhosis induced by oral intake of thioacetamide in rats. Hepatology 21:199-206, 1995
21. Council of Europe: European convention for the protection of vertebrate animals used for experimental and other scientific purposes. Addendum III. Strasbourg, 1982
22. Philipp BW, Shapiro DJ: Improved methods for the assay and activation of 3-hydroxy-3-methylglutamy-Co A reductase. J Lipid Res 20:583-593, 1979
23. Folch J, Less M, Sloane-Stanley GH: A single methods for the isolation and purification of total lipids from animal tissues. J Biochem 226:497-503, 1957
24. Skipski WP, Barclay M: Thin layer chromatography of lipids. In Methods in Enzymology. JM Lowenstein (ed). New York, Academic Press, 1969, pp 530-598
25. Morrison MR, Smith LN: Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron fluoride methanol. J Lipid Res 5:600-607, 1968
26. Reynolds ES: The use of lead citrate at high PH as an electron-opaque stain in electron microscopy. J Cell Biol 17:208-212, 1963
27. Dixon WJ, Brown MB, Engelman L, Jennrich RI: BMDP Statistical Software Manual. Berkeley, University of California Press, 1990
28. Popper H: Pathological aspects of cirrhosis. Am J Pathol 87:228-257, 1977
29. Moshage H, Yap S-H: Molecular and cellular biology of the liver. Curr Opin Gastroenterol 9:367-373, 1993
30. Bissel DM: Lipocyte activation and hepatic fibrosis. Gastroenterology 102:1803-1804, 1992
31. Franke H, Zimmermann T, Dargel R: Changes in intra- and extrahepatic VLDL in the rat following acute injury by thioacetamide. Virchows Arch (Cell Pathol) 48:277-288, 1985
32. Muscaritoli M, Cangiano C, Cascino A, Ceci F, Caputo V, Martino P, Serra P, Fanelli FR: Exogenous lipid clearance in compensated liver cirrhosis. JPEN 10:599-603, 1986
33. Nassar BA, Das UN, Huang Y-S, Ells G, Horrobin DF: The effect of chemical hepatocarcinogenesis on liver phospholipid composition in rats fed n-6 and n-3 fatty acid-supplemented diets. Chem Hepatocarcinogen 199:365-368, 1992
34. Gonzalez J, Periago JL, Gil A, Cabré E, Abad-Lacruz A, Gassull MA, Sánchez de Medina F: Malnutrition-related polyunsaturated fatty acid changes in plasma lipid fractions of cirrhotic patients. Metabolism 41:954-960, 1992
35. Franke H, Zimmermann T, Dargel R: Qualitative and quantitative changes in hepatic lipoprotein particles following acute injury of the rat liver induced by thioacetamide. Virchows Arch (Cell Pathol) 44:99-113, 1983
36. Yamazaki RK, Shen T, Schade GB: A diet rich in (n-3) fatty acids increased peroxisomal beta-oxidation activity and lowers plasma triacylglycerols without inhibiting glutathione-dependent detoxication activities in the rat liver. Biochim Biophys Acta 920:62-67, 1987
37. Herzberg GR: Dietary regulation of fatty acid and triglyceride metabolism. Can J Physiol Pharmacol 69:1637-1647, 1991
38. Lieber CS, Robin SJ, Li J, De Carli LM, Mak KM, Fasulo JM, Leo MA: Phosphatidyl choline protects against fibrosis and cirrhosis in the baboon. Gastroenterology 106:152-159, 1994