Prolonged expression of the c-kit receptor in germ cells of intersex fetal testes

Journal of Pathology

Volumn 178, Issue 2, 1996, Pages 166-169

  Rajpert De Meyts, Ewa ^a   Jørgensen, Niels ^a   Müller, Jørn ^a   Skakkebæk, Niels E ^a  

^a University of Copenhagen   (Denmark)

Author keywords

c kit; Gonadal dysgenesis; Sex differentiation; Testicular development; Testicular neoplasms

Indexed keywords

STEM CELL FACTOR;

ARTICLE; CLINICAL ARTICLE; FETUS; GERM CELL TUMOR; GONADAL DYSGENESIS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; PROTO ONCOGENE; SEX CHROMOSOME MOSAICISM; SEX DIFFERENTIATION DISORDER;

GESTATIONAL AGE; GONADAL DYSGENESIS; HERMAPHRODITISM; HUMANS; IMMUNOENZYME TECHNIQUES; MALE; MOSAICISM; PILOT PROJECTS; PROTO-ONCOGENE PROTEINS C-KIT; SEX DIFFERENTIATION DISORDERS; TESTICULAR NEOPLASMS; TESTIS;

EID: 0030022440     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9896(199602)178:2<166::AID-PATH436>3.0.CO;2-2     Document Type: Article

References (21)

1. Schellhas HF. Malignant potential of the dysgenetic gonad. Obstet Gynecol 1974; 44: 298-309, 455-462.
2. Scully RE. Neoplasia associated with anomalous sexual development and abnormal sex chromosomes. Pediatr Adolesc Endocrinol 1981, 8: 203-217.
3. Savage MO, Lowe DG Gonadal neoplasia and abnormal sexual differentiation Clin Endocrinol 1990, 32: 519-533.
4. Berkowitz GD Abnormalities of gonadal determination and differentiation Sem Perinatol 1992, 16: 289-298.
5. Skakkebæk NE, Berthelsen JG, Giwercman A, Muller J. Carcinoma-in-situ of the testis possible origin from gonocytes and precursor of all types of germ cell tumours except spermatocytoma. Int J Androl 1987; 10: 19-28
6. Müller J, Skakkebæk NE, Ritzén M, Ploen L, Petersen KE. Carcinoma in situ of the testis in children with 45,X/46,XY gonadal dysgenesis. J Pediatr 1985, 106: 431-436.
7. Wallace TM, Levin HS Mixed gonadal dysgenesis. A review of 15 patients reporting single cases of malignant intratubular germ cell neoplasia of the testis, endometrial adenocarcinoma, and a complex vascular anomaly. Arch Pathol Lab Med 1990, 114: 679-688.
8. Ramani P, Yeung CK, Habeebu SSM Testicular intratubular germ cell neoplasia in children and adolescents with intersex. Am J Surg Pathol 1993, 17: 1124-1133.
9. Giwercman A. Carcinoma-in-situ of the testis screening and management. Scand J Urol Nephrol 1992; Suppl 148.
10. Jørgensen N, Rajpert-De Meyts E, Græm N, Müller J, Giwercman A, Skakkebæk NE. Expression of immunohistochemical markers for testicular carcinoma in situ by normal human fetal germ cells. Lab Invest 1995; 72: 223-231
11. Strohmeyer T, Peter S, Hartmann M, et al. Expression of the hst-1 and c-kit protooncogenes in human testicular germ cell tumours. Cancer Res 1991; 51: 1811-1816.
12. Rajpert-De Meyts E, Skakkebæk NE. Expression of the c-kit product in carcinoma-in-situ and invasive testicular germ cell tumours. Int J Androl 1994; 17: 85-92.
13. Coulombre JL, Russell ES. Analysis of the pieiotropism at the W locus in the mouse. The effect of W and W substitution upon postnatal development of germ cells. J Exp Zool 1954, 126: 277-295.
14. Nishimune Y, Haneji T, Kitamura Y The effects of Steel mutations on testicular germ cell differentiation. J Cell Physiol 1980, 105: 137-141.
15. f testes. Development 1992, 114: 861-867.
16. Yarden Y, Kuang W-J, Yang-Feng T, et al. Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand. EMBO J 1987; 6: 3341-3351
17. Manova K, Bachvarova RF. Expression of c-kit encoded at the W locus of mice in developing embryonic germ cells and presumptive melanoblasts. Dev Biol 1991; 146: 312-324.
18. Sell S, Pierce B. Maturation arrest of stem cell differentiation is a common pathway for the cellular origin of teratocarcinomas and epithelial cancers Lab Invest 1994; 70: 6-22.
19. Dolci S, Wiliams DE, Ernst MK, et al Requirement for mast cell growth factor for primordial germ cell survival in culture. Nature 1991; 352: 809-811.
20. Godin I, Deed R, Cooke J, Zsebo K, Dexter M, Wyllie CC Effects of the Steel gene product on mouse primordial germ cell in culture. Nature 1991; 352: 807-809.
21. Iemura A, Tsai M, Ando A, Wershil BK, Galli SJ The c-kit ligand, stem cell factor, promotes mast cell survival by suppressing apoptosis. Am J Pathol 1994; 144: 321-328.