Multiple B- and T-cell epitopes on a major allergen of Kentucky Bluegrass pollen

Immunology

Volumn 87, Issue 2, 1996, Pages 283-290

  Zhang, L ^c   Yang, M ^a   Chong, P ^b   Mohapatra, S S ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

^b Department of Protein Engineering   (Canada)

^c HEALTH CANADA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; EPITOPE; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; POLLEN ANTIGEN; SYNTHETIC PEPTIDE;

ALLERGY; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; CELL PROLIFERATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; MONONUCLEAR CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 0030022439     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.1996.467533.x     Document Type: Article

References (37)

1. MOHAPATRA S.S. & SEHON A.H. (1992) Therapeutic potential of recombinant allergens. Int Arch Allergy Immunol 99, 265.
2. MOHAPATRA S.S. (1992) Diagnosis and therapy of IgE mediated allergies with recombinant allergens: Poa pratensis IX as a model. In: Advances in Treatment of Allergic Diseases (ed. M. Debelic), pp. 4-15. Pharmacia Allergy Research Foundation, Uppsala.
3. ATASSI M.Z., RUAN K.H., JINNAI K., OSHIMA M. & ASHIZAWA T. (1992) Epitope-specific suppression of antibody response in experimental autoimmune myasthenia gravis by a monomethoxy-polyethelene glycol conjugate of myasthenogenic synthetic peptide. Proc Natl Acad Sci USA 89, 5852.
4. ASHBRIDGE K.R., BACKSTROM B.T., LIU H.X. et al. (1992) Mapping of T helper cell epitopes by using peptides spanning the 19KDa protein of Mycobacterium tuberculosis. Evidence for unique and shared epitopes in the stimulation of antibody and delayed-type hypersensitivity responses. J Immunol 148, 2248.
5. EVAVOLD B.D. & ALLEN P.M. (1991) Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand. Science 252, 1308.
6. EVAVOLD B.D., WILLIAMS S.G., HSU B.L., BUUS S. & ALLEN P.M. (1992) Complete dissection of the Hb(64-76) determinant using T helper 1, T helper 2 clones, and T cell hybridomas. J Immunol 148, 347.
7. O'HEHIR R.E. & LAMB J.R. (1990) Immunomodulation of cellular responses to house dust mite using non-stimulatory peptides. J Allergy Clin Immunol 85, 200.
8. BENJAMIN D.C., BERZOFSKY J.A., EAST I.J. et al. (1984) The antigenic structure of proteins: a reappraisal. Annu Rev Immunol 2, 67.
9. KING T.P. (1976) Chemical and biological properties of some atopic allergens. Adv Immunol 23, 77.
10. LOMBARDERO M., HEYMANN P.W., PLATTS-MILLS T.A.E., FOX J.W. & CHAPMAN M.D. (1990) Conformational stability of B cell epitopes on group I and group II Dermatophagoides spp. allergens. Effect of thermal and chemical denaturation on the binding of murine IgG and human IgE antibodies. J Immunol 144, 1353.
11. NILSEN B.M., SLETTEN K, Paulsen B.S., O'NEILL M. & HALBEEK H.V. (1991) Structural analysis of the glycoprotein allergen Art v II from the pollen of mugwort (Artemisia vulgaris L.). J Biol Chem 266, 2660.
12. POLO F., AYUSO R. & CARREIRA J. (1991) Studies on the relationship between structure and IgE-binding ability of Parietaria judaica allergen I. Mol Immunol 28, 169.
13. BRAMUCCI M., ROLL D., COOK R. & DURBAN E. (1989) Identification of consensus epitope structures expressed in recombinant DNA libraries. Mol Immunol 26, 741.
14. ATASSI H. & ATASSI M.Z. (1986) Antibody recognition of ragweed allergen Ra3: localization of the full profile of the continuous antigenic sites by synthetic overlapping peptides representing the entire protein chain. Eur J Immunol 16, 229.
15. STEWART G.A., ARMSTRONG L., KRSKA K. et al. (1990) Epitope mapping analysis of the major mite allergens using synthetic peptides. In: Epitopes of A topic Allergens (ed. A.H. Sehon, D. Kraft & G. Kunkel), p. 41. The UCB Institute of Allergy, Brussels.
16. ELSAYED S. & APOLD J. (1983) Immunochemical analysis of cod fish allergen M: locations of the immunoglobulin binding sites as demonstrated by native and synthetic peptides. Allergy 38, 449.
17. MAZUR G., STEIGEMANN W. & BAUR X. (1990) Chironomid allergens: location of B-and T-cell epitopes in the 3-D structure. In: Epitopes of A topic Allergens (eds. A.H. Schon, D. Kraft & G. Kunkel), p. 48. The UCB Institute of Allergy, Brussels.
18. WALSH B.J. & HOWDEN M.E.H. (1989) A method for detection of IgE binding sequences of allergens based a modification of epitope mapping. J Immunol Meth 121, 275.
19. COFFMAN R.L., SEYMOUR B.W., LEBMAN D.A. et al. (1988) The role of helper T cell products in mouse B cell differentiation and isotype regulation. Immunol Rev 102, 5.
20. FINKELMAN F.D., KATONA I.M., MOSMANN T.R. & COFFMAN R.L. (1988) Interferon-γ regulates the isotypes of immunoglobulin secreted during in vivo humoral immune responses. J Immunol 140, 1022.
21. STEVENS T.L., BOSSOE A., SANDERS V.M. et al. (1988) Regulation of antibody isotype secretion by subsets of antigen-specific helper T cells. Nature 334, 255.
22. BRINER T., KUO M.C., KEATING K.M. & ROGERS B.L. (1993) Peripheral T-cell tolerance induced in naive and primed mice by subcutaneous injection of peptides from the major cat allergen Feld I. Proc Natl Acad Sci USA 90, 7608.
23. MOHAPATRA S.S., HILL R.D. & SEHON A.H. (1990) Complementary DNA cloning, expression in E. coli and IgE epitope mapping of a Poa p allergen. In: Epitopes of Atopic Allergens (eds A.H. Schon, D. Kraft & G. Kunkel), p. 61. The UCB Institute of Allergy, Brussels.
24. MOHAPATRA S.S., HILL R.D. & SEHON A.H. (1990) Molecular cloning of grass pollen allergens; progress and perspectives. Aerobiologia 6, 205.
25. ZHANG L., OLSEN E., KISIL F.T. et al. (1992) Mapping of antibody binding epitopes of a recombinant Poa p IX allergen. Mol Immunol 29, 1383.
26. SILVANOVICH A., ASTWOOD J., ZHANG L. et al. (1991) Nucleotide sequence analysis of three cDNAs for Poa p IX isoallergens of Kentucky bluegrass pollen. J Biol Chem 266, 1204.
27. MERRIFIELD R.B. (1969) Solid phase peptide synthesis. Adv Enzymol 32, 221.
28. ZHANG L., KISIL F.T., SEHON A. & MOHAPATRA S.S. (1992) Induction of IgE antibodies in mice with recombinant grass pollen antigens. Immunology 76, 158.
29. KOLBE L., HEUSSER C.H. & KOLSCH E. (1995) Isotype-associated recognition of allergen epitopes and its modulation by antigen dose. Immunology 84, 285.
30. VAN DER STOEP N., VAN DER LINDEN J. & LOGTENBERG T. (1993) Molecular evolution of the human immunoglobulm E response: high incidence of shared mutations and clonal relatedness among epsilon VH5 transcripts from three unrelated patients with atopic dermatitis. J Exp Med 177, 99.
31. LERNER R.A. (1982) Tapping the immunological repertoire to produce antibodies of predetermined specificity. Nature 299, 592.
32. BABBIT B.P., ALLEN P.M., MATSUEDA G., HABER E. & UNANUE E.R. (1985) Binding of immunogenic peptides to Ia histocompatibility molecules. Nature 317, 359.
33. GUILLET J.G., LAI M.Z., BRINER T.J. et al. (1987) Immunological self, nonself discrimination. Science 235, 865.
34. LECLERC C., PEZEWLOCKI G., SCHUTZE M.P. & CHEDID L. (1987) A synthetic vaccine constructed by co-polymerization of B and T cell determinants. Eur J Immunol 17, 269.
35. GREEN N., ALEXANDER H., OLSON A. et al. (1982) Immunogenic structure of the influenza virus hemagglutinin. Cell 28, 477.
36. FRANCIS M.J., HASTINGS G.Z., SYRED A.D., MCGINN B., BROWN F. & ROWLANDS D.J. (1987) Nonresponsiveness to a foot and mouth disease virus peptide overcome by addition of foreign helper T cell determinants. Nature 330, 168.
37. EBNER C., SZEPFALUSI Z., FERREIRA F. et al. (1993) Identification of multiple T cell epitopes on Bet VI, the major birch pollen allergen, using specific T cell clones and overlapping peptides. J Immunol 150, 1047.