Obese pigs fed a high cholesterol diet from birth to 2 months are less susceptible than lean pigs to atherosclerosis

Journal of Nutrition

Volumn 126, Issue 2, 1996, Pages 564-573

  Hackman, Anne M ^b   Pond, Wilson G ^a   Mersmann, Harry J ^a   Wong, William W ^b   Krook, Lennart P ^c   Zhang, Shide ^b  

^a U S DEPARTMENT OF AGRICULTURE   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c Department of Molecular Biology and Genetics   (United States)

Author keywords

atherosclerosis; cholesterol; infant; obesity; pigs

Indexed keywords

CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; CHOLESTEROL METABOLISM; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; GENETIC SUSCEPTIBILITY; LEAN BODY WEIGHT; LIVER MICROSOME; MALE; NEWBORN; NONHUMAN; OBESITY; SWINE;

EID: 0030022010     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/126.2.564     Document Type: Article

References (23)

1. Berenson, G. S., Wattigney, W. A., Tracy, R. E., Newman, W. P., III, Srinivasan, S. R., Webber, L. S., Dalferes, E. R., Jr. & Strong, J. P. (1992) Atherosclerosis of the aorta and coronary arteries and cardiovascular risk factors in persons aged 6 to 30 years and studied at necropsy (The Bogalusa Heart Study). Am. J. Cardiol. 70: 851-858.
2. Black, D. D. & Davidson, N. O. (1989) Intestinal apolipoprotein synthesis and secretion in the suckling pig. J. Lipid Res. 30: 207-218.
3. BMDP (1990) 2V Analysis of Variance and Covariance with Repeated Measures (Dixon, W. J., ed.). BMDP Statistical Software, Inc., Los Angeles, CA.
4. Brown, M. S., Goldstein, J. L. & Dietsch, J. M. (1979) Active and inactive forms of 3-hydroxy-3-methylglutaryl coenzyme A reductase in the liver of the rat. J. Biol. Chem. 254: 5144-5149.
5. Castelli, W. P., Doyle, J. T., Gordon, T., Hames, C. G., Hjortland, M. C., Hulley, S. B., Kagan, A. & Zukel, W. J. (1977) HDL cholesterol and other lipids in coronary heart disease. The cooperative lipoprotein phenotyping study. Circulation 55: 767-772.
6. Fall, C. H. D., Barker, D. J. P., Osmond, C., Winter, P. D., Clark, P. M. S. & Hales, C. N. (1992) Rektion of infant feeding to adult serum cholesterol concentration and death from ischaemic heart disease. Br. Med. J. 304: 801-805.
7. Freedman, D. S., Srinivasan, S. R. & Cresanta, J. L. (1987) Serum lipids and lipoproteins. Pediatrics 80: 789-796.
8. Goff, D. C., Jr., Shekelle, R. B., Katan, M. B., Gotto, A. M., Jr. & Stamler, J. (1992) Does body fatness modify the association between dietary cholesterol and risk of coronary death? Arterioscler. Thromb. 12: 755-761.
9. Hetzer, H. O. &. Harvey, W. R. (1967) Selection for high and low fatness in swine. J. Anim. Sci. 26: 1244-1251.
10. Holman, R. L., McGill, H. C., Jr., Strong, J. P. &. Geer, J. C. (1958) The natural history of atherosclerosis: the early aortic lesions as seen in New Orleans in the middle of the 20th century. Am. J. Pathol. 34: 209-235.
11. Kartnel, W. B., Castelli, W. P. & Gordon, T. (1979) Cholesterol in the prediction of atherosclerotic disease. New perspectives based on the Framingham study. Ann. Intern. Med. 90: 85-91.
12. Mahley, R. W. (1979) Dietary fat, cholesterol and accelerated atherosclerosis. Atherosclerosis Rev. 5: 1-34.
13. Mersmann, H. J. (1991) Characteristics of obese and lean swine. In: Swine Nutrition (Miller, E. R., Ullrey, D. E. & Lewis, A. J., eds.), pp. 75-86. Butterworth-Heineman, Stoneham, MA.
14. Milliken, G. A. & Johnson, D. E. (1987) Analysis of Messy Data, vol. 1, p. 31. Van Nostrand Reinhold Co., NY.
15. National Cholesterol Education Program (1992) Report of the expert panel on blood cholesterol levels in children and adolescents. Pediatrics 89: 525-584.
16. Newman, W. P., III, Freedman, D. S., Voors, A. W., Gard, P. D., Srinivasan, S. R., Cresanta, J. L., Williamson, G. D., Webber, L. S. & Berensen, G. S. (1986) Relation of serum lipoproteins and systolic blood pressure to early atherosclerosis: The Bogalusa Heart Study. N. Engl. J. Med. 314: 138-144.
17. Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group (1990) Relationship of atherosclerosis in young men to serum lipoprotein cholesterol concentrations and smoking. J. Am. Med. Assoc. 264: 3018-3024.
18. Patterson, B. W., Wong, W. W., Sheng, H.-P., Mersmann, H. J., Insull, W., Klein, P. J., Fiorotto, M. L. & Pond, W. G. (1992) Neonatal genetically lean and obese pigs respond differently to dietary cholesterol. J. Nutr. 122: 1830-1839.
19. Pond, W. G. (1982) Nutrition and heart disease: the pig as an experimental model. In: Pig Model for Biomedical Research (Roberts, H. R. &. Dodds, W. J., eds.), pp. 43-59. Pig Research Institute, Miaoli, Taiwan.
20. Pond, W. G., Mersmann, H. J. & Yen, J. T. (1985) Effect of obesity per se on plasma lipid and aortic responses to diet in swine. Proc. Soc. Exp. Biol. Med. 179: 90-95.
21. 2O: a rapid procedure for isolation, combustion, and isotopic assay of erythrocyte cholesterol. J. Lipid Res. 32: 1049-1056.
22. Wong, W. W., Hachey, D. L., Insull, W., Opekun, A. R. &. Klein, P. D. (1993) Effect of dietary cholesterol on cholesterol synthesis in breast-fed and formula-fed infants. J. Lipid Res. 34: 1403-1411.
23. Wong, W. W., Lee, L. S. & Klein, P. D. (1987) Deuterium and oxygen-18 measurements on microliter samples of urine, plasma, saliva and human milk. Am. J. Clin. Nutr. 45: 905-913.