The cocaine-like behavioral effects of meperidine are mediated by activity at the dopamine transporter

European Journal of Pharmacology

Volumn 297, Issue 1-2, 1996, Pages 9-17

  Izenwasser, Sari ^a   Newman, Amy Hauck ^a   Cox, Brian M ^b   Katz, Jonathan L ^a  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^b UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

Author keywords

Cocaine; Dopamine transporter; Meperidine

Indexed keywords

3BETA (4 FLUOROPHENYL) 2BETA TROPANECARBOXYLIC ACID METHYL ESTER; COCAINE; DOPAMINE; DOPAMINE TRANSPORTER; MORPHINE; NALTREXONE; OPIATE AGONIST; PETHIDINE; RADIOLIGAND;

AMINE TRANSPORT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BEHAVIOR; BINDING AFFINITY; BINDING COMPETITION; CAUDATE NUCLEUS; CONTROLLED STUDY; DISCRIMINATIVE STIMULUS; DOPAMINE UPTAKE; DRUG MECHANISM; INTRAMUSCULAR DRUG ADMINISTRATION; LIGAND BINDING; MALE; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PUTAMEN; RAT; SQUIRREL MONKEY;

EID: 0030021764     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(95)00696-6     Document Type: Article

References (44)

1. Andrews, H.L., 1942, Cortical effects of demerol, J. Pharmacol. Exp. Ther. 76, 89.
2. Barrett, J.E., 1974, Effects of alcohol, chlordiazepoxide, cocaine, and pentobarbital on responding maintained under fixed-interval schedules of food or shock presentation, J. Pharmacol. Exp. Ther. 196, 605.
3. Bertalmio, A.J. and J.H. Woods, 1992, Discriminative stimulus effects of cyclorphan: selective antagonism with naltrexone, Psychopharmacology 106, 189.
4. 3H]dopamine uptake is similar in both the rat striatum and nucleus accumbens, Eur. J. Pharmacol. 173, 215.
5. Boja, J.W., F.I. Carrol, M.A. Rahman, A. Philip, A.H. Lewin and M.J. Kuhar, 1990, New, potent cocaine analogs: ligand binding and transport studies in rat striatum, Eur. J. Pharmacol. 184, 329.
6. Carlsson, A. and M. Lindquist, 1969, Central and peripheral monoaminergic membrane-pump blockade by some addictive analgesics and antihistamines, J. Pharm. Pharmacol. 21, 460.
7. Carroll, F.I., A.H. Lewin, J.W. Boja and M.J. Kuhar, 1992, Cocaine receptor: biochemical characterization and structure-activity relationships of cocaine analogues at the dopamine transporter, J. Med. Chem. 35, 969.
8. Cook, L., J.F. McElroy and K.W. Rohrbach, 1992, DUP 734 differentially antagonizes the locomotor effects of cocaine, d-amphetamine and apomorphine in mice and rats, Soc. Neurosci. Abstr. 18, 230.
9. Cox, B.M. and M. Weinstock, 1964, Quantitative studies of the antagonism by nalorphine of some of the actions of morphine-like analgesic drugs, Br. J. Pharmacol. 22, 289.
10. Fahim, I., M. Ismail and O.H. Osman, 1972, The role of 5-hydroxytryptamine and noradrenaline in the hyperthermic reaction induced by pethidine in rabbits pretreated with pargyline, Br. J. Pharmacol. 46, 416.
11. Gilbert, P.E. and W.R. Martin, 1975, Antagonism of the convulsant effects of heroin, d-propoxyphene, meperidine, normeperidine and thebaine by naloxone in mice, J. Pharmacol. Exp. Ther. 192, 538.
12. Glennon, R.A. and I. Lucki, 1988, Behavioral Models of Serotonin Receptor Activation (Humana Press, Clifton, NJ) p. 253.
13. Goldberg, S.R., W.H. Morse and D.M. Goldberg, 1981, Acute and chronic effects of naltrexone and naloxone on schedule-controlled behavior of squirrel monkeys and pigeons, J. Pharmacol. Exp. Ther. 216, 500.
14. Hake, D.F. and N.H. Azrin, 1963, An apparatus for delivering pain shock to monkeys, J. Exp. Anal. Behav. 6, 297.
15. Himmelsbach, C.K., 1942, Studies of the addiction liability of 'demerol', J. Pharmacol. Exp. Ther. 75, 64.
16. Himmelsbach, C.K., 1943, Further studies of the addiction liability of demerol, J. Pharmacol. Exp. Ther. 79, 5.
17. Huggins, R.A., W.G. Glass and A.R. Bryan, 1950, Protective action of n-allyl-normorphine against respiratory depression produced by some compounds related to morphine, Proc. Soc. Exp. Biol. Med. 75, 540.
18. Isbell, H., 1955, Withdrawal symptoms in 'primary' meperidine addicts, Fed. Proc. 14.
19. Izenwasser, S., L.L. Werling and B.M. Cox, 1990, Comparison of the effects of cocaine and other inhibitors of dopamine uptake in rat striatum, nucleus accumbens, olfactory tubercle, and medial prefrontal cortex, Brain Res. 520, 303.
20. 3H]serotonin uptake by cocaine: comparison between chopped tissue slices and synaptosomes, Life Sci. 50, 541.
21. Izenwasser, S., A.H. Newman and J.L. Katz, 1993a, Cocaine and several sigma receptor ligands inhibit dopamine uptake in rat caudate-putamen, Eur. J. Pharmacol. 243, 201.
22. Izenwasser, S., J.G. Rosenberger and B.M. Cox, 1993b, The cocaine analog WIN 35,428 binds to two sites in fresh rat caudate-putamen: significance of assay procedures, Life Sci./Pharmacol. Lett. 52, PL 141.
23. Izenwasser, S., P. Terry, B. Heller, J.M. Witkin and J.L. Katz, 1994, Differential relationships among dopamine transporter affinities and stimulant potencies of various uptake inhibitors, Eur. J. Pharmacol. 263, 277.
24. Jasinski, D.R. and J.G. Nutt, 1973, Progress report on the clinical assessment program of the Addiction Research Center, Proceedings of the 35th Meeting, Committee on Problems of Drug Dependence (National Academy of Sciences, National Research Council, Chapel Hill, NC) p. 108.
25. Jasinski, D.R. and K.L. Preston, 1986, Evaluation of tilidine for morphine-like subjective effects and euphoria, Drug Alcohol Depend. 18, 273.
26. Kelkar, S.V., S. Izenwasser, J.L. Katz, C.L. Klein, N. Zhu and M.L. Trudell, 1994, Synthesis, cocaine receptor affinity, and dopamine uptake inhibition of several new 2β-substituted-3β-phenyltropanes, J. Med. Chem. 37, 3875.
27. Kelleher, R.T., C.A. Gill, W.C. Riddle and L. Cook, 1963, On the use of the squirrel monkey in behavioral and pharmacological experiments, J. Exp. Anal. Behav. 6, 249.
28. Kozikowski, A.P., M. Roberti, L. Xiang, J.S. Bergmann, P.M. Callahan, K.A. Cunningham and K.M. Johnson, 1992, Structure-activity relationship studies of cocaine: replacement of the C-2 ester group by vinyl argues against H-bonding and provides an esterase-resistant, high affinity cocaine analogue, J. Med. Chem. 35, 4764.
29. Leander, J.D., 1978, Comparing the effects of anileridine, alphaprodine and fentanyl on schedule-controlled responding by pigeons, J. Pharmacol. Exp. Ther. 206, 624.
30. Leander, J.D. and D.E. McMillan, 1977, Meperidine effects on schedule-controlled responding, J. Pharmacol. Exp. Ther. 201, 434.
31. 3H]Cocaine binding sites in caudate-putamen, J. Pharmacol. Exp. Ther. 251, 131.
32. 3H]2β-carbomethoxy-3β-(4-fluorophenyl)tropane, Mol. Pharmacol. 36, 518.
33. Martin, W.R. and J.W. Sloan, 1977, Neuropharmacology and neurochemistry of subjective effects, analgesia, tolerance and dependence produced by narcotic analgesics, in: Drug Addiction I (Springer-Verlag, Berlin) p. 43.
34. Menkel, M., P. Terry, M. Pontecorvo, J.L. Katz and J.M. Witkin, 1991, Selective sigma ligands block stimulant effects of cocaine, Eur. J. Pharmacol. 201, 251.
35. Miller, J.W. and H.H. Anderson, 1954, The effect of n-demethylization on certain pharmacologic actions of morphine, codeine, and meperidine in the mouse, J. Pharmacol. Exp. Ther. 112, 191.
36. Munson, P.J. and D. Rodbard, 1980, LIGAND: a versatile approach for characterization of ligand-binding systems, Anal. Biochem. 107, 220.
37. Peterson, G.L., 1977, A simplification of the protein assay method of Lowry et al., which is more generally applicable, Anal. Biochem. 83, 346.
38. Polonio, P. and M.B. Lisbon, 1947, Pethidine addiction, Lancet 592.
39. Ritz, M.C., R.J. Lamb, S.R. Goldberg and M.J. Kuhar, 1987, Cocaine receptors on dopamine transporters are related to self-administration of cocaine, Science 237, 1219.
40. Winter, C.A. and L. Flataker, 1956, Effect of N-allylnormorphine upon massive doses of narcotic drugs, Proc. Soc. Exp. Biol. Med. 93, 158.
41. Witkin, J.M. and J.B. Acri, 1995, Effects of ifenprodil on stimulatory, discriminative stimulus, and convulsant effects of cocaine, Behav. Pharmacol. (in press).
42. Witkin, J.M., J.D. Leander and L.A. Dykstra, 1983, Modification of behavioral effects of morphine, meperidine and normeperidine by naloxone and by morphine tolerance, J. Pharmacol. Exp. Ther. 225, 275.
43. Witkin, J.M., P. Terry, P. Hickey, M. Pontecorvo, J. Ferkany and J.L. Katz, 1993, Effects of the selective sigma receptor ligand, 6-[6-(4-hydroxypiperidinyl)hexyloxyl]-3-methylflavone (NPC 16377), on behavioral and toxic effects of cocaine, J. Pharmacol. Exp. Ther. 266, 473.
44. Zacny, J.P., J.L. Lichtor, W. Binstock, D.W. Coalson, T. Cutter, D.C. Flemming and B. Glosten, 1993, Subjective, behavioral and physiological responses to intravenous meperidine in healthy volunteers, Psychopharmacology 111, 306.