Endotoxin inhibits catabolism of low density lipoproteins in vivo: An experimental study in the rat

Scandinavian Journal of Clinical and Laboratory Investigation

Volumn 56, Issue 1, 1996, Pages 53-61

  Xu, N ^a   Nilsson, A ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Endotoxin; In vivo; Lipoproteins; Metabolism

Indexed keywords

ENDOTOXIN; LOW DENSITY LIPOPROTEIN; TRIACYLGLYCEROL;

ANIMAL MODEL; ARTICLE; BLOOD ANALYSIS; CONTROLLED STUDY; HYPERLIPIDEMIA; ISOTOPE LABELING; LIPID METABOLISM; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALIA;

EID: 0030020686     PISSN: 00365513     EISSN: None     Source Type: Journal    
DOI: 10.1080/00365519609088588     Document Type: Article

References (28)

1. Kaufmann RL, Matson CF, Beisel WR. Hypertriglyceridemia produced by endotoxin: role of impaired triglyceride disposal mechanisms. J Infect Dis 1976; 113: 548-55.
2. Gallin JI, Kaye D, O'Leary WM. Serum lipid in infection. N Engl J Med 1969; 281: 1081-6.
3. Kaufmann RL, Matson CF, Rowberg AH, Beisel WR. Defective lipid disposal mechanisms during infections in rhesus monkeys. Metabolism 1976; 25: 615-24.
4. Rouzer CA, Cerami A. Hypertriglyceridemia associated with trypansoma brucei infection in rabbits: role of defective triglyceride removal. Mol Biochem Parasitol 1980; 2: 31-8.
5. Wolfe RR, Shaw JHF, Durkot MJ. Effect of sepsis on VLDL kinetics: responses in basal state and during glucose infusion. Am J Physiol 1985; 248: E732-E40.
6. Alvarez C, Ramos A. Lipids, lipoproteins, and apoproteins in serum during infection. Clin Chem 1986; 32: 142-5.
7. Sakaguchi S. Metabolic disorders of serum lipoproteins in endotoxin-poisoned mice: the role of high density lipoprotein (HDL) and triglyceride-rich lipoproteins. Microbiol Immunol 1982; 26: 101-34.
8. Sakaguchi O, Sakaguchi S. Alterations of lipid metabolism in mice injected with endotoxin. Microbiol Immunol 1979; 23: 71-85.
9. Bagby GJ, Spitzer JA. Lipoprotein lipase activity in rat heart and adipose tissue during endotoxin shock. Am J Physiol 1980; 238: H325-30.
10. Badby GJ, Corell CB, Martinez RR. Triglycerol kinetics in endotoxic rats with suppressed lipoprotein lipase activity. Am J Physiol 1987; 253: E59-64.
11. Feingold KR, Staprans I, Memon RA, Moser AH, Shigenaga JK, Doerrler W, et al. Endotoxin rapidly induces changes in lipid metabolism that produce hypertriglyceridemia: low doses stimulate hepatic triglyceride production while high doses inhibit clearance. J Lipid Res 1992; 33: 1765-76.
12. Schmahl FW, Wabnitz RW, Rox G, Drysch K, Richardt G, Poetter E. Effects of gabexate mesilate on the reactions of lipid metabolism in endotoxin shock. Adv Shock Res 1983; 9: 43-7.
13. Victorov AV, Gladkaya EM, Navikov DK, Kosykh VA, Yurkiv VA. Lipopolysaccharide toxin can directly stimulate the intracellular accumulation of lipids and their secretion into medium in the primary culture of rabbit hepatocytes. FEBS Lett 1989; 256: 155-8.
14. Freingold KR, Soued M, Adi S, Staprans I, Shigenaga J, Doerrler W, et al. Tumor necrosis factor-induced hepatic very-low-density lipoportein production and increased serum triglyceride levels in diabetic rats. Diabetes 1990; 39: 1569-74.
15. Spooner CE, Markowitz NP, Saravolatz LO. The role of tumor necrosis factor in sepsis. Clin Immunol Immunopathol 1992; 62: 811-7.
16. Alexander HR, Doherty GM, Buresh CM, Venzon DJ, Norton JA. A recombinant human receptor antogonist to interleukin-1 improves survival after lethal endotoxemia in mice. J Exp Med 1991; 173: 1029-32.
17. Liao W, Floren C-H. Endotoxin inhibit endocytotic catabolism of low-density lipoproteins in Hep G2 cells. Hepatology 1992; 16: 224-31.
18. Havel RJ, Eder HA, Bragdon JH. The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J Clin Invest 1955; 34: 1345-53.
19. Fraker PJ, Speck JC. Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphenylglycol uril. Biochem Biophys Res Commun 1978; 80: 849-57.
20. Bierman RL, Stein O, Stein Y. Lipoprotein uptake and metabolism by aortic smooth muscle cells in tissue culture. Circ Res 1974; 35: 136-50.
21. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurements with folin phenol reagent. J Biol Chem 1951; 193: 265-75.
22. Liao W, Florén C-H. Both polysaccharide and lipid A parts of endotoxins are needed for the inhibitory effects of endotoxins on cellular LDL uptake. Scand J Clin Lab Invest 1992; 52: 183-8.
23. Liao W, Florén C-H. Tumor necrosis factor upregulates expression of low density lipoprotein receptor on Hep G2 cells. Hepatology 1993; 17: 898-907.
24. Liu J, Shoyab M, Grove RI. Induction of Egr-1 by oncostatin M precedes up-regulation of low density lipoprotein receptors in Hep G2. Cell Growth Differ 1993; 4: 611-6.
25. Stopeck AT, Nicholson AC, Mancini FP, Hajjar DP. Cytokine regulation of low density lipoprotein receptor gene transcription in Hep G2 cells. J Biol Chem 1993; 268: 17489-94.
26. Cannon JG, Tompkins RG, Gelfand JA, Michie HR, Stanford GG, van der Meer JWM, et al. Circulating interleukin-1 and tumor necrosis factor in septic shock and experimental endotoxin fever. J Infect Dis 1990; 161: 79-84.
27. Martich GD, Danner RL, Ceska M, Suffredini AF. Detection of interleukin-8 and tumor necrosis factor in normal humans after intravenous endotoxin: the effect of antiinflammatary agents. J Exp Med 1991; 173: 1021-4.
28. Michie HR, Manogue KR, Spriggs DR, Revhaug A, O'Dwyer S, Dinarello CA, et al. Detection of circulating tumor necrosis factor after endotoxin administration. N Engl J Med 1988; 318: 1481-6.