Inhibition of prostanoid formation in intact cells by 2,5-di-(tert-butyl)-1,4-benzohydroquinone, a blocker of Ca2+-ATPases

British Journal of Pharmacology

Volumn 117, Issue 3, 1996, Pages 540-544

  Leis, Hans J ^a   Zach, Doris ^a   Huber, Evelyn ^a   Ziermann, Laszlo ^a   Gleispach, Helmut ^a   Windischhofer, W ^a  

^a ST ANNA CHILDREN S HOSPITAL   (Austria)

Author keywords

BHQ; Cyclo oxygenase; Prostaglandins; Thromboxane

Indexed keywords

1,4 BENZOQUINONE DERIVATIVE; 12 HYDROXYICOSATETRAENOIC ACID; 2,5 DI TERT BUTYLHYDROQUINONE; ADENOSINE TRIPHOSPHATASE (CALCIUM); ARACHIDONIC ACID; BRADYKININ; CALCIMYCIN; ENZYME INHIBITOR; MELITTIN; PROSTACYCLIN; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; PROSTANOID; THAPSIGARGIN; THROMBOXANE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; ENDOPLASMIC RETICULUM; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; THROMBOCYTE;

ARACHIDONIC ACID; BLOOD PLATELETS; BRADYKININ; CALCIMYCIN; CALCIUM-TRANSPORTING ATPASES; CELL LINE; CYCLOOXYGENASE INHIBITORS; ENZYME INHIBITORS; HUMANS; IMIDAZOLES; IONOPHORES; PLATELET AGGREGATION INHIBITORS; PROSTAGLANDINS; THAPSIGARGIN;

EID: 0030020253     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15224.x     Document Type: Article

References (22)

1. BERRIDGE, M.J. (1987). Inositol triphosphate and diacylglycerol: two interacting second messengers. Annu. Rev. Biochem., 56, 159-193.
2. BERRIDGE, M.J. & IRVINE, R.F. (1984). Inositol triphosphate, a novel second messenger in cellular signal transduction. Nature, 312, 315-321.
3. 2+ pools. J. Biol. Chem., 266, 13646-13653.
4. 2+ pool. J. Biol. Chem., 264, 15192-15198.
5. KODAMA, H., AMAGAI, Y., SUDO, S., KASAI, S. & YAMAMOTO, S. (1981). Establishment of a clonal osteogenic cell line from newborn mouse calvaria. Jpn. J. Oral. Biol., 23, 899-901.
6. LEIS, H.J., HOHENESTER, E., GLEISPACH, H., MALLE, E. & MAYER, B. (1987a). Measurement of prostaglandins, thromboxanes and hydroxy fatty acids by stable isotope dilution gas chromatography/mass spectrometry. Biomed. Environ. Mass Spectrom., 14, 617-621.
7. LEIS, H.J., MALLE, E., MAYER, B. KOSTNER, G.M., ESTERBAUER, H. & GLEISPACH, H. (1987b). Quantitative measurement of 5-, 12-, and 15-hydroxyeicosatetraenoic acid by stable isotype dilution gas chromatography-negative ion chemical ionization mass spectrometry. Anal. Biochem., 162, 337-344.
8. 18O-labelled standards of hydroxy-eicosatetraenoic acids and thromboxanes for quantitative measurement by gas chromatography/ mass spectrometry. Biomed. Environ. Mass Spectrom., 13, 483-488.
9. 2+ sensing by the osteoblast-like cell line, MC3T3-E1. Cell Calcium, 15, 447-456.
10. LEIS, H.J., ZACH, D., HUBER, E., ZIERMANN, L., GLEISPACH, H. & WINDISCHHOFER, W. (1995). On the inhibition of prostanoid formation by SK&F 96365, a blocker of receptor-operated calcium entry. Br. J. Pharmacol., 114, 598-601.
11. MALCOLM, K.C. & FITZPATRICK, F.A. (1992). Indirect actions of thapsigargin on human platelets: activation of eicosanoid biosynthesis and cellular signalling pathways. J. Pharmacol. Exp. Ther., 260, 1244-1249.
12. MALLE, E., NIMPF, J., LEIS, H.J., WURM, H., GLEISPACH, H. & KOSTNER, G.M. (1987). Cyclooxygenase and lipoxygenase metabolites during platelet aggregation: quantitative measurement by negative ion chemical ionization - gas chromatography/ mass spectrometry. Prost. Leukotr. Med., 27, 53-70.
13. 2+ transport pathways in thymic lymphocytes by econazole, miconazole, and SK&F 96365. Am. J. Physiol., 264, C654-C662.
14. MAYER, B., MOSER, R., LEIS, H.J. & GLEISPACH, H. (1986). Rapid separation of arachidonic acid metabolites by silicic acid chromatography for subsequent quantitative analysis by gas chromatography-mass spectrometry. J. Chromatogr., 378, 430-436.
15. MERRITT, J.E., ARMSTRONG, W.P., BENHAM, C.D., HALLAM, T.J., JACOB, R.J., JAXA-CHAMIEC, A., LEIGH, B.K., MCCARTHY, S.A., MOORES, K.F., & RINK, T.J. (1990). SK&F, 96365, a novel inhibitor of receptor-mediated calcium entry. Biochem. J., 271, 515-522.
16. 2+ sequestration. FEBS Lett., 224, 331-336.
17. MUSTARD, J.F., KINLOUGH-RATHBONE, R.L. & PACKHAM, M.A. (1989). Isolution of human platelets from plasma by centrifugation and washing. In Methods in Enzymology, Vol. 169, ed. J. Hawinger, pp. 3-11. New York: Academic Press.
18. OHUCHI, K., TAKAHASHI, C., HIRASAWA, N., WATANABE, M., FUJIKI, H. & TSURU-FUJI, S. (1989). Stimulation of histamine release and arachidonic acid metabolism in rat peritoneal mast cells by thapsigargin, a non-TPA-type tumor promoter. Biochim. Biophys. Acta, 1003, 9-14.
19. 2+, cAMP, and phospholipid-derived messengers in coupling mechanisms of insulin secretion. Physiol. Rev., 67, 1185-1248.
20. RANA, R.S. & HOKIN, L.E. (1990). Role of phosphoinositides in transmembrane signalling. Physiol. Rev., 70, 115-164.
21. 2+ stores by specific inhibition of the endoplasmic reticulum. Proc. Natl. Acad. Sci. U.S.A., 87, 2466-2470.
22. 2+-ATPase. FEBS Lett., 304, 109-113.