Interleukin 1α and γ-interferon induction of nitric oxide production from murine tumor-derived endothelial cells

Cancer Research

Volumn 56, Issue 4, 1996, Pages 886-891

  Chang, Ming Jei ^a,b   Modzelewski, Ruth A ^a   Russell, Derick M ^a   Johnson, Candace S ^a,b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 1ALPHA; NITRIC OXIDE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BRAIN; CANCER; ENZYME INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; VASCULAR ENDOTHELIUM; YOLK SAC;

ANIMALS; ARGININE; DRUG INTERACTIONS; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; FEMALE; FIBROSARCOMA; INTERFERON-GAMMA, RECOMBINANT; INTERLEUKIN-1; KINETICS; MALE; MICE; MICE, INBRED C3H; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITROARGININE; OMEGA-N-METHYLARGININE; RECOMBINANT PROTEINS; TIME FACTORS;

EID: 0030020159     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Hibbs, J. B. Synthesis of nitric oxide from L-arginine: a recently discovered pathway induced by cytokines with antitumour and antimicrobial activity. Res. Immunol., 142: 565-569, 1991.
2. Nathan, C., and Xie, Q. Nitric oxide synthases: roles, tolls, and controls. Cell, 78: 915-918, 1994.
3. Knowles, R. G., and Moncada, S. Nitric oxide synthases in mammals. Biochem. J., 298: 249-258, 1994.
4. Moncada, S. D., and Higgs, A. The L-arginine-nitric oxide pathway. N. Engl J. Med., 329: 2002-2112, 1993.
5. Schmidt, H. H., and Walter, U. NO at work. Cell, 78: 919-925, 1994
6. Maragos, C. M., Wang, J M., Hrabie, J. A , Oppenheim, J. J., and Keefer, L. K. Nitric oxide/nucleophile complexes inhibit the in vitro proliferation of A375 melanoma cells via nitric oxide release Cancer Res., 53: 564-568, 1993.
7. Li, L., Kilbourn, R G., Adams, J., and Fidler, I. J Role of nitric oxide in lysis of tumor cells by cytokine-activated endothelial cells. Cancer Res., 51: 2531-2535, 1991
8. Hibbs, J. B., Jr, Taintor, R R., Vavrin, Z., and Rachlin, E. M. Nitric oxide: a cytotoxic activated macrophage effector molecule. Biochem. Biophys. Res. Commun , 157 87-94, 1988.
9. Stuehr, D. J., and Nathan, C. F Nitric oxide: a macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells. J. Exp. Med., 169: 1543-1555, 1989.
10. G-vitro-L-arginine. Cancer Res., 54 6458-6463, 1994
11. Radomski, M W , Jenkins, D. C., Holmes, L., and Moncada, S. Human colorectal adenocarcinoma cells: differential nitric oxide synthesis determines their ability to aggregate platelets. Cancer Res., 51: 6073-6078, 1991
12. Andrade, S., Hart, I , and Piper, P. Inhibitors of nitric oxide synthase selectively reduce flow in tumor-associated neovasculature Br J. Pharmacol., 107: 1092-1095, 1992.
13. Maeda, H , Noguchi, Y., Sato, K., and Akaike, T. Enhanced vascular permeability in solid tumor is mediated by nitric oxide and inhibited by both new nitric oxide scavenger and nitric oxide synthase inhibitor. Jpn J. Cancer Res., 85: 331-334, 1994.
14. Kubes, P., and Granger, D. Nitric oxide modulates microvascular permeability. Am J. Physiol., 262: 611-615, 1992.
15. ω-amino-L-arginine. J. Natl. Cancer Inst., 84: 1008-1016, 1992
16. Kilbourn, R G., and Belloni, P Endothelial cell production of nitrogen oxides in response to interferon γ in combination with tumor necrosis factor, interleukin-1, or endotoxin. J Natl. Cancer Inst., 82: 772-776, 1990.
17. Fast, D. J., Lynch, R. C , and Leu, R. W. Nitric oxide production by rumor targets in response to TNF: paradoxical correlation with susceptibility to TNF-mediated cytotoxicity without direct involvement in the cytotoxic mechanism J. Leuk. Biol , 52 255-261, 1992.
18. Perrella, M A., Yoshizumi, M , Fen, Z., Tsai, J-C., Hsieh, C-M., Kourembanas, S , and Lee, M-E. Transforming growth factor-β1, but not dexamethasone, down-regulates nitric-oxide synthase mRNA after its induction by interleukin-1β in rat smooth muscle cells. J. Biol. Chem., 269: 14595-14600, 1994.
19. Munoz-Fernandez, M., and Fresno, M Involvement of nitric oxide on the cytokine induced growth of glial cell. Biochem. Biophys. Res. Commun., 194. 319-325, 1993.
20. Braunschweiger, P. G., Johnson, C. S , Kumar, N., Ord, V., and Furmanski, P. Antitumor effects of recombinant human interleukin-1α in RIF-1 and Panc02 solid tumors. Cancer Res., 48. 6011-6016, 1988.
21. Johnson, C. S., Chang, M-J., Braunschweiger, P. G , and Furmanski, P. Acute hemorrhagic necrosis of tumor induced by interleukin-1α: effects independent of tumor necrosis factor. J. Natl. Cancer Inst., 12: 842-848, 1990.
22. 31P-nuclear magnetic resonance studies of the effect of recombinant human interleukin-1α on the bioenergetics of RIF-1 tumors. Cancer Res , 49: 6379-6382, 1989.
23. Johnson, C S. Interleukin-1: therapeutic potential for solid tumors. Cancer Invest., 11: 600-608, 1993.
24. Braunschweiger, P. G., Johnson, C. S., Kumar, N , Ord, V., and Furmanski, P. The effect of adrenalectomy and dexamethasone on interleukin-1α induced responses in RIF-1 tumours. Br. J. Cancer, 61: 9-13, 1990.
25. Braunschweiger, P. G., Kumar, N , Constantinidis, I., Wehrle, J. P., Glickson, J. D., Johnson, C. S., and Furmanski, F Potentiation of interleukin 1α mediated antitumor effects by ketoconazole. Cancer Res., 50. 4709-4717, 1990.
26. Modzelewski, R. A., Davies, P., Watkins, S. C., Auerbach, R., Chang, M-J , and Johnson, C. S. Isolation and identification of fresh tumor-derived endothelial cells from a murine RIF-1 fibrosarcoma Cancer Res., 54: 336-339, 1994.
27. Twentyman, P. R., Brown, J. M , Gray, J. W., Frank, A. J., Scloes, M. A., and Kallman, R. F. A new mouse tumor model system (RIF-1) for comparison of end-point studies. J. Natl. Cancer Inst., 64: 595-604, 1980.
28. Zetter, B. R. Culture of capillary endothelial cells. In: E. A. Jaffe (ed.), Biology of Endothelial Cells, pp. 14-26. Boston Martinus Nijhoff, 1984.
29. Wang, S-J., Greer, P , and Auerbach, R. Characterization of an endothelial cell line established from yolk sacs of transgenic mice carrying an activated fps/fes allele. FASEB J., 8: 419, 1994.
30. Folkman, J , Handenschild, C. C., and Zetter, B. R. Long-term culture of capillary endothelial cells. Proc. Natl. Acad. Sci. USA, 76: 5217-5221, 1979.
31. 15N] nitrate in biological fluids. Anal. Biochem., 126: 131-138, 1982
32. North, R. J., Neubauer, R. H., Huang, J J., Newton, R C., and Loveless, S E. Interleukin 1-induced T cell-mediated regression of immunogenic murine tumors: requirement for an adequate level of already acquired host concomitant immunity. J. Exp. Med., 168: 2031-2043, 1988.
33. Le, J., and Vilcek, J. Tumor necrosis factor and interleukin 1: cytokines with multiple overlapping biological activities. Lab. Invest., 56: 234-248, 1987.
34. Fidler, I. J., and Lieber, S. Quantitative analysis of the mechanism of glucocorticoid enhancement of experimental metastasis. Res. Commun. Chem. Pathol. Pharmacol., 4: 607-613, 1972.
35. Marumo, T., Nakaki, T., Nagata, K., Miyata, M., Adachi, H., Esumi, H., Suzuki, H , Saruta, T., and Kato, R. Dexamethasone inhibits nitric oxide synthase mRNA induction by interleukin-1α and tumor necrosis factor-α in vascular smooth muscle cells. Japan. J. Pharmacol., 63: 361-367, 1993.
36. Johnson, C S., Chang, M-J., Yu, W-D., Modzelewski, R A , Grandis, J. R., Vlock, D. R., and Furmanski, P. Synergistic enhancement by interleukin-1α of cisplatin-mediated antitumor activity in RIF-1 tumor-bearing C3H/HeJ mice. Cancer Chemother. Pharmacol., 32: 339-346, 1993.
37. Chang, M-J., Yu, W-D., Reyno, L. M., Modzelewski, R. A., Egorin, M. J., Erkmen, K., Vlock, D R., Furmanski, P., and Johnson, C. S. Potentiation by interleukin 1α of cisplatin and carboplatin antitumor activity: schedule-dependent and pharmacokinetic effects in the RIF-1 tumor model. Cancer Res., 54: 5380-5386, 1994.
38. Geller, D. A., Nussler, A. K., Di Silvio, M., Lowenstein, C. J , Shapiro, R. A., Wang, S. C., Simmons, R. L., and Billiar, T. R. Cytokines, endotoxin, and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes. Proc. Natl. Acad. Sci. USA, 90: 522-526, 1993.
39. Lepoivre, M., Fieschi, F., Coves, J., Thelander, L., and Fontecave, M. Inactivation of ribonucleotide reductase by nitric oxide. Biochem Biophys. Res Commun., 179. 442-448, 1991.
40. Kwon, N. S , Stuehr, D. J., and Nathan, C. F. Inhibition of tumor cell ribonucleotide reductase by macrophage-derived nitric oxide. J. Exp. Med., 174: 761-767, 1991.
41. Hibbs, J. B., Jr , Taintor, R. R., and Vavrin, Z. Macrophage cytotoxicity: role for L-arginine deiminase and imino nitrogen oxidation to nitrite. Science (Washington DC), 235: 473-476, 1987
42. Reif, D. W., and Simmons, R. D Nitric oxide mediates iron release from ferritin. Arch. Biochem. Biophys., 283. 537-541, 1990.
43. Ngyuen, T., Brunson, D., Crespi, C. L., Penman, B. W., Wishnok, J S., and Tannenbaum, S. R DNA damage and mutation in human cells exposed to nitric oxide in vitro. Proc Natl. Acad. Sci. USA, 89: 3030-3034, 1992.
44. Buttery, L. D., Springall, D. R , Andrade, S. S., Riveros-Moreno, V , Hart, I., Piper, P. J., and Polak, J. M. Induction of nitric oxide synthase in the neo-vasculature of experimental tumours in mice. J. Pathol., 171: 311-319, 1993.
45. Dvorak, H. F., Nagy, J. A , Dvorak, J T., and Dvorak, A. M. Identification and characterization of the blood vessels of solid rumors that are leaky to circulating macromolecules. Am. J. Pathol., 133: 95-109, 1988.
46. Besedovsky, H. O., Del Rey, A., Sorkin, E., and Dinarello, C. A. Immunoregulatory feedback between interleukin-1 and glucocorticoid hormones. Science (Washington DC), 233: 652-654, 1986.
47. Radomski, M., Palmer, R., and Moncada, S. Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells. Proc. Natl. Acad. Sci. USA, 87: 10043-10047, 1990.
48. Jenkins, D. C., Charles, I. G , Thomsen, L. L., Moss, D. W., Holmes, L. S., Baylis, S. A., Rhodes, P., Westmore, K., Emson, P. C., and Moncada, S Roles of nitric oxide in tumor growth. Proc. Natl. Acad. Sci USA, 92: 4392-4396, 1995.