Benzylphosphonic acid inhibitors of human prostatic acid phosphatase

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 3, 1996, Pages 311-314

  Schwender, Charles F ^a   Beers, Scott A ^a   Malloy, Elizabeth A ^a   Cinicola, Jacqueline J ^a   Wustrow, David J ^a   Demarest, Keith D ^a   Jordan, Jerold ^a  

^a R W JOHNSON PHARMACEUTICAL RES I   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 TRIFLUOROMETHYLBENZHYDRYLPHOSPHONIC ACID; ACID PHOSPHATASE; ACID PHOSPHATASE INHIBITOR; ALPHA (2 PHENYLETHYL)BENZYLPHOSPHONIC ACID; BENZYLPHOSPHONIC ACID DERIVATIVE; ENZYME INHIBITOR; PHOSPHONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN TISSUE; MALE; PROSTATE; STRUCTURE ACTIVITY RELATION;

EID: 0030019955     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0960-894X(96)00018-2     Document Type: Article

References (13)

1. Future correspondence should be directed to the author at his present address: LeukoSite, Inc., 215 First Street, Cambridge, MA 02142.
2. Zhang, Z-Y.; Maclean, D.; McNamara, J.; Sawyer, T. K.; and Dixon, J. E., Biochem. 1994, 33, 2285.
3. Watanabe, H.; Nakai, M.; Komazawa, K.; Sakurai, H., J.Med.Chem. 1994, 37, 876.
4. Lau, K. H.; Tanimoto, H.; Baylink, D. J., Endocrinology, 1988, 123, 2858.
5. Babko, M.; Wolfe, H. R.; Saha, A.; Dolle, R. E.; Fisher, D. K.; and Higgins, T. J.; Bioorg. Med. Chem. Lett., 1995, 5, 353.
6. Wrobel, J.; Dietrich, A, Tetrahedron Lett. 1993, 34, 3543.
7. Myers, J. K.; Widlanski, T. S.; Science 1993, 262, 1451.
8. Wang, Q.; Dechert, U.; Jirik, F.; Withers, S. G.; Biochem. Biophys. Res. Commun. 1994, 200, 577.
9. Schneider, G.; Lindqvist, Y.; Vihko, P., EMBO J., 1993, 12, 2609.
10. Nishida, S.; J. Org. Chem, 1967, 32, 2692.
11. Weber, E.; Seichter, W.; Goldberg, I. Chem. Ber. 1990, 123, 811.
12. Schwender, C.F.; Beers, S.A.; Malloy, E.; Demarest, K.; Minor, L.; and Lau, K. H. W. Bioorg. Med. Chem. Lett., 1995, 5, 1801.
13. A. Burger, A., U.S. 2,917,533 (Dec. 15, 1959).