Melanoxazal, new melanin biosynthesis inhibitor discovered by using the larval haemolymph of the silkworm, Bombyx mori: Production, isolation, structural elucidation, and biological properties

Journal of Antibiotics

Volumn 49, Issue 6, 1996, Pages 513-518

  Takahashi, Senji ^a   Hashimoto, Ryuju ^a,d   Hamano, Kunikatsu ^b   Suzuki, Tomoo ^c   Nakagawa, Akira ^a  

^a TEIKYO UNIVERSITY   (Japan)

^b TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

^c UTSUNOMIYA UNIVERSITY   (Japan)

^d KISSEI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG; MELANOXAZAL; MONOPHENOL MONOOXYGENASE; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG ISOLATION; DRUG MANUFACTURE; DRUG POTENCY; DRUG STRUCTURE; ENZYME INHIBITION; HEMOLYMPH; LARVA; MELANOGENESIS; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SILKWORM;

EID: 0030018880     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.49.513     Document Type: Article

References (10)

1. HIRUMA, K. & L. M. RIDDIFORD: Molecular mechanisms of cuticular melanization in the tobacco hornworm, Manduca sexta (L.) (Lepidoptera: Sphingidae). Int. J. Insect Morphol. & Embryol. 22: 103-117, 1993
2. ARGOUDELIS, A. D.; F. REUSSER, S. A. MIZSAK & L. BACZYNSKYJ: Antibiotics produced by Streptomyces ficellus. II. Feldamycin and nojirimycin. J. Antibiotics 29: 1007-1014, 1976
3. TOMITA, K.; N. ODA, M. OHBAYASHI, H. KAMEI, T. MIYAKI & T. OKI: A new screening method for melanin biosynthesis inhibitors using Streptomyces bikiniensis. J. Antibiotics 43: 1601-1605, 1990
4. ISHIHARA, Y.; M. OKA, M. TSUNAKAWA, K. TOMITA, M. HATORI, H. YAMAMOTO, H. KAMEI, T. MIYAKI, M. KONISHI & T. OKI: Melanostatin, a new melanin synthesis inhibitor. Production, isolation, chemical properties, structure and biological activity. J. Antibiotics 44: 25-32, 1991
5. KOMIYAMA, K.; S. TAKAMATSU, Y. TAKAHASHI, M. SHINOSE, M. HAYASHI, H. TANAKA, Y. IWAI, S. OMURA & G. IMOKAWA: New inhibitors of melanogenesis, OH-3984 K1 and K2. 1. Taxonomy, fermentation, isolation and biological characteristics. J. Antibiotics 46: 1520-1525, 1993
6. TAKAMATSU, S.; M. C. RHO, M. HAYASHI, K, KOMIYAMA, H. TANAKA, S. OMURA & G. IMOKAWA: New inhibitors of melanogenesis, OH-3984 K1 and K2. II. Physico-chemical properties and structural elucidation. J. Antibiotics 46: 1526-1529, 1993
7. LEE, H. C.; H. KOSHINO, M. C. CHUNG, H. J. LEE & Y. H. KHO: MR304A, a new melanin synthesis inhibitor produced by Trichoderma harzianum. J. Antibiotics 48: 1168-1170, 1995
8. HASHIMOTO, R.; S. TAKAHASHI, K. HAMANO & A. NAKAGAWA: A new melanin biosynthesis inhibitor, melanoxadin from fungal metabolite by using the larval haemolymph of the silkworm, Bombyxmori. J. Antibiotics 48: 1052-1054, 1995
9. HASHIMOTO, R.; S. TAKAHASHI, K. HAMANO, T. MORI & A. NAKAGAWA: New method for screening the melanin biosynthesis inhibitor by using the larval haemolymph of the silkworm, Bombyx mori, and the inhibitory activity of trichoviridin. Biosci. Biotech. Biochem. 58: 1725-1726, 1994
10. PRETSCH, E.; W. SIMON, J. SEIBL & T. CLERC: Tables of Spectral Data for Structure Determination of Organic Compounds. Ed., W. FRESENIUS et al., pp. C135, Springer-Verlag, Berlin, 1989