PCBs do not induce DNA breakage in vitro in human lymphocytes

Mutagenesis

Volumn 11, Issue 4, 1996, Pages 383-389

  Belpaeme, K ^a   Delbeke, K ^a   Zhu, L ^a   Kirsch Volders, M ^a  

^a VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHALASIN B; DIMETHYL SULFOXIDE; DNA; POLYCHLORINATED BIPHENYL;

ARTICLE; CONTROLLED STUDY; DNA STRAND BREAKAGE; GENOTOXICITY; HUMAN; HUMAN CELL; LYMPHOCYTE CULTURE; MICRONUCLEUS TEST; MUTAGEN TESTING; MUTAGENICITY; NORMAL HUMAN; PRIORITY JOURNAL;

ADULT; DNA; DNA DAMAGE; HUMANS; LYMPHOCYTES; MICRONUCLEUS TESTS; MUTAGENICITY TESTS; MUTAGENS; POLYCHLORINATED BIPHENYLS;

EID: 0030018828     PISSN: 02678357     EISSN: None     Source Type: Journal    
DOI: 10.1093/mutage/11.4.383     Document Type: Article

References (50)

1. Al-Sabti, K. (1985) Carcinogenic-mutagenic chemicals induced chromosomal aberrations in the kidney cells of three cyprinids. Comp. Biochem. Physiol., 82C, 489-493.
2. Al-Sabti, K. (1986) Clastogenic effects of five carcinogenic-mutagenic chemicals on cells of the common carp, Cyprinus carpio L. Comp. Biochem. Physiol., 1, 5-9.
3. Ariyoshi, T., Shiiba, S., Hasegawa, H. and Arizono, K. (1990) Effects of the environmental pollutants on heme oxygenase activity and cytochrome P-450 content in fish. Bull. Environ. Contam. Toxicol., 44, 189-196.
4. Bruce, W.R. and Heddle, J.A. (1979) The mutagenic activity of 61 agents as determined by the micronucleus, Salmonella, and sperm abnormality assays. Can. J. Genet. Cytol., 21, 319-334.
5. Butterworth, F.M., Pandey, P., McGowen, R.M., Ali-Sadat, S. and Walia, S. (1995) Genotoxicity of polychlorinated biphenyls (PCBs): recombinogenesis by biotransformation products. Mutat. Res., 342, 61-69.
6. Chadwick, R.W., George, S.E., Kohan, M.J., Williams, R.W., Allison, J.C., Hayes, Y.O. and Chang, J. (1993) Potentiation of 2,6-dinitrotoluene genotoxicity in Fischer-344 rats by pretreatment with Aroclor 1254. Toxicology, 80, 153-171.
7. Darnerd, P.O. and Brandt, I. (1986) 3,3′,4,4′-Tetrachlorobiphenyl in pregnant mice enrichment of phenol and methyl sulphone metabolites in late gestational fetuses. Xenobiotica, 16, 295-306.
8. De Voogt, P., Wells, D.E., Reutergardh, L. and Brinkman, U.A.TH. (1990) Biological activity, determination and occurrence of planar, mono- and diortho PCBs. Int. J. Environ. Anal. Chem., 40, 1-46.
9. Dunkel, V.C., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H.S. and Simmon, V.F. (1984) Reproducibility of microbial mutagenicity assays: I. Tests with S.typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen., 6(Suppl. 2), 1-254.
10. Fernandez, M., Gauthier, L. and Jaylet, A. (1989) Use of newt larvae for in vivo genotoxicity testing of water: results on 19 compounds evaluated by the micronucleus test. Mutagenesis, 4, 17-26.
11. Garthoff, L.H., Friedman, L., Farber, T.M., Locke, K.K., Sobotka, T.J., Green, S., Hurley, N.E., Peters, E.L., Story, G.E., Moreland, F.M., Graham, C.H., Keys, J.E., Taylor, M.J., Scalera, J.V., Rothlein, J.E., Marks, E.M., Cerra, F.E., Rodi, S.B. and Sporn, E.M. (1977) Biochemical and cytogenetic effects in rats caused by short-term ingestion of Aroclor 1254 or Firemaster BP6. J. Toxicol. Environ. Hlth, 3, 769-796.
12. Green, S., Carr, J.V., Palmer, K.A. and Oswald, E.J. (1975b) Lack of cytogenetic effects in bone marrow and spermatogonial cells in rats treated with polychlorinated biphenyls (Aroclor 1242 and 1254). Bull. Environ. Toxicol., 13, 14-22.
13. Green, S., Sauro, F.M. and Friedman, L. (1975a) Lack of dominant lethality in rats treated with polychlorinated biphenyls (Aroclor 1242 and 1254). Food Cosmet. Toxicol., 13, 507-510.
14. Haworth, S., Lawlor, T., Mortelmans, K., Speck, W. and Zeiger, E. (1983) Salmonella mutagenicity test results for 250 chemicals. Environ. Mutagen. Suppl., 1, 3-142.
15. Heddle, J.A., Cimino, M.C., Hayashi, M., Romagna, F., Shelby, M.D., Tucker, J.D., Vanparys, P. and MacGregor, J.T. (1991) Micronuclei as an index of cytogenetic damage: past, present, and future. Environ. Mol. Mutagen., 18, 277-291.
16. Hoopengarner, R., Samuel, A. and Krause, D. (1972) Polychlorinated biphenyl interactions with tissue culture cells. Environ. Hlth Perspect., 1, 155.
17. Hsia, M.T.S., Lin, F.S.D. and Allen, J.R. (1978) Comparative mutagenicity and toxic effects of 2,5,2′,5′-tetrachlorobiphenyl and its metabolites in bacterial and mammalian test systems. Res. Commun. Chem. Pathol. Pharmacol., 21, 485-496.
18. McKelvey-Martin, V.J., Green, M.H.L., Schmezer, P., Pool-Zobel, B.L., De Méo, M.P. and Collins, A. (1993) The single cell gel electrophoresis assay (comet assay): a European review. Mutat. Res., 288, 47-63.
19. Meisner, L.F., Roloff, B., Sargent, L. and Pitot, H. (1992) Interactive cytogenetic effects on rat bone-marrow due to chronic ingestion of 2,5,2′,5′ and 3,4,3′,4′ PCBs. Mutat. Res., 283, 179-183.
20. Millisher, R., Girault, F., Heywood, R., Clarke, G., Hossack, D. and Clair, M. (1979) Decabromobiphenyl: toxicological study. Toxicol. Eur. Res., 2, 155-161.
21. Murk, A., Morse, D., Boon, J. and Brouwer, A. (1994) In vitro metabolism of 3,3′,4,4′-tetrachlorobiphenyl in relation to ethoxyresorufin-O-deethylase activity in liver microsomes of some wildlife species and rat. Environ. Toxicol. Pharmacol., 270, 253-261.
22. Natarajan A.T. and Obe G. (1986) How do in vivo mammalian assays compare to in vitro assays in their ability to detect mutagens. Mutat. Res., 167, 189-201.
23. Nath, R.G., Randerath, E. and Randerath, K. (1991) Short-term effects of the tumor promoting polychlorinated biphenyl mixture, Aroclor 1254, on I-compounds in liver, kidney and lung DNA of male Sprague-Dawley rats. Toxicology, 68, 275-289.
24. Nilsson, B. and Ramel, C. (1974) Genetic tests on Drosophila melanogaster with polychlorinated biphenyls. Hereditas, 77, 319-322.
25. Odashima, S. (1976) The cooperative development in Japan of methods for screening chemicals for carcinogeicity. In Bartsch, R. and Tomatis, L. (eds), Screening Tests for Chemical Carcinogenesis. IARC, Lyon, Scientific Publication no. 12, pp. 61-75.
26. Olive, R.L. and Durand, R.E. (1992) Detection of hypoxic cells in a murine tumor with the use of the comet assay. J. Natl Cancer Inst., 84, 9, 707-711.
27. Peakall, D.B., Linder, J.L. and Bloom, S.E. (1972) Embryotic mortality and chromosomal alternations caused by Aroclor 1254 in ring doves. Environ. Hlth Perspect., 1, 103-104.
28. Pienta, R.J. (1980) Transformation of Syrian hamster embryo cells by diverse chemicals and correlation with their reported carcinogenic and mutagenic activities. Chem. Mutagens, 6, 175-202.
29. Poland, A. and Glover, E. (1980) 2,3,7,8-Tetrachlorodibenzo-p-dioxin: segregation of toxicity with the Ah locus. Ann. Mol. Pharmacol., 17, 86-94.
30. Safe, S. (1984) Polychloronated biphenyls (PCBs) and polybrominated biphenyls (PBBs): biochemistry, toxicology, and mechanism of action. Crit. Rev. Toxicol., 13, 319-395.
31. Safe, S. (1989) Polychlorinated biphenyls (PCB's): mutagenicity and carcinogenicity. Mutat. Res., 220, 31-47.
32. Safe, S. (1992) Toxicology, structure-function relationship, and human and environmental health impacts of polychlorinated biphenyls: progress and problems. Environ. Hlth Perspect., 100, 259-268.
33. Safe, S., Bandiera, S., Sawyer, T., Robertson, L., Safe, L., Parkinson, A., Thomas, P.E., Ryan, D.E., Reik, L.M., Levin, W., Denomme, M.A. and Fujita, T. (1985) PCBs: structure-function relationships and mechanism of action. Environ. Hlth Perspect., 60, 47-56.
34. Sargent, L., Roloff, B. and Meisner, L. (1989) In vitro chromosome damage due to PCB interactions. Mutat. Res., 224, 79-88.
35. Schoeny, R. (1982) Mutagenicity testing of chlorinated biphenyl and chlorinated dibenzofurans. Mutat. Res., 101, 45-56.
36. Schoeny, R.S., Smith, C.C., and Loper, J.C. (1979) Non-mutagenicity for Salmonella of the chlorinated hydrocarbons Aroclor 1254, 1,2,4-trichlorobezene, mitrex and kepone. Mutat. Res., 68, 125-132.
37. Shahin, M.M., Andrillon, P., Goetz, N., Bore, P., Bugaut, A. and Kalopissis, G. (1979) Studies on the mutagenicity of p-phenylenediamine in S.typhimurium. Presence of PCB's in rat-liver microsomal fraction induced by Aroclor. Mutat. Res., 68, 327-336.
38. Silberhorn, E.M., Glauert, H.P. and Robertson, L.W. (1990) Carcinogenicity of polyhalogenated biphenyls: PCBs and PBBs. Crit. Rev. Toxicol., 20, 6, 439-496.
39. Singh, N.P., McCoy, M.T., Tice, R.R. and Schneider, E.L. (1988) A simple technique for quantitation of low levels of damage in individual cells. Exp. Cell Res., 175, 184-191.
40. Stadnicki, S.S., Lin, F.S.D. and Allen, J.R. (1979) DNA single strand breaks caused by 2,2′,5,5′-tetrachlorobiphenyl and its metabolites. Res. Commun. Chem. Pathol Pharmacol., 24, 313.
41. Tice, R.R. (1995) The single cell gel/comet assay: a microgel electrophoretic technique for the detection of DNA damage and repair in individual cells. Environ. Mutagen., in press.
42. Vian, L., Bichet, N. and Gouy, D. (1993) The micronucleus test on isolated human lymphocytes. Mutat Res., 291, 93-102.
43. Vijayalaxmi, R., Tice, R. and Strauss, G.H.S. (1992) Assessment of radiation-induced DNA damage in human blood lymphocytes using the single cell gel technique. Mutat. Res., 271, 243-252.
44. Wassom, J.S., Huff, J.E. and Loprieno, N. (1978) A review of the genetic toxicology of chlorinated dibenzo-p-dioxins. Mutat. Res., 47, 141-160.
45. Watanabe, M., Honda, S., Hayashi, M. and Matsuda, T. (1982) Mutagenic effects of combinations of chemical carcinogens and environmental pollutants in mice as shown by the micronucleus test. Mutat. Res., 97, 43-48.
46. Wong, A., Basrur, P.K. and Safe, S. (1979) The metabolically mediated DNA damage and subsequent repair by 4-chlorobiphenyl in Chinese hamster ovary cells. Res. Commun. Chem. Pathol. Pharmacol., 24, 543-570.
47. Wyndham, C., Devenish, J. and Safe, S. (1976) The in vitro metabolism, macromolecular binding and bacterial mutagenicity of 4-chlorobiphenyl, a model PCB substrate. Res. Commun. Chem. Pathol. Pharmacol., 15, 563-570.
48. Wyndham, C. and Safe, S. (1978) In vitro metabolism of 4-chlorobiphenyl by control and induced rat liver microsomes. Biochemistry, 17, 208-215.
49. Yoshimura, H. and Yamamoto, H. (1973) Metabolic studies on polychlorinated biphenyls, I. Metabolic fate of 3,4,3′,4′-tetrachlorobiphenyl in rats. Chem. Pharmacol. Bull., 21, 1168-1169.
50. Zeiger, E., Anderson, B., Haworth, S., Lawlor, T. and Mortelmans, K. (1988) Salmonella mutagenicity tests: IV. Results from the testing of 300 chemicals. Environ. Mol. Mutagen., 11(Suppl. 12), 1-157.