Elevated expression levels of an Ig transgene in mice links the IgH 3' enhancer to the regulation of IgH expression

International Immunology

Volumn 8, Issue 7, 1996, Pages 1149-1157

  Arulampalam, Velmurugesan ^a   Furebring, Christina ^b   Samuelsson, Annika ^a   Lendahl, Urban ^a   Borrebaeck, Carl ^b   Lundkvist, Inger ^c   Pettersson, Sven ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b LUND UNIVERSITY   (Sweden)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Ig gene regulation; IgH enhancers; Locus control region; Transgenic mice

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; MONOCLONAL ANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY PRODUCTION; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; ENHANCER REGION; GENE EXPRESSION; GENE LOCUS; GENE REARRANGEMENT; HYBRIDOMA; IMMUNIZATION; IMMUNOGLOBULIN GENE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; RNA ANALYSIS; TRANSCRIPTION REGULATION; TRANSGENE;

EID: 0030018779     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/8.7.1149     Document Type: Article

References (46)

1. Lefranc, G. and Lefranc, M. P. 1990. Regulation of the immunoglobulin gene transcription. Biochimie 72:7.
2. H gene promoter that includes a functional consensus sequence. Cell 41:479.
3. Grosschedl, R. and Baltimore, D. 1985. Cell-type specificity of immunoglobulin gene expression is regulated by at least three DMA sequence elements. Cell 41:885.
4. Pettersson, S., Cook, G P., Bruggemann, M., Williams, G. T. and Neuberger, M. S. 1990. A second B cell-specific enhancer 3′ of the immunoglobulin heavy-chain locus. Nature 344:165.
5. Dariavach, P., Williams, G. T., Campbell, K., Pettersson, S and Neuberger, M. S. 1991, The mouse IgH 3′-enhancer Eur. J. Immunol. 21:1499.
6. Lieberson, R., Giannini, S. L., Birshtein, B. K. and Eckhardt, L. A. 1991. An enhancer at the 3′ end of the mouse immunoglobulin heavy chain locus. Nucleic Acids Res. 19:933.
7. Matthias, P. and Baltimore, D. 1993. The immunoglobulin heavy chain locus contains another B-cell-specific 3′ enhancer close to the alpha constant region. Mol. Cell. Biol. 13:1547.
8. Madisen, L. and Groudine, M. 1994. Identification of a locus control region in the immunoglobulin heavy-chain locus that deregulates c-myc expression in plasmacytoma and Burkitt's lymphoma cells. Genes Dev. 8:2212.
9. Forrester, W. C., van Gederen, C., Jenuwein, T. and Grosschedl, R. 1994. Dependence of enhancer mediated transcription of the immunoglobulin mu gene on nuclear matrix attachment regions. Science 265:1221.
10. Grant, P. A., Arulampalam, V., Ahrlund-Richter, L. and Pettersson, S. 1992. Identification of Ets-like lymphoid specific elements within the immunoglobulin heavy chain 3′ enhancer. Nucleic Acids Res. 20:4401.
11. Arulampalam, V., Grant, P. A., Samuelsson. A., Lendahl, U. and Pettersson, S. 1994. Lipopolysaccharide-dependent transactivation of the temporally regulated immunoglobulin heavy chain 3′ enhancer, Eur. J. Immunol. 24:1671.
12. Meyer, K. B., Skogberg, M., Margenfeld, C., Ireland, J. and Pettersson, S. 1995. Repression of the immunoglobulin heavy chain 3′ enhancer by helix-loop-helix protein Id3 via a fuctionally important E47/E12 binding site: implications for developmental control of enhancer function. Eur J. Immunol. 25:1770
13. Neurath, M. F., Max, E. E. and Strober, W. 1995. Pax5 (BSAP) regulates the murine immunoglobulin 3′ alpha enhancer by suppressing binding of NF-alpha P, a protein that controls heavy chain transcription. Proc. Natl Acad Sci. USA 92:5336.
14. Grant, P., Thompson, C. B. and Pettersson, S, 1995. IgM receptor mediated transactivation of the IgH 3′ enhancer couples a novel Elf-AP-1 protein complex to the development control of enhancer function. EMBO J., 14:4501.
15. Serwe, M. and Sablitzky, F. 1993, V(D)J recombination in B cells is impaired but not blocked by targeted deletion of the immunogiobulin heavy chain intron enhancer. EMBO J, 12:2321.
16. Gu, H., Zou, Y R. and Rajewsky, K. 1993. Independent control of immunogiobulin switch recombination at individual switch regions evidenced through Cre-loxP mediated gene targetting. Cell 73:1155.
17. Cogné, M., Lansford, R., Bottaro. A., Zhang, J., Gorman, J., Young. F., Cheng, H. L. and Alt, F. W. 1994. A class switch region at the 3′ end of the immunogiobulin heavy chain locus. Cell 77:737.
18. Grosschedl, R., Weaver, D., Baltimore, D. and Costantini, F. 1984. Introduction of a mu immunogiobulin gene into the mouse germ line: specific expression in lymphoid cells and synthesis of functional antibody. Cell 38:647.
19. Weaver, D., Costantini, F., Imanishi-Kari, T. and Baltimore, D. 1985. A transgenic immunogiobulin mu gene prevents rearrangement of endogenous genes. Cell 42:117.
20. Rusconi, S. and Kohler, G. 1985. Transmission and expression of a specific pair of rearranged immunogiobulin mu and kappa genes in a transgenic mouse line. Nature 314:330.
21. Nussenzweig, M. C., Shaw, A. C., Sinn, E., Danner, D. B., Holmes, K. L., Morse, H. and Leder, P. 1987 Allelic exclusion in transgenic mice that express the membrane form of immunogiobulin mu Science 236:816.
22. Stall, A. M., Kroese, F. G., Gadus, F. T., Sieckmann, D. G., Herzenberg, L. A. and Herzenberg, L. A. 1988. Rearrangement and expression of endogenous immunogiobulin genes occur in many murine B cells expressing transgenic membrane IgM. Proc. Natl Acad. Sci. USA 85:3546.
23. Neuberger, M. S., Caskey, H. M., Pettersson S., Williams, G. T. and Surani, M. A. 1989. Isotype exclusion and transgenic down-regulation in immunoglobulin-lambda1 transgenic mice. Nature 338:350.
24. Pettersson, S., Sharpe, M. J., Gilmore, D, R., Surani, M. A. and Neuberger, M. S. 1989. Cellular selection leads to age-dependent and reversible down-regulation of transgenic immunogiobulin light chain genes. Int. Immunol. 1:509.
25. Lieberson, R., Ong, J., Shi, X. and Eckhardt, L. A. 1995. Immunogiobulin gene transcription ceases upon deletion of a distant enhancer. EMBO J. 14:6229.
26. Neuberger, M. S. 1983. Expression and regulation of immunogiobulin heavy chain gene transfected into lymphoid cells. EMBO J. 2:1373.
27. Sharpe, M. J., Neuberger, M., Pannell, R., Surani, M. A. and Milstein, C. 1990. Lack of somatic mutation in a kappa light chain transgene. Eur. J. Immunol. 20:1379.
28. Cook, G. P., Meyer, K. B., Neuberger, M. S. and Pettersson, S. 1995. Regulated activity of the IgH intron enhancer (E mu) in the T lymphocyte lineage. Int. Immunol. 7:89.
29. Yuan, D., Dang, T., Hawley, J., Jenuwein, T. and Grosschedl, R. 1995. Role of the OCTA site in regulation of IgH chain gene transcription during B cell activation. Int. Immunol. 7:1163.
30. Thompson, C. B., Wang, C. Y, Ho, I. C., Bohjanen, P. R., Petryniak, B., June, C. H., Miesfeldt, S., Zhang, L., Nabel, G. J., Karpinski, B., et al. 1992. cis-acting sequences required for inducible interleukin-2 enhancer function bind a novel Ets-related protein Elf-1. Mol Cell. Biol. 12:1043.
31. Jenuwein. T. and Grosschedl, R. 1991. Complex pattern of immunoglobulin mu gene expression in normal and transgenic mice: nonoverlapping regulatory sequences govern distinct tissue specificities. Genes Dev. 5:932.
32. Weinberger, J., Parmjit, S. J. and Sharp, P. A. 1988. Localization of a repressive sequence contributing to B-cell specificity in the immunoglobulin heavy-chain enhancer. Mol, Cell. Biol. 8:988.
33. Scheuermann, R. H. and Chen, U. 1989. A developmental-specific factor binds to suppressor sites flanking the immunoglobulin heavy-chain enhancer. Genes Dev. 3:1255.
34. Neurath, M. F., Strober, W., and Wakatsuki, Y. 1994. The murine Ig 3′ alpha enhancer is a target site with represser function for the B cell lineage-specific transcription factor BSAP (NF-HB, S alpha-BP). J. Immunol. 153:730.
35. Corcoran, L. M., Karvelas, M., Nossal, G. J. V., Ye, Z.-S., Jacks, T. and Baltimore, D. 1993. Oct-2, although not required for early B-cell development, is critical for later B-cell maturation and for postnatal survival. Genes Dev. 7:570.
36. Corcoran, L. M. and Karvelas, M. 1994. Oct-2 is required early in T cell-independent B cell activation for G1 progression and proliferation. Immunity 1:635.
37. Gerster, T., Picard, D. and Schaffner, W. 1986. During B-cell differentiation enhancer activity and transcription rate of immunoglobulin heavy chain genes are high before mRNA accumulation. Cell 45:45
38. Gerster, T., Picard, D. and Schaffner, W. 1986. During B-cell differentiation enhancer activity and transcription rate of immunoglobulin heavy chain genes are high before mRNA accumulation. Cell 45:45.
39. Caterina, J. J., Ryan, T. M., Pawlik, K. M., Palmiter, R. D., Brinster, R. L., Behringer, R. R. and Townes, T. M. 1991. Human beta-globin locus control region: analysis of the 5′ DNase I hypersensitive site HS 2 in transgenic mice. Proc. Natl Acad. Sci. USA 88:1626.
40. Fraser, P., Pruzina, S., Antoniou, M. and Grosveld, F. 1993. Each hypersensitive site of the human beta-globin locus control region confers a different developmental pattern of expression on the globin genes. Genes Dev. 7 106.
41. Wijgerde, M., Grosveld, F. and Fraser, P. 1995. transcription complex stability and chromatin dynamics in vivo. Nature 377:209.
42. Giannini, S. L., Singh, M., Calvo, C. F, Ding, G. and Birshtein, B. K. 1993, DNA regions flanking the mouse Ig 3′ alpha enhancer are differentially methylated and DNAase I hypersensitive during B cell differentiation, J. Immunol. 150:1772.
43. Pettersson, S., Grant, P., Andersson, A., Faxen, M., Samuelsson, A., Skogberg, M. and Arulampalam, V. 1995. The 3′ end of the IgH locus: an important regulator of B-lymphoid development. The Immunologist 3:146.
44. Harriman, W., Volk, H., Defranoux, N. and Wabl, M. 1993. Immunoglobulin class switch recombination. Annu. Rev. Immunol. 11:361.
45. Rajewsky, K., Forster, I. and Cumano, A. 1987. Evolutionary and somatic selection of the antibody repertoire in the mouse. Science 238:1088.
46. Brüggemann, M. Williams, G. T., Bindon, C. I., Clark, M. R., Walker, M. R., Jefferis, R., Waldman, H., Neuberger, M. S. 1987. Comparison of the effector functions of human immunoglobulins using a matched set of chimeric antibodies. J Exp. Med. 166:1351.