Further minor metabolites of staurosporine produced by a Streptomyces longisporoflavus strain

Journal of Antibiotics

Volumn 49, Issue 6, 1996, Pages 519-526

  Cai, Yang ^a,b   Fredenhagen, Andreas ^a   Hug, Paul ^a   Meyer, Thomas ^a   Peter, Heinrich H ^a  

^a CIBA GEIGY LTD   (Switzerland)

^b PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN KINASE C; STAUROSPORINE DERIVATIVE; TAN 1030A; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG ISOLATION; DRUG POTENCY; DRUG STRUCTURE; ENZYME INHIBITION; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STREPTOMYCES;

EID: 0030018778     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.49.519     Document Type: Article

References (18)

1. NISHIZUKA, Y.: The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Nature 334: 661-665, 1988
2. NISHIZUKA, Y.: The role of protein kinase C in cell surface signal transduction and tumor promotion. Nature 308: 693-698, 1984
3. OMURA, S.; Y. IWAI, A. HIRANO, A. NAKAGAWA, J. AWAYA, H. TSUCHIYA, Y. TAKAHASHI & R. MASUMA: A new alkaloid AM-2282 of Streptomyces origin. Taxonomy, fermentation, isolation and preliminary characterization. J. Antibiotics 30: 275-282, 1977
4. TAMAOKI, T.; H. NOMOTO, I. TAKAHASHI, Y. KATO, M. MORIMOTO & F. TOMITA: Staurosporine, a potent inhibitor of phospholipid/calcium dependent protein kinase. Biochem. Biophys. Res. Commun. 135: 397-402, 1986
5. FUNATO, N.; H. TAKAYANAGI, Y. KONDO, Y. TODA, Y. HARIGAYA, Y. IWAI & S. OMURA: Absolute configuration of Staurosporine by X-ray analysis. Tetrahedron Lett. 1994: 1251-1254, 1994
6. NYE, S. H.; S. P. SQUINTO, D. J. GLASS, T. N. STITT, P. HANTZOPOULOS, M. J. MACCHI, N. S. LINDSAY, N. Y. IP & G. D. YANCOPOULOS: K-252a and Staurosporine selectively block autophosphorylation of neurotropin receptors and neurotropin-mediated responses. Mol. Biol. Cell 3: 677-686, 1992
7. UTZ, I.; S. HOFER, U. REGENASS, W. HILBE, J. THALER, H. GRUNICKE & J. HOFMANN: The protein kinase C inhibitor CGP 41251, a staurosporine derivative with antitumor activity, reverses multidrug resistance. Int. J. Cancer 57: 104-110, 1994
8. WAKUSAWA, S.; K. INOKO, K. I. MIYAMOTO, S. KAJITA, T. HASEGAWA, K. HARIMAYA & M. KOYAMA: Staurosporine derivatives reverse mutlidrug resistance without correlation with their protein kinase inhibitory activities. J. Antibiotics 46: 353-355, 1993
9. MEYER, T.; U. REGENASS, D. FABBRO, E. ALTERI, J. RÖSEL, M. MÜLLER, G. CARAVATTI & A. MATTER: A derivative of staurosporine (CGP 41251) shows selectivity for protein kinase C inhibition and in vitro anti-proliferative as well as in vivo anti-tumor activity. Int. J. Cancer 43: 851-856, 1989
10. DAVIS, P. D.; C. H. HILL, E. KEECH, G. LAWTON, J. S. NIXON, A. D. SEDGWICK, J. WADSWORTH, D. WESTMACOTT & S. E. WILKINSON: Potent selective inhibitors of protein kinase C. FEBS Lett. 259: 61-63, 1989
11. CAI, Y.; A. FREDENHAGEN, P. HUG & H. H. PETER: A nitro analogue of staurosporine and other minor metabolites produced by a Streptomyces longisporoflavus strain. J. Antibiotics 38: 143-148, 1995
12. TANIDA, S.; M. TAKIZAWA, T. TAKAHASHI, S. TSUBOTANI & S. HARADA: TAN-999 and TAN-1030A, new indolo-carbazole alkaloids with macrophage-activating properties. J. Antibiotics 42: 1619-1630, 1989
13. TAKAHASHI, I.; Y. SAITOH, M. YOSHIDA, H. SANO, H. NAKANO, M. MORIMOTO & T. TAMAOKI: UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physicochemical properties, structural determination and biological activities. J. Antibiotics 42: 571-576, 1989
14. CARAVATII, G.; T. MEYER, A. FREDENHAGEN, U. TRINKS, H. METT & D. FABBRO: Inhibitory activity and selectivity of staurosporine derivatives towards protein kinase C. Bioorg. Med. Chem. Letters 4: 399-404, 1994
15. YASUZAWA, T.; T. IIDA, M. YOSHIDA, N. HIRAYAMA & M. TAKAHASHI: The structures of the novel protein kinase C inhibitors K-252a, b, c, and d. J. Antibiotics 39: 1072-1078, 1986
16. KOSHINO, H.; H. OSADA & K. ISONO: A new inhibitor of protein kinase C, RK-1409 (7-oxostaurosporine). II. Fermentation, isolation, physico-chemical properties, and structure. J. Antibiotics 45: 195-198, 1992
17. GHISALBA, O. & P. HOEHN-THIERRY: Personal communication
18. CAI, Y.; A. FREDENHAGEN, P. HUG & H. H. PETER: The staurosporine producing strain Streptomyces longisporoflavus produces metabolites related to K252a. Evidence for the biosynthetic pathway of K252a. J. Antibiotics, submitted